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Edible Red Seaweed Hypnea asiatica Ameliorates High-Fat Diet-Induced Metabolic Diseases in Mice
Shigeru Murakami,Chihiro Hirazawa,Toshiki Mizutani,Takuma Ohya,Rina Yoshikawa,Ning Ma,Takahiko Ikemori,Takashi Ito,Chiaki Matsuzaki 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.11
Metabolic diseases, including obesity, diabetes, and fatty liver disease, are dramatically increasing around theworld. Seaweed is low in calories and rich in many active ingredients that are necessary for maintaining good health, and isexpected to be effective for preventing metabolic diseases. The purpose of this study was to examine the effects of a traditionalJapanese edible seaweed Hypnea asiatica (H. asiatica) on obesity, using a mouse model. H. asiatica was dried andpowdered, mixed with a high-fat diet, and fed to male C57BL/6J mice for 13 weeks. On the last day of the experiment, bloodsamples were collected under anesthesia and biochemical parameters such as lipids and adipokines were measured. Liver andadipose tissue were excised, weighed, and oxidant/antioxidant parameters were measured. Some mice were perfused with afixative solution containing formalin, and tissue specimens were prepared. A glucose tolerance test was used to assess insulinresistance. The inhibition of lipase activity was evaluated in vitro. Thirteen-week supplementation with H. asiatica suppressedbody weight gain, body fat accumulation, and blood glucose levels. H. asiatica also improved fatty liver and hypercholesterolemia,and reduced the oxidant and inflammatory parameters of serum and liver. H. asiatica increased fecal triglycerideexcretion and polyphenol-rich ethanol extract of H. asiatica inhibited lipase activity in vitro. These results suggest thatpolysaccharides and polyphenols in H. asiatica may ameliorate obesity and diabetes by inhibiting intestinal fat absorption andreducing oxidative stress and inflammation. H. asiatica may be useful in preventing metabolic diseases such as obesity,diabetes, and fatty liver.
Towards the Creation of an ECU Model Exchange Market
Kazuaki Murakami,Norifumi Yoshimatsu,Pradeep Rao,Shigeru Oho,Satoshi Shimada 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
Model based design can be used to address the challenges brought about by complex ECU designs. This paper introduces the use of models at various stages of ECU design and highlights their advantages. We particularly focus on the use of software models in ECU design and discuss their classification based on their use in the embedded system design flow. We discuss some of the issues involved in the use of the software models in ECU design and identify directions for research to facilitate greater use of software models in mainstream ECU design.
A System Concept for EFD/CFD Integration
Shigeya Watanabe,Shigeru Kuchi-ishi,Hiroyuki Kato,Takeshi Aoyama,Keiichi Murakami,Atsushi Hashimoto,Naoyuki Fujita,Yuichi Matsuo 한국항공우주학회 2008 한국항공우주학회 학술발표회 논문집 Vol.- No.-
A trail towards integration of EFD (Experimental Fluid Dynamics) and CFD (Computational Fluid Dynamics), that is. the development of a system called Digital/Analog Hybrid Wind Tunnel, is introduced. The aim of the system is to improve efficiency, accuracy, and reliability of aerodynamic characteristics evaluation in aerospace vehicle developments through mutual support between EFD and CFD. The function of the system consists of optimization of test planning utilizing pretest CFD calculations, an accurate correction of the wind tunnel wall and support interaction effects through CFD, CFD data refinement based on EFD data, the most probable aerodynamic characteristics estimation based on both EFD and CFD data, database including EFD and CFD data at an identical condition, and so forth. Key technical challenges in the system development, such as an automatic grid generation and high-speed solver development for CFD, a highly efficient data reduction technique for image measurement data. and techniques integrating EFD and CFD. are addressed.
Iseki, Mineo,Matsunaga, Shigeru,Murakami, Akio,Ohno, Kaoru,Shiga, Kiyoshi,Yoshida, Kazuichi,Sugai, Michizo,Takahashi, Tetsuo,Hori, Terumitsu,Watanabe, Masakatsu Korean Society of Photoscience 2002 Journal of Photosciences Vol.9 No.2
Euglena gracilis abruptly changes its swimming direction after a sudden increase or decrease in incident light intensity, that is, step-up or step-down photophobic responses, resulting in photoavoidance or photoaccumulation, respectively. To identify the photoreceptor molecules for these UV-A/blue-light type photobehaviors, we purified a flavoprotein from isolated putative photosencory organelles (PFBs) of Euglena. The purified flavoprotein, which noncovalently bound flavin adenine dinucleotide (FAD), seemed to be a heterotetramer of alpha- and beta-subunits. Predicted amino acid sequences of each of the subunits were similar to each other and contained two FAD-binding domains each followed by an adenylyl cyclase catalytic domain. The purified flavoprotein actually showed adenylyl cyclase activity, being drastically elevated by blue-light irradiation. Suppression of gene expression of the flavoprotein (Photoactivated Adenylyl Cyclase, PAC) by RNA interference (RNAi) caused loss of the step-up photophobic response, demonstrating that PAC actually mediates photoavoidance of Euglena.
Kaoru Yamashita,Akira Tsuchitani,Hideyuki Murakami,Masanori Okuyama,Shigeru Arita,Tsunehisa Tanaka,Yaowu Mo,Yoshihiko Suzuki 한국물리학회 2003 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.42 No.IV
Arrayed ultrasonic microsensors using piezoelectric PZT (Pb(Zr,Ti)O3) thin lms on micromachined silicon diaphragms have been fabricated and combined with BBD (Backet Brigade Device) for signal processing. The ultrasonic sensors are designed to compose an electrical phased array for three-dimensional object detection in air. The resonant frequencies of the elements were scattered in the error range of 12 % and the objects could not be detected due to the beat in the sum of delayed element waveforms. Each element has been tuned by adequate poling less than 10 V to make its resonant frequency equal to a center value. The frequency scattering was reduced within the range of 2 % and the tuned array could give the objects by summing up of the delayed signals. Three-dimensional object detection has been demonstrated using the tuned sensor combined with the BBD delay circuit.4