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Kim, Min Ju,Rehman, Shafiq Ur,Amin, Faiz Ul,Kim, Myeong Ok Elsevier 2017 Nanomedicine Vol.13 No.8
<P><B>Abstract</B></P> <P>Amyloid-beta (Aβ<SUB>1-42</SUB>) plaques and neurofibrillary tangles (NFTs) are the main hallmarks considered to be associated with neuroinflammation in Alzheimer's disease (AD). Recently, nanoparticle-based targeted drug delivery approaches have been found to be a useful tool in the neurotherapeutics field. Therefore, we examined and compared the neuroprotective effect of anthocyanins alone and anthocyanin-loaded poly (ethylene glycol)-gold nanoparticles (PEG-AuNPs) in Aβ<SUB>1-42</SUB>-injected mouse and <I>in vitro</I> models of AD. We determined that anthocyanins alone or conjugated with PEG-AuNPs (AnPEG-AuNPs) reduced Aβ<SUB>1-42</SUB>-induced neuroinflammatory and neuroapoptotic markers via inhibiting the p-JNK/NF-κB/p-GSK3β pathway in both <I>in vivo</I> and <I>in vitro</I> AD models. However, anthocyanins loaded with PEG-AuNPs were more effective compared to anthocyanins alone. Taken together, these results demonstrate that PEG-coated gold anthocyanins nanoparticles could be a new therapeutic agent in the field of nanomedicine to prevent neurodegenerative diseases such as AD.</P> <P><B>Graphical Abstract</B></P> <P>This study addresses the enhanced delivery of the anthocyanins loaded with PEG-gold nanoparticles in the mice brain. Herein, the particles can penetrate the BBB with less toxicity profiles and enhance neuroprotection against β-amyloid <SUB>1-42</SUB> induced neuroinflammation and neurodegeneration. In this study the anthocyanins loaded PEG-gold nanoparticles are more effective as compared to anthocyanins alone.</P> <P>[DISPLAY OMISSION]</P>
Ijlal Haider,Habib-ur-Rehman Khalid,Umair Shafiq Khan 제어로봇시스템학회 2014 제어로봇시스템학회 국제학술대회 논문집 Vol.2014 No.10
This paper estimates the performance of a Conventional PID versus Fuzzy Logic based PID for the process of controlling Non-Linear SI-Engine Speed and AFR (Air to Fuel Ratio). Dynamic SI Engine Model regarding Speed and AFR is discussed, and Fuzzy Logic PID control is shown to have better performance over Conventional PID control algorithm. Design and Simulation Results are shown using MATLAB/Simulink.
Ali, Tahir,Kim, Min Ju,Rehman, Shafiq Ur,Ahmad, Ashfaq,Kim, Myeong Ok Springer-Verlag 2017 Molecular Neurobiology Vol.54 No.8
<P>Nanomedicine is an emerging research area. In this study, we investigated the neuroprotective efficacy of anthocyanin-loaded polyethylene glycol-gold nanoparticles (PEG-AuNPs) for enhancing the neuroprotective efficacy of anthocyanins in an amyloid beta (A beta)(1-42) mouse model of Alzheimer's disease. We observed that both anthocyaninloaded PEG-AuNPs and anthocyanins treatment (12 mu g/g/day for 14 days) ameliorated memory impairments in the A beta(1-42)-injected mice. However, the anthocyanin-loaded PEG-AuNPs were more effective than free anthocyanins. Anthocyanin-loaded PEG-AuNPs protected pre-and post-synaptic proteins from A beta(1-42)-induced synaptic dysfunction. Interestingly, the anthocyanin-loaded PEG-AuNPs also regulated the p-PI3K/p-Akt/p-GSK3 beta pathway and, as a result, prevented the hyperphosphorylation of tau protein at serines 413 and 404 in the A beta(1-42)-injected mice. Western blot results of cytochrome c, Bax/Bcl2, caspases and poly (ADP-ribose) polymerase-1 expression levels, and immunohistochemical Nissl and Fluoro-Jade B staining also indicated that the anthocyanin-loaded PEG-AuNPs inhibited apoptosis and neurodegeneration in the A beta(1-42)-injected mice. Our results suggest that the conjugation of dietary polyphenolic compounds with gold nanoparticles, such as anthocyanin-loaded PEG-AuNPs, is a novel approach that may represent an important and promising nanomedicine strategy to prevent age-associated neurodegenerative diseases.</P>
An Innovative Approach to Track Moving Object based on RFID and Laser Ranging Information
( Gaoli Liang ),( Ran Liu ),( Yulu Fu ),( Hua Zhang ),( Heng Wang ),( Shafiq Ur Rehman ),( Mingming Guo ) 한국인터넷정보학회 2020 KSII Transactions on Internet and Information Syst Vol.14 No.1
RFID (Radio Frequency Identification) identifies a specific object by radio signals. As the tag provides a unique ID for the purpose of identification, RFID technology effectively solves the ambiguity and occlusion problem that challenges the laser or camera-based approach. This paper proposes an approach to track a moving object based on the integration of RFID and laser ranging information using a particle filter. To be precise, we split laser scan points into different clusters which contain the potential moving objects and calculate the radial velocity of each cluster. The velocity information is compared with the radial velocity estimated from RFID phase difference. In order to achieve the positioning of the moving object, we select a number of best matching clusters to update the weights of the particle filter. To further improve the positioning accuracy, we incorporate RFID signal strength information into the particle filter using a pre-trained sensor model. The proposed approach is tested on a SCITOS service robot under different types of tags and various human velocities. The results show that fusion of signal strength and laser ranging information has significantly increased the positioning accuracy when compared to radial velocity matching-based or signal strength-based approaches. The proposed approach provides a solution for human machine interaction and object tracking, which has potential applications in many fields for example supermarkets, libraries, shopping malls, and exhibitions.
Ahmad, Fayyaz,Jang, T.S.,Carrasco, Juan A.,Rehman, Shafiq Ur,Ali, Zulfiqar,Ali, Nukhaze Elsevier 2018 Applied mathematics and computation Vol.334 No.-
<P><B>Abstract</B></P> <P>An efficient iterative method is developed for the static analysis of large deflections of an infinite beam with variable cross-section resting on a nonlinear foundation. A pseudo spring constant is added and explicit matrix operators are introduced to perform differentiation through Green’s function. The nonlinearity of the problem is handled with quasilinearization. To compute the solution of the quasilinear differential equation with prescribed accuracy, a new discretization method for solving quasilinear differential equations involving up to the 4th order derivative is used. The discretization method is based on relating discretizations of up to the fourth order derivative of the solution with a discretization of the solution by using a suitable Green function. Numerical experiments show that the error incurred by the discretization can be made small for the two first derivatives and that the method proposed in the paper converges fast and has good accuracy.</P>
Ahmad, Ashfaq,Ali, Tahir,Kim, Min Woo,Khan, Amjad,Jo, Myeung Hoon,Rehman, Shafiq Ur,Khan, Muhammad Sohail,Abid, Noman Bin,Khan, Mehtab,Ullah, Rahat,Jo, Min Gi,Kim, Myeong Ok Elsevier 2019 clinical and experimental Vol.90 No.-
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>In metabolic disorders, adiponectin and adiponectin receptors (AdipoR1/R2) signaling has a key role in improving nonalcoholic fatty liver disease (NAFLD) in obesity-associated diabetes.</P> <P><B>Objective</B></P> <P>To the best of our knowledge, here, we reported for the first time the underlying mechanistic therapeutic efficacy of the novel osmotin, a homolog of mammalian adiponectin, against NAFLD in leptin-deficient <I>ob/ob</I> and <I>db/db</I> mice.</P> <P><B>Methods</B></P> <P>The <I>ob/ob</I> and <I>db/db</I> mice were treated with osmotin at a dose of 5 μg/g three times a week for two weeks. To co-relate the <I>in vivo</I> results we used the human liver carcinoma HepG2 cells, subjected to knockdown with small siRNAs of AdipoR1/R2 and PPARα genes and treated with osmotin and palmitic acid (P.A.). MTT assay, Western blotting, immunohistofluorescence assays, and plasma biochemical analyses were applied.</P> <P><B>Results</B></P> <P>Osmotin stimulated AdipoR1/R2 and its downstream APPL1/PPAR-α/AMPK/SIRT1 pathways in <I>ob/ob</I> and <I>db/db</I> mice, and HepG2 cells exposed to P.A. Mechanistically, we confirmed that knockdown of AdipoR1/R2 and PPARα by their respective siRNAs abolished the osmotin activity in HepG2 cells exposed to P.A. Overall, the <I>in vivo</I> and <I>in vitro</I> results suggested that osmotin protected against NAFLD through activation of AdipoR1/R2 and its downstream APPL1/PPAR-α/AMPK/SIRT1 pathways as shown by the reduced body weight, blood glucose level and glycated hemoglobin, improved glucose tolerance, attenuated insulin resistance and hepatic glucogenesis, regulated serum lipid parameters, and increased fatty acid oxidation and mitochondrial functions.</P> <P><B>Conclusion</B></P> <P>Our findings strongly suggest that novel osmotin might be a potential novel therapeutic tool against obesity/diabetes-induced NAFLD and other metabolic disorders.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Osmotin <I>via</I> AdipoRs dependently reduced palmitic acid-induced toxicity <I>in vitro</I>. </LI> <LI> Osmotin regulated AdipoRs/APPL1/PPAR-α/AMPK/SIRT1 pathways in <I>ob/ob</I> and <I>db/db</I> mice. </LI> <LI> Osmotin regulated AdipoRs/APPL1/PPAR-α/AMPK/SIRT1 pathways in HepG2 cells. </LI> <LI> Osmotin regulated the impaired insulin signaling both <I>in vivo</I> and <I>in vitro</I> studies. </LI> <LI> Osmotin treatment regulated plasma chemistry associated with metabolic disorders. </LI> </UL> </P>