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RISS 인기검색어
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- 저자 : Schultheiß, Jan (검색결과 2 건)
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Anke Schloesser,Tuba Esatbeyoglu,Gerhard Schultheiß,Henning Vollert,Kai Luersen,Alexandra Fischer,Gerald Rimbach 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.9
Type 2 diabetes mellitus (T2DM) is a common and increasingly prevalent metabolic disorder, and effective preventive strategies against this disease are needed. The aim of the present study was to evaluate the potential antidiabetic properties of a dietary apple/kale extract (AKE), which was rich in phlorizin and flavonoids, in laboratory mice. Mice were fed a control diet, a Western-type high-sugar, high-fat diet (WTD), or a WTD plus AKE for 10 weeks. Body weight, food and energy intake, body composition, and blood glucose level were recorded in addition to the postprandial rise in blood glucose concentration after a single administration of glucose (oral glucose tolerance test, OGTT). Furthermore, changes in glucose-induced short-circuit current (ISC) in response to AKE and phlorizin administration were evaluated in situ in intestinal tissues with Ussing chambers. In addition, the in vitro inhibition of α-glucosidase by AKE was determined. The present data suggest that supplementation of an AKE to a WTD significantly improved both blood glucose levels and OGTT in mice. Furthermore, in situ uptake of glucose was significantly inhibited by AKE. Finally, we showed that AKE significantly inhibits α-glucosidase activity in vitro. We conclude that AKE exhibits antidiabetic properties by a dual mechanism, including the inhibition of α-glucosidase and sodium-dependent glucose transporter 1 (SGLT1). Thus, AKE has the potential to serve as a natural plant bioactive compound for dietary prevention strategies against T2DM.
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Han, Hyoung-Su,Koruza, Jurij,Patterson, Eric A.,Schultheiß, Jan,Erdem, Emre,Jo, Wook,Lee, Jae-Shin,Rö,del, Jü,rgen Elsevier Science Publishers 2017 Journal of the European Ceramic Society Vol. No.
<P><B>Abstract</B></P> <P>This paper relates the microstructure, crystallographic structure, ferroelectric, and piezoelectric properties of (K<SUB>0.5</SUB>Na<SUB>0.5</SUB>)NbO<SUB>3</SUB> (KNN) ceramics modified with 0.38mol% K<SUB>5.4</SUB>Cu<SUB>1.3</SUB>Ta<SUB>10</SUB>O<SUB>29</SUB> (KCT) and different amounts of CuO. Results revealed that the addition of KCT and CuO were effective in enhancing the sinterability of KNN. The internal bias field (<I>E</I> <SUB>ib</SUB>) increased from 0.3kV/mm to 0.58kV/mm at 0.5mol% CuO–added KNN+KCT ceramics. The increase of <I>E</I> <SUB>ib</SUB> corresponds very well with the observed increase of the mechanical quality factor (<I>Q</I> <SUB>m</SUB>) from 112 to 2665 for 0.5mol% CuO. Besides, addition of 0.5mol% CuO to KNN+KCT resulted in a large increase of the EPR signal, which is related to the increased amount Cu<SUP>2+</SUP> and a corresponding increase of the concentration of defect dipoles. This result is in good agreement with the increased <I>E</I> <SUB>ib</SUB> and the resulting hardening behavior.</P>
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