A Randomized Double-Blind Placebo-Control Study to Assess the Efficacy and Safety of OLNP-05 Versus Placebo for the Treatment of Subjects with Premature Ejaculation

Sanjib Kumar Panda,Somashekara Nirvanashetty,Vivek A. Parachur,Nilima Mohanty 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.9

Premature ejaculation (PE) is one of the foremost sex-related health problems among men. The global occurrence ranges from 20% to 30%, according to various studies. PE has a great impact on the men's quality of life, with deleterious effects such as embarrassment, frustration, and feeling of incompetence. Considering the necessity of treatment of PE, this study was planned to compare the efficacy and safety of OLNP-05 versus placebo for treating subjects suffering from PE. In this randomized clinical study, 60 men with PE were enrolled and randomly assigned to receive either OLNP-05 or placebo one capsule twice daily for a period of 8 weeks. Subjects were evaluated during visits on day 1, day 28, and day 56. Mean change from baseline in intravaginal ejaculatory latency time (IELT), improvement in premature ejaculation profile (PEP), and Clinical Global Impression-Improvement scale (CGI-I) were used to assess the efficacy of treatment. P-value <.05 was considered significant. At the end of the treatment, the improvement in IELT score in the OLNP-05 group was remarkably higher than the placebo. Subjects in the OLNP-05 treatment group also reported significantly greater improvement in PEP subscale score. Majority of OLNP-05-treated subjects were found to be in the “much improved” category as per CGI-I assessment. The result confirms the safety and efficacy of OLNP-05, therefore suggesting that OLNP-05 may be a safe and effective intervention for the management of PE.

Electric Spring for Voltage and Power Stability and Power Factor Correction

Jayantika Soni,Sanjib Kumar Panda 전력전자학회 2015 ICPE(ISPE)논문집 Vol.2015 No.6

Electric Spring, a new smart grid technology, has earlier been used for providing voltage and power stability in a weakly regulated/stand-alone renewable energy source powered grid. It has been proposed as a demand side management technique to provide voltage and power regulation. Buildings provide a great avenue to implement electric spring effectively. In this paper, a new control scheme is presented for the implementation of electric spring, in conjunction with non-critical building loads like central air conditioning system. This control scheme would be able to provide power factor correction of the system, voltage support, and current balance for the critical loads, such as the building’s security system, in addition to the existing characteristics of electric spring of voltage and power stability. Thus, the improvised control scheme opens new avenues for utilization of the electric spring to a greater extent by providing voltage and power stability and enhancing the power quality in the renewable energy powered microgrids.

Comprehensive Loss Analysis of Isolated Bidirectional Matrix based AC-DC Converter

Prathamesh Pravin Deshpande,Amit Kumar Singh,Hau Chong Aih,Merlin Chai,Sanjib Kumar Panda 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5

In this paper a comparison of traditional two stage back-to-back AC-DC converter with matrix based ACDC converter using comprehensive loss analysis is presented. The two-stage AC-DC converter uses a boost rectifier with power factor correction at the grid side while a full bridge converter at the load end. A current control based closed loop control is developed for the grid end converter while synchronous rectification is used for the corresponding half when full bridge converter is operated in the bidirectional mode. Matrix based AC-AC converter eliminates the use of DC-link and hence the bulky DC link capacitor. Space Vector Modulation based switching scheme is used for matrix based single stage converter. As, the matrix based converter uses back-to-back switches, it contributes to maximum proportion of the total loss followed by input LC filter and controlled rectifier part of the AC-DC converter. Maximum efficiency calculated is about 95.5 % for the matrix based converter, while for two stage converter is about 80 %. Matrix based converter provides higher efficiency, power density, reliability, etc.

Tap Changing Transformer based Dual Active Bridge Bi-Directional DC-DC Converter

Shiva S.M,Naga Brahmendra Yadav Gor,Pritam Das,Sanjib Kumar Panda 전력전자학회 2015 ICPE(ISPE)논문집 Vol.2015 No.6

Voltage fed Dual Active Bridge (VF-DAB) is the simplest isolated bidirectional DC-DC converter topology with least number of high frequency tank elements. This paper addresses the issue of Phase Shift operated VFDAB when used for energy storage applications due to their variable nature in terminal voltage based on the state of charge. Circulation currents and limitations in the soft-switching range are the main drawbacks of VF-DAB when operated with phase shift control within the two active bridges and widely varying voltage at one port. This affect their overall efficiencies at low and mid loads. In this paper, a modification in VF-DAB is proposed which reduces the drawbacks of the conventional phase shift controlled DAB by having variable transformer turns ratio, thereby improving the efficiency of the overall converter at medium and light loads. The analysis and design guidelines for the proposed converter are briefly explained and validated with experimental results.

Redox status and oxalate exudation determines the diff erential tolerance of two contrasting varieties of ‘Assam tea’ [ Camelia sinensis (L.) O. Kuntz] in response to aluminum toxicity

Sanjenbam Sanjibia Devi,Bedabrata Saha,Jay Prakash Awasthi,Preetom Regon,Sanjib Kumar Panda 한국원예학회 2020 Horticulture, Environment, and Biotechnology Vol.61 No.3

The tea plant [ Camellia sinensis (L.) O. Kuntz] is a well-known hyper-accumulator of aluminum (Al 3+ ) that can grow inacidic soils contaminated with excess levels of Al 3+ . In this work, we used various assays for ascorbate–glutathione cyclecomponents and other antioxidant enzymes to show that the alterations in the redox status after Al 3+ treatment on tea cultivars,TV23 (tolerant) and S3A1 (sensitive), is responsible for their diff erential tolerance to Al 3+ stress. A lower dose of Al 3+stress hastened the growth rate as suggested by an increase in biomass with respect to the control in both roots and leaves,but on further increasing the dose, the reverse occurred. Organic acid exudation has a major role in Al 3+ detoxifi cation. Thisstudy also reports the involvement of oxalate as a major exudate, since the activity of glycolate oxidase (GO) was found todrastically increase under the Al 3+ stress condition. The increment in reactive oxygen species production and accumulationwas quantitated in terms of malondialdehyde (MDA), super oxide anion (O 2−) , and hydrogen peroxide (H 2 O 2) , which wasfollowed by a rapid increase in the activity of many stress-responsive antioxidant enzymes, including superoxide dismutase(SOD), catalase (CAT), and peroxidase (POX). The results indicated that diff erential tolerance to Al 3+ toxicity in tea varietiesis linked to their oxidative stress response; and, antioxidant enzymes, as a crucial constituent of the defense response,appear to function diff erentially in the two cultivars. This is the fi rst report showing diff erential tolerance of two contrastingvarieties of ‘Assam Tea’ to Al 3+ stress.

A New Control Scheme to Process Ripple Power Through Isolation stage of the Three-stage Solid State Transformer

Naga Brahmendra Yadav Gorla,Sandeep Kolluri,Merlin Chai,Sanjib Kumar Panda 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5

Three-stage solid state transformer (SST) consists of a multilevel AC-DC converter in stage-1 followed by dual active bridge (DAB) isolated DC-DC converters in stage-2 and a three-phase inverter in stage-3. The output filters of stage-1 are designed to filter both switching frequency based harmonics and second harmonic ripple generated due to singlephase power processing. As a result, the use of less reliable electrolytic capacitors in stage-1 is inevitable. In this paper, a new control scheme is proposed for the SST to transfer the second harmonic ripple current from the output of stage-1 to the output of stage-2 in each phase. When the three phases are connected at the output of stage-2, the second harmonic ripple currents which are phase shifted by 2π/3 radians add to zero. As a result, the capacitive filter requirement at the medium voltage DC (MVDC) bus is reduced, which is realized using reliable film capacitors. The operating principles along with detailed mathematical analysis and simulation results are presented.