http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Sangkyung Choen (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
-
Sangkyung Choen,Michael S. Kent,Abhijit J. Chaudhari,Simon R. Cherry,Ana Krtolica,Allison L. Zwingenberger 대한핵의학회 2023 핵의학 분자영상 Vol.57 No.1
Purpose We evaluated the kinetics of the hypoxia PET radiotracers, [18F]fluoromisonidazole ([18F]FMISO) and [18F]fluoroazomycin-arabinoside ([18F]FAZA), for tumor hypoxia detection and to assess the correlation of hypoxic kineticparameters with static imaging measures in canine spontaneous tumors. Methods Sixteen dogs with spontaneous tumors underwent a 150-min dynamic PET scan using either [18F]FMISO or [18F]FAZA. The maximum tumor-to-muscle ratio (TMRmax) > 1.4 on the last image frame was used as the standard thresholdto determine tumor hypoxia. The tumor time-activity curves were analyzed using irreversible and reversible two-tissuecompartment models and graphical methods. TMRmaxwas compared with radiotracer trapping rate (k3), influx rate (Ki), anddistribution volume (VT). Results Tumor hypoxia was detected in 7/8 tumors in the [18F]FMISO group and 4/8 tumors in the [18F]FAZA group. Allhypoxic tumors were detected at > 120 min with [18F]FMISO and at > 60 min with [18F]FAZA. [18F]FAZA showed betterfit with the reversible model. TMRmaxwas strongly correlated with the irreversible parameters (k3 and Ki) for [18F]FMISOat > 90 min and with the reversible parameter (VT) for [18F]FAZA at > 120 min. Conclusions Our results showed that [18F]FAZA provided a promising alternative radiotracer to [18F]FMISO with detectingthe presence of tumor hypoxia at an earlier time (60 min), consistent with its favorable faster kinetics. The strong correlationbetween TMRmaxover the 90–150 min and 120–150 min timeframes with [18F]FMISO and [18F]FAZA, respectively, withkinetic parameters associated with tumor hypoxia for each radiotracer, suggests that a static scan measurement (TMRmax) isa good alternative to quantify tumor hypoxia.
-
Kitae Kim,Sangkyung Choen,Jaewoo Hwang,Moonjung Jang,Junghee Yoon,Mincheol Choi 한국임상수의학회 2018 한국임상수의학회지 Vol.35 No.6
A 7-year-old intact female Shih-Tzu with chylothorax was presented. Percutaneous popliteal computedtomographic lymphangiography was performed to evaluate the thoracic duct and seek any potential cause of chylothorax. Despite two attempts, visualization of the thoracic duct failed and perianal subcutaneous computed tomographiclymphangiography with injection of iodinated, nonionic water-soluble contrast medium (0.6 ml/kg) was performed. Asingle branch of intact thoracic duct and dilated and tortuous lymphatics were detected. It was diagnosed as idiopathicchylothorax. Perianal subcutaneous lymphangiography is considered a less-invasive, easy and reliable method tovisualize lymphatics in patients with chylothorax.
-
Siheon Lee,Sungkyun Hong,Seungji Kim,Dayoung Oh,Sangkyung Choen,Mincheol CHOI,Junghee YOON 대한수의학회 2020 Journal of Veterinary Science Vol.21 No.4
Background: Quantitative evaluation of renal cortical echogenicity (RCE) has been tried and developed in human and veterinary medicine. Objectives: The objective of this study was to propose a method for evaluating RCE quantitatively and intuitively, and to determine associations between ultrasonographic renal structural distinction and estimated glomerular filtration rate (eGFR) in canine chronic kidney disease (CKD). Methods: Data were collected on 63 dogs, including 27 with normal kidney function and 36 CKD patients. Symmetric dimethylarginine and creatinine concentrations were measured for calculating eGFR. RCE was evaluated as 3 grades on ultrasonography images according to the distinction between the renal cortex and outer medulla. The RCE grade of each kidney was measured. Results: There was a significant difference in eGFR between the group normal and CKD (p < 0.001). As mean of RCE grades (the mean values of each right and left kidney's RCE grade) increases, the proportion of group CKD among the patients in each grade increases (p < 0.001). Also, severity of RCE (classified as "high" if any right or left kidney evaluated as RCE grade 3, "low" otherwise) and eGFR is good indicator for predicting group CKD (p < 0.001). Conclusions: The degree of distinction between the renal cortex and the outer medulla is closely related to renal function including eGFR and the RCE grade defined in this study can be used as a method of objectively evaluating RCE.
DBpia연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
