lncRNAtor: a comprehensive resource for functional investigation of long non-coding RNAs

Park, Charny,Yu, Namhee,Choi, Ikjung,Kim, Wankyu,Lee, Sanghyuk Oxford University Press 2014 Bioinformatics Vol.30 No.17

<P><B>Motivation:</B> A number of long non-coding RNAs (lncRNAs) have been identified by deep sequencing methods, but their molecular and cellular functions are known only for a limited number of lncRNAs. Current databases on lncRNAs are mostly for cataloging purpose without providing in-depth information required to infer functions. A comprehensive resource on lncRNA function is an immediate need.</P><P><B>Results:</B> We present a database for functional investigation of lncRNAs that encompasses annotation, sequence analysis, gene expression, protein binding and phylogenetic conservation. We have compiled lncRNAs for six species (human, mouse, zebrafish, fruit fly, worm and yeast) from ENSEMBL, HGNC, MGI and lncRNAdb. Each lncRNA was analyzed for coding potential and phylogenetic conservation in different lineages. Gene expression data of 208 RNA-Seq studies (4995 samples), collected from GEO, ENCODE, modENCODE and TCGA databases, were used to provide expression profiles in various tissues, diseases and developmental stages. Importantly, we analyzed RNA-Seq data to identify coexpressed mRNAs that would provide ample insights on lncRNA functions. The resulting gene list can be subject to enrichment analysis such as Gene Ontology or KEGG pathways. Furthermore, we compiled protein–lncRNA interactions by collecting and analyzing publicly available CLIP-seq or PAR-CLIP sequencing data. Finally, we explored evolutionarily conserved lncRNAs with correlated expression between human and six other organisms to identify functional lncRNAs. The whole contents are provided in a user-friendly web interface.</P><P><B>Availability and implementation:</B> lncRNAtor is available at http://lncrnator.ewha.ac.kr/.</P><P><B>Contact:</B> sanghyuk@ewha.ac.kr</P><P><B>Supplementary information:</B> Supplementary data are available at <I>Bioinformatics</I> online.</P>

miRseqViewer: multi-panel visualization of sequence, structure and expression for analysis of microRNA sequencing data

Jang, Insu,Chang, Hyeshik,Jun, Yukyung,Park, Seongjin,Yang, Jin Ok,Lee, Byungwook,Kim, Wankyu,Kim, V. Narry,Lee, Sanghyuk Oxford University Press 2015 Bioinformatics Vol.31 No.4

<P><B>Summary:</B> Deep sequencing of small RNAs has become a routine process in recent years, but no dedicated viewer is as yet available to explore the sequence features simultaneously along with secondary structure and gene expression of microRNA (miRNA). We present a highly interactive application that visualizes the sequence alignment, secondary structure and normalized read counts in synchronous multipanel windows. This helps users to easily examine the relationships between the structure of precursor and the sequences and abundance of final products and thereby will facilitate the studies on miRNA biogenesis and regulation. The project manager handles multiple samples of multiple groups. The read alignment is imported in BAM file format. Implemented features comprise sorting, zooming, highlighting, editing, filtering, saving, exporting, etc. Currently, miRseqViewer supports 84 organisms whose annotation is available at miRBase.</P><P><B>Availability and implementation:</B> miRseqViewer, implemented in Java, is available at https://github.com/insoo078/mirseqviewer or at http://msv.kobic.re.kr.</P><P><B>Contact:</B> sanghyuk@ewha.ac.kr</P>

A White-Light-Emitting Molecule: Frustrated Energy Transfer between Constituent Emitting Centers

Park, Sanghyuk,Kwon, Ji Eon,Kim, Se Hun,Seo, Jangwon,Chung, Kyeongwoon,Park, Sun-Young,Jang, Du-Jeon,Medina, Begoñ,a Miliá,n,Gierschner, Johannes,Park, Soo Young American Chemical Society 2009 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.131 No.39

<P>White-light-emitting single molecules are promising materials for use in a new generation of displays and light sources because they offer the possibility of simple fabrication with perfect color reproducibility and stability. To realize white-light emission at the molecular scale, thereby eliminating the detrimental concentration- or environment-dependent energy transfer problem in conventional fluorescent or phosphorescent systems, energy transfer between a larger band-gap donor and a smaller band-gap acceptor must be fundamentally blocked. Here, we present the first example of a concentration-independent ultimate white-light-emitting molecule based on excited-state intramolecular proton transfer materials. Our molecule is composed of covalently linked blue- and orange-light-emitting moieties between which energy transfer is entirely frustrated, leading to the production of reproducible, stable white photo- and electroluminescence.</P>

Associations of active and passive tobacco exposure with elevated blood pressure in Korean adolescents

Hyerin Park(Hyerin Park),Hyunsuk Jeong(Hyunsuk Jeong),Hyeon Woo Yim(Hyeon Woo Yim),Sanghyuk Bae(Sanghyuk Bae) 한국역학회 2024 Epidemiology and Health Vol.46 No.-

The Relationship between Fear of Competition and Stress as Perceived by Elite Athletes

Park Sanghyuk,Ahn Hyosung 상명대학교 글로벌문화예술교육연구소 2024 Research in Dance and Physical Education Vol.8 No.1

The purpose of this study was to verify the relationship between elite athletes perceived fear of competition and stress related to training and competition. To solve this purpose, relevant data was collected, results were calculated based on data analysis procedures, and discussed based on previous research. The difference in fear of competition according to stress level was found to be statistically significant, and in particular, the group experiencing severe stress was found to feel more fear of competition than the normal stress group. In addition, as a result of conducting a correlation analysis to determine the relationship between stress and fear of competition, stress and fear of competition were shown to be positively correlated, and it was confirmed that as fear of competition increased, stress also increased, and the factors affecting competition fear were identified. As a result of the analysis, it was confirmed that all fear factors had an effect on stress, with an effect of approximately 39%.

A study on the Development of a Fear of Competition Scale for Elite Athletes

Park Sanghyuk,Ahn Hyosung 상명대학교 글로벌문화예술교육연구소 2024 Research in Dance and Physical Education Vol.8 No.1

This study was conducted with the purpose of developing a scale to measure the fear of competition that elite athletes feel before competition. Accordingly, data to verify construct validity were collected, results were calculated based on data analysis procedures, and the following conclusions were obtained. First, the fear of competition perceived by elite athletes was finalized to be 12 questions in four factors: burden of expectations from people around them, threat of injury in competition, concern about results such as failure, and loss of effort. Second, as a result of cross-validating the difference in fear of competition according to gender in the developed fear of competition scale, female athletes showed a higher level of fear than male athletes. Therefore, the fear of competition scale developed in this study was confirmed to be valid. Based on these research results, we discussed them from the perspective of prior research and field application.

Tetraphenylimidazole-Based Excited-State Intramolecular Proton-Transfer Molecules for Highly Efficient Blue Electroluminescence

Park, Sanghyuk,Seo, Jangwon,Kim, Se Hun,Park, Soo Young WILEY-VCH Verlag 2008 Advanced Functional Materials Vol.18 No.5

<P>Aiming for highly efficient blue electroluminescence, we have designed and synthesized a novel class of tetraphenylimidazole- based excited-state intramolecular proton-transfer (ESIPT) molecules with covalently linked charge-transporting functional groups (carbazole- and oxadiazole-functionalized hydroxyl-substituted tetraphenylimidazole (HPI), i.e., HPI-Cbz and HPI-Oxd, respectively). High T<SUB>g</SUB> (ca. 130 °C) amorphous films of HPI-Cbz and HPI-Oxd showed intense and ideal blue-light emission (λ<SUB>max</SUB> = 462 and 468 nm, Φ<SUB>PL</SUB> = 0.44 and 0.38) with a large Stokes shift of over 160 nm and a narrow full width at half-maximum of less than 65 nm. Organic light-emitting devices using HPI-Cbz and HPI-Oxd as the emitting layer generated an efficient blue electroluminescence (EL) emission peaking at around 460 nm with excellent CIE coordinates of (x, y) = (0.15, 0.11). A maximum external quantum efficiency of 2.94%, and a maximum brightness of 1 229 cd m<SUP>−2</SUP> at 100 mA cm<SUP>−2</SUP>, as well as a low turn-on voltage of 4.8 V were achieved in this work.</P> <B>Graphic Abstract</B> <P>Novel hydroxyl-substituted tetraphenylimidazole derivatives promise efficient bright-blue electroluminescence as shown in the figure. Devices based on these structures attained current densities of 1.96 cd A<SUP>−1</SUP> and quantum efficiencies of up to 2.94%. The devices also showed much improved morphological and thermal stability. <img src='wiley_img/1616301X-2008-18-5-ADFM200700827-content.gif' alt='wiley_img/1616301X-2008-18-5-ADFM200700827-content'> </P>

Interaction effect of serum 25-hydroxyvitamin D levels and CYP1A1, CYP1B1 polymorphisms on blood pressure in an elderly population

Park, Hye Y.,Kim, Jin H.,Bae, Sanghyuk,Choi, Yi Y.,Park, Jae Y.,Hong, Yun-Chul Wolters Kluwer Health | Lippincott Williams Wilkin 2015 Journal of Hypertension Vol.33 No.1

OBJECTIVE:: Hypertension and vitamin D deficiency are prevalent worldwide, especially in the elderly. Considering the possibility of gene–environment contributions to disease development, we evaluated the influence of certain cytochrome P450 polymorphisms and vitamin D levels on blood pressure (BP). METHODS:: We measured serum 25-hydroxyvitamin D levels [25(OH)D] and BP in 535 individuals over 60 years old and identified single-nucleotide polymorphisms (SNPs) of CYP1A1 and CYP1B1 in lymphocyte DNA. Repeated measure analyses were used to determine the statistical association. RESULTS:: The relationship between 25(OH)D and SBP or DBP was inversely significant, and influence of several CYP1A1 and CYP1B1 SNPs on BP was found across different genotypes. Estimated effect of 25(OH)D levels on BP in the group with higher risky genotype scores of selected SNPs (rs4646421, rs2551188, and rs1056836) was greater (&bgr; = −2.841, P = 0.004 for SBP; &bgr; = −2.035, P = 0.001 for DBP) than the group with lower genotype score (&bgr; = −0.878, P = 0.347 for SBP; &bgr; = 0.037, P = 0.947 for DBP), and synergistic interaction between vitamin D levels and genotype variations was observed (P-interaction = 0.081 for SBP and 0.008 for DBP). When stratified by the hypertension medication status, interaction effect was found only in individuals taking medication (P-interaction = 0.004 for SBP and 0.001 for DBP). CONCLUSION:: Genetic variations in CYP1A1 and CYP1B1 and the serum levels of 25(OH)D showed synergistic effect on BP, especially in individuals currently in treatment for hypertension.

Vision-based Guidance for Loitering over a Target

Park, Sanghyuk The Korean Society for Aeronautical and Space Scie 2016 International Journal of Aeronautical and Space Sc Vol.17 No.3

This paper presents a vision-based guidance method that allows a fixed-wing aircraft to orbit around a target at a given radius. The guidance method uses a simple formula that regulates a relative side-bearing angle estimated by a vision system. The global asymptotic stability of the associated guidance law is demonstrated, and a linear analysis is performed to facilitate the proper selection of the relevant control parameters. A flight experiment is presented to demonstrate the feasibility and performance of the proposed guidance method.

Vision-based Guidance for Loitering over a Target

Sanghyuk Park 한국항공우주학회 2016 International Journal of Aeronautical and Space Sc Vol.17 No.3

This paper presents a vision-based guidance method that allows a fixed-wing aircraft to orbit around a target at a given radius. The guidance method uses a simple formula that regulates a relative side-bearing angle estimated by a vision system. The global asymptotic stability of the associated guidance law is demonstrated, and a linear analysis is performed to facilitate the proper selection of the relevant control parameters. A flight experiment is presented to demonstrate the feasibility and performance of the proposed guidance method.