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Role of Ganglioside GD1a on the Differentiation of Human Mesenchymal Stem Cell into Osteoblast
Hyo-Jung Yang,Jae-Sung Ryu,Jung-Woo Jin,Jin-Hyoung Cho,Eun-Jeong Jeong,So-Dam Lee,So-Hyun Lee,Young-Kug Choo 한국당과학회 2009 한국당과학회 학술대회 Vol.2009 No.1
We isolated human mesenchymal stem cells (hMSC) from dental pulp. These cells are multipotent and serve as precursors for various mesoderm-type cells such as osteoblasts, chondroblasts and adipocytes, as well as several other types of cells. This study investigated the possible role of gangliosides in osteoblast differentiation of hMSCs. Gangliosides, which exist in glycosphingolipid-enriched domains on the cell membrane The role of gangliosides that play in osteoblastogenesis is not yet clearly understood. Therefore, in this study, We investigated the relationship between gangliosides and osteoblast differentiation of human mesenchymal stem cells (hMSCs). The results of high-performance thin-layer chromatography (HPTLC) showed that ganglioside GD1a expression was increased during the differentiation of hMSCs into osteoblasts. Furthermore, we showed that involvement of alkaline phosphate (ALP) with GD1a by immunostaining. Taken together, these results suggest that gangliosides GD1a may play a role in the osteoblast differentiation process of hMSCs.
Implemented edge shape of an electrical stimulus capsule
Woo, Sang Hyo,Kim, Tae Wan,Lee, Jyung Hyun,Kim, Pil Un,Won, Chui Ho,Cho, Jin Ho Wiley (John WileySons) 2009 INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMP Vol.5 No.1
<P>BACKGROUND: Recently, a capsule endoscope has been developed and many researchers have been trying to develop locomotive capsules. To develop locomotive capsules, the inner volume of the capsule has to be large enough to insert actuators, and the edge shape of the exterior capsule has to be suitable for locomotion. There are many locomotional methods, but an electrical stimulus method provides the appropriate power consumption, plus the shape of the capsule is the same as general telemetry capsules. In this paper, the optimal shape of the electrical stimulus capsule (ESC) was designed and implemented to provide the appropriate inner volume and moving speed of the capsule. METHODS: A simple mathematical model was used to simulate various capsule shapes, and simple mathematical formulae were used to simulate the relationship between the shape of the edge of the capsule and the contraction force of the small intestine. The optimal edge shape of the capsule was decided based on the crossing point of the volume and moving speed. To verify the simulation, two capsules were implemented as the control and experimental groups. RESULTS: From the in vitro experiments, four fresh intestines were used to measure the moving speed of the capsules. The average speed of the proposed capsule was 0.125 +/- 0.096 cm/s (20 V, 10 ms, 20 Hz), while the control group capsule was only 0.016 +/- 0.33 cm/s (20 V, 10 ms, 20 Hz), and both groups showed a significant difference from the statistical analysis (p < 0.001, Mann-Whitney rank sum test). CONCLUSIONS: This paper presents a proposed design for the external shape of the ESC that could fill the need of researchers who want more inner volume and doctors who want to prevent the capsule from being stuck in the intestine.</P>
( Sung-woo Ahn ),( Nam-joon Yi ),( Kyung-chul Yoon ),( Hyo-sin Kim ),( Suk-kyun Hong ),( Hyeyoung Kim ),( Jin-young Choi ),( Joon Koo Han ),( Min Uk Kim ),( Hyo-cheol Kim ),( Kwang-woong Lee ),( Kyung 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Pediatric liver transplantation (PLT) has been the key therapy for end stage liver disease and the outcome has been excellent. However, still surgical complication associated with small recipient is the main cause of graft loss. In the present study, we assessed recent advances in outcome of PLTs through our experience. Methods: A total of 237 PLTs performed between Mar 1988 and July 2015 were analyzed. Three chronological periods were investigated: the initial period (1988-2007, n=117), the mid-term period in which our PLT management protocol was settled down (2008-2011, n=61), and the period in which surgical procedures were refined for small children (2012-2015, n=59). Results: The grafts’ (84% vs. 82% vs. 98%) and patients’ (84% vs. 87% vs. 98%) survival have been improved (p<0.05), whereas the proportion of Child class C (12% vs. 21% vs. 34%), the proportion of deceased donor (25% vs. 41% vs. 54%), and split PLT (15%vs. 20% vs. 39%) increased (p<0.05). The incidence of surgical complication has been improved, especially in hepatic artery (4% vs. 12% vs. 0%) but there was no significance. ABO incompatible PLT has introduced on the last period (9%). Conclusions: The quality of the PLT has recently been standardized through a large volume of experience, and the operation has been proven to improve the survival outcome. However, a constant evaluation of our experience is critical for further progress.
Metabolomic understanding of intrinsic physiology in Panax ginseng during whole growing seasons
Hyo-Jung Lee,Jaesik Jeong,Alexessander Couto Alves,Sung-Tai Han,Gyo In,Eun-Hee Kim,Woo-Sik Jeong,Young-Shick Hong 고려인삼학회 2019 Journal of Ginseng Research Vol.43 No.4
Background: Panax ginseng Meyer has widely been used as a traditional herbal medicine because of itsdiverse health benefits. Amounts of ginseng compounds, mainly ginsenosides, vary according to seasons,varieties, geographical regions, and age of ginseng plants. However, no study has comprehensivelydetermined perturbations of various metabolites in ginseng plants including roots and leaves as theygrow. Methods: Nuclear magnetic resonance (1H NMR)ebased metabolomics was applied to better understandthe metabolic physiology of ginseng plants and their association with climate through global profiling ofginseng metabolites in roots and leaves during whole growing periods. Results: The results revealed that all metabolites including carbohydrates, amino acids, organic acids, andginsenosides in ginseng roots and leaves were clearly dependent on growing seasons from March toOctober. In particular, ginsenosides, arginine, sterols, fatty acids, and uracil diphosphate glucoseesugarswere markedly synthesized from March until May, together with accelerated sucrose catabolism,possibly associated with climatic changes such as sun exposure time and rainfall. Conclusion: This study highlights the intrinsic metabolic characteristics of ginseng plants and their associationswith climate changes during their growth. It provides important information not only forbetter understanding of the metabolic phenotype of ginseng but also for quality improvement of ginsengthrough modification of cultivation.