Moderate Exercise Enhances the Production of Interferon-γ and Interleukin-12 in Peripheral Blood Mononuclear Cells

Alireza Zamani,Iraj Salehi,Mahdi Alahgholi-Hajibehzad 대한면역학회 2017 Immune Network Vol.17 No.3

The purpose of this study was to explore the effect of two months moderate exercise on levels of IFN-g, IL-12, IL-6 and IL-4 in serum and supernatants of in vitro mitogen-activated (PHA for 48 h) whole blood (WB) and peripheral blood mononuclear cells (PBMCs). Sixteen healthy males participated in running program (30 min/day, 5 days/ week). Blood samples were collected in three stages; 24 h before to start exercise, 48 h and two months after the last session of the exercise. The samples were analyzed for the cytokines by ELISA. The levels of IFN-g and IL-12 were increased significantly in activated PBMCs culture after exercise and were back to normal level after two months rest. A significant elevation of IFN-g/IL-4 ratio was observed in activated PBMCs culture by acting possibly on IFN-g. The results suggest that short moderate intensity exercise enhances Th1 immune inflammatory and anti-allergic conditions in response to mitogen.

Right Atrial Strain in the Assessment of Right Heart Mechanics in Patients with Heart Failure with Reduced Ejection Fraction

Farveh Vakilian,Alireza Tavallaie,Hedieh Alimi,Hoorak Poorzand,Maryam Salehi 한국심초음파학회 2021 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.29 No.2

BACKGROUND: Cardiac catheterization is the gold standard for cardiopulmonary hemodynamic assessment, although its widespread use could be restricted due to its invasive nature. The aim of this study is to compare multiple echocardiography parameters, including right atrial (RA) strain, with right heart catheterization (RHC) data in patients with heart failure reduced ejection fraction (HFrEF) in the assessment of right heart hemodynamics. METHODS: Patients with HFrEF (defined by left ventricular ejection fraction [LVEF] ≤ 35%) were enrolled prospectively in this study. All patients underwent echocardiography and RHC. RA pressure (RAP), right ventricular end diastolic pressure (RVEDP), systolic pulmonary artery pressure (sPAP) and pulmonary vascular resistance (PVR) were calculated in RHC. Right ventricular (RV) diastolic and systolic function, RAP, RA size, sPAP and PVR were also measured by echocardiography. RESULTS: Fifty patients (36 men) aged 13–51 years with LVEF ≤ 35% were enrolled in this study. There was a significant correlation between echocardiography and catheterization data (r > 0.6, p < 0.001). The RV diastolic grading had significant relation with RA volume (p < 0.001) and RA strain (p < 0.001) in echocardiography, and with RVEDP (p = 0.01) and RAP (p < 0.001) in RHC. There were significant relations between the New York Heart Association classification and RV diastolic function grading (p < 0.001), with RA strain (p = 0.019), and size (p = 0.04). CONCLUSIONS: RA function, as assessed by strain imaging, correlates with right heart hemodynamics in patients with HFrEF.

Gas sensing behavior of Cu2O and CuO/Cu2O composite nanowires synthesized by template-assisted electrodeposition

Hadiyan Moein,Salehi Alireza,Mirzanejad Hamid 한국세라믹학회 2021 한국세라믹학회지 Vol.58 No.1

Metal oxide-based conductometric gas sensors are one of the promising candidates for highly sensitive, harsh environment resilient, low cost and nontoxic sensors for industrial applications. Here we present conductometric gas sensors based on Cu 2 O and CuO/Cu 2 O composite nanowires investigated towards few VOCs and CO gases. The Cu 2 O nanowires with an average length of 8 μm and diameter of 180 nm were synthesized through template-assisted electrodeposition of Cu 2 O into a polycarbonate membrane pores, from an aqueous solution. The CuO/Cu 2 O composite nanowires were obtained by annealing the synthesized Cu 2 O nanowires in an oxygen environment. The morphology, dimension, and crystallography of the synthesized nanowires are studied using scanning electron microscopy and X-ray diff raction measurements before and after annealing process. Our proposed sensor based on Cu 2 O nanowires showed a fast response in sensing ethanol gas at 250 °C response values of 178 and 15% towards 50 and 1 ppm of ethanol, respectively. CuO/Cu 2 O nanowires behaved selective and sensitive at 150 °C with a response value of 55% towards 500 ppm of CO.

Effects of Herbal combination (Melissa officinalis L. and Nepeta menthoides Boiss. & Buhse) on insomnia severity, anxiety and depression in insomniacs: Randomized placebo controlled trial

Maryam Ranjbar,Ali Firoozabadi,Alireza Salehi,Zahra Ghorbanifar,Mohammad M. Zarshenas,Khosro Sadeghniiat-Haghighi,Hossein Rezaeizadeh 한국한의학연구원 2018 Integrative Medicine Research Vol.7 No.4

Background: Insomnia is a prevalent disorder leading to psychological problems such as anxiety and depression. Methods: This study investigates the effect of a combination of herbs (Melissa officinalis L. and Nepeta menthoides Boiss. & Buhse) on anxiety and depression for insomniacs and on insomnia severity. This study is a double-blind randomized placebo-controlled clinical trial. A total number of 67 participants met the inclusion criteria who were diagnosed as cases of insomnia. The patients were randomized into the herbal treatment or placebo groups. The herbal treatment group received a combination of Melissa officinalis and Nepeta menthoides Boiss. & Buhse. The primary outcomes were insomnia, depression and anxiety. We used per-protocol analysis. Results: The all outcomes of herbal treatment were significantly improved compared with placebo in the ISI, BAI and BDI scores after four weeks’ treatment (p value: 0.008, 0.005 and <0.001 respectively). Conclusion: A combination of Melissa officinalis L. and Nepeta menthoides Boiss. & Buhse may improve insomnia and its comorbid depression and anxiety.

Design Second Order Vibration Reduction

Meysam Kazeminasab,Zahra Esmaeili,Alireza Salehi,Mahdi Mirshekaran,Farzin Piltan 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.7

Design of a robust controller for multi input-multi output (MIMO) nonlinear uncertain dynamical system can be a challenging work. This paper focuses on the design and analysis of a high performance adaptive baseline sliding mode control for second order nonlinear uncertain system, in presence of uncertainties to reduce the vibration. In this research, sliding mode controller is a robust and stable nonlinear controller which selected to control of robot manipulator. The proposed approach effectively combines of design methods from switching sliding mode controller, adaptive model-free baseline controller and linear Proportional-Derivative (PD) control to improve the performance, stability and robustness of the sliding mode controller. Sliding mode controller has two important subparts, switching and equivalent. Switching part (discontinuous part) is very important in uncertain condition but it causes chattering phenomenon. To solve the chattering, the most common method used is linear boundary layer saturation method, but this method lost the stability. To reduce the chattering with respect to stability and robustness; linear controller is added to the switching part of the sliding mode controller. The linear controller is to reduce the role of sliding surface slope and switching (sign) function. The nonlinearity term of the sliding mode controller is used to eliminate the decoupling and nonlinear term of link’s dynamic parameters. However nonlinearity term of sliding mode controller is very essential to reliability but in uncertain condition or highly nonlinear dynamic systems it can cause some problems. To solve this challenge the baseline controller is used as online tune or adaptive controller. This controller improves the stability and robustness, reduces the chattering as well and reduces the level of energy due to the torque performance as well.

Variable localization of Toll-like receptors in human fallopian tube epithelial cells

Amjadi, Fatemehsadat,Zandieh, Zahra,Salehi, Ensieh,Jafari, Reza,Ghasemi, Nasrin,Aflatoonian, Abbas,Fazeli, Alireza,Aflatoonian, Reza The Korean Society for Reproductive Medicine 2018 Clinical and Experimental Reproductive Medicine Vol.45 No.1

Objective: To determine the localization, expression, and function of Toll-like receptors (TLRs) in fallopian tube epithelial cells. Methods: The localization of TLRs in fallopian tube epithelial cells was investigated by immunostaining. Surprisingly, the intensity of staining was not equal in the secretory and ciliated cells. After primary cell culture of fallopian tube epithelial cells, ring cloning was used to isolate colonies of ciliated epithelial cells, distinct from non-ciliated epithelial cells. The expression of TLRs 1-10 was examined by quantitative real-time polymerase chain reaction, and protein localization was confirmed by immunostaining. The function of the TLRs was determined by interleukin (IL)-6 and IL-8 production in response to TLR2, TLR3, TLR5, TLR7, and TLR9 ligands. Results: Fallopian tube epithelial cells expressed TLRs 1-10 in a cell-type-specific manner. Exposing fallopian tube epithelial cells to TLR2, TLR3, TLR5, TLR7, and TLR9 agonists induced the secretion of proinflammatory cytokines such as IL-6 and IL-8. Conclusion: Our findings suggest that TLR expression in the fallopian tubes is cell-type-specific. According to our results, ciliated cells may play more effective role than non-ciliated cells in the innate immune defense of the fallopian tubes, and in interactions with gametes and embryos.

Survival Prognostic Factors of Male Breast Cancer in Southern Iran: a LASSO-Cox Regression Approach

Shahraki, Hadi Raeisi,Salehi, Alireza,Zare, Najaf Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.15

We used to LASSO-Cox method for determining prognostic factors of male breast cancer survival and showed the superiority of this method compared to Cox proportional hazard model in low sample size setting. In order to identify and estimate exactly the relative hazard of the most important factors effective for the survival duration of male breast cancer, the LASSO-Cox method has been used. Our data includes the information of male breast cancer patients in Fars province, south of Iran, from 1989 to 2008. Cox proportional hazard and LASSO-Cox models were fitted for 20 classified variables. To reduce the impact of missing data, the multiple imputation method was used 20 times through the Markov chain Mont Carlo method and the results were combined with Rubin's rules. In 50 patients, the age at diagnosis was 59.6 (SD=12.8) years with a minimum of 34 and maximum of 84 years and the mean of survival time was 62 months. Three, 5 and 10 year survival were 92%, 77% and 26%, respectively. Using the LASSO-Cox method led to eliminating 8 low effect variables and also decreased the standard error by 2.5 to 7 times. The relative efficiency of LASSO-Cox method compared with the Cox proportional hazard method was calculated as 22.39. The19 years follow of male breast cancer patients show that the age, having a history of alcohol use, nipple discharge, laterality, histological grade and duration of symptoms were the most important variables that have played an effective role in the patient's survival. In such situations, estimating the coefficients by LASSO-Cox method will be more efficient than the Cox's proportional hazard method.

Identification and Prioritization of the Driving Factors of Labor Productivity in the Melli Bank: Iranian Scenario

Mostafa Bahrami,Mahdi Salehi,Mohsen Akbarzadeh,Alireza Morsali 한국유통과학회 2013 The Journal of Industrial Distribution & Business( Vol.4 No.1

Purpose - Labor productivity is extremely important to the profitability and competitive advantage of organizations that provide services to customers, such as banks. This study investigates the factors driving labor productivity in Iran’s Melli Bank. Research design, data, methodology - Five managerial, psychosocial, cultural, and individual factors are identified and their relative importance for labor productivity prioritized using AHP. The required data are then collected through a questionnaire designed for a pairwise comparison of the driving factors of labor productivity and their subcategories. Results - The study outcomes reveal that the managerial and individual factors are the most important. Specifically, the most important factors in increasing labor productivity in the branches of Melli Bank are having a competent supervisor, promotion opportunities, fair working conditions, conscientiousness, the right tools, and a correspondence between skills and work. Conclusions - Implementing AHP using Expert Choice software revealed that, among the driving factors of labor productivity (i.e., managerial, psychosocial, cultural, environmental, and personal), managerial factors were considered the most important by the respondents.

Effects of Two Chemotherapy Regimens, Anthracycline-based and CMF, on Breast Cancer Disease Free Survival in the Eastern Mediterranean Region and Asia: A Meta-Analysis Approach for Survival Curves

Zare, Najaf,Ghanbari, Saeed,Salehi, Alireza Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3

Background: To compare the effects of two adjuvant chemotherapy regimens, anthracycline-based and cyclophosphamide, methotrexate, fluorourical (CMF) on disease free survival for breast cancer patients in the Eastern Mediterranean region and Asia. Methods: In a systematic review with a multivariate mixed model meta-analysis, the reported survival proportion at multiple time points in different studies were combined. Our data sources were studies linking the two chemotherapy regimens on an adjuvant basis with disease free survival published in English and Persian in the Eastern Mediterranean region and Asia. All survival curves were generated with Graphdigitizer software. Results: 14 retrospective cohort studies were located from electronic databases. We analyzed data for 1,086 patients who received anthracycline-based treatment and 1,109 given CMF treatment. For determination of survival proportions and time we usesb the transformation Ln (-Ln(S)) and Ln (time) to make precise estimations and then fit the model. All analyses were carried out with STATA software. Conclusions: Our findings showed a significant efficacy of anthracycline-based adjuvant therapy regarding disease free survival of breast cancer. As a limitation in this meta-analysis we used studies with different types of anthracycline-based regimens.

Spatial Inequalities in the Incidence of Colorectal Cancer and Associated Factors in the Neighborhoods of Tehran, Iran: Bayesian Spatial Models

Mansori, Kamyar,Solaymani-Dodaran, Masoud,Mosavi-Jarrahi, Alireza,Motlagh, Ali Ganbary,Salehi, Masoud,Delavari, Alireza,Asadi-Lari, Mohsen The Korean Society for Preventive Medicine 2018 Journal of Preventive Medicine and Public Health Vol.51 No.1

Objectives: The aim of this study was to determine the factors associated with the spatial distribution of the incidence of colorectal cancer (CRC) in the neighborhoods of Tehran, Iran using Bayesian spatial models. Methods: This ecological study was implemented in Tehran on the neighborhood level. Socioeconomic variables, risk factors, and health costs were extracted from the Equity Assessment Study conducted in Tehran. The data on CRC incidence were extracted from the Iranian population-based cancer registry. The $Besag-York-Molli{\acute{e}}$ (BYM) model was used to identify factors associated with the spatial distribution of CRC incidence. The software programs OpenBUGS version 3.2.3, ArcGIS 10.3, and GeoDa were used for the analysis. Results: The Moran index was statistically significant for all the variables studied (p<0.05). The BYM model showed that having a women head of household (median standardized incidence ratio [SIR], 1.63; 95% confidence interval [CI], 1.06 to 2.53), living in a rental house (median SIR, 0.82; 95% CI, 0.71 to 0.96), not consuming milk daily (median SIR, 0.71; 95% CI, 0.55 to 0.94) and having greater household health expenditures (median SIR, 1.34; 95% CI, 1.06 to 1.68) were associated with a statistically significant elevation in the SIR of CRC. The median (interquartile range) and mean (standard deviation) values of the SIR of CRC, with the inclusion of all the variables studied in the model, were 0.57 (1.01) and 1.05 (1.31), respectively. Conclusions: Inequality was found in the spatial distribution of CRC incidence in Tehran on the neighborhood level. Paying attention to this inequality and the factors associated with it may be useful for resource allocation and developing preventive strategies in at-risk areas.