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RISS 인기검색어
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- 저자 : Saima Amin (검색결과 3 건)
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Comparative proteomics and global genome-wide expression data implicate role of ARMC8 in lung cancer
Amin, Asif,Bukhari, Shoiab,Mokhdomi, Taseem A,Anjum, Naveed,Wafai, Asrar H,Wani, Zubair,Manzoor, Saima,Koul, Aabid M,Amin, Basit,Qurat-ul-Ain, Qurat-ul-Ain,Qazi, Hilal,Tyub, Sumira,Lone, Ghulam Nabi,Q Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9
Background: Cancer loci comprise heterogeneous cell populations with diverse cellular secretions. Therefore, disseminating cancer-specific or cancer-associated protein antigens from tissue lysates could only be marginally correct, if otherwise not validated against precise standards. Materials and Methods: In this study, 2DE proteomic profiles were examined from lysates of 13 lung-adenocarcinoma tissue samples and matched against the A549 cell line proteome. A549 matched-cancer-specific hits were analyzed and characterized by MALDI-TOF/MS. Results: Comparative analysis identified a total of 13 protein spots with differential expression. These proteins were found to be involved in critical cellular functions regulating pyrimidine metabolism, pentose phosphate pathway and integrin signaling. Gene ontology based analysis classified majority of protein hits responsible for metabolic processes. Among these, only a single non-predictive protein spot was found to be a cancer cell specific hit, identified as Armadillo repeat-containing protein 8 (ARMC8). Pathway reconstruction studies showed that ARMC8 lies at the centre of cancer metabolic pathways. Conclusions: The findings in this report are suggestive of a regulatory role of ARMC8 in control of proliferation and differentiation in lung adenocarcinomas.
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Growth and Detachment of 5 Helix DNA Ribbons
Bashar, Saima,Hwang, Si Un,Lee, Junwye,Amin, Rashid,Dugasani, Sreekantha Reddy,Ha, Tai Hwan,Park, Sung Ha American Scientific Publishers 2016 Journal of Nanoscience and Nanotechnology Vol.16 No.4
<P>We report on the concentration-dependent surface-assisted growth and time-temperature dependent detachment of one-dimensional 5 helix DNA ribbons (5HR) on a mica substrate. The growth coverage ratio was determined by varying the concentration of the 5HR strands in a test tube, and the detachment rate of 5HR on mica was determined by varying the incubation time at a fixed temperature on a heat block. The topological changes in the concentration-dependent attachment and the time-temperature-dependent detachment for 5HR on mica were observed via atomic force microscopy. The observations indicate that 5HR started to grow on mica at similar to 10 nM and provided full coverage at similar to 50 nM. In contrast 5HR at 65 degrees C started to detach from mica after 5 min and was completely removed after 10 min, The growth and detachment coverage show a sinusoidal variation in the growth ratio and a linear variation with a rate of detachment of 20%/min, respectively. The physical parameters that control the stability of the DNA structures on a given substrate should be studied to successfully integrate DNA structures for physical and chemical applications.</P>
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Pankajkumar Yadav,Ekta Yadav,Amita Verma,Saima Amin 한국약제학회 2014 Journal of Pharmaceutical Investigation Vol.44 No.6
Poor water solubility is one of the reasons forerratic absorption after oral administration of furosemide(FSM), an antihypertensive loop diuretic. Self nano emulsifyingdrug delivery system (SNEDDS) is a novel drugdelivery system utilized to improve the water solubility,permeability and ultimately bioavailability. FSM solubilitywas determined in various vehicles oils, surfactants and cosurfactants. Self emulsification region for the rationaldesign of SNEDDS formulations were identified bypseudoternary diagrams. Developed formulations werecharacterized by zeta potential determination, droplet sizeanalysis, dilution test, viscosity determination, in vitrodissolution studies and in vivo pharmacodynamic evaluation. A remarkable increase in dissolution was observed forthe optimized SNEDDS when compared with the plainFSM and marketed formulation by in vitro dissolutionstudies. The pharmacological effect of FSM was improvedby SNEDDS formulation as compared to plain FSM. Thestudy confirmed that the SNEDDS formulation can be usedas a possible alternative to traditional oral formulations ofFSM to improve its bioavailability.
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