Poster Session : PS 0124 ; Cardiology : Riser Blood Pressure Pattern and Sleep Apnea-Hypopnea Syndrome: Prevalence and Comorbidity

( Belen Roig Espert ),( Juan Jose Tamarit Garcia ),( Carmen Ricart Olmo ),( Pedro Rollan Garcia ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Objective: Determine the prevalence and morbidity of sleep apnea-hypopnea syndrome (SAHS) in hypertensive patients with riser pattern. Methods: Were selected the fi rst 100 consecutive patients valued, from January 1 2013, into the hypertension doctor`s offi ce of two hospitals. Inclusion criteria: Being hypertensive with a riser pattern at the ambulatory blood pressure monitoring. The diagnosis of SAHS was performed by polysomnography in patients with riser pattern. As an comorbidity we considered: obesity, hypercholesterolemia, smoking, heart failure, ischemic heart disease, ischemic cerebrovascular disease, peripheral artery disease and renal disease. Results: We reviewed 897 hypertensive patients until arrived to the fi rst 100 patients with a riser pattern. Of them: - SAHS: 83 - Mean age: 71 ± 16.7 - Men: 75 - Years of evolution of hypertension: 8.4 - Body mass index: 29.04 (CI 27.62-31.02) - Total cholesterol: 236 (95% CI 213-254) - Smokers: 32% - Comorbidity 72%: dyslipidemia 60%, type 2 diabetes mellitus 32%, benign prostatic hyperplasia 24%, left ventricular hypertrophy 16%, microalbuminuria 13%, ischemic heart disease 12%, transient ischemic attack 9% - Risk by SCORE: normal 8%, light20%, moderate 16%, high 48%, very high 8% - Erectile dysfunction: 36% Conclusions: We detected a prevalence of SAHS fi ve times higher among hypertensive patients than in the general population and especially in patients with riser pattern. Those patients have been associated higher incidence of cardiovascular effects. We can say that maintaining a high suspicion of SAHS, will lead to an early diagnosis and therefore better treatment of hypertension. The existence of SAHS entails greater comorbidity, SAHS is considered as an independent vascular factor risk for angina and peripheral artery disease. Therefore maintaining a high suspicion of this disease would lead to early treatment to prevent the onset of these cardiovascular events.

Encouraging Editorial Flexibility in Cases of Textual Reuse

Miguel Roig 대한의학회 2017 Journal of Korean medical science Vol.32 No.4

Because many technical descriptions of scientific processes and phenomena are difficult to paraphrase and because an increasing proportion of contributors to the scientific literature are not sufficiently proficient at writing in English, it is proposed that journal editors re-examine their approaches toward instances of textual reuse (similarity). The plagiarism definition by the US Office of Research Integrity (ORI) is more suitable than other definitions for dealing with cases of ostensible plagiarism. Editors are strongly encouraged to examine cases of textual reuse in the context of both, the ORI guidance and the offending authors' proficiency in English. Editors should also reconsider making plagiarism determinations based exclusively on text similarity scores reported by plagiarism detection software.

CYP1A1, GSTM1, GSTT1 and TP53 Polymorphisms and Risk of Gallbladder Cancer in Bolivians

Sakai, Kazuaki,Loza, Ernesto,Roig, Guido Villa-Gomez,Nozaki, Ryoko,Asai, Takao,Ikoma, Toshikazu,Tsuchiya, Yasuo,Kiyohara, Chikako,Yamamoto, Masaharu,Nakamura, Kazutoshi Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.2

The Plurinational State of Bolivia (Bolivia) has a high incidence rate of gallbladder cancer (GBC). However, the genetic and environmental risk factors for GBC development are not well understood. We aimed to assess whether or not cytochrome P450 (CYP1A1), glutathione S-transferase mu 1 (GSTM1), theta 1 (GSTT1) and tumor suppressor protein p53 (TP53) genetic polymorphisms modulate GBC susceptibility in Bolivians. This case-control study covered 32 patients with GBC and 86 healthy subjects. GBC was diagnosed on the basis of histological analysis of tissues at the Instituto de Gastroenterologia Boliviano-Japones (IGBJ); the healthy subjects were members of the staff at the IGBJ. Distributions of the CYP1A1 rs1048943 and TP53 rs1042522 polymorphisms were assayed using PCR-restriction fragment length polymorphism assay. GSTM1 and GSTT1 deletion polymorphisms were detected by a multiplex PCR assay. The frequency of the GSTM1 null genotype was significantly higher in GBC patients than in the healthy subjects (odds ratio [OR], 2.35; 95% confidence interval [CI], 1.03-5.37; age-adjusted OR, 3.53; 95% CI, 1.29-9.66; age- and sex-adjusted OR, 3.40; 95% CI, 1.24-9.34). No significant differences were observed in the frequencies of CYP1A1, GSTT1, or TP53 polymorphisms between the two groups. The GSTM1 null genotype was associated with increased GBC risk in Bolivians. Additional studies with larger control and case populations are warranted to confirm the association between the GSTM1 deletion polymorphism and GBC risk suggested in the present study.

High Frequency of TP53 but not K-ras Gene Mutations in Bolivian Patients with Gallbladder Cancer

Asai, Takao,Loza, Ernesto,Roig, Guido Villa-Gomez,Ajioka, Yoichi,Tsuchiya, Yasuo,Yamamoto, Masaharu,Nakamura, Kazutoshi Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13

Although genetic characteristics are considered to be a factor influencing the geographic variation in the prevalence of gallbladder cancer (GBC), they have not been well studied in Bolivia, which has a high prevalence rate of GBC. The purpose of this study was to examine the frequency of TP53 and K-ras mutations in Bolivian patients with GBC and to compare them with our previous data obtained in other high-GBC-prevalence countries, namely Japan, Chile, and Hungary. DNA was extracted from cancer sites in paraffin-embedded tissue from 36 patients using a microdissection technique. TP53 mutations at exons 5 to 8 and K-ras mutations at codons 12, 13 and 61 were examined using direct sequencing techniques. The data obtained were compared with those in the other high-GBC-prevalence countries. Of the 36 patients, 18 (50.0%) had a TP53 mutation (one mutation in each of 17 patients and three mutations in one patient), and only one (2.8%) had a K-ras mutation. Of the 20 TP53 mutations, 12 were of the transition type (60.0%). This rate was significantly lower than that in Chile (12/12, P<0.05). In addition, three mutations were of the CpG transition type (15.0%), which is a feature of endogenous mutation. All three were found in the hot spot region of the TP53 gene. In contrast, G:C to T:A transversion was found in Bolivia, suggesting the presence of exogenous carcinogens. Our findings suggest that the development of GBC in Bolivia is associated with both exogenous carcinogens and endogenous mechanisms. The identification of an environmental risk factor for GBC is needed to confirm these findings.

Poster Session : PS 0400 ; Infectious Disease ; Procalcitonin and C-Reactive Protein Prognostic Value in Sepsis

( Juan Jose Tamarit Garcia ),( Belen Roig Espert ),( Carmen Ricart Olmo ),( Pedro Rollan Garcia ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Objective: To determine the prognostic value of procalcitonin (PCT) and C Reactive Protein (CRP) in monitoring patients with sepsis admitted into the Internal Medicine Service of two hospitals. Methods: Prospective, observational study in which 82 patients with sepsis were included from April 2013 to April 2014. Were excluded patients under 18 years, hematologic malignancy, HIV positive, patients on immunosuppressive and those with a fatal disease in the next 24 hours. It was considered as a favorable survival at 28 days. Were evaluated as controls 23 patients admitted with systemic infi ammatory response syndrome of non-infectious origin that underwent the baseline determination of PCT and CRP. Results: - Male 72%. - Blood culture positive 71%. - Mortality 32%. - Infections: pulmonary (41%), gastrointestinal (26%), genitourinary (19%), skin and appendages (7%), other (7%) - PCT had a sensitivity and specifi city of 78% and 80% respectively with a PPV of 90% and a NPV of 62% for the diagnosis of sepsis compared with the control group (SIRS without sepsis). - The persistence of the marker or its increase at 48 hours, allowed to predict mortality with a sensitivity and specifi city of 80% and 87% respectively, with a PPV of 94% and a NPV of 60%. - PCT allows predicting mortality (p=0.00001), sensitivity 80%, specifi city 87%. - PCR was shown to be a useful evolutionary marker (p>0.05, sensitivity 50%, specifi city 33.3%). Conclusions: The semiquantitative determination of the PCT is a fast, simple, reliable method that can be used as a prognostic marker in sepsis. The persistence of high levels of this protein at 48 hours predicts poor prognosis. Conversely when its value decreases or becomes negative correlates with good performance. Instead elevated CRP lasts for several days without differences exist between patients with good or poor outcome.

Multimorbidity and Its Impact on Workers: A Review of Longitudinal Studies

Cabral, Giorgione G.,de Souza, Ana C. Dantas,Barbosa, Isabelle R.,Jerez-Roig, Javier,Souza, Dyego L.B. Occupational Safety and Health Research Institute 2019 Safety and health at work Vol.10 No.4

Objective: This study investigates the impact of multimorbidity on work through a literature review of longitudinal studies. Methods: A systematic review was carried out in the databases Lilacs, SciELO, PAHO, PubMed/Medline, Scopus, Web of Science, and Cochrane. There were no restrictions regarding the year of publication or language to maximize the identification of relevant literature. The quality of studies was assessed by the protocol STrengthening the Reporting of OBservational studies in Epidemiology (STROBE). Results: An initial database search identified 7522 registries, and at the end of the analysis, 7 manuscripts were included in the review. Several studies have demonstrated direct and indirect impacts of multimorbidity on the health of workers. For this, the number of missed days due to health-related issues was evaluated, as well as the reduction in work productivity of the unhealthy worker, vulnerability of the worker with multimorbidity regarding higher indices of dismissal and recruitment difficulties, and incidence of early retirement and/or receipt of benefits due to disabilities. Conclusions: Multimorbidity has a negative impact on work, with damages to quality of life and work productivity, worsening the absenteeism/presenteeism indices, enhancing the chances of temporary or permanent leaves, and lowering employability and admission of individuals with multimorbidity.

Experimental and numerical study on the detection of fatigue failure in hydraulic turbines

Xavier Sánchez-Botello,Adolfo de la Torre,Rafel Roig,Esteve Jou,Oscar de la Torre,Javier Ayneto,Xavier Escaler 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.10

Detecting fatigue cracks in hydraulic turbine runners is costly, as it requires stopping the unit, emptying it of water and accessing the runner for inspection. Thus, an alternative way based on monitoring the changes of the structural modal response induced by the formation and growth of a crack was investigated. To do so, the crack propagation induced by a resonance was numerically predicted and experimentally machined on a disk-like structure that resembles a Kaplan turbine runner. The analysis of the results shows how the different stages of the fatigue crack growth can be monitored based on the change of the natural frequencies and mode shapes of several specific modes. Based on the obtained results, a structural health monitoring system is being designed to monitor the turbine runner modes of vibration without the need to stop and inspect the unit.

Multimorbidity and Its Impact on Workers: A Review of Longitudinal Studies

Giorgione G. Cabral,Ana C. Dantas de Souza,Isabelle R. Barbosa,Javier Jerez-Roig,Dyego L.B. Souza 한국산업안전보건공단 산업안전보건연구원 2019 Safety and health at work Vol.10 No.4

Objective: This study investigates the impact of multimorbidity on work through a literature review of longitudinal studies. Methods: A systematic review was carried out in the databases Lilacs, SciELO, PAHO, PubMed/Medline, Scopus, Web of Science, and Cochrane. There were no restrictions regarding the year of publication or language to maximize the identification of relevant literature. The quality of studies was assessed by the protocol STrengthening the Reporting of OBservational studies in Epidemiology (STROBE). Results: An initial database search identified 7522 registries, and at the end of the analysis, 7 manuscripts were included in the review. Several studies have demonstrated direct and indirect impacts of multimorbidity on the health of workers. For this, the number of missed days due to health-related issues was evaluated, as well as the reduction in work productivity of the unhealthy worker, vulnerability of the worker with multimorbidity regarding higher indices of dismissal and recruitment difficulties, and incidence of early retirement and/or receipt of benefits due to disabilities. Conclusions: Multimorbidity has a negative impact on work, with damages to quality of life and work productivity, worsening the absenteeism/presenteeism indices, enhancing the chances of temporary or permanent leaves, and lowering employability and admission of individuals with multimorbidity.

Design, setup and routine operation of a water treatment system for the monitoring of low activities of tritium in water

C.D.R. Azevedo,A. Baeza,E. Chauveau,J.A. Corbacho,J. Diaz,J. Domange,C. Marquet,M. Martinez-Roig,F. Piquemal,C. Roldan,J. Vasco,J.F.C.A. Veloso,N. Yahlali Korean Nuclear Society 2023 Nuclear Engineering and Technology Vol.55 No.7

In the TRITIUM project, an on-site monitoring system is being developed to measure tritium (³H) levels in water near nuclear power plants. The quite low-energy betas emitted by ³H have a very short average path in water (5 ㎛ as shown by simulations for 18 keV electrons). This path would be further reduced by impurities present in the water, resulting in a significant reduction of the detection efficiency. Therefore, one of the essential requirements of the project is the elimination of these impurities through a filtration process and the removal of salts in solution. This paper describes a water treatment system developed for the project that meets the following requirements: the water produced should be of near-pure water quality according to ISO 3696 grade 3 standard (conductivity < 10 µS/cm); the system should operate autonomously and be remotely monitored.

Oxidation and Removal of Industrial Textile Dyes by a Novel Peroxidase Extracted from Post-harvest Lentil (Lens culinaris L.) Stubble

Nazaret Hidalgo,Giulia Mangiameli,Teresa Manzano,Galina G. Zhadan,John F. Kennedy,Valery L. Shnyrov,Manuel G. Roig 한국생물공학회 2011 Biotechnology and Bioprocess Engineering Vol.16 No.4

The degradation and removal of a series of dyes used in the textile industry for polyester/wool (PES/WO) blends and present in effluents, such as Green, Ash-Grey, Black, Navy Blue, Red and Yellow Domalan, and Orange and Red Bemacid, by catalytic action, in the presence of H_2O_2, of extracts of a novel peroxidase from postharvest lentil stubble was investigated. The extracts of this peroxidase (LSP) were effective in degrading these lastgeneration textile dyes, especially Green Domalan, Orange Bemacid, Grey and Black Domalan. A sensitivity study was carried out for Green Domalan biodegradation to determine the effects of process parameters such as pH,H_2O_2, enzyme and dye concentrations, contact and centrifugation times, and temperature. Standard ecotoxicity studies performed with Vibrio fischeri revealed that the dye solutions treated with peroxidase and H_2O_2 were less ecotoxic than the untreated ones.