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Chang-Kwon Lee,Junghwan Kim,원경종,Hwan Myung Lee,Hyo Jin Kim,Hui Yul Roh,Hyo-Jun Park,신화섭,박태규,Bokyung Kim,이상목 대한약학회 2006 Archives of Pharmacal Research Vol.29 No.11
The role of mitogen-activated protein kinase (MAPK) in the decreased contractile response to phorbol ester in aortic smooth muscle strips from deoxycorticosterone acetate (DOCA)-salt hypertensive rats was examined. Norepinephrine (NE) evoked greater contractility in aortic strips from DOCA rats than in those of sham-operated rats. 12-Deoxyphorbol 13-isobutyrate (DPB) induced contraction in Ca2+-free medium, which was diminished in strips from DOCA rats compared to sham-operated rats. Vasoconstrictions induced by these stimulants were inhibited by SB203580 and PD098059, inhibitors of p38 MAPK and extracellular signalregulated kinase (ERK) 1/2, respectively, in both strips. The phosphorylation of p38 MAPK and ERK1/2 induced by NE was greater in strips from DOCA rats compared to those from shamoperated rats, and this phosphorylation was inhibited by the kinase inhibitors. DPB increased the phosphorylation of p38 MAPK and ERK1/2 in strips from both animals, and the increment of p38 MAPK phosphorylation by the stimulant was diminished in strips from DOCA rats compared to sham-operated rats. These findings suggest that the Ca2+-independent contraction evoked by DPB results from the activation of MAPKs in rat aortic smooth muscle and that the attenuated contractility by DPB in DOCA rat appears to be associated with diminished p38 MAPK activity.
임신 중기 임부의 치주병 관련 위험요인과 일부 치주병 병원체의 분포
하정은 ( Jung Eun Ha ),여보미 ( Bo Mi Yeo ),노희열 ( Hui Yul Roh ),백대일 ( Dai Il Paik ),배광학 ( Kwang Hak Bae ) 대한예방치과·구강보건학회 2010 大韓口腔保健學會誌 Vol.34 No.4
Objectives. The objectives of this cross-sectional study were to examine the periodontal condition and health behavior of pregnant women and to analyze the distribution of periodontal pathogens by oral health behaviors. Methods. This study was designed as a hospital-based cross-sectional study. Pregnant women were recruited at about 24 weeks gestation from March 2009 to April 2010 at the obstetrics clinic of general hospital located in Seoul, South Korea. The information of demographic, behavior and health conditions that may influence periodontitis were collected. Full mouth periodontal probing was taken by one trained examiner for the diagnosis of periodontitis. The periodontitis was defined as periodontal attachment loss of 3.5 mm and over on 2 or more sites not on same tooth. Subgingival biofilm and gingival crevicular fluid were collected using two sterilized paper point (#20) for quantitative analysis of prevotella intermedia, porphyromonas gingivalis and treponema denticola. Results. One hundred thirteen pregnant women were included. Adjusted odds ratio of use the floss or interdental brush was 0.22. Pregnant women using the floss or interdental brush, and receiving the scaling before pregnancy had the lower level of T. denticola, P. gingivalis and P. intermedia than pregnant women who didn`t use the floss or interdental brush and not receive the scaling. Conclusions. Oral health behaviors, such as use the floss or interdental brush, may be enable to promote the women`s oral health and to prevent the preterm birth.
Lee, Chang-Kwon,Kim, Jung-Kwan,Won, Kyung-Jong,Lee, Hwan-Myung,Kim, Hyo-Jin,Roh, Hui-Yul,Park, Hyo-Jun,Shin, Hwa-Sup,Park, Tae-Kyu,Kim, Bo-Kyung,Lee, Sang-Mok The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.11
The role of mitogen-activated protein kinase (MAPK) in the decreased contractile response to phorbol ester in aortic smooth muscle strips from deoxycorticosterone acetate (DOCA)-salt hypertensive rats was examined. Norepinephrine (NE) evoked greater contractility in aortic strips from DOCA rats than in those of sham-operated rats. 12-Deoxyphorbol 13-isobutyrate (DPB) induced contraction in $Ca^{2+}-free$ medium, which was diminished in strips from DOCA rats compared to sham-operated rats. Vasoconstrictions induced by these stimulants were inhibited by SB203580 and PD098059, inhibitors of p38 MAPK and extracellular signal-regulated kinase (ERK) 1/2, respectively, in both strips. The phosphorylation of p38 MAPK and ERK1/2 induced by NE was greater in strips from DOCA rats compared to those from sham-operated rats, and this phosphorylation was inhibited by the kinase inhibitors. DPB increased the phosphorylation of p38 MAPK and ERK1/2 in strips from both animals, and the increment of p38 MAPK phosphorylation by the stimulant was diminished in strips from DOCA rats compared to sham-operated rats. These findings suggest that the $Ca^{2+}-independent$ contraction evoked by DPB results from the activation of MAPKs in rat aortic smooth muscle and that the attenuated contractility by DPB in DOCA rat appears to be associated with diminished p38 MAPK activity.
Lee, Hwan Myung,Won, Kyung-Jong,Kim, Junghwan,Park, Hyo-Jun,Kim, Hyo Jin,Roh, Hui Yul,Lee, So Hee,Lee, Chang-Kwon,Kim, Bokyung The Japanese Pharmacological Society 2007 Journal of pharmacological sciences Vol.103 No.4
<P>Although spleen tyrosine kinase (Syk) has crucial roles in various cells, its function on vascular smooth muscle contraction has not been determined. In the present study, we performed experiments to determine if Syk contributes to the endothelin-1 (ET-1)-mediated contraction in rat aortic smooth muscle. ET-1-induced contraction of aortic strips was inhibited by piceatannol, PD98059, and SB203580, inhibitors of Syk, extracellular signal-regulated kinase 1/2 (ERK1/2), and p38 mitogen-activated protein kinase (MAPK), respectively. Piceatannol also attenuated high K<SUP>+</SUP>-induced contraction. ET-1 dose-dependently enhanced the activity of Syk and this was inhibited by piceatannol in both rat aortic strip and rat aortic smooth muscle cells. The phosphorylation of p38 MAPK and heat shock protein 27 (HSP27), but not that of ERK1/2, in response to ET-1 was inhibited by both piceatannol and SB203580. These results suggest that Syk may play an important role in the regulation of aortic smooth muscle contraction induced by ET-1, which may be mediated by the p38 MAPK/HSP27 signaling pathway.</P>
Kim, Jung-Hwan,Lee, Chang-Kwon,Park, Hyo-Jun,Kim, Hyo-Jin,So, Hyun-Ha,Lee, Keun-Sang,Lee, Hwan-Myung,Roh, Hui-Yul,Choi, Wahn-Soo,Park, Tae-Kyu,Kim, Bo-Kyung Korean Physical Therapy Science 2006 대한물리치료과학회지 Vol.13 No.2
We investigated whether increased contractile responsiveness to epidermal growth factor (EGF) is associated with altered activation of mitogen-activated protein kinase (MAPK) in the aortic smooth muscle of deoxycorticosterone acetate (DOCA)-salt hypertensive rats. EGF induced contraction and MAPK activity in aortic smooth muscle strips, which were significantly increased in tissues from the DOCA-salt hypertensive rats compared with those from sham-operated rats. AG1478, PD98059, and LY294002, inhibitors of EGF receptor (EGFR) tyrosine kinase, MAPK/extracellular signal-regulated kinase (ERK) kinase, and phosphatidylinositol 3-kinase (PI3K), respectively, inhibited the contraction and the activity of ERK1/2 that were elevated by EGF. Y27632 and GF109203X, inhibitors of Rho kinase and protein kinase C, respectively, attenuated EGF-induced contraction, with no diminution of ERK1/2 activity. Although EGF also elevated the activity of EGFR tyrosine kinase in both sham-operated and DOCA-salt hypertensive rats, the expression and the magnitude of activation did not differ between strips. These results strongly suggest that EGF induces contraction by the activation of ERK1/2, which is regulated by the PI3K pathway in the aortic smooth muscle of DOCA-salt hypertensive rats.