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- 저자 : Ren Yandong (검색결과 2 건)
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Chengyao Liu,Shan Ren,Shifeng Zhao,Yandong Wang 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.11
Purpose: Accumulating evidence suggests that microRNA-145 (miR-145) plays an important role in osteoarthritis (OA), which is achronic progressive joint disease. Long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) promotesmetastasis in cancers and functions as a sponge for miR-145. However, the role of MALAT1/miR-145 in OA pathogenesishas not yet been elucidated. Materials and Methods: The expression of MALAT1 and miR-145 was examined by quantitative real-time PCR; the interactionbetween miR-145, MALAT1 and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) 5 was verified by luciferasereporter assay. Correlations among MALAT1, miR-145, and ADAMTS5 were analyzed by Spearman rank analysis. Chondrocytesviability and cartilage extracellular matrix (ECM) degradation were investigated with cell viability assay and Western blottinganalyzing expression of ADAMTS5, collagen type 2 alpha 1 (COL2A1), aggrecan (ACAN), and cartilage oligomeric matrix protein(COMP). Results: MALAT1 was upregulated, and miR-145 was downregulated in OA samples and IL-1β-induced chondrocytes. Mechanically,miR-145 could directly bind to MALAT1 and ADAMTS5. Moreover, miR-145 expression was negatively correlated withMALAT1 and ADAMTS5 expression in OA patients, whereas MALAT1 and ADAMTS5 expression was positively correlated. Functionally,overexpression of MALAT1 inhibited chondrocyte viability and promoted cartilage ECM degradation in IL-1β-inducedchondrocytes. In support thereof, MALAT1 silencing and miR-145 upregulation exerted the opposite effect in IL-1β-inducedchondrocytes. Moreover, the effect of MALAT1 was counteracted by miR-145 upregulation, and ADAMTS5 restoration couldabate miR-145 effects. Conclusion: An MALAT1/miR-145 axis contributes to ECM degradation in IL-1β-induced chondrocytes through targeting ADAMTS5,suggesting that MALAT1/miR-145/ADAMTS5 signaling may underlie human OA pathogenesis.
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Flexible Cu2O/Cu film self-powered photodetector for high visible light selection and fast response
Liu Yonghao,Zhao Dawei,Sun Ximing,Cui Feng,Zhang Shan,Shang Xue,Xuan Zhen,Xiao Juqing,Wang Jiapeng,Ren Yandong 한국물리학회 2024 Current Applied Physics Vol.58 No.-
Spectral selection is one of the key performance parameters for visible light photodetectors (VLPD). However, as the absorbing layer of the VLPD, the semiconductor has strong ultraviolet light absorption, leading to poor visible light selectivity of the VLPD. This work fabricated a flexible photovoltaic VLPD based on Cu2O/Cu Schottky junction by annealing Cu foil. Under zero bias, the Cu2O/Cu VLPD showed the responsivity of 14 mA/W, the response time of 1 ms, and the detectivity of 8.8 × 1011 Jones to 620 nm light. Moreover, the detection band of the device is in the range of 500–640 nm, indicating excellent visible light selectivity. Optical and electrical characterization shows that the high visible selectivity of the device is mainly attributed to the fact that the penetration depth of visible light in Cu2O film matches the position of the Cu2O/Cu Schottky junction. This, in turn, induces the effective separation of the photogenerated carriers excited by the visible light. In addition, the bend detection performance of the device is demonstrated. This work provides a reference for improving the spectral selectivity of visible photodetectors.
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