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Marc Ferrer,Óscar Soto-Angona,María Soler-Artigas,Pol Ibáñez,Christian Fadeuilhe,Raúl Felipe Palma-Álvarez,Raquefet Lidai,Sebastian Vargas-Cáceres,María Ángeles Torrecilla,Anna López,Josep Antoni Ramo 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.3
Objective: Agitation in patients diagnosed with personality disorders (PD) is one of the most frequent crises in emergency departments (ED). Although many medications have been tested, their effectiveness has been small or non-significant, and no specific drugs are supported by the available evidence. This study aimed to evaluate the efficacy of Inhaled loxapine (IL) as a therapeutic option for agitated patients with PD. Methods: A naturalistic, unicentric, prospective study was carried out. Thirty subjects diagnosed with PD and attending the ED with episodes of agitation were recruited most of whom were women diagnosed with Borderline Personality Disorder. Subjects were treated with a single dose of IL (9.1 mg). Efficacy was assessed with the Clinical Global Impression scale, the Excited Component of the Positive and Negative Syndrome Scale (PANSS-EC) and the Agitation-Calmness Evaluation Scale (ACES). Patients were followed 60 minutes after administration to measure IL effect and its duration. Results: IL exhibited an overall efficacy in managing mild to severe agitation, with a quick onset of effect and persistence. ‘Effect of time’, where IL efficacy is maintained over time, is more marked in higher-severity agitation. No additional treatments were needed to improve agitation during the follow-up time. Conclusion: Results suggest that IL could be a safe and effective option to manage agitation in PD.
Antonio Silvestre,Fernando Almeida,Pablo Renovell,Elena Morante,Raúl López 대한정형외과학회 2013 Clinics in Orthopedic Surgery Vol.5 No.3
Background: A two-stage revision remains as the “gold standard” treatment for chronically infected total knee arthroplasties. Methods: Forty-five septic knee prostheses were revised with a minimum follow-up of 5 years. Static antibiotic-impregnated cement spacers were used in all cases. Intravenous antibiotics according to sensitivity test of the culture were applied during patients' hospital stay. Oral antibiotics were given for another 5 weeks. Second-stage surgery was undertaken after control of infection with normal erythrocyte sedimentation rate and C-reactive protein values. Extensile techniques were used if needed and metallic augments were employed for bone loss in 32 femoral and 29 tibial revisions. Results: The average interval between the first-stage resection and reimplantation was 4.4 months. Significant improvement was obtained with respect to visual analog scale pain and clinical and functional scores, and infection was eradicated in 95.6% of cases following a two-stage revision total knee arthroplasty. Radiographic evaluation showed suitable alignment without signs of mechanical loosening. Conclusions: This technique is a reasonable procedure to eradicate chronic infection in knee arthroplasty and provides proper functional and clinical results. However, it sometimes requires extensile surgical approaches that could imply arduous surgeries. Metallic augments with cementless stems available in most of the knee revision systems are a suitable alternative to handle bone deficiencies, avoiding the use of bone allografts with its complications.
M. Isabel Enríquez-Salazar,Fabiola Veana,Cristóbal N. Aguilar,Iliana M. De la Garza-Rodríguez,Mercedes G. Lo´pez,Olga M. Rutiaga-Quiñones,Jesú s A. Morlett-Chávez,Raúl Rodríguez-Herrera 한국식품과학회 2017 Food Science and Biotechnology Vol.26 No.4
Aguamiel is a beverage produced by some Agave species that is consumed in its fresh or fermented form. Despite its uses and popularity, seasonal effects on its microbial and chemical profiles are unknown. In this study, using aguamiel collected from A. salmiana and A. atrovirens during different seasons, we identified microorganisms by sequencing the 16S and 18S rDNA genes and determined their chemical profiles. In total, 49 microbial strains were identified (38 bacteria and 11 yeasts). The highest richness and biodiversity were observed during winter and summer. Different lactic acid bacteria and yeast genera with potential industrial applications were identified, such as Acetobacter, Lactobacillus, Leuconostoc, and Clavispora. The analysis of the chemical profiles indicated the presence of maltooligosaccharides and fructooligosaccharides, which are associated with human health improvements, during spring in Agave aguamiel. Aguamiel can be used in the food industry due to its microbiological and chemical profiles.
B. Rebollo‑Plata,M. P. Sampedro,M. G. G?mez‑Espinoza,M. Guzm?n‑Altamirano,J. G. Cabal‑Velarde,O. Portillo‑Moreno,A. Lobo‑Guerrero,M. L?pez‑Fuentes,Ra?l A. Morales‑Luckie 한국탄소학회 2023 Carbon Letters Vol.33 No.1
Lead sulfide ( PbS ) nanocrystals anchored on nitrogen-doped multiwalled carbon nanotubes ( CNx ) have been synthesized employing an environmentally friendly and inexpensive wet chemistry process. CNx?PbS composites have been examined by scanning electron microscopy, X-ray diffraction and Raman spectroscopy. Theorical ab initio calculations have been developed to determine the samples structural, morphological and optical properties to explain the experimental evidences. The PbS nanoparticles exhibit of 4 nm to 27 nm particle size with a face-centered cubic crystal structure and are homogeneously distributed along the carbon nanotubes. The nitrogen-doped CNTs acts as binding sites for the PbS clusters as ab initio theoretical study suggests.