Evaluation of the analgesic and anti-inflammatory properties of methanolextract of Artanema sesamoides Benth roots in animal models

Malaya Gupta,UK Mazumder,V Thamil Selvan,L Manikandan,Senthilkumar GP,R Suresh,P Gomathi,B Ashok Kumar 경희대학교 융합한의과학연구소 2008 Oriental Pharmacy and Experimental Medicine Vol.8 No.2

The methanol extract of the root of Artanema sesamoides Family Scrophuilariaceae (MEAS) was investigated for possible analgesic and anti-inflammatory effects in animals. Three models were used to study the extract effects on nociception, which were acetic acid-induced writhing response, hot-plate method and the tail flick test in mice. The antiinflammatory effects were evaluated using carrageenan, dextran, histamine and serotonin induced rat paw oedema (acute) and cotton pellet induced granuloma (chronic) models in rats. Results of the study revealed that the extract exhibited significant (P < 0.001) analgesic effect at a dose of 50, 100 and 200 mg/kg b.w p.o in mice in all the models. In acute model, the MEAS also exhibited significant (P < 0.001) antiinflammatory effect in all the above mentioned doses. In chronic model (cotton pellet induced granuloma) the MEAS 200 mg/kg and indomethacin 10 mg/kg showed that inhibition of granuloma formation 25.0% and 47.7% respectively (P < 0.001). The MEAS and indomethacin were effectively preventing the transudation of the fluid. Thus, the present study revealed that the methanol extract of the root of Artanema sesamoides exhibited significant analgesic and antiinflammatory activity. The methanol extract of the root of Artanema sesamoides Family Scrophuilariaceae (MEAS) was investigated for possible analgesic and anti-inflammatory effects in animals. Three models were used to study the extract effects on nociception, which were acetic acid-induced writhing response, hot-plate method and the tail flick test in mice. The antiinflammatory effects were evaluated using carrageenan, dextran, histamine and serotonin induced rat paw oedema (acute) and cotton pellet induced granuloma (chronic) models in rats. Results of the study revealed that the extract exhibited significant (P < 0.001) analgesic effect at a dose of 50, 100 and 200 mg/kg b.w p.o in mice in all the models. In acute model, the MEAS also exhibited significant (P < 0.001) antiinflammatory effect in all the above mentioned doses. In chronic model (cotton pellet induced granuloma) the MEAS 200 mg/kg and indomethacin 10 mg/kg showed that inhibition of granuloma formation 25.0% and 47.7% respectively (P < 0.001). The MEAS and indomethacin were effectively preventing the transudation of the fluid. Thus, the present study revealed that the methanol extract of the root of Artanema sesamoides exhibited significant analgesic and antiinflammatory activity.

Pre clinical studies of $Streblus$ $asper$ Lour in terms of behavioural safety and toxicity

Kumar, R.B. Suresh,Puratchikodi, A.,Prasanna, Angelene,Dolai, Narayan,Majumder, Piyali,Mazumder, U.K.,Haldar, P.K. 경희한의학연구센터 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.4

$Streblus$ $asper$ Lour (Family: Moraceae) is a medicinal plant wildly grows in most part of Asian countries. It has many traditional uses like leprosy, piles, diarrhoea, dysentery, elephantiasis, cancer etc. This present study was relates in terms of behavioural safety and toxicity studies of methanol and petroleum ether extracts of $S.$ $asper$. Brine Shrimps lethality bioassay method was established for the present study and cytotoxicity was reported in terms of 50% lethality concentration ($LC_{50}$). Different concentrations of drug solutions were added to the Brine Shrimps, surviving shrimps were counted after 24 h and 50% lethality concentration ($LC_{50}$) were assessed. Acute toxicity was studied on Swiss albino mice after single dose. Sub-Chronic toxicity was performed for 28 days and assessed with biochemical and histopathological parameters. On cytotoxicity studies of brine shrimps it was found methanol extract of $S.$ $asper$ (MESA) was weakly toxic, may be due to the presence of cardiac glycosides and bioactive compounds, however petroleum ether extract of $S.$ $asper$ (PESA) was non toxic. But, in case of acute and sub-acute toxicity study both extracts were found to be non-toxic.

Pre clinical studies of Streblus asper Lour in terms of behavioural safety and toxicity

R. B. Suresh Kumar,A. Puratchikodi,Angelene Prasanna,Narayan Dolai,Piyali Majumder,U. K. Mazumder,P. K. Haldar 경희대학교 융합한의과학연구소 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.4

Streblus asper Lour (Family: Moraceae) is a medicinal plant wildly grows in most part of Asian countries. It has many traditional uses like leprosy, piles,diarrhoea, dysentery, elephantiasis, cancer etc. This present study was relates in terms of behavioural safety and toxicity studies of methanol and petroleum ether extracts of S. asper. Brine Shrimps lethality bioassay method was established for the present study and cytotoxicity was reported in terms of 50% lethality concentration (LC_(50)). Different concentrations of drug solutions were added to the Brine Shrimps, surviving shrimps were counted after 24 h and 50% lethality concentration (LC_(50)) were assessed. Acute toxicity was studied on Swiss albino mice after single dose. Sub-Chronic toxicity was performed for 28 days and assessed with biochemical and histopathological parameters. On cytotoxicity studies of brine shrimps it was found methanol extract of S. asper (MESA) was weakly toxic, may be due to the presence of cardiac glycosides and bioactive compounds, however petroleum ether extract of S. asper (PESA) was non toxic. But, in case of acute and sub-acute toxicity study both extracts were found to be non-toxic.

A Desirable Strategy for Resource Allocation using Virtual Machine in Cloud

B. Abinaya.,J. Suganthi,R. G. Suresh Kumar,T. Nalini 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.5

Cloud computing is a facsimile of legalizing ubiquitous, expedient, on-demand network access to a shared pool of configurable computing resources that can be rapidly furnished and released with negligible management effort. It relies on sharing computing resources rather than having local servers or personal devices to handle applications. The resource allocation, still lack on sustaining tools that enable developers to compare different resource allocation strategies in cloud computing. In this paper we initiate the concept of “skewness” to measure the bumpy utilization of a server. By minimizing skewness, we can improve the overall utilization of servers in the face of multidimensional resource constraints. Here we use skewness metric to combine VMs with different resource characteristics suitably so that the capacities of servers are well utilized.

Performance of Broiler Chickens Fed Low Protein, Limiting Amino Acid Supplemented Diets Formulated Either on Total or Standardized Ileal Digestible Amino Acid Basis

Kumar, C. Basavanta,Gloridoss, R.G.,Singh, K.C.,Prabhu, T.M.,Suresh, B.N. Asian Australasian Association of Animal Productio 2016 Animal Bioscience Vol.29 No.11

The aim of present experiment was to investigate the effect of protein reduction in commercial broiler chicken rations with incorporation of de-oiled rice bran (DORB) and supplementation of limiting amino acids (valine, isoleucine, and/or tryptophan) with ration formulation either on total amino acid (TAA) or standardized ileal digestible amino acids (SIDAA). The experimental design consisted of $T_1$, TAA control; $T_2$ and $T_3$, 0.75% and 1.5% protein reduction by 3% and 6% DORB incorporation, respectively by replacing soybean meal with supplemental limiting amino acids to meet TAA requirement; $T_4$, SIDAA control, $T_5$ and $T_6$, 0.75% and 1.5% protein reduction by DORB incorporation (3% and 6%) with supplemental limiting amino acids on SIDAA basis. A total of 360 dold fast growing broiler chicks (Vencobb-400) were divided into 36 homogenous groups of ten chicks each, and six dietary treatments described were allocated randomly with six replications. During 42 days trial, the feed intake was significantly (p<0.05) reduced by TAA factor compared to SIDAA factor and protein factor significantly (p<0.05) reduced the feed intake at 1.5% reduction compared to normal protein group. This was observed only during pre-starter phase but not thereafter. The cumulative body weight gain (BWG) was significantly (p<0.05) reduced in TAA formulations with protein step-down of 1.5% ($T_3$, 1,993 g) compared to control ($T_1$, 2,067 g), while under SIDAA formulations, BWG was not affected with protein reduction of 1.5% ($T_6$, 2,076 g) compared to $T_4$ (2,129 g). The feed conversion ratio (FCR) was significantly (p<0.05) reduced in both TAA and SIDAA formulations with 1.5% protein step-down ($T_3$, 1.741; $T_6$, 1.704) compared to respective controls ($T_1$, 1.696; $T_4$, 1.663). The SIDAA formulation revealed significantly (p<0.05) higher BWG (2,095 g) and better FCR (1.684) compared to TAA formulation (2,028 g; 1.721). Intake of crude protein and all limiting amino acids (SID basis) was higher in SIDAA group than TAA group with resultant higher nitrogen retention (4.438 vs 4.027 g/bird/d). The nitrogen excretion was minimized with 1.5% protein reduction (1.608 g/bird) compared to normal protein group (1.794 g/bird). The serum uric acid concentration was significantly reduced in $T_3$ (9.45 mg/dL) as compared to $T_4$ (10.75 mg/dL). All carcass parameters were significantly (p<0.05) higher in SIDAA formulation over TAA formulation and 1.5% protein reduction significantly reduced carcass, breast and thigh yields. In conclusion, the dietary protein can be reduced by 0.75% with TAA formulation and 1.5% with SIDAA formulation through DORB incorporation and supplementation of limiting amino acids and among formulations, SIDAA formulation was better than TAA formulation.

Characterising the dynamic seals used in absorber rod drive mechanisms in Indian FBR

Kaushal, Nihal,Patri, Sudheer,Kumar, R. Suresh,Meikandamurthy, C.,Sreedhar, B.K.,Murugan, S.,Raghupathy, S. Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.10

Dynamic seals are one of the critical components of Absorber Rod Drive Mechanism of Fast Breeder Reactors, requiring separate experimental development. Their significance can't be overemphasized considering that the availability and re-usability of Control Rod Drive Mechanisms of Fast Breeder Test Reactor is governed by the failure rate of dynamic seals (bellows). For prototype and subsequent Fast Breeder Reactors in India, choice of the dynamic seal is changed to an in-house designed & developed labyrinth type V-ring seal. The present work is related to the numerical investigations carried out to gain insights into the sealing mechanism and the thermal behaviour of these seals. The results indicate that the seal geometry is very important for obtaining optimum performance. By changing the geometry of the present seal, performance enhancement by more than 50% in important indices is obtained. Further, the results point out that caution shall be exercised when the seal material & its operating temperature are changed. Also, the numerical model developed in this study will be useful for developing more robust dynamic seals in future.

Breeding of Productive Bivoltine Hybrid, CSR16${\times}$CSR17 of Silkworm Bombyx mori L.

Reddy, N.Mal,Basavaraja, H.K.,Kumar, N.Suresh,Joge, P.G.,Kalpana, G.V.,Dandin, S.B.,Datta, R.K. Korean Society of Sericultural Science 2004 International Journal of Industrial Entomology Vol.8 No.2

The breeding work was initiated by utilizing two Japanese hybrids namely C135${\times}$N134 and N137${\times}$C146 along with two evolved Indian breeds, J14 and A24. The breed CSR16 which is characterized with marked larvae and white dumbbell cocoons was evolved from the Japanese hybrid C135${\times}$N134 by crossing with J14, while the breed CSR17 which is characterized with plain larvae and white oval cocoons was evolved from the Japanese hybrid N137${\times}$C146 by crossing with A24. The hybrid of these evolved breeds i.e., CSR16${\times}$CSR17 has shown superior over control hybrid $KA{\times}{NB_4}{D_2}$ and on par with the ruling hybrid of CSR2${\times}$CSR4. The hybrid CSR16${\times}$CSR17 was authorized during 1999 by Central Silk Board, Bangalore, Government of India for commercial exploitation during favourable months based on national level race authorization test.

Breeding of Productive Bivoltine Hybrid, CSR16 x CSR17 of Silkworm Bombyx mori L.

N. Mal Reddy,G.V. Kalpana,S. B. Dandin,R. K. Datta,H. K. Basavaraja,N. Suresh Kumar,P. G. Joge 한국잠사학회 2004 International Journal of Industrial Entomology Vol.8 No.2

The breeding work was initiated by utilizing two Japanese hybrids namely C135 ´ N134 and N137 ´ C146 along with two evolved Indian breeds, J14 and A24. The breed CSR16 which is characterized with marked larvae and white dumbbell cocoons was evolved from the Japanese hybrid C135 ´ N134 by crossing with J14, while the breed CSR17 which is characterized with plain larvae and white oval cocoons was evolved from the Japanese hybrid N137 ´ C146 by crossing with A24. The hybrid of these evolved breeds i.e., CSR16 ´ CSR17 has shown superior over control hybrid KA ´ NB4D2 and on par with the ruling hybrid of CSR2 ´ CSR4. The hybrid CSR16 ´ CSR17 was authorized during 1999 by Central Silk Board, Bangalore, Government of India for commercial exploitation during favourable months based on national level race authorization test.

Breeding of Productive Bivoltine Hybrid, CSR16×CSR17 of Silkworm Bombyx mori L.

( N. Mal Reddy ),( H. K. Basavaraja ),( N. Suresh Kumar ),( P. G. Joge ),( G. V. Kalpana ),( S. B. Dandin ),( R. K. Datta ) 한국잠사학회 2007 International Journal of Industrial Entomology Vol.8 No.2

The breeding work was initiated by utilizing two Japanese hybrids namely C135×N134 and N137×C146 along with two evolved Indian breeds, J14 and A24. The breed CSR16 which is characterized with marked larvae and white dumbbell cocoons was evolved from the Japanese hybrid C135×N134 by crossing with J14, while the breed CSR17 which is characterized with plain larvae and white oval cocoons was evolved from the Japanese hybrid N137×C146 by crossing with A24. The hybrid of these evolved breeds i.e., CSR16×CSR17 has shown superior over control hybrid KA×NB4D2 and on par with the ruling hybrid of CSR2×CSR4. The hybrid CSR16×CSR17 was authorized during 1999 by Central Silk Board, Bangalore, Government of India for commercial exploitation during favourable months based on national level race authorization test.