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Gu Qianqun,Fang Yuchun,Wang Changyun,Li Bafang,Mao Wenjun 한국생약학회 1998 Natural Product Sciences Vol.4 No.2
An acid polysaccharide (SFP), was extracted from alga Sargassum fusiforme in hot water, was purified by ion exchange chromatography on DEAE-cellulose. The PC, chemical analysis, electrophoresis and IR of SFP indicated that it was a kind of alginate with a mol. wt. of 13,000 and a molar ratio of mannuronic acid to guluronic acid 2.75. Pharmacological tests showed that SFP could prolong the survival duration of mice suffering from ascitic Sarcoma 180 with a rate of life prolongation of 63.44%.
Secalonic acid D; A Cytotoxic Constituent from Marine Lichen-derived Fungus Gliocladium sp. T31
Ren, Hong,Tian, Li,Gu, Qianqun,Zhu, Weiming The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.1
Secalonic acid D(SAD) was isolated as the major secondary metabolite of the marine lichen-derived fungus Gliocladium sp. T31. Its structure was established on the basic of physicochemical and spectroscopic data. This is the first report on the isolation of SAD from this fungus, as well as its inhibitory effect on K562 cell cycle and its cytotoxicity against several tumor cell lines in vitro.
Lin, Aiqun,Wu, Guangwei,Gu, Qianqun,Zhu, Tianjiao,Li, Dehai 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.7
Chemical investigation of an Antarctic deep-sea derived fungus Penicillium sp. PR 19 N-1 yielded five new eremophilane-type sesquiterpenes 1-5 and a new rare lactam-type eremophilane 6, together with three known compounds 7-9. The structures of these diverse sesquiterpenes were determined by extensive NMR and mass spectroscopic analyses. Compounds 1, 2, 4-6, 8 and 9 were evaluated for their cytotoxities against HL-60 and A-549 human cancer cell lines, and 5 was the most active one with $IC_{50}$ value of $5.2{\mu}M$ against the A-549 cells.
Secalonic acid D; A Cytotoxic Constituent from Marine Lichen-derived Fungus Gliocladium sp. T31
Hong Ren,Li Tian,Qianqun Gu,Weiming Zhu 대한약학회 2006 Archives of Pharmacal Research Vol.29 No.1
Secalonic acid D (SAD) was isolated as the major secondary metabolite of the marine lichenderived fungus Gliocladium sp. T31. Its structure was established on the basic of physicochemical and spectroscopic data. This is the first report on the isolation of SAD from this fungus, as well as its inhibitory effect on K562 cell cycle and its cytotoxicity against several tumor cell lines in vitro.
Two Indolocarbazole Alkaloids with Apoptosis Activity from a Marine-derived Actinomycete Z2039-2
Rui Liu,Tianjiao Zhu,Dehai Li,Jingyan Gu,Wei Xia,Yuchun Fang,HongbingLiu,Weiming Zhu,Qianqun Gu 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.3
Bioassay-guided fractionation of the EtOAc extract from the fermentation broth of a marinederived actinomycete Z2039-2 led to the isolation of two known indolocarbazole alkaloids, K252c (1) and arcyriaflavin A (2). 1 and 2 exhibited moderate cytotoxic activities against the K562 cell line, and induced apoptotic activities at 10 and 100 µM, respectively. This is the first report on the significant apoptosis inducing effect of indolocarbazole alkaloids against K562 cancer cells.
Two new meroterpenoids produced by the endophytic fungus Penicillium sp. SXH-65
Xinhua Sun,Xianglan Kong,Huquan Gao,Tianjiao Zhu,Guangwei Wu,Qianqun Gu,Dehai Li 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.8
Two new meroterpenoids, arisugacins I (1) andJ (2), together with five known meroterpenoids includingarisugacin B (3), arisugacin F (4), arisugacin G (5), territremB (6) and territrem C (7) were isolated from anendophytic fungus Penicillium sp. SXH-65. Their structureswere determined by extensive spectroscopic experimentsand comparison with literature data. Theircytotoxicities were evaluated against Hela, HL-60 andK562 cell lines, and only 3 and 4 exhibited weak cytotoxicitiesagainst Hela, HL-60 and K562 cell lines withIC50 values ranging from 24 to 60 lM.