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      • KCI등재

        Universal tolerance of nab­paclitaxel for gynecologic malignancies in patients with prior taxane hypersensitivity reactions

        Kathryn Maurer,Chad Michener,Haider Mahdi,Peter G. Rose 대한부인종양학회 2017 Journal of Gynecologic Oncology Vol.28 No.4

        Objective: To report on the incidence of nab-paclitaxel hypersensitivity reactions (HSRs) inpatients with prior taxane HSR. Methods: From 2005 to 2015, all patients who received nab-paclitaxel for a gynecologicmalignancy were identified. Chart abstraction included pathology, prior therapy, indicationfor nab-paclitaxel, dosing, response, toxicities including any HSR, and reason fordiscontinuation of nab-paclitaxel therapy. Results: We identified 37 patients with gynecologic malignancies with a history of paclitaxelHSR who received nab-paclitaxel. Six patients (16.2%) had a prior HSR to both paclitaxel anddocetaxel while the other 31 patients had not received docetaxel. No patients experienced aHSR to nab-paclitaxel. Median number of cycles of nab-paclitaxel was 6 (range 2–20). Twelvepatients received weekly dosing at 60 to 100 mg/m2. The remainder of patients received 135mg/m2(n=13), 175 mg/m2(n=9), or 225 mg/m2(n=3). Thirty four patients (91.9%) receivedreceived nab-paclitaxel in combination with carboplatin (n=28, 75.7%), IP cisplatin (n=1,2.7%), carboplatin and bevacizumab (n=3, 8.1%), or carboplatin and gemcitabine (n=2,5.4%). Reasons for discontinuing nab-paclitaxel included completion of adjuvant therapy(n=16), progressive disease (n=18), toxicity (n=1), and death (n=1). There were no grade4 complications identified during nab-paclitaxel administration. Grade 3 complicationsincluded: neutropenia (n=9), thrombocytopenia (n=4), anemia (n=1), and neurotoxicity (n=1). Conclusion: Nab-paclitaxel is well-tolerated with no HSRs observed in this series of patientswith prior taxane HSR. Given the important role of taxane therapy in nearly all gynecologicmalignancies, administration of nab-paclitaxel should be considered prior to abandoningtaxane therapy

      • PARALLEL MULTI-DELAY SIMULATION

        Lee,Yun Sik,Kim,Chun Kyung,Maurer,Peter M. 대한전자공학회 1995 ICVC : International Conference on VLSI and CAD Vol.4 No.1

        The Multi-Delay Parallel (MDP) technique is an unconventional multi-delay logic simulation algorithm in that it uses no timing wheel, or event-sorting mechanism of any kind. Instead, wide bit-fields containing net values corresponding to several different times are used to resolve out-of-order events. Bit-parallel operations are performed to simulate gates at the required times. The MDP technique was designed to be implemented in hardware, and is currently being implemented as a hardware accelerator, but the current software version of the algorithm has proven to be competitive with conventional interpretive event-driven multi-delay simulation. because the MDP technique can resolve out-of-order events without backing up, or taking any special notice of them, similar techniques may prove useful for multi-processor event-driven simulation. Two alignment and variable alignment. The fixed alignment algorithm provides bit-fields that are wide enough to capture any event that could occur during the simulation of and input vector, while the variable alignment algorithm uses a minimum-width bit field which is just wide enough to capture those events that could occur at an individual step in the simulation. Block diagrams for the hardware accelerator of the MDP algorithm are included. The hardware simulator is capable of processing more than 25,000,000 gates per second at a clock speed of 25MHZ.

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