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PARK, KYUNG MIN,JEONG, MOONCHEOL,PARK, KEE JAI,KOO, MINSEON ational Association for Food Protection 2018 Journal of food protection Vol.81 No.10
<B>ABSTRACT</B><P>Bacillus cereus has long been recognized as an important pathogen in foodborne poisoning worldwide. Fresh vegetables are often contaminated with enterotoxigenic B. cereus and have been implicated as a vehicle for the transmission of this bacterium. This study reports on the occurrence, virulence gene profile, and antibiotic resistance of B. cereus in fresh vegetables. Of 102 examined samples, 48 (47%) of the samples were contaminated with B. cereus (>1 log CFU/g) and 7 (6.8%) of the samples showed more than 3 log CFU/g. In total, 118 B. cereus isolates were examined for the virulence genes nheA, nheB, nheC, hblA, hblC, hblD, cytK, and entFM and for resistance to antibiotics. Of these B. cereus isolates, 70% harbored nheA, nheB, nheC, and cytK. Eighteen (80%) of 21 isolates from bell peppers possessed eight enterotoxin genes. B. cereus isolates were susceptible to imipenem, vancomycin, gentamicin, erythromycin, ciprofloxacin, and chloramphenicol, whereas 22.4% of isolates from garlic chives, 48.7% from perilla leaf, and 40.5% from romaine lettuce showed antibiotic resistance to rifampin and 6% of isolates from garlic chives exhibited resistance to tetracycline. Three isolates from garlic chives were resistant to both tetracycline and rifampin. Raw vegetables were revealed to be major sources of B. cereus containing multiple toxin genes and exhibiting antibiotic resistance. Therefore, the potential health risks of consuming these vegetables raw or undercooked should not be underestimated. This study provides basic information for monitoring the antibiotic resistance and toxigenicity of B. cereus in the food chain during vegetable distribution and for developing food safety management to reduce the contamination with and transmission of B. cereus.</P>
Association of Low Aerobic Fitness with Hyperfiltration and Albuminuria in Men
PARK, MINSEON,KO, YOUNGJIN,SONG, SANG HOON,KIM, SEONGBEEN,YOON, HYUNG-JIN The American College of Sports Medicine 2013 Medicine and science in sports and exercise Vol.45 No.2
PURPOSE: The purpose of this study was to evaluate the association of low aerobic fitness (AF), a quantitative phenotype primarily modified by physical activity, with the earlier markers of chronic kidney disease (CKD). METHODS: Maximum oxygen uptake (V˙O2max), the best index of AF, was estimated in an apparently healthy population of 34,769 adults without known history of diabetes and/or hypertension, and its association with renal function and albuminuria was analyzed retrospectively. V˙O2max was estimated using a cycle ergometer. Glomerular filtration rate was estimated with the Modification of Diet in Renal Disease Study equation. Glomerular hyperfiltration was defined as estimated glomerular filtration rate above the age- and sex-specific 97.5th percentile. Albuminuria was detected with dipstick urinalysis on fast morning urine and defined as ≥1+. RESULTS: V˙O2max levels were negatively correlated with the odds ratios of glomerular hyperfiltration in men (Ptrend = 0.039), not in women. V˙O2max was associated with glomerular hyperfiltration in young men (≤ the median age; Ptrend < 0.001), but not in old men. V˙O2max levels were negatively correlated with the odds ratio of albuminuria in men (Ptrend < 0.001), but not in women. These findings suggest that low AF may be associated with earlier markers of CKD in men. This association was not observed in women. CONCLUSION: From the results of this study, it can be concluded that low AF may be a possible independent, modifiable risk factor for CKD in men.
Frequency-Domain Data Augmentation of Vibration Data for Fault Diagnosis using Deep Neural Networks
Minseon Gwak,Seunghyun Ryu,Yongbeom Park,Hyeon-Woo Na,PooGyeon Park 제어로봇시스템학회 2022 제어로봇시스템학회 국제학술대회 논문집 Vol.2022 No.11
This paper proposes a data augmentation method for vibration data-based fault diagnosis using deep neural networks. The proposed method is devised to deal with the practical problem in applying trained models to facilities, where frequency-domain features of data vary according to the change in the working environment of the facilities. In the proposed method, training data are augmented by scaling the frequency-domain features of raw training data by small amounts generated by a normal distribution. The proposed method is implemented to preserve the symmetricity of the positive and negative frequency-domain components and return the real part of the complex inverse transformed data as final augmented data. The advantage of the proposed method is verified by simulation, where the operating conditions of training and test data differ. Moreover, it is shown that the proposed method can improve the accuracy of models better compared to a time-domain data augmentation using similar random scaling.
Park, Minseon,Lee, Bok-Soon,Jeon, Soung-Hoo,Nam, Hyun-Ja,Lee, Gwang,Kim, Chul-Ho,Cho, Hyeseong,Lee, Jae-Ho American Society for Biochemistry and Molecular Bi 2015 The Journal of biological chemistry Vol.290 No.3
<P>Hepatocyte growth factor (HGF) and its receptor, Met, regulate skeletal muscle differentiation. In the present study, we identified a novel alternatively spliced isoform of Met lacking exon 13 (designated Δ13Met), which is expressed mainly in human skeletal muscle. Alternative splicing yielded a truncated Met having extracellular domain only, suggesting an inhibitory role. Indeed, Δ13Met expression led to a decrease in HGF-induced tyrosine phosphorylation of Met and ERK phosphorylation, as well as cell proliferation and migration via sequestration of HGF. Interestingly, in human primary myoblasts undergoing differentiation, Δ13Met mRNA and protein levels were rapidly increased, concomitantly with a decrease in wild type Met mRNA and protein. Inhibition of Δ13Met with siRNA led to a decreased differentiation, whereas its overexpression potentiated differentiation of human primary myoblasts. Furthermore, in notexin-induced mouse injury model, exogenous Δ13Met expression enhanced regeneration of skeletal muscle, further confirming a stimulatory role of the isoform in muscle cell differentiation. In summary, we identified a novel alternatively spliced inhibitory isoform of Met that stimulates muscle cell differentiation, which confers a new means to control muscle differentiation and/or regeneration.</P>
노인의 외로움 영향요인: 다층모형을 활용한 개인 및 지역 요인 분석
박민선 ( Minseon Park ),김미리 ( Miri Kim ),정순둘 ( Soondool Chung ) 한국조사연구학회 2023 조사연구 Vol.24 No.2
본 연구는 노인의 외로움에 영향을 미치는 개인적, 지역적 요인들을 다층적으로 분석하고 노인의 외로움 완화 방안을 제시하기 위한 목적으로 수행되었다. 이를 위해 「연령통합 및 세대통합 조사」자료에서 만 65세 이상 노인 600명을 대상으로 2-수준 위계적 선형모형을 활용하여 분석을 실시하였다. 분석결과는 다음과 같이 나타났다. 첫째, 노인의 외로움에 대한 총분산에서 지역수준의 분산의 비율이 28.5%로 나타나 다층모형을 적용할 수 있는 것으로 확인되었다. 둘째, 개인수준에서 노인의 사회적 지지 수준이 낮을수록 그리고 노후불안의 수준이 높은 노인일수록 외로움 수준이 높은 것으로 나타났다. 셋째, 시· 군 · 구 지역수준에서 거주지역의 연령다양성이 낮을수록, 문화기반시설 수가 적을수록, 그리고 사회복지예산비중이 낮을수록 노인이 외로움을 많이 느끼는 것으로 확인되었다. 연구결과에 기반하여 노인의 외로움을 완화하기 위한 실천적, 정책적 논의를 제시하였다. The aim of the study is to investigate the influence of individual and regional factors on the loneliness experienced by older adults, and to propose intervention plans to alleviate this issue. The study analyzed data of 600 older adults aged 65 and above from the 「Survey on Age Integration and Generational Integration」, using a 2-level hierarchical linear model(HLM). The results of the analysis are as follows. First, the regional-level variance accounted for 28.5% of the total variance in loneliness among older adults, indicating that a multilevel model analysis was appropriate for analyzing the data. Second, at the individual level, the study found that older people with lower social support and higher aging anxiety were more likely to experience higher levels of loneliness. Third, at the regional level, it was confirmed that older adults living in si-gun-gu areas with higher age diversity, fewer cultural infrastructure, and lower proportion of the social welfare budget were more likely to show higher levels of loneliness among older adults. Based on the results of the study, practical and policy discussions were presented to alleviate loneliness among older adults.