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Yuji Yamada,Yoshihiro Kai,Noriyuki Kida,Hitoshi Koda,Minoru Takeshima,Kenji Hoshi,Kazuyoshi Gamada,Toru Morihara 대한견주관절의학회 2022 대한견주관절의학회지 Vol.25 No.4
Background: Massive rotator cuff tears (MRCTs) with subscapularis (SSC) tears cause severe shoulder dysfunction. In the present study, the influence of SSC tears on three-dimensional (3D) shoulder kinematics during scapular plane abduction in patients with MRCTs was examined. Methods: This study included 15 patients who were divided into two groups: supraspinatus (SSP) and infraspinatus (ISP) tears with SSC tear (torn SSC group: 10 shoulders) or without SSC tear (intact SSC group: 5 shoulders). Single-plane fluoroscopic images during scapular plane elevation and computed tomography (CT)-derived 3D bone models were matched to the fluoroscopic images using two-dimensional (2D)/3D registration techniques. Changes in 3D kinematic results were compared. Results: The humeral head center at the beginning of arm elevation was significantly higher in the torn SSC group than in the intact SSC group (1.8±3.4 ㎜ vs. −1.1±1.6 ㎜, p<0.05). In the torn SSC group, the center of the humeral head migrated superiorly, then significantly downward at 60° arm elevation (p<0.05). In the intact SSC group, significant difference was not observed in the superior-inferior translation of the humeral head between the elevation angles. Conclusions: In cases of MRCTs with a torn SSC, the center of the humeral head showed a superior translation at the initial phase of scapular plane abduction followed by inferior translation. These findings indicate the SSC muscle plays an important role in determining the dynamic stability of the glenohumeral joint in a superior-inferior direction in patients with MRCTs.
Hand Movement-Induced Eyeblink Bursts in a Patient With Parkinson’s Disease
Gohei Yamada,Noriyuki Matsukawa 대한파킨슨병및이상운동질환학회 2022 Journal Of Movement Disorders Vol.15 No.2
The blink reflex is a brainstem reflexevoked by mechanical stimulation of the cornea, electricalstimulation of the supraorbital nerve, auditory stimulation, visualstimulation, and mechanical or electrical stimulation of thelimbs. Here, we present the first case of eyeblink bursts that wereinduced while the patient performed hand movement.
Moito Iijima,Noriyuki Okonogi,Nakako Izumi Nakajima,Yukie Morokoshi,Hiroaki Kanda,Taiju Yamada,Yusuke Kobayashi,Kouji Banno,Masaru Wakatsuki,Shigeru Yamada,Tadashi Kamada,Daisuke Aoki,Sumitaka Hasegaw 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.2
Objective: Programmed cell death-ligand 1 (PD-L1) is expressed in tumor cells and has been shown to predict clinical outcomes of several types of malignancies. The aim of this study was to investigate the effects of carbon-ion (C-ion) beam irradiation on PD-L1 expression in human uterine cervical adeno/adenosquamous carcinoma (UCAA) cells and clinical samples and to identify the prognostic factors for outcomes after C-ion radiotherapy (CIRT). Methods: The effects of C-ion irradiation on PD-L1 expression in human UCAA and cervical squamous cell carcinoma cells were examined by flow cytometry. We examined PD-L1 expression in UCAA biopsy specimens from 33 patients before CIRT started (pre-CIRT) and after 12 Gy (relative biological effectiveness [RBE]) irradiation (post-12Gy-C) in 4 fractions of CIRT to investigate the correlation between PD-L1 status and clinical outcomes. Results: The PD-L1 expression was upregulated by C-ion beam in a dose-dependent manner in HeLa and SiHa cells through phosphorylated Chk1. The overall frequencies of pre-CIRT and post-12Gy-C PD-L1 positivity were 45% (15/33) and 67% (22/33), respectively. The post-12Gy-C PD-L1 expression was significantly elevated compared to the pre-CIRT PD-L1 expression. There was no significant relationship between the pre-CIRT PD-L1 status and clinical outcomes, such as local control (LC), progression-free survival (PFS), and overall survival (OS). However, the post-12Gy-C PD-L1 expression had better correlation with PFS, but not with LC and OS. Conclusion: CIRT can induce PD-L1 expression in UCAA and we propose that PD-L1 expression after starting CIRT may become as a predictive prognostic marker in CIRT for UCAA.
Mizuna Takahashi,Keiichi Uchida,Shinichiro Yamada,Noriyuki Sugino,Yukihito Higashi,Kazuhiro Yamada,Akira Taguchi 대한골다공증학회 2016 Osteoporosis and Sarcopenia Vol.2 No.4
Abstract Mandibular cortical erosion detected on dental panoramic radiographs is associated with increased risk of osteoporosis in older adults. Additionally, many reports have demonstrated an association between decreased number of teeth present and osteoporosis. However, whether mandibular cortical erosion is associated with a decreased number of teeth remains unclear. The purpose of this study, therefore, was to clarify the association between mandibular cortical erosion and number of teeth present in Japanese men and women aged 40 years and older. Among patients who visited our university hospital and underwent dental panoramic radiography for the diagnosis of dental diseases, 839 patients (293 men and 546 women) aged 40e89 years (mean [SD], 63.7 [10.6] years) participated in this study. Multiple regression analysis revealed that mildly to moderately eroded cortex (p ¼ 0.007) and severe eroded cortex (p < 0.001) were significantly associated with a decreased number of teeth present. Analysis of covariance adjusted for covariates revealed a significant association between mandibular cortical erosion category and number of teeth present (p < 0.001). Subjects with a severely eroded cortex had significantly fewer teeth present than those with a normal cortex (mean [SE], 20.7 [0.5] vs. 23.4 [0.3], p < 0.001) or mildly to moderately eroded cortex (22.2 [0.4], p ¼ 0.04). Subjects with a mildly to moderately eroded cortex had significantly fewer teeth present than those with a normal cortex (p ¼ 0.033). Our results suggest the significant association between mandibular cortical erosion and number of teeth present in Japanese men and women aged 40 years and older.
Distinction between Chronic Enteropathy Associated with the SLCO2A1 Gene and Crohn’s Disease
Shunichi Yanai,Satoko Yamaguchi,Shotaro Nakamura,Keisuke Kawasaki,Yosuke Toya,Noriyuki Yamada,Makoto Eizuka,Noriyuki Uesugi,Junji Umeno,Motohiro Esaki,Eiko Okimoto,Shunji Ishihara,Tamotsu Sugai,Takayu 거트앤리버 소화기연관학회협의회 2019 Gut and Liver Vol.13 No.1
Background/Aims: We recently identified recessive mutations in the solute carrier organic anion transporter family member 2A1 gene (SLCO2A1 ) as causative variants of chronic nonspecific multiple ulcers of the small intestine (chronic enteropathy associated with SLCO2A1, CEAS). The aim of this study was to investigate the gastroduodenal expression of the SLCO2A1 protein in patients with CEAS and Crohn’s disease (CD). Methods: Immunohistochemical staining for SLCO2A1 was performed with a polyclonal antibody, HPA013742, on gastroduodenal tissues obtained by endoscopic biopsy from four patients with CEAS and 29 patients with CD. Results: The expression of SLCO2A1 was observed in one of four patients (25%) with CEAS and in all 29 patients (100%) with CD (p<0.001). The three patients with CEAS without SLCO2A1 expression had a homozygous splice-site mutation in SLCO2A1, c.1461+1G>C (exon 7) or c.940+1G>A (exon 10). The remaining one CEAS patient with positive expression of SLCO2A1 had compound heterozygous c.664G>A and c.1807C>T mutations. Conclusions: Immunohistochemical staining for SLCO2A1 in gastroduodenal tissues obtained by endoscopic biopsy is considered useful for the distinction of CEAS from CD.
( Masumi Hasegawa ),( Hiroyuki Okamura ),( Mami Murakawa ),( Kazutoshi Takeuchi ),( Keiichi Yamada ),( Kiyotaka Uchikura ),( Noriyuki Harada ),( Junji Matsumura ) 한국목재공학회 2019 한국목재공학회 학술발표논문집 Vol.2019 No.1
Some fire-retardant woods with no documented fire performance have occasionally been sold in the market. It is important to know whether the required amount of chemical fire retardant is present in all sections of a wood sample. In this study, nondestructive measurement of chemical retention in fire-retardant treated wood was experimentally investigated using air-coupled ultrasonic and micro focus X-ray computed tomography. Wood samples were impregnated with different chemical concentrations. First, the ultrasonic wave velocities of wood samples were measured before and after impregnation. The percent changes in velocity exhibited a positive correlation with the chemical retention. Second, the images of wood sample were captured using X-ray CT before and after impregnation. The changes in integrated brightness values calculated from the captured images also showed a positive correlation with the chemical retention at a 1% significance level. These findings suggest that it is possible to evaluate the distributions of chemical retention in fire-retardant wood.