Association of a VDR Gene Polymorphism with Risk of Colorectal Cancer in Kashmir

Rasool, Sabha,Kadla, Showkat Ahmad,Khan, Tanzeela,Qazi, Falak,Shah, Nisar Ahmad,Basu, Javed,Khan, Bilal Ahmad,Ahktar, Qulsum,Sameer, Aga Syed,Ganai, Bashir Ahmad Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10

Roles of the vitamin D receptor in etiology of cancers, including colorectal cancer, have been repeatedly stressed in different parts of the world. A case control study aimed to evaluate the relationship between the two was therefore initiated in Kashmir, known both for its increasing incidence of gastrointestinal cancers and deficiency of micro-nutrients especially vitamin D. The study included a total of 617 subjects (312 colorectal cancer cases and 305 controls), with sampling carried out over a period of 5 years. DNA samples from the blood of the subjects were analyzed for start codon Fok I VDR polymorphism. We obtained a 1.3 fold increased risk among individuals homozygous for f variants as compared to subjects homozygous for F allele (odds ratio OR 1.3, 95%CI, 0.861-1.65). Our study also showed statistically significant results when dwelling and tumor location characteristics were stratified with Fok I polymorphism, all of which suggests a possible role of Fok I polymorphism in the etiology of CRC in Kashmir.

Synthesis and characterization of PANI/MOF-199/Ag nanocomposite and its potential application as non-enzymatic electrochemical sensing of dopamine

Nisar Asia,Khan Muzamil Ahmad,Hussain Zakir 한국세라믹학회 2022 한국세라믹학회지 Vol.59 No.3

In this research study, a highly selective and sensitive electrochemical sensor was designed by coating the glassy carbon electrode (GCE) with the novel PANI/MOF-199/Ag nanocomposite for the non-enzymatic electrochemical detection of dopamine (DA). PANI/MOF-199/Ag nanocomposite was prepared by the in situ chemical oxidative polymerization of aniline monomer in the presence of MOF-199 followed by the deposition of Ag nanoparticles using an in situ chemical reduction route. Characterization techniques such as Scanning electron microscopy (SEM), X-ray powder diffraction (XRD), Fourier transform infra-red spectroscopy (FTIR), and Raman analysis were used to find out the successful synthesis of the prepared samples. Meanwhile, the electrochemical performance was investigated by chronoamperometry (CA) and cyclic voltammetry (CV) not only at different molar concentrations of DA but also with various compositions of Ag nanoparticles loaded. The PANI/MOF-199/Ag-3% modified electrode exhibited good electro-catalytic activity with high sensitivity of 1.421 μA μM−1 cm− 2 and a low detection limit (LOD) of 0.22 μM (S/N = 3) towards DA. Moreover, in the presence of common interfering biological compounds such as glucose (Glu), uric acid (UA), and ascorbic acid (AA), the fabricated electrochemical sensor was found selective to DA detection.

A novel kind of Hermite based Frobenius type Eulerian polynomials

Waseem Ahmad Khan,Kottakkaran Sooppy Nisar,MEHMET ACIKGOZ,UGUR DURAN 장전수학회 2019 Proceedings of the Jangjeon mathematical society Vol.22 No.4

After the inspirational innovation of fuzzy set by Zadeh in 1965, Kramosil and Michalek in 1975 pioneered the concept of fuzziness in metric spaces and very rst they formulated the notion of fuzzy met- ric spaces. Jungck introduced the idea of commutativity (in 1976) and compatibility (1986) in metric spaces and same are utilized by Subrah- manyam (in 1995) in fuzzy metric spaces to prove an analogues version of Jungck result. In this paper, we prove common xed point theorems for a pair of self-maps by introducing a new contraction which neither requires completeness of spaces nor continuity and compatible property of maps. An open problem and an example is given to justify the im- portance of our main result.

Simultaneous reduction and sulfonation of graphene oxide for efficient hole selectivity in polymer solar cells

Asghar Ali,Zuhair S. Khan,Mahmood Jamil,Yaqoob Khan,Nisar Ahmad,S. Ahmed 한국물리학회 2018 Current Applied Physics Vol.18 No.5

We developed sulfonated, reduced graphene oxide (S-RGO) through fuming/concentrated sulfuric acid treatment of graphene oxide (GO) in ambient conditions. It was demonstrated that the optical band gap and electrical conductivity of S-RGO are easily tunable, and depend on the level of reduction and sulfonation of GO. Whereas, reduction and sulfonation were found dependent on SO3 content, acid strength, and gas tightness of the reaction mixture. It's actually the water content of oleum that determines the nature of the final product. The easily adjustable band gap and electrical conductivity suggest that S-RGO can be employed as a potential hole extraction layer (HEL) material for several donor-acceptor systems. For P3HT:PC61BM based inverted polymer solar cells, it was observed that the shape of the JeV curve is tailorable with the choice of HEL. Compared to a 2.75% power conversion efficiency (PCE) attained with PEDOT:PSS, a PCE of 2.80% was achieved with tuned S-RGO. Our results imply that an S-RGO of sufficiently high band gap and conductivity can replace some of the state of the art HEL materials for a host of device applications.

High rate capability and long cycle stability of Cr₂O₃ anode with CNTs for lithium ion batteries

Abbas, Syed Mustansar,Ahmad, Nisar,Ata-ur-Rehman, Nisar,Rana, Usman Ali,Khan, Salah Ud-Din,Hussain, Shabbir,Nam, Kyung-Wan Elsevier 2016 ELECTROCHIMICA ACTA Vol.212 No.-

<P><B>Abstract</B></P> <P>The present study describes the synthesis of nanocomposite materials based on chromium oxide (Cr<SUB>2</SUB>O<SUB>3</SUB>) nanoparticles and carbon nanotubes (CNTs) (Cr<SUB>2</SUB>O<SUB>3</SUB>–CNT<SUB>(x%)</SUB>) by <I>in-situ</I> chemical co-precipitation method. The physical studies of these materials using a wide range of analytical techniques reveal high surface area and narrow pore size distribution of these nanocomposite materials, indicating homogenous dispersion of Cr<SUB>2</SUB>O<SUB>3</SUB> nanoparticles (particle sizes ∼20-30nm) on the surface of CNTs. The first cycle discharge capacity of 1120 <SUP> mAhg -1 </SUP> for electrodes fabricated from Cr<SUB>2</SUB>O<SUB>3</SUB> alone, which is improved for Cr<SUB>2</SUB>O<SUB>3</SUB>–CNT<SUB>(0.08%)</SUB> nanocomposite (1199 <SUP> mAhg -1 </SUP> ). This nanocomposite material achieved an overall reversible capacity of 995.3 <SUP> mAhg -1 </SUP> after 200 cycles, which can be attributed to the high surface area and the large mesoporous volume of Cr<SUB>2</SUB>O<SUB>3</SUB> nanoparticles interconnected with highly conducting network of CNTs. At higher current densities, the Cr<SUB>2</SUB>O<SUB>3</SUB>–CNT<SUB>(x%)</SUB> nanocomposite electrodes exhibited high lithium storage capacity compared to the electrode fabricated from Cr<SUB>2</SUB>O<SUB>3</SUB> nanoparticles alone. Overall, the Cr<SUB>2</SUB>O<SUB>3</SUB>–CNT<SUB>(0.08%)</SUB> nanocomposite electrode displayed high stability under varying current rates with overall high capacity retention and highest reversible capacity of 719 <SUP> mAhg -1 </SUP> at a current rate of 2000 <SUP> mAhg -1 </SUP> . This highly enhanced rate capability and excellent cycling stability of Cr<SUB>2</SUB>O<SUB>3</SUB>–CNT<SUB>(0.08%)</SUB> nanocomposite electrode can be ascribed to the synergistic effect of CNTs (anchored with the Cr<SUB>2</SUB>O<SUB>3</SUB> nanoparticles). The outcome of this study offers a possibility of improving lithium ion storage of Cr<SUB>2</SUB>O<SUB>3</SUB> nanoparticles by carefully controlling their size and shape along with the use of a suitable buffering matrix like CNTs.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

ON SOME FORMULAS FOR THE GENERALIZED APPELL TYPE FUNCTIONS

Agarwal, Praveen,Jain, Shilpi,Khan, Mumtaz Ahmad,Nisar, Kottakkaran Sooppy Korean Mathematical Society 2017 대한수학회논문집 Vol.32 No.4

A remarkably large number of special functions (such as the Gamma and Beta functions, the Gauss hypergeometric function, and so on) have been investigated by many authors. Motivated the works of both works of both Burchnall and Chaundy and Chaundy and very recently, Brychkov and Saad gave interesting generalizations of Appell type functions. In the present sequel to the aforementioned investigations and some of the earlier works listed in the reference, we present some new differential formulas for the generalized Appell's type functions ${\kappa}_i$, $i=1,2,{\ldots},18$ by considering the product of two $_4F_3$ functions.

Antimicrobial Evaluation and Characterization of Copper Nanoparticles Synthesized by the Simple Chemical Method

Arshad Hussain Wazir,Qudratullah Khan,Nisar Ahmad,Faizan Ullah,Imdadullah Quereshi,Hazrat Ali 한국재료학회 2022 한국재료학회지 Vol.32 No.2

Copper nanoparticles (CuNPs) are considered of great importance due to their high catalytic and antimicrobial activities. This study focuses on the preparation and characterization of CuNPs, and on their antibacterial/antifungal activities. A copper salt (copper sulfate pentahydrate) as precursor, starch as stabilizing agent, and ascorbic acid as reducing agent were used to fabricate CuNPs. The resulting product was characterized via different techniques such as X-ray diffractrometry (XRD), Fourier Transform Infrared (FTIR) spectroscopy, and Scanning electron microscopy (SEM) to confirm its characteristic properties. Employing the Scherrer formula, the mean crystallite sizes of copper (Cu) and cuprous oxide (Cu2O) nanocrystals were found to be 29.21 and 25.33 nm, respectively, as measured from the main X-ray diffraction peaks. The functional groups present in the resulting CuNPs were confirmed by FTIR. In addition, the engineered CuNPs showed antibacterial and antifungal activity against tested pathogenic bacterial and fungal strains.

A Novel Compact Ultra-Wideband Frequency-Selective Surface-Based Antenna for Gain Enhancement Applications

Din Iftikhar Ud,Ullah Waheed,Abbasi Nisar Ahmad,Ullah Sadiq,Shihzad Waleed,Khan Bilawal,Jayakody Dushantha Nalin K. 한국전자파학회 2023 Journal of Electromagnetic Engineering and Science Vol.23 No.2

This article presents a compact ultra-wideband (UWB) circular monopole antenna with a frequency-selective surface (FSS) for gain enhancement. The proposed antenna has a circular patch with circular cuts at the edges and is excited by a microstrip feed. The bottom plane is truncated and further modified by two triangular cuts at the sides and one rectangular cut in the middle to improve the radiation characteristics of the UWB antenna. The antenna is designed on an FR-4 substrate with a thickness of 1.6 mm, a relative permittivity of 4.3, and planner dimensions of 30 mm × 30 mm. To improve the proposed antenna’s gain, an FSS is designed that consists of periodic unit cells of metal printed on the upper layer of an FR-4 substrate with dimensions of 0.11λ × 0.11λ at the lowest operating frequency of 3.3 GHz. The FSS shows a very low transmission coefficient and linearly reducing reflection phase with increasing frequency over a frequency range of 3.3–10.8 GHz. The gain of the proposed antenna is increased from 3 dB to 8.1 dB at 9 GHz by placing the antenna on the FSS. Moreover, the prototype of the proposed antenna is fabricated, and the experimental results are measured, which show close agreements with simulated results. The FSS-based antenna has directional radiation patterns, making it a potential candidate for ground-penetrating radar and UWB applications.

Reversal of Multidrug Resistance and Computational Studies of Pistagremic Acid Isolated from Pistacia integerrima

Rauf, Abdur,Uddin, Ghias,Raza, Muslim,Ahmad, Aftab,Jehan, Noor,Ahmad, Bashir,Nisar, Muhammad,Molnar, Joseph,Csonka, Akos,Szabo, Diana,Khan, Ajmal,Farooq, Umar,Noor, Mah Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.4

Pistagremic acid (PA) is a bioactive triterpenoid isolated from various parts of Pistacia integerrima plants. The aim of this research was to investigate PA for reversion of multidrug resistant (MDR) mediated by P-glycoprotein using rhodamine-123 exclusion study on a multidrug resistant human ABCB1 (ATP-binding cassette, sub-family B, member 1) gene-transfected mouse T-lymphoma cell line in vitro. Results were similar to those with verapamil as a positive control. Docking studies of PA and standard Rhodamine123 were carried out against a P-gp crystal structure which showed satisfactory results. Actually, PA cannot bind exactly where co-crystallized ligand of P-gp is already present. However, the docking study predicted that if a compound gives a lesser score then it may have some potency. The docking scores of PA and Rhodamine were similar. Therefore, we can conclude that there are certain important chemical features of PA which are responsible for the inhibiting potency of P-gp.

Retention and stability of bioactive compounds in functional peach beverage using pasteurization, microwave and ultrasound technologies

Saira Sattar,Muhammad Imran,Zarina Mushtaq,Muhammad Haseeb Ahmad,Muhammad Sajid Arshad,Melvin Holmes,Joanne Maycock,Muhammad Faisal Nisar,Muhammad Kamran Khan 한국식품과학회 2020 Food Science and Biotechnology Vol.29 No.10

The peach functional beverages pasteurized for10 min at 90 C, microwaved for 1.5 min at 850 W ofpower and sonicated for 90 min at 20 kHz of frequencywere selected to keep in storage for up to 30 days inrefrigerator to examine the changes happened to theirphysicochemical characteristics and functional components. It was observed that the pH and the cloud values ofall processed juice samples reduces with the storage time,whereas, the total soluble solids almost remain consistentparticularly in microwave and ultrasound treated samples. While storage period causes the decrement in total phenoliccontent (TPC) and total flavonoid content of treated beveragesamples, but ultrasound processing showed greaterretention of TPC value up to 5.7% more than other techniquesduring storage. The similar trend was observed forantioxidant activity where the ultrasound treatment showedimproved free radicals (2,2-diphenyl-1-picrylhydrazyl and2,20-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid)scavenging activities except ferric ion reducing antioxidantpower after 30 days of storage.