Taxus wallichiana Zucc. 현탁세포에서 Jasmonic Acid-Cellulase 복합 Elicitor가 Paclitaxel 생합성에 미치는 영향

Nguyen Ngoc Hoi,Hoang Van Luong,Nguyen Van Long,Vu Binh Duong,변상요(Sang Yo Byun) 한국생물공학회 2010 KSBB Journal Vol.25 No.2

Taxus wallichiana Zucc. 현탁세포배양에서 항암제 paclitaxel 생합성 연구를 수행하였다. 현탁세포배양에서 exponential phase의 최고 생장 속도는 0.14 day-1이었으며 배가시간이 4.96 day이었다. Paclitaxel은 배양초기에 생성되지 않고 exponential phase 말기부터 서서히 생성되어 stationary phase에서도 이어지며 declined phase에서 최고치를 나타내었다. Paclitaxel의 생산을 촉진하기 위하여 elicitor를 사용하였다. 여러 elicitor 중 jasmonic acid와 cellulase가 paclitaxel의 생성을 증가시켰다. Elicitor는 접종과 동시에 투여했을 때 가장 효과가 좋았으며, jasmonic acid와 cellulase의 combination으로 효과가 더욱 증진했는데 각각 투여할 때보다 1.8배 및 3.1배 paclitaxel 생성이 증가되었다. Cell cultures of Taxus wallichiana Zucc. were made to enhance the production of anticancer agent paclitaxel. In suspension cultures, the maximum cell growth rate in exponential growth phase was 0.14 day-1 which was correlated to 4.96 days of cell doubling time. The production of paclitaxel was non-growth associated. The paclitaxel production was started after the exponential growth phase and increased to declined phase where the maximum concentration was observed. Various elicitors were tested to enhance the production of paclitaxel. The combination of two elicitors of jasmonic acid and cellulase increased the production of paclitaxel 1.8 and 3.1 times compared to paclitaxel production by individual elicitor respectively.

Novel acid gas removal process based on self-heat recuperation technology

Van Duc Long, Nguyen,Lee, Moonyong Elsevier 2017 INTERNATIONAL JOURNAL OF GREENHOUSE GAS CONTROL Vol.64 No.-

<P><B>Abstract</B></P> <P>Chemical absorption is the most common technology used in the acid gas removal unit (AGRU) for treating natural gas. On the other hand, the regenerator requiring large amounts of energy needed for the latent heat of a phase change makes this an energy intensive process. In this study, several distillation columns with a modified heat circulation module based on self-heat recuperation technology were proposed to enhance the energy efficiency of the AGRU. This innovative self-heat recuperation technology circulates the latent and sensible heat in the thermal process. All simulations were conducted using ASPEN HYSYS V8.6, while KG-TOWER<SUP>®</SUP> software was employed to size all the columns. The results showed that the proposed modified configuration can save up 62.5% and 45.9% in terms of the reboiler duty and operating cost, respectively, compared to a conventional AGRU. This brought a saving of 38.0% in terms of the total annual cost. The results also indicated that the carbon emissions could be saved up to 45.4%. The proposed process can be employed to both close-boiling mixtures and wide-boiling mixtures. In addition, a sensitive analysis of the utility costs on the performance of the suggested AGRU configuration were investigated. The retrofit an existing acid gas removal process was performed to enhance both the energy efficiency and capacity.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Novel energy-efficient SHRT-based AGRU configurations were proposed. </LI> <LI> The proposed configuration could save up to 38.0% of the total annual cost. </LI> <LI> Pre-heating can enhance the energy efficiency of a heat pump. </LI> <LI> Energy requirement is reduced significantly lowering the electricity/steam cost ratio. </LI> <LI> The proposed configurations are also promising in a retrofit project. </LI> </UL> </P>

Improvement of the Deethanizing and Depropanizing Fractionation Steps in NGL Recovery Process Using Dividing Wall Column

Long, Nguyen Van Duc,Lee, Moonyong The Society of Chemical Engineers, Japan 2012 Journal of chemical engineering of Japan Vol.45 No.4

<P>In this work, our aim is to utilize a dividing wall column to improve the performance of the deethanizing and depropanizing fractionation steps in natural gas liquid processing. Starting from an initial conventional column sequence, the initial designs of the conventional dividing wall column and a top dividing wall column are obtained by maintaining the number of trays. In succession, they are optimized to reduce the energy consumption using factorial design. The results show that the conventional dividing wall column and the top dividing wall column can offer many benefits to the system, e.g., curbing the operating cost including refrigeration cost, and minimizing the reboiler and condenser duty. Furthermore, by using a dividing wall column, both the purity of ethane and its recovery rate are increased. The influence of utility prices on the operating cost saving of the conventional and the top dividing wall columns is also investigated. In addition, to further enhance the dividing wall column performance, heating is integrated on the top and an interreboiling system is installed at the bottom section of the dividing wall column.</P>

Analysis of the Output Ripple of the DC-DC Boost Charger for Li-Ion Batteries

Nguyen, Van-Sang,Tran, Van-Long,Choi, Woojin,Kim, Dae-Wook The Korean Institute of Power Electronics 2014 JOURNAL OF POWER ELECTRONICS Vol.14 No.1

In the design of battery chargers, limiting the output ripple current according to the manufacturer's recommendation is important for reliable service and extended battery life. Ripple components can cause internal heating of the battery and thus reduce the service life of the battery. Care must be exerted in the design of the switching converter for the charge application through the accurate estimation of the output current ripple value. This study proposes a method to reduce the output current ripple of the converter and presents a detailed analysis of the output current ripple of the DC-DC boost converter to provide a guideline for the design of the battery charger.

Intensified Distillation‐Based Separation Processes: Recent Developments and Perspectives

Long, Nguyen Van Duc,Minh, Le Quang,Ahmad, Faizan,Luis, Patricia,Lee, Moonyong VCH VERLAGSGESELLSCHAFT 2016 Chemical Engineering & Technology Vol.39 No.12

<P><B>Abstract</B></P><P>Greater sustainability can be achieved by decreasing the production costs, energy consumption, equipment size, and environmental impact as well as improvement of the raw material yields, remote control, and process flexibility. Process intensification (PI) as the main route for improving the process performance is used widely in heat transfer, reactions, separation, and mixing, which results in plant compactness, cleanliness, and energy efficiency. Some of the main intensified separation processes and improvement mechanisms are reviewed briefly with the main focus on the PI of distillation processes, which are the most important separation methods. In addition to these technologies, the potential and reliability of reactive separation processes are addressed briefly, which will enable higher efficiency and capacity.</P>

Novel hybrid-blower-and-evaporator-assisted distillation for separation and purification in biorefineries

Van Duc Long, Nguyen,Hong, Jimin,Nhien, Le Cao,Lee, Moonyong Elsevier 2018 Chemical engineering and processing Vol.123 No.-

<P><B>Abstract</B></P> <P>The production of biofuels and biochemicals from biomass-based feedstock, which is one of the most promising strategies for replacing petroleum-based resources and thus alleviating global warming, has received increasing attention in recent years. However, this strategy is energy-intensive due to the low product concentrations after transformation step. In this study, a novel hybrid-blower-and-evaporator-assisted distillation configuration (HBED) was proposed for enhancing process efficiency in bioproduct production from biomass. Several important industrial cases have been investigated to demonstrate the proposed configuration. By applying HBED, light components are partially removed in an evaporator, and the latent heat can be circulated during the process, leading to a substantial improvement in energy efficiency. A blower can increase the energy efficiency of an evaporator significantly, while the combination of an evaporator and blower can substantially reduce the size, capital cost, and operating cost of the distillation column. The results show that the proposed HBED configuration can achieve significant energy savings. Notably, the operating costs can be reduced by up to 45.4%, 26.3%, and 36.7% for the levulinic acid, 2,3-butanediol, and furfural purification processes, respectively. Furthermore, the CO<SUB>2</SUB> emissions of a conventional column and the proposed configuration are evaluated and compared.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Novel hybrid-blower-and-evaporator-assisted distillation configurations were proposed. </LI> <LI> An evaporator can reduce the size, investment and operating costs of distillation. </LI> <LI> A blower can increase the energy efficiency of an evaporator significantly. </LI> <LI> The proposed configurations can handle large quantities of water and/or solvent. </LI> <LI> Substantial saving in operating cost could be achieved in biorefineries. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Organic-inorganic nano-laminate phototransistors with visible-light absorption by using molecular layer deposition

Nguyen Van Long,Sung Myung Mo 한국진공학회 2019 한국진공학회 학술발표회초록집 Vol.2019 No.2

Analysis of the Output Ripple of the DC–DC Boost Charger for Li-Ion Batteries

Van-Sang Nguyen,Van-Long Tran,Woojin Choi,Dae-Wook Kim 전력전자학회 2014 JOURNAL OF POWER ELECTRONICS Vol.14 No.1

In the design of battery chargers, limiting the output ripple current according to the manufacturer’s recommendation is important for reliable service and extended battery life. Ripple components can cause internal heating of the battery and thus reduce the service life of the battery. Care must be exerted in the design of the switching converter for the charge application through the accurate estimation of the output current ripple value. This study proposes a method to reduce the output current ripple of the converter and presents a detailed analysis of the output current ripple of the DC?DC boost converter to provide a guideline for the design of the battery charger.

CONVERT THE REAL CHART TO APPLICATION SOFTWARE PROGRAM

Nguyen Long Van 한국콘텐츠학회 2009 ICCC International Digital Design Invitation Exhib Vol.2009 No.12

The mission of topic is research, design to convert the chart of carrying out to execute certain real work to the interface on computer. Carry out with the specific object: convert 14 testing to find the error and repair computer oneself charts (Start chart, the fired component - Chart B, individual problem - Cart D, can not boot - Chart F and H, intermittent failed - chart IWF, power supply - Chart PS, etc) of authors: SuSan, Mary Rals and Roberr Me Laughlin.

Review of Retrofitting Distillation Columns Using Thermally Coupled Distillation Sequences and Dividing Wall Columns to Improve Energy Efficiency

Long, Nguyen Van Duc,Lee, Moonyong The Society of Chemical Engineers Japan 2014 Journal of chemical engineering of Japan Vol.47 No.2