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Characterization of the Two Methylation Steps Involved in the Biosynthesis of Mycinose in Tylosin
Kim, Eunji,Song, Myoung Chong,Kim, Myoun Su,Beom, Ji Yoon,Lee, Eun Yeol,Kim, Dong-Myung,Nam, Sang-Jip,Yoon, Yeo Joon American Chemical Society and American Society of 2016 Journal of natural products Vol.79 No.8
<P>The S-adenosyl-L-methionine-dependent O-methyltransferases TylE and TylF catalyze the last two methylation reactions in the tylosin biosynthetic pathway of Streptomyces fradiae. It has long been known that the TylE-catalyzed C2''-O-methylation of the 6-deoxy-D-allose bound to demethylmacrocin or demethyllactenocin precedes the Ty1F-catalyzed C3''-O-methylation of the D-javose (C2''-O-methylated 6-deoxy-D-allose) attached to macrocin or lactenocin. This study reveals the unexpected substrate promiscuity of TylE and TylF responsible for the biosynthesis of D-mycinose (Cr''-O-methylated D-javose) in tylosin through the identification of a new minor intermediate 2''-O-demethyldesmycosin (2; 3''-methyl-demethyllactenocin), which lacks a 2''-O-methyl group on the mycinose moiety of desmycosin, along with 2''-O-demethyltylosin (1; 3''-methyl-demethylmacrocin) that was previously detected from the S. fradiae mutant containing a mutation in the tylE gene. These results unveil the unique substrate flexibility of TylE and TylF and demonstrate their potential for the engineered biosynthesis of novel glycosylated macrolide derivatives.</P>
우리나라 양식 흰다리새우, Litopenaeus vannamei에 대한 법정전염병 모니터링 (2010~2013)
김수미 ( Su Mi Kim ),최민지 ( Min Ji Choi ),김석렬 ( Seok Ryel Kim ),강서경 ( Seo Kyeong Kang ),황혜연 ( Hye Yeon Hwang ),장인권 ( In Kwon Jang ),김진우 ( Jin Woo Kim ),지보영 ( Bo Young Jee ),신기원 ( Ki Won Shin ),박명애 ( Myoun 한국어병학회 2014 한국어병학회지 Vol.27 No.2
Since the Aquatic life disease control act was established in 2009, we have monitored OIE notifiable and legally designated diseases which are associated with white shrimp Litopenaeus vannamei but are as yet outbreak in South Korea. We had monitored only two viral diseases of YHD and IMN, but further added IHHN, TS and WTD in an attempt to reinforce monitoring as a countermeasure against the increasing possibility of imported diseases led by continuous growth in global fisheries trade. We also increased the number of monitoring areas, and shrimp farms. In 2013, we examined a total of 2,650 white shrimp from 29 hatcheries and farms to check whether they were infected with any of the 5 diseases (YHD, IMN, IHHN, TS, WTD). The result showed that none of the samples contained the viruses. To regulation of the exotic diseases from landing in our country and to strengthen prevention, management and control of the diseases on a national level, we must continue the surveillance monitoring of the diseases.
Kim, Eunji,Song, Myoung Chong,Kim, Myoun Su,Beom, Ji Yoon,Jung, Jin A,Cho, Hang Soo,Yoon, Yeo Joon American Chemical Society 2017 ACS combinatorial science Vol.19 No.4
<P>Anthracyclines, such as doxorubicin, are effective anticancer drugs composed of a tetracyclic polyketide aglycone and one or more deoxysugar moieties, which play a critical role in their biological activity. A facile one-pot combinatorial biosynthetic system was developed for the generation of a range of glycosylated derivatives of anthracyclines. Cocultivation of Streptomyces venezuelae mutants producing two anthracycline aglycones with eight different nucleotide deoxysugar-producing S. venezuelae mutants that coexpress a substrate-flexible glycosyltransferase led to the generation of 16 aklavinone or e-rhodomycinone glycosides containing diverse deoxysugar moieties, seven of which are new. This demonstrates the potential of the one-pot combinatorial biosynthetic system based on cocultivation as a facile biological tool capable of combining diverse aglycones and deoxysugars to generate structurally diverse polyketides carrying engineered sugars for drug discovery and development.</P>
Unprecedented Noncanonical Features in the WS9326A Nonribosomal Peptide Synthetase Assembly Line
Jung Min KIM,Myoun-Su KIM,Munhyung BAE,Ye-Eun JUNG,Jeong Sang YI,Sunghoon HWANG,Myoung Chong SONG,Yeon Hee BAN,Eun Seo BAE,Suckchang HONG,Sang Kook LEE,Sun-Shin CHA,Dong-Chan OH,Yeo Joon YOON 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
A growing number of nonribosomal peptide synthetase (NRPS) assembly lines violating the “co-linearity rule,” where the number and order of NRPS modules indicate to the number and sequence of amino acids in the corresponding product, have been discovered. To understand biosynthetic mechanism of such NRP, NRPS of Streptomyces sp. SNM55 was investigated. Systematic inactivation of NRPS domains and translocation of the thioesterase (TE) domains unveiled several unprecedented nonlinear NRPS assembly processes during the biosynthesis of the cyclodepsipeptide WS9326A in S. sp. SNM55. The WS9326 NRPS assembly line involves two type II TE (TEII)-like enzymes responsible for the transfer of activated amino acids from two stand-alone adenylation (A)-thiolation (T) didomain modules with different specificities to the ‘A-less’ condensation (C)-T module, which operates iteratively, catalyzing two chain elongation steps. This biosynthetic pathway includes the first example of NRPS module skipping, where the interpolated C and T domains are required for chain transfer. Understanding such untapped nonlinear biosynthetic strategies will provide potentially valuable tools for engineered biosynthesis of these complex natural products.