Evaluation of non-completion of intraperitoneal chemotherapy in patients with advanced epithelial ovarian cancer

Laura Moulton Chambers,Ji Son,Milena Radeva,Robert DeBernardo 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.6

Objective: To identify factors associated with non-completion of intraperitoneal withintravenous chemotherapy [IP/IV] in women with epithelial ovarian cancer (EOC). Methods: This was an Institutional Review Board approved, retrospective cohort study inwomen with stage III EOC following optimal cytoreductive surgery (CRS) (<1 cm) followedby IP/IV chemotherapy from 2000–2016. Demographic, surgical, and oncologic variableswere collected. Pearson χ2 test and 2 sample t-test evaluated for variables associated with IP/IV chemotherapy completion. Kaplan-Meier survival analysis was performed for progressionfreesurvival (PFS) and overall survival (OS). Results: Of 96 women, 71.9% (n=69) completed 6 cycles of IP/IV chemotherapy. The majorityhad high grade serous histology (n=82; 85.4%) and stage IIIC disease (n=83; 86.5%). Common reasons for IP/IV chemotherapy discontinuation were grade 3–4 gastrointestinal(n=10; 37.0%), neurologic (n=6; 22.2%), hematologic (n=3; 11.1%), renal toxicities (n=3;11.1%) and port infections (n=3; 11.1%). Incidence of IP port complications was 20.8%(n=20). Port complications (48.0% vs. 11.6%; p<0.001) and hospitalization duringchemotherapy (29.6% vs. 2.9%; p<0.001) were more frequent in patients who discontinuedIP/IV chemotherapy. Patients who completed IP/IV chemotherapy had higher rates of homedischarge following CRS (92.2% vs. 72.0%; p<0.01) and lower Eastern Cooperative OncologyGroup (ECOG) score (0 vs. 1.0; p=0.04). There was no significant difference in PFS (p=0.51)nor OS (p=0.38) between the cohorts. Conclusion: In this series, the rate of IP/IV chemotherapy completion is high. Non-homedischarge and higher ECOG status following CRS are associated with IP/IV chemotherapynon-completion and should be considered in treatment planning.

Sentinel lymph node mapping in endometrial and cervical cancer: a survey of practices and attitudes in gynecologic oncologists

Laura Moulton Chambers,Roberto Vargas,Chad M. Michener 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.3

Objective: To determine patterns among gynecologic oncologists in sentinel lymph node mapping (SLNM) for endometrial cancer (EC) and cervical cancer (CC). Methods: A online survey assessing the practice of SLNM, including incidence, patterns of usage, and reasons for non-use was distributed to Society of Gynecologic Oncology candidate and full members in August 2017. Descriptive statistics and univariate analysis was performed. Results: The 1,117 members were surveyed and 198 responses (17.7%) were received. Of the 70% (n=139) performing SLNM, the majority reported use for both CC and EC (64.0%) or EC alone (33.1%). In those using SLNM in EC, the majority (86.6%) performed SLNM in >50% of cases for all patients (56.3%), International Federation of Gynecology and Obstetrics grade 1 (43.0%) and 2 (42.2%). Reported benefits of SLNM in EC were reduced surgical morbidity (89.6%), lymphedema (85.2%), and operative time (63.7%). Among those using SLNM for CC, the majority (73.1%) did so in >50% of cases. In EC, 77.2% and 21.3% reported that micro-metastatic disease (0.2–2.0 cm) and isolated tumor cells (ITCs) should be treated as node positive, respectively. In those not using SLNM for EC (n=64) and CC (n=105), concerns were regarding efficacy of SLNM and lack of training. When queried regarding training, 73.7% felt that SLNM would impact skill in full lymphadenectomy (LND). Conclusion: The SLNM is utilized frequently among gynecologic oncologists for EC and CC staging. Common reasons for non-uptake include uncertainty of current data, lack of training and technology. Concerns exist regarding impact of SLNM in fellowship training of LND.

Polymerisation and characterisation of conducting polyaniline nanoparticle dispersions

S. E. Moulton,P. C. Innis,Kane-Maguire,O. Ngamna,G. G. Wallace 한국물리학회 2004 Current Applied Physics Vol.4 No.2-4

Micellar emulsion chemical polymerisation of polyaniline (PANI) using dodecylbenzenesulfonic acid (DBSA) as the micelle anddopant was performed at 20.C. It was necessary to use a ratio of 1:1:1 for aniline, oxidant (ammonium persulfate APS) and DBSAto produce the PANIÆDBSA in the emeraldine salt (ES) form in large quantities (40 g). The resulting polymer was a nanodispersionwith spherical particles 10±2 nm in diameter and an electrical conductivity of 15±3 Scm. 1 as determined by transmission electronmicroscopy (TEM) and the four-point probe method, respectively. UVvis spectral characterisation showed the nanodispersion tobe highly doped. Complete deprotonation of the polymer to the emeraldine base form using 0.5 M NaOH was only possible upondilution to approximately 0.05% w/v polymer. Reduction of the polymer to leucoemeraldine using phenylhydrazine was relativelyslow; however, oxidation to pernigraniline in 0.25 M APS occurred instantaneously.

음소체계의 언어지도화

Willam G. Moulton 文學과 言語硏究會 1987 문화와 융합 Vol.8 No.-

방언지리학의 기법이 금세기 전환기에 이르러 발전되기 시작했을 때 학자들은 종전의 유용한 역사적 언어연구에다가 새로운 지리적 측면을 첨가하였다. 그래서 역사-지리적인 historical-geographical 양면적인 접근이 가능하도록 하였다. 이 두 측면은 시간과 공간이라는 언어 외적인 요소들에 관심을 둠으로써 우리들은 그것들을 언어 외적인 영역으로서 관찰할 수 있게 되었다. 금세기동안 많은 언어학자들은 언어 내적인 면, 곧 구조언어적인 음운, 문법, 어휘 어미 연구에 기여해 왔다. 이런 세 가지 측면이 시간과 공간적인 요소와 분명히 유리되어 처음 연구되었을지라도 최근에는 역사적인 면과 결합되었고, 역사적 구조(historical-structure) 연구는 많은 학자들에 의해 기술되었다.

음소체계의 언어지도화

Willam G,Moulton,이상규 한국문화융합학회 1987 문화와 융합 Vol.8 No.-

On the structure of the tight-span of a totally split-decomposable metric

Huber, K.T.,Koolen, J.H.,Moulton, V. Elsevier 2006 European journal of combinatorics : Journal europ& Vol.27 No.3

<P><B>Abstract</B></P><P>The tight-span of a finite metric space is a polytopal complex with a structure that reflects properties of the metric. In this paper we consider the tight-span of a totally split-decomposable metric. Such metrics are used in the field of phylogenetic analysis, and a better knowledge of the structure of their tight-spans should ultimately provide improved phylogenetic techniques. Here we prove that a totally split-decomposable metric is cell-decomposable. This allows us to break up the tight-span of a totally split-decomposable metric into smaller, easier to understand tight-spans. As a consequence we prove that the cells in the tight-span of a totally split-decomposable metric are zonotopes that are polytope isomorphic to either hypercubes or rhombic dodecahedra.</P>

Phylogeny of the Diptera Using a Multi-Gene Approach

Jungwook Kim,Norman Barr,Brian Weigmann,Kevin Moulton 한국응용곤충학회 2005 한국응용곤충학회 학술대회논문집 Vol.2005 No.05

Injective optimal realizations of finite metric spaces

Koolen, J.H.,Lesser, A.,Moulton, V.,Wu, T. North-Holland Pub. Co ; Elsevier Science Ltd 2012 Discrete mathematics Vol.312 No.10

A realization of a finite metric space (X,d) is a weighted graph (G,w) whose vertex set contains X such that the distances between the elements of X in G correspond to those given by d. Such a realization is called optimal if it has minimal total edge weight. Optimal realizations have applications in fields such as phylogenetics, psychology, compression software and internet tomography. Given an optimal realization (G,w) of (X,d), there always exist certain ''proper'' maps from the vertex set of G into the so-called tight span of d. In [A. Dress, Trees, tight extensions of metric spaces, and the cohomological dimension of certain groups: a note on combinatorial properties of metric spaces, Adv. Math. 53 (1984) 321-402], Dress conjectured that any such map must be injective. Although this conjecture was recently disproven, in this paper we show that it is possible to characterize those optimal realizations (G,w) for which certain generalizations of proper maps-that map the geometric realization of (G,w) into the tight span instead of its vertex set-must always be injective. We also prove that these ''injective'' optimal realizations always exist, and show how they may be constructed from non-injective ones. Ultimately it is hoped that these results will contribute towards developing new ways to compute optimal realizations from tight spans.

Δ additive and Δ ultra-additive maps, Gromov's trees, and the Farris transform

Dress, A.,Holland, B.,Huber, K.T.,Koolen, J.H.,Moulton, V.,Weyer-Menkhoff, J. Elsevier 2005 Discrete Applied Mathematics Vol.146 No.1

<P><B>Abstract</B></P><P>In phylogenetic analysis, one searches for phylogenetic trees that reflect observed similarity between a collection of species in question. To this end, one often invokes two simple facts: (i) Any tree is completely determined by the metric it induces on its leaves (which represent the species). (ii) The resulting metrics are characterized by their property of being <I>additive</I> or, in the case of dated rooted trees, <I>ultra-additive</I>. Consequently, searching for additive or ultra-additive metrics <I>A</I> that best approximate the metric <I>D</I> encoding the observed similarities is a standard task in phylogenetic analysis. Remarkably, while there are efficient algorithms for constructing optimal ultra-additive approximations, the problem of finding optimal additive approximations in the <SUB>l1</SUB> or <SUB>l∞</SUB> sense is NP-hard. In the context of the theory of δ-<I>hyperbolic</I> groups, however, good additive approximations <I>A</I> of a metric <I>D</I> were found by Gromov already in 1988 and shown to satisfy the bound∥D-A<SUB>∥∞</SUB>⩽Δ(D)⌈<SUB>log2</SUB>(#X-1)⌉,where Δ(D), the <I>hyperbolicity</I> of <I>D</I>, i.e. the maximum of all expressions of the formD(u,v)+D(x,y)-max(D(u,x)+D(v,y),D(u,y)+D(v,x))(u,v,x,y∈X). Yet, besides some notable exceptions (e.g. Adv. Appl. Math. 27 (2001) 733–767), the potential of Gromov's concept of hyperbolicity is far from being fully explored within the context of phylogenetic analysis. In this paper, we provide the basis for a systematic theory of Δ <I>ultra-additive</I> and Δ <I>additive</I> approximations. In addition, we also explore the average and worst case behavior of Gromov's bound.</P>