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Hydrochlorothiazide의 microcapsule 제조와 평가
남상철,박목순,나성범,이계원,지웅길 충남대학교 약학대학 의약품개발연구소 1990 藥學論文集 Vol.6 No.-
The microcapsules of hydrochlorothiazide using Eudragit RL were prepared by the solvent evaporation process in liquid paraffin phase, and the microcapsules of hydrochlorothiazide using Ethylcellulose were prepared by the solvent evaporation process in water phases. The size distribution, drug content, interaction between the drug and the polymer, dissolution test, observation of SEM were investigated. The results are summarized as belows. The Eudragit RL microcapsules and Ethylcellulose microcapsules obtained were spherical, uniform and free flowing particles. As the dispersing agents (Eudragit RL-magnesium stearate, Ethylcellulose-sod, lauryl sulfate) were fixed, the preparation of microcapsules showed constant in particle size distribution. The actual drug contents of the Eudragit RL microcpasules were lower than theoretical drug contents, but the actural drug contents of the Ethylcellulose were higher than those. No interaction between the polymer and the drug was observed from the results of TLC, UV, IR, DSC. The release of hydrochlorothiazide from the Eudragit RL microcapsules except for the release in pH 8.0 phosphate buffer solution was not increased when the drug: polymer ratio was increased. The dissolution rate of hydrochlorothiazide from Ethylcellulose microcapsules increased with increasing drug: polymer ratio. Scanning electron micrograph study revealed that microcapsules prepared by this method showed comparatively rough surface when drug: polymer ratio was decreased.
고분자 혼합법과 다중 에멀젼법에 의해 제조된 생분해성 미립구로부터 펩타이드의 용출에 관한 연구
정구영,김중권,박목순,명평근 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10
The novel microsphere blending and multiple emulsion method by single process was tried to prepare sustained release microspheres which release a physiologically active substance for long periods of time. A drug was separately dissolved in each of two or more oils containing biodegradable polymers to give the primary oil phases. The primary oil phases were dispersed in single aqueous phase in succession. From the drug-dispersed solution, the organic solvent was removed to produce microspheres. The accelerated drug release from the microsphere formulation prepared by single process through the multiple emulsion method was very similar to a physical blending of separately prepared microspheres using the same polymers. But long term release was not same. In this study, leuprorelin acetate loaded poly(lactide-co-glycolide) microsphere formulation for one-month delivery was developed by the multi-emulsion method followed by solvent extraction/evaporation method.
병풀(Centella asiatica) 엑스-베타시클로텍스트린 고체 분산체를 함유한 폴록사머 407 히드로겔 제조 및 피부투과
김경국,곽은선,이계원,박진규,박목순,지웅길 충남대학교 약학대학 의약품개발연구소 1998 藥學論文集 Vol.14 No.-
Extract of Centella asiatica(ECA), which is poorly water-soluble extract from the Centella asiatica is known to express excellent wound healing properties. ECA-β-cyclodextrin (asiaticoside-β-cyclodextrin and genin-β-cyclodextrin) solid dispersion system, which was prepared by freeze-drying method, was formulated as gels containing poloxamer 407 and propylene glycol, and evaluated with respect to their viscosity. stability, skin permeation and drug amount in the skin of hairless mouse. The average molar ratio asiaticoside-β-CD and genin-β-CD was 1:1,7 and 1:22, respectively. When the molar ratio of genin and β-CD was 1:5, madecassic acid made 100% solid dispersion system and asiatic and about 65%. In dissolution study, >99% of asiaticoside from asiaticoside-β-CD was dissolved in 5 minutes, and >99% madecassic acid and >64% asiatic acid from genin-β-CD. The apparent viscosity of poloxamer 407 gels with ECA-β-CD solid dispersion system increased in proportion to poloxamer 407 and gels showed that asiaticoside was most stable and madecassic acid stable and asiatic acid similar to stability of gel with free ECA. The permeation amount of asiaticoside in poloxamer gels through-hairless mouse skin decreased as the concentration of poloxamer 407 increased. When propylene glycol was added at the level of 10%, the permeation amount of asiaticoside at poloxamer gels through hairless mouse skin increased but from 15% it decreased. The permeation of asiaticoside into the skin of hairless mouse was estimated to be about 0.10 ㎍/㎠.
Hyun Mork Lee 충청수학회 2021 충청수학회지 Vol.34 No.3
We introduce high-order Hopfield neural networks with Leakage delays. Furthermore, we study the uniqueness and existence of Hopfield artificial neural networks having the weighted pseudo almost periodic forcing terms on finite delay. Our analysis is based on the differential inequality techniques and the Banach contraction mapping principle.
마이크로플루다이저를 이용한 아클라루비신 리포좀의 제조 및 평가
박목순(Mork Soon Park),박진규(Jin Kyu Park),이계원(Gye Won Lee),백명기(Myoung Ki Baek),지웅길(Ung Kil Lee) 대한약학회 1998 약학회지 Vol.42 No.3
In order to attain a sustained release at targeted organs in a prolonged time which can reduce the side effects and maximize the therapeutic effect, aclarubicin (ACL) was entrapped into liposomes of different lipid compositions using Microfluidizer, and dry liposomes were prepared by lyophilization. The dry aclarubicin-entrapped liposomes were evaluated in terms of mean particle size and size distribution, entrapment efficiency and in vitro drug release profile. The Entrapment efficiency of liposome, when the concentration of aclarubicin and lipid were 0.5 to 1.0mg/ml and 200mcmol/ml,respectively, was over 80% using Microfluidizer, in contrast to 70% of entrapment efficiency using hand-shaking method. Mean particle size and size distribution of aclarubicin-entrapped liposomes of various lipid compositions did not change considerably by the freeze drying. The range of particle size was between 80 and 200nm. Among aclarubicin-entrapped liposomes, ACL-liposome of PC/DPPC/CH0L/TA displayed the most significant sustained release. The addition of DPPC appeared to be favorable for the control of release. In general, aclarubicin entrapped in liposomes was less stable than free aclarubicin either in pH 7.4 phosphate buffer or in human plasma. Formulation I(t1/2, 20.3 hr) devoid of lipid additive was the most unstable in the phosphate-buffer solution while formulation II(t1/2, 40.7 hr) with cardiolipin was the most stable. Half lives of aclarubicin-entrapped liposomes in human plasma were 43.2, 50.7, 35.9 and 35.3 hr for formulation I. II, III and IV, respectively, in contrast to 57.8 hr for free aclarubicin.
Hyun Mork Lee,Hyun Ho Jang,Chan Mi Yun 충청수학회 2018 충청수학회지 Vol.31 No.1
By using of the Banach fixed point theorem, the theory of a strongly continuous semigroup of operators and resolvent opera-tor, we investigate the existence and uniqueness of S-asymptotically ω-periodic mild solutions for some differential (integrodifferential) equations with piecewise constant argument when specially ω is an integer.
Hyun Mork Lee 충청수학회 2015 충청수학회지 Vol.28 No.3
Of concern is the existence, uniqueness, and continuous dependence of a mild solution of a nonlocal Cauchy problem for a semilinear mixed Volterra-Fredholm functional integrodifferential equation. Our analysis is based on the theory of a strongly continuous semigroup of operators and the Banach fixed point theorem.
EXISTENCE OF FUNCTIONAL DIFFERENTIAL EQUATIONS WITH STEPANOV FORCING TERMS
Hyun Mork Lee 충청수학회 2020 충청수학회지 Vol.33 No.3
We introduce a new concept of Stepanov weighted pseudo almost periodic functions of class $r$ which have been established by recently in \cite{Shan}. Furthermore, we study the uniqueness and existence of Stepanov weighted pseudo almost periodic mild solutions of partial neutral functional differential equations having the Stepanov pseudo almost periodic forcing terms on finite delay.
리포좀에 봉입된 아클라루비신의 약물동태, 세포독성, 항암효과 및 비장/혈구 세포독성
박목순(Mork Soon Park),박진규(Jin Kyu Park),이계원(Gye Won Lee),명평근(Pyung Keun Myung),석대은(Dai Eun Sok),황성주(Sung Joo Hwang),지웅길(Ung Kil Lee) 大韓藥學會 1998 약학회지 Vol.42 No.3
Aclarubicin(ACL)-entrapped freeze dried liposomes were prepared using Microfludizer to attain a sustained release at targeted organs in a prolonged time so that it can reduce the side effect and maximize the therapeutic effect. The freeze-dried liposomes were evaluated for pharmacokinetics, antitumor activity against Sarcoma 180, cytotoxicity against L1210 and A549 tumor cells, spleen toxicity and myelosuppressive action. The AUC0->8hr values were 122+/-42, 382+/-140, 419+/-171, 835+/-206 and 443+/-309mcg min/ml for free ACL. ACL-liposome formulation I, II, III and IV, respectively. Cytotoidcity of ACL-entrapped liposomes against L1210 and A549 tumor cells was 2-4 times higher than that of free aclarubicin. ACL-liposome formulation I(PC/CHOL/TA) showed the most potent antitumor activity against Sarcoma 180 in mice. The loss of body weight was much smaller with ACL-entrapped liposomes than free ACL after I.p. injection at a dose of 2 mg/kg/day. Compared to free ACL, ACL-entrapped liposomes expressed a lower and delayed spleen toxicity up to 5th day after I.v. administration. Myelosupperssion seemed to be lower with ACL-entrapped liposome of PC/PC-hydrate/CHOL/TA (formulation III) than free aclarubicin.