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The Incidence and Mortality of Liver Cancer and its Relationship with Development in Asia
Mohammadian, Maryam,Soroush, Ali,Mohammadian-Hafshejani, Abdollah,Towhidi, Farhad,Hadadian, Fatemeh,Salehiniya, Hamid Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.4
Background: Liver cancer (LC) is the sixth world most common cancer and the second leading cause of cancer death. Due to the importance and necessity of awareness about the incidence and mortality of diseases to perform prevention programs, this study focused on data for LC and its relationship with the human development index (HDI) and its components in Asia in 2012. Materials and Methods: This ecological study was based on GLOBOCAN data for Asian countries. We assessed correlations between standardized incidence rates (SIR) and standardized mortality rates (SMR) of LC with HDI and its components using of SPSS18. Results: A total of 582,420 incident cases and 557,097 deaths were recorded in Asian countries in 2012. The five with the highest SIR were Mongolia, Lao PDR, Vietnam, Republic of Korea and Thailand and those with the highest SMR were Mongolia, Lao PDR, Vietnam, Cambodia and Thailand. A negative relation was observed between HDI and LC for SIR of 0.049 (P=0.748) and for SMR of 0.07 (P=0.645), with life expectancy at birth a positive relation for SIR of 0.061 (P=0.687) and a negative relation for SMR of 0.079 (P=0.603), with the average years of education a negative relation fo SIR of 0.476 (p=0.952) and for SMR of 0.032 (P=0.832), and with the country income level per person a negative relation for SMI of 0.11 (p=0.465) and for SMR of 0.113 (P=0.455). Conclusions: The incidence of LC is more in less developed and developing countries but statistically significant correlations were not found between standardized incidence and mortality rates of LC, and HDI and its dimensions.
Upregulation of Mir-34a in AGS Gastric Cancer Cells by a PLGA-PEG-PLGA Chrysin Nano Formulation
Mohammadian, Farideh,Abhari, Alireza,Dariushnejad, Hassan,Zarghami, Faraz,Nikanfar, Alireza,Pilehvar-Soltanahmadi, Yones,Zarghami, Nosratollah Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.18
Background: Nano-therapy has the potential to revolutionize cancer therapy. Chrysin, a natural flavonoid, was recently recognized as having important biological roles in chemical defenses and nitrogen fixation, with anti-inflammatory and anti-oxidant effects but the poor water solubility of flavonoids limitstheir bioavailability and biomedical applications. Objective: Chrysin loaded PLGA-PEG-PLGA was assessed for improvement of solubility, drug tolerance and adverse effects and accumulation in a gastric cancer cell line (AGS). Materials and Methods: Chrysin loaded PLGA-PEG copolymers were prepared using the double emulsion method (W/O/W). The morphology and size distributions of the prepared PLGA-PEG nanospheres were investigated by 1H NMR, FT-IR and SEM. The in vitro cytotoxicity of pure and nano-chrysin was tested by MTT assay and miR-34a was measured by real-time PCR. Results: 1H NMR, FT-IR and SEM confirmed the PLGA-PEG structure and chrysin loaded on nanoparticles. The MTT results for different concentrations of chrysin at different times for the treatment of AGS cell line showed IC50 values of 68.2, 56.2 and $42.3{\mu}M$ and 58.2, 44.2, $36.8{\mu}M$ after 24, 48, and 72 hours of treatment, respectively for chrysin itslef and chrysin-loaded nanoparticles. The results of real time PCR showed that expression of miR-34a was upregulated to a greater extent via nano chrysin rather than free chrysin. Conclusions: Our study demonstrates chrysin loaded PLGA-PEG promises a natural and efficient system for anticancer drug delivery to fight gastric cancer.
Mohammadian, Jamal,Sabzichi, Mehdi,Molavi, Ommoleila,Shanehbandi, Dariush,Samadi, Nasser Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.11
Docetaxel, recognized as a stabilizing microtubule agent, is frequently administrated as a first line treatment for prostate cancers. Due to high side effects of monotherapy, however, combinations with novel adjuvants have emerged as an alternative strategy in cancer therapy protocols. Here, we investigated the combined effects of stattic and docetaxel on the DU145 prostate cancer cell line. Cytotoxicity was evaluated by MTT assay. To understand molecular mechanisms of stattic action, apoptotic related genes including Bcl-2, Mcl-1, Survivin and Bax were evaluated by real-time RT-PCR. Alteration in the expression of pro-apoptotic Bax and anti-apoptotic Bcl-2 genes and Bax/Bcl-2 ratio were investigated via the $2^{{\Delta}{\Delta}CT}$ method. The $IC_{50}$ values for docetaxel and stattic were $3.7{\pm}0.9nM$ and $4.6{\pm}0.8{\mu}M$, respectively. Evaluation of key gene expression levels revealed a noticeable decrease in antiapoptotic Bcl-2 and Mcl-1 along with an increase in pro-apoptotic Bax mRNA levels (p<0.05). Our results suggest that combination of a STAT3 inhibitor with doctaxel can be considered as a potent strategy for induction of apoptosis via increasing Bax mRNA expression.
Mohammadian-Behbahani Mohammad-Reza 한국원자력학회 2024 Nuclear Engineering and Technology Vol.56 No.9
Radiation detection at high count rate suffers from pulse pile-up, where the counting data and energy information of the system are affected by the overlapping of the system output pulses. There exist various pile-up correction strategies to recover the true information of the pulses, among which pulse-tail extrapolation is a well-known method focused on in this study. Present work aims to use a mono-exponential model for extrapolating the pileup-distorted trailing edge of a pulse, to provide a reference line for calculating the true amplitude of its subsequent overlapping pulse. To this goal, the auto-regression on linear operations (ARLO) method is examined and compared with two integrationbased methods (the Foss and the Matheson methods), as well as the non-linear least squares (NLS) method. Despite a higher sensitivity to noise, the ARLO method was able to provide a simple, non-iterative solution with a performance over 400 times faster than the NLS algorithm, according to the analysis of a high count rate set of experimental pulses from a NaI(Tl) detection system. Foss and Matheson methods also provided solutions reasonably faster than NLS (but not surpassing ARLO), performing exactly the same as each other with results very close to NLS, benefiting from their non-iterative nature.
Non-Pharmacological Treatments of Psoriasis in Persian Medicine a Narrative Review
Farshad Mohammadian Rasanan,Hoorieh Mohammadi Kenari,Mohammadreza Ghassemi,Ali Jabbari Sabbagh,Jale Aliasl,Ali Ghobadi 대한약침학회 2022 Journal of pharmacopuncture Vol.25 No.1
Psoriasis is a chronic disease that has no definitive cure. In this review study, the main sources of Persian Medicine (PM) such as the Canon of Medicine (by Avicenna) and AlHavi (by Rhazes) were assessed to identify non-pharmacological treatments for psoriasis. Several treatments that are recommended for this disease include nutritional advice, lifestyle modifications, and manipulation therapy such as wet cupping (Hijamah), leech therapy, and phlebotomy (Fasd). These recommendations may help to prevent recurrence and be useful in improving psoriasis. The efficacy of PM recommendations to improve psoriasis should be evaluated in future studies.
Incidence and Mortality of Bladder Cancer and their Relationship with Development in Asia
Pakzad, Reza,Mohammadian-Hafshejani, Abdollah,Mohammadian, Mahdi,Pakzad, Iraj,Safiri, Saeid,Khazaei, Salman,Salehiniya, Hamid Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.16
Background: Over the past decade, bladder cancer was associated with a significant increase. Given the importance of the impact of socioeconomic status on the distribution of cancer incidence and mortality, and the need to information on these parameters for prevention planning, the aim of this study was to evaluate data for bladder cancer and their relationship with human development index (HDI) and its components in Asia in 2012. Materials and Methods: The study was conducted based on data from the world data of cancer and the World Bank (including the HDI and its components). The incidence and mortality rates were drawn for Asian countries. To analyze data, correlation tests between incidence and death rates, and HDI and its components were employed with a significance level of 0.05 using SPSS software. Results: A total incidence of 696,231 cases (68.7% in males and 31.3% in females, sex ratio of 2.19:1) and 524,465 deaths (67.0% in men and 32.9% in women, sex ratio was 2.03:1) were recorded in Asian countries in 2012. Correlation between HDI and standardized incidence rate was 0.241 overall (p=0.106), 0.236 in men (p=0.114) and -0.250 in women (p=0.094). Also between HDI and standardized mortality rate 0.025 (p=0.871) in men 0.118 (p=0.903) and in women 0.014 (p=0.927). Conclusions: Bladder cancer incidence is higher in developed countries, but the rate is declining, and in less developed and developing countries it is growing. There was no statistically significant correlation between the standardized incidence rate of bladder cancer and the HDI and its dimensions in Asia, except for the level of education.
Mohammad-Reza Mohammadian-Behbahani Korean Nuclear Society 2024 Nuclear Engineering and Technology Vol.56 No.9
Radiation detection at high count rate suffers from pulse pile-up, where the counting data and energy information of the system are affected by the overlapping of the system output pulses. There exist various pile-up correction strategies to recover the true information of the pulses, among which pulse-tail extrapolation is a well-known method focused on in this study. Present work aims to use a mono-exponential model for extrapolating the pileup-distorted trailing edge of a pulse, to provide a reference line for calculating the true amplitude of its subsequent overlapping pulse. To this goal, the auto-regression on linear operations (ARLO) method is examined and compared with two integration-based methods (the Foss and the Matheson methods), as well as the non-linear least squares (NLS) method. Despite a higher sensitivity to noise, the ARLO method was able to provide a simple, non-iterative solution with a performance over 400 times faster than the NLS algorithm, according to the analysis of a high count rate set of experimental pulses from a NaI(Tl) detection system. Foss and Matheson methods also provided solutions reasonably faster than NLS (but not surpassing ARLO), performing exactly the same as each other with results very close to NLS, benefiting from their non-iterative nature.
Non-iterative pulse tail extrapolation algorithms for correcting nuclear pulse pile-up
Mohammad-Reza Mohammadian-Behbahani 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.12
Radiation detection systems working at high count rates suffer from the overlapping of their output electric pulses, known as pulse pile-up phenomenon, resulting in spectrum distortion and degradation of the energy resolution. Pulse tail extrapolation is a pile-up correction method which tries to restore the shifted baseline of a piled-up pulse by extrapolating the overlapped part of its preceding pulse. This needs a mathematical model which is almost always nonlinear, fitted usually by a nonlinear least squares (NLS) technique. NLS is an iterative, potentially time-consuming method. The main idea of the present study is to replace the NLS technique by an integration-based non-iterative method (NIM) for pulse tail extrapolation by an exponential model. The idea of linear extrapolation, as another non-iterative method, is also investigated. Analysis of experimental data of a NaI(Tl) radiation detector shows that the proposed non-iterative method is able to provide a corrected spectrum quite similar with the NLS method, with a dramatically reduced computation time and complexity of the algorithm. The linear extrapolation approach suffers from a poor energy resolution and throughput rate in comparison with NIM and NLS techniques, but provides the shortest computation time.
Rafiemanesh, Hosein,Mohammadian-Hafshejani, Abdollah,Ghoncheh, Mahshid,Sepehri, Zahra,Shamlou, Reza,Salehiniya, Hamid,Towhidi, Farhad,Makhsosi, Behnam Reza Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.5
Background: This study aimed to investigate the standardized incidence and mortality rate of colorectal cancer and its relationship with the human development index (HDI) across the world in 2012. Materials and Methods: This ecologic study was conducted for assessment of the correlation between age-specific incidence rate (ASIR) and age-specific mortality rate (ASMR) with HDI and its components. Data for SIR and SMR for every country for the year 2012 were obtained from the global cancer project. We used a bivariate method for assessment of the correlation between SIR and SMR and HDI. Statistical significance was assumed at P<0.05. Statistical analyses were performed using SPSS (Version 22.0, SPSS Inc.). Results: Countries with the highest SIR of colorectal cancer in the world in 2012, were Republic of Korea, Slovakia, Hungary and countries with the highest SMR were Hungary, Croatia and Slovakia. The correlation between SIR of colorectal cancer and the HDI was 0.712 ($P{\leq}0.001$), with life expectancy at birth 0.513 ($P{\leq}0.001$), with mean years of schooling 0.641 ($P{\leq}0.001$) and with level of income per each person of the population 0.514 (P=0.013). In addition, the correlation between SMR of colorectal cancer and the HDI was 0.628 ($P{\leq}0.001$), with life expectancy at birth 0.469 ($P{\leq}0.001$), with mean years of schooling 0.592 ($P{\leq}0.001$) and with level of income per each person of the population 0.378 (P=0.013). Conclusions: The highest SIR and SMR of colorectal cancer was in the WHO Europe region. There was a positive correlation between HDI and SIR and SMR of colorectal cancer.
Lack of Any Relationship of Stomach Cancer Incidence and Mortality with Development in Asia
Rafiei, Elahe,Mohammadian-Hafshejani, Abdollah,Towhidi, Farhad,Makhsosi, Behnam Reza,Salehiniya, Hamid Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.8
Background: The aim of this study was to evaluate the incidence and mortality of stomach cancer, and its relationship with the Human Development Index (HDI) and its components in Asia in 2012. Materials and Methods: This ecological study wa conducted based on GLOBOCAN project of WHO for Asian countries. We assessed the correlations between standardized incidence rates (SIR) and standardized mortality rates (SMR) of stomach Cancer with HDI and its components using SPSS18. Results: A total of 696,231 cases (68.7% in males and 31.3% in females, ratio of 2.19:1) and 524,465 deaths (67.1% in men and 33.0% in women, ratio 2.03:1) were included in 2012. Five countries with the highest SIR of stomach cancer were Republic Korea, Mongolia, Japan, China and Tajikistan. Five countries with the highest SMR of stomach cancer were Mongolia, Tajikistan, Kyrgyzstan, Kazakhstan and China. Correlation between HDI and SIR was 0.241 (p = 0.106), in men 0.236 (p = 0.114) and in women -0.250 (p = 0.094). Also between HDI and SMR -0.250 (p = 0.871) in men -0.018 (p = 0.903) and in women -0.014 (p = 0.927). Conclusions: No significant correlation was observed between the SIR of stomach cancer, and the HDI and its dimensions, such as life expectancy at birth, mean years of schooling, and income level of the population.