Response to the Editor

Hiromi Matsumoto,Hiroshi Hagino,Takashi Wada 대한골다공증학회 2016 Osteoporosis and Sarcopenia Vol.2 No.4

.

Diagnosis of knee osteoarthritis and gait variability increases risk of falling for osteoporotic older adults: The GAINA study

Hiromi Matsumoto,Hiroshi Hagino,Hirofumi Sageshima,Mari Osaki,Shinji Tanishima,Chika Tanimura 대한골다공증학회 2015 Osteoporosis and Sarcopenia Vol.1 No.1

Objectives: To examine the relationship between history of falling, and musculoskeletal disease, bone mass, muscle strength, muscle mass, kyphosis, and gait speed and variability in osteoporotic older adults. Methods: The GAINA study, which began in 2014, is a population-based prospective study of subject cohorts from the town of Hino, Tottori Prefecture, Japan. Participants were recruited from among individuals who had an annual town-sponsored medical check-up in 2014, between May and June. A total 223 of residents were screened for our study. Inclusion criteria were osteoporotic older adults who had: (1) a ?70% young adult mean (YAM) bone mass as assessed using quantitative ultrasound (QUS) methods, (2) a prior hip fracture or vertebral fracture, (3) fragility fractures other than hip and vertebral fractures and <80% YAM of bone mass. From the total screened, 91 residents (mean age, 76.0 ± 8.0 years; 22 men and 69 women) met the eligibility criteria. History of falling, diagnosis of musculoskeletal disease, bone mass, grip strength, muscle mass, kyphosis, and gait speed were assessed. Gait variability analysis was based on acceleration in three directions: mediolateral (ML), vertical (VT), and anteroposterior (AP) using a wireless triaxial accelerometer. Subjects were classified as belonging to a nonfall group or fall group based on their history of falling. Results: During the previous 12 months, 26 falls were reported by 16 subjects (5 men and 11 women). Sixteen of the 91 included patients (17.6%) fell (22% men and 15% women), and 8 of the 16 subjects reported multiple falls. In a multivariable analysis, diagnosis of knee osteoarthritis and higher gait variability had a significant independent relationship with falling in these osteoporotic adults. Conclusions: Diagnosis of knee osteoarthritis and gait variability are associated with previous falls in osteoporotic older adults. Accelerometrybased gait analysis may be a useful tool with which to assess the risk of falling in this population.

Locomotive syndrome presents a risk for falls and fractures in the elderly Japanese population

Hiromi Matsumoto,Hiroshi Hagino,Takashi Wada,Eri Kobayashi 대한골다공증학회 2016 Osteoporosis and Sarcopenia Vol.2 No.3

“Locomotive syndrome” is used to designate the condition of individuals with musculoskeletal disease who are highly likely to require nursing care. This article reviews screening, prevalence, causal and related factors, and the relationship between locomotive syndrome and falls and fractures in older adults with this syndrome. A few self-administered questionnaire tools are available to assess individuals for locomotive syndrome. Additionally, screening methods, including a physical functioning assessment, are appropriate for detailed discrimination of locomotive syndrome. The prevalence of locomotive syndrome is significantly higher in women than in men, and tends to increase markedly from 70 years of age. More severe locomotive syndrome is related to knee pain, osteoporosis, sarcopenia, and lumbar disease. The incidence of falling in locomotive syndrome is higher than the incidence for the older population in general. Locomotive training including squats and a unipedal standing exercise has been recommending to prevent locomotive syndrome. This training improves muscle strength and balance function for older people who have a risk for locomotive syndrome.

DQRUMA / PAR Method for Multimedia Wireless Access Networks

Tetsuya Yamashita,Takashi Matsumoto,Tomohiro Haruki,Hiromi Okada 대한전자공학회 1998 대한전자공학회 심포지엄 논문집 Vol.3 No.-

Relationship among Osteoporosis, Sarcopenia, Locomotive Syndrome, and Spinal Kyphosis in Older Individuals Living in a Local Mountain Area

Tanishima Shinji,Hagino Hiroshi,Matsumoto Hiromi,Tanimura Chika,Nagashima Hideki 대한척추외과학회 2023 Asian Spine Journal Vol.17 No.6

Study Design: Cross-sectional cohort study.Purpose: This study investigated the relationship among osteoporosis, sarcopenia, locomotive syndrome, and spinal kyphosis in older individuals living in a mountain area.Overview of Literature: Kyphosis greatly reduces the quality of life of older individuals. Osteoporosis and sarcopenia are kyphosiscausing factors.Methods: This cross-sectional study included 361 individuals aged ≥65 years (mean age, 75.0 years) living in a local mountain area and underwent medical check-ups from 2014 to 2018. The survey items included kyphosis index, body mass index, back pain prevalence, back pain Visual Analog Scale score, Oswestry Disability Index, walking speed, grip strength, skeletal mass index, osteoporosis (% young adult mean [YAM]), LOCOMO 5 score, and presence of sarcopenia (Asian Working Group for Sarcopenia). The participants were divided into the N (kyphosis index: <12; n=229, 63.4%), M (kyphosis index: 12–15; n=99, 27.4%), and K (kyphosis index: ≥15; n=33, 9.2%) groups. <i>p</i> -values of <0.05 were considered statistically significant. An association factor of kyphosis (kyphosis index: ≥15) was investigated with logistic regression analysis.Results: Age and LOCOMO 5 scores were significantly higher (<i>p</i> <0.05) and %YAM and walking speed were significantly lower (<i>p</i> <0.05) in the K group than in the M and N groups. Other survey items showed significant differences. Only %YAM (odds ratio, 0.20; 95% confidence interval, 0.04–0.96) was an independent factor associated with a kyphosis index of ≥15.Conclusions: Decreased muscle mass and muscle strength would be related to kyphosis; however, no such relations were noted. Bone loss was significantly related to kyphosis. Osteoporosis-induced decrease in vertebral body height is present in the background. Sarcopenia and locomotive syndrome were not related to kyphosis, whereas decreased bone density was independently associated with kyphosis in older individuals living in a mountain area.

Inhaled Corticosteroid and Secondary Glaucoma: A Meta-analysis of 18 Studies

Ishii Mai,Horita Nobuyuki,Takeuchi Masaki,Matsumoto Hiromi,Ebina-Shibuya Risa,Hara Yu,Kobayashi Nobuaki,Mizuki Nobuhisa,Kaneko Takeshi 대한천식알레르기학회 2021 Allergy, Asthma & Immunology Research Vol.13 No.3

Purpose Guidelines and systematic reviews frequently warn of inhaled corticosteroid (ICS)-induced glaucoma. However, most of the published studies deny it. Methods We performed a systematic review of randomized, cohort, nested-case control, cross-sectional studies by using Meta-analyses of Observational Studies in Epidemiology statement. Four major databases, PubMed, EMBASE, Cochrane Search Manager, and the Web of Science Core Collection as well as meta-analysis were used. Studies comparing incidence, prevalence and intraocular pressure (IOP) between patients who were treated with and without ICSs were included. A random-model meta-analysis was performed using the inverse variance method. Results Out of 623 studies screened, 18 with 31,665 subjects were finally included. No significant difference between the 2 groups was observed for crude glaucoma incidence (odds ratio [OR], 0.95; 95% confidence interval [CI], 0.86–1.04; P = 0.26; I 2 = 0%; P for heterogeneity = 0.57) as a primary endpoint, adjusted glaucoma incidence (OR, 0.90; 95% CI, 0.65–1.24; P = 0.64), crude prevalence (OR, 1.82; 95% CI, 0.23–14.19; P = 0.57), adjusted prevalence (OR, 1.22; 95% CI, 0.50–2.96; P = 0.66), IOP change during ICS treatment (mean difference [MD] +0.01 mmHg; 95% CI, −0.19–0.20; P = 0.95), and single measurement IOP (MD +0.37 mmHg; 95% CI, −0.24–0.97; P = 0.23). Time-to-event analysis for glaucoma development as one of the secondary endpoints (adjusted hazard ratio, 0.52; 95% CI, 0.28–0.96) suggested a reverse association between ICS and glaucoma. Conclusions The ophthalmological side effects of ICSs, such as glaucoma and intraocular hypertension, should not be exaggerated.