http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Lee, Eun-Sil,Kim, Hwan-Mook,Lee, Sung-Dong,Lee, Kwang-Seung,Park, Song-Kyu,Lee, Chang-Woo,Lee, Ki-Ho,Lee, Ki-Hoon,Lee, Jun-Soo,Hwang, Woo-Ik,In, Man-Jin,Kim, Dong-Chung The Korean Society for Applied Biological Chemistr 2010 Applied Biological Chemistry (Appl Biol Chem) Vol.53 No.3
A lipid-soluble ginseng extract possesses an anticancer activity against advanced human lung tumors in an established murine xenograft model without any sign of toxicity. The extract also shows a potent anti-proliferative activity against human cancer cell lines, leading to expansion of its preclinical applications to specific human tumor types.
Lee, Kang Uk,Lee, Jung Hie,Lee, Dong Young,Youn, Jong Chul,Kim, Jeong Lan,Moon, Seok Woo,Kim, Bong-Jo,Ryu, Seung-Ho,Kim, Moon Doo,Lee, Chang-Uk,Lee, Nam-Jin,Chang, Sung Man,Kim, Young Hoon,Kim, Do Hoo Korean College of Neuropsychopharmacology 2015 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.13 No.2
<P><B>Objective</B></P><P>We examined the difference in responses to donepezil between carriers and non-carriers of the A allele at the +4 position of the choline acetyltransferase (ChAT) gene in Koreans.</P><P><B>Methods</B></P><P>Patients who met the criteria for probable Alzheimer’s disease (AD) (n=199) were recruited. Among these, 145 completed the 12-week follow-up evaluation and 135 completed the 26-week scheduled course. Differences and changes in the Korean version of the mini-mental state examination (MMSE-KC) score, Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Neuropsychological Assessment Battery (CERAD-K[N]) wordlist subtest score (WSS), CERAD-K(N) total score (TS), and the Korean version of geriatric depression scale (GDS-K) score between baseline and 12 weeks or 26 weeks were assessed by the Student’s <I>t</I>-test.</P><P><B>Results</B></P><P>At 12 weeks, the changes in the MMSE-KC score, CERAD-K(N) WSS, and CERAD-K(N) TS from baseline were not significant between ChAT A allele carriers and non-carriers; however, at 26 weeks, these changes were significantly larger in ChAT A allele carriers than in non-carriers (<I>p</I>=0.02 for MMSE-KC and <I>p</I>=0.03 for CERAD-K(N) WSS respectively).</P><P><B>Conclusion</B></P><P>Our findings in this study suggested that presence of the A allele at the +4 position of ChAT might positively influence the treatment effect of donepezil in the early stages of AD in Koreans.</P>
Characterization of Lateral Type Field Emitters with Carbon-Based Surface Layer
Lee, Myoung-Bok,Lee, Jae-Hoon,Kwon, Ki-Rock,Lee, Hyung-Ju,Hahm, Sung-Ho,Lee, Jong-Hyun,Lee, Jung-Hee,Choi, Kyu-Man The Korean Infomation Display Society 2001 Journal of information display Vol.2 No.3
Lateral type poly-silicon field emitters were fabricated by utilizing the LOCOS (Local Oxidation of Silicon) process. For the implementation 'of an ideal field emission device with quasi-zero tunneling barrier, a new and fundamental approach has used conducted by introducing an intelligent carbon-based thin layer on the cathode tip surface via a field-assisted self-aligning of carbon (FASAC) process. Fundamental lowering of the turn-on field for the electron emission was feasible through the control of both the tip shape and surface barrier height.
Lee, Woong-Hee,Jang, Sunhyae,Lee, Jung-Suk,Lee, Young,Seo, Eun-Young,You, Kwan-Hee,Lee, Seung-Chul,Nam, Kwang-Il,Kim, Jin-Man,Kee, Sun-Ho,Yang, Jun-Mo,Seo, Young- Joon,Park, Jang-Kyu,Kim, Chang Deok,L The Society for Investigative Dermatology, Inc 2005 The Journal of investigative dermatology Vol.125 No.5
We isolated a human gene encoding keratinocyte proline-rich protein (hKPRP). hKPRP gene is located in the region of epidermal differentiation complex on chromosome 1q21, and its ∼2.5 kb mRNA encodes 579 amino acid protein with high proline content (18%). The mRNA level of hKPRP was markedly increased at both 7 and 14 d after treatment with 1.2 mM calcium in cultured normal human epidermal keratinocytes. In situ hybridization demonstrated that hKPRP was expressed in upper granular layer of normal epidermis with characteristic intermittent pattern. In psoriatic lesion, hKPRP expression was increased as compared with normal skin and showed continuous pattern. Immunohistochemical analysis also confirmed the expression of hKPRP at the protein level. Western blot analysis showed that hKPRP protein of ∼70 kDa size was significantly increased by calcium in a time-dependent manner. In mouse tissue blot assays, the expression of KPRP was detected in stomach and skin tissues, and began at 17.5 embryonic days. Additionally, hKPRP expression was detected in the periderm of human fetal skin from 16 wk estimated gestational age. Together, these results suggest that hKPRP is an epidermal marker expressed in stratified squamous epithelia and has a potential role in keratinocytes differentiation.Journal of Investigative Dermatology (2005) 125, 995–1000; doi:10.1111/j.0022-202X.2005.23887.x
Culture Parameters for Nonactin Production by Streptomyces viridochromogenes JM-4151
Lee, Sang-Han,Lee, Dong-Sun,Lee, Jin-Man,Kim, Tae-Ho,Kim, Jong-Guk,Han, Kab-Cho,Lee, Jin-Sik,Kwon, Gi-Seok Korean Society of Life Science 2001 Journal of Life Science Vol.11 No.1
Nonactin is the parent compound of a group of ionophore antibiotics, that known as the macrotetrolides. In previous report, in th course of screening superoxide radical-generating compounds from microbial sources, we first screened Streptomyces viridochromogenes JM-4151 that produces nonactin. It was proved that nonactin is superoxide radical-producing compound. In present study, we examined the optimal culture conditions of nonacin. Th optimal culture conditions for nonactin production were as follows: 1% soluble starch, 1% yeast extract, 0.2% ammonium nitrate, 0.06% magnesium sulfate, 0.2% calcium carbonate, initial pH 7.0 at 28$^{\circ}C$ for 96 h. The highest nonactin production was achieved in the production medium of initial pH7.0 at 28$^{\circ}C$ for 96h. The threshold level of dissolved oxygen was found to be above 33.2% at 28$^{\circ}C$ when 1% soluble starch was used as a carbon source. These results suggest that S. viridochromogenes JM-4151 might be a possible strain for industrial nonactin producer.
Cryptogenic Organizing Pneumonia: Serial High-Resolution CT Findings in 22 Patients.
Lee, Ju Won,Lee, Kyung Soo,Lee, Ho Yun,Chung, Man Pyo,Yi, Chin A,Kim, Tae Sung,Chung, Myung Jin American Roentgen Ray Society, etc.] 2010 American Journal of Roentgenology Vol.195 No.4
<P>OBJECTIVE: We conducted a review of serial high-resolution CT (HRCT) findings of cryptogenic organizing pneumonia (COP). MATERIALS AND METHODS: Over the course of 14 years, we saw 32 patients with biopsy-confirmed COP. Serial HRCT scans were available for only 22 patients (seven men and 15 women; mean age, 52 years; median follow-up period, 8 months; range, 5-135 months). Serial CT scans were evaluated by two chest radiologists who reached a conclusion by consensus. Overall changes in disease extent were classified as cured, improved (i.e., ??10% decrease in extent), not changed, or progressed (i.e., ??10% increase in extent). When there were remaining abnormalities, the final follow-up CT images were analyzed to express observers' ideas regarding what type of interstitial lung disease the images most likely suggested. RESULTS: The two most common patterns of lung abnormality on initial scans were ground-glass opacification (86% of patients [19/22]) and consolidation (77% of patients [17/22]), distributed along the bronchovascular bundles or subpleural lungs in 13 patients (59%). In six patients (27%), the disease disappeared completely; in 15 patients (68%), the disease was decreased in extent; and in one patient (5%), no change in extent was detected on follow-up CT. When lesions remained, the final follow-up CT findings were reminiscent of fibrotic nonspecific interstitial pneumonia in 10 of 16 patients (63%). CONCLUSION: Although COP is a disease with a generally good prognosis, most patients (73%) with COP have some remaining disease seen on follow-up CT scans, and, in such cases, the lesions generally resemble a fibrotic nonspecific interstitial pneumonia pattern.</P>
Lee, Jinwoo,Na, Hyon Bin,Kim, Byoung Chan,Lee, Jin Hyung,Lee, Byoungsoo,Kwak, Ja Hun,Hwang, Yosun,Park, Je-Geun,Gu, Man Bock,Kim, Jaeyun,Joo, Jin,Shin, Chae-Ho,Grate, Jay W.,Hyeon, Taeghwan,Kim, Jungb Royal Society of Chemistry 2009 Journal of materials chemistry Vol.19 No.42
<P>A magnetically-separable and highly-stable enzyme system was developed by adsorption of enzymes in superparamagnetic hierarchically ordered mesocellular mesoporous silica (M-HMMS) and subsequent enzyme crosslinking. Superparamagnetic nanoparticles were homogeneously incorporated into hierarchically-ordered mesocellular mesoporous silica (HMMS) by the decomposition of a preformed iron propionate complex. The size of the incorporated superparamagnetic nanoparticles was around 5 nm, generating a magnetically separable host with high pore volumes and large pores (M-HMMS). α-chymotrypsin (CT) was adsorbed into M-HMMS with high loading (∼30 wt%) in less than 30 minutes. Glutaraldehyde (GA) treatment of adsorbed CT resulted in nanometer scale crosslinked enzyme aggregates in M-HMMS (CLEA-M). The activity of these CT aggregates in M-HMMS (CLEA-M-CT) was 34 times than that of simply adsorbed CT in M-HMMS, due to an effective prevention of enzyme leaching during washing <I>via</I> a ship-in-a-bottle approach. CLEA-M-CT maintained the initial activity not only under shaking (250 rpm) for 30 days, but also under recycled uses of 35 times. The same approach was employed for the synthesis of CLEA-M of lipase (CLEA-M-LP), and proven to be effective in improving the loading, activity, and stability of enzyme when compared to those of adsorbed LP in M-HMMS.</P> <P>Graphic Abstract</P><P>Crosslinked enzyme aggregates in magnetitie-coated mesoporous silica, fabricated <I>via</I> a two-step procedure of enzyme adsorption and crosslinking, were highly active, highly stable, and easily recyclable using a magnet. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b909109b'> </P>
Nonactin hinders intracellular glycosylation in virus-infected baby hamster kidney cells.
Lee, Jin-Man,Kim, Jong-Guk,Kim, Tae-Ho,Lee, Do S,Kim, Jae H,Cho, Somi K,Riu, Key Z,Lee, Dong-Sun,Lee, Sang-Han D. A. Spandidos 2010 MOLECULAR MEDICINE REPORTS Vol.3 No.1
<P>Potent antiviral agents hinder virus-infected cell machinery, leading to rescue from viral damage. In this study, we aimed to identify selective intracellular glycosylation inhibitor(s) that do not suppress glycoprotein synthesis. Our results showed that nonactin is a potent inhibitor of intracellular glycosylation. First, we examined the effects of nonactin on syncytium formation and cytopathic activity in virus-infected baby hamster kidney cells. Nonactin effectively inhibited syncytium formation in a concentration-dependent manner, and infectious virus production was markedly reduced. However, glycoprotein synthesis was not affected. In the presence of 5 ?g/ml nonactin, we observed the intracellular accumulation of vesicular stomatitis virus-G protein as well as syncytium formation, but no significant effects on Newcastle disease virus-hemagglutinin-neuramidase glycoprotein synthesis. Our results collectively indicate that nonactin potentially inhibits glycosylation by acting as a suppressor of intracellular glycosylation trafficking.</P>
Fuel Spiking Test for the Surge Margin Measurement in a Gas Turbine Engine
Lee, Jin-Kun,Lee, Kyung-Jae,Ha, Man-Ho,Kim, Chun-Taek,Yang, Soo-Seok,Lee, Dae-Sung The Korean Society of Propulsion Engineers 2004 한국추진공학회지 Vol.8 No.2
가스터빈엔진 압축기의 서지마진을 구하기 위하여 연료 돌출 시험을 수행하였다. 본 시험에 사용된 연료 돌출 신호는 엔진 제어기 신호에 중첩되어 연료 밸브를 제어하는 데 사용되었으며 신호 중첩을 위해 연료 제어기와 함수 발생기로 구성된 보조시스템이 사용되었다. 한국항공우주연구원의 고공엔진시험설비에서 실제 엔진 시험이 이루어졌으며 예비 시험결과, 연료 돌출 신호는 연료 라인과 압축기 토출부에서의 압력 신호와 잘 일치하였다. 이에 따라 특정 속도에서의 서지점을 측정하기 위한 시험이 수행되었으며 시험 결과 연료 돌출시험이 서지 측정에 매우 효과적임을 확인하였다. A fuel spiking test was performed to measure the surge margin of the compressor in a gas turbine engine. During the test, fuel spiking signal is superposed on the engine controller demand signals and the combined signals are used to control a fuel control valve. For the superposition, a subsystem composed of a fuel controller and a function generator is used. The real engine test was performed at the Altitude Engine Test Facility (AETF) in Korea Aerospace Research Institute (KARI). In the preliminary test, the fuel spiking signals are in good agreement with the dynamic pressure at the fuel line and at the compressor discharge point. After the preliminary test, a fuel spiking test to measure the surge point at a specific engine speed was performed. The test results show that the fuel spiking test is very effective in the measurement of surge.
1-Chloro-1-phenyl-2-carboethoxy-2-cyanoethene 유도체에 대한 thioglycolic acid 치환제의 합성
이영행,이채호,이갑상,이만구 圓光大學校 1984 論文集 Vol.18 No.2
The substitution products of thioglycolic acid to the derivatives of 1-chloro-1-phenyl-2-carboethoxy-e-cyano ethene synthesized 1-Chloro-1-phenyl-2-carboethoxy-2-cyanoethene [Ⅴ], 1-chloro-10(4-chlorophenyl)-2-carboethoxy-2-cyanoethene[Ⅳ] and 1-chloro-1-(4-methoxyphenyl)-2-carboethoxy-2-cyanoethene[Ⅶ] undergo substitution reactions with thioglycolic acid to form s-[(1-phenyl-2-carboethoxy-2-cyano) ethenyl]-thioglycolic acid s-[(1-(4-chlorophenyl)-2-carboethoxy-e-cyano] ethenyl]-thioglycolic acid and s-[1-(4-methoxyphenyl)-2-carboethoxy-2-cyano] ethenyl]-thioglycolic acid, respectively. The structure of products were identified by elemental analysis, potentiometric titration, infrared and nmr spectra.