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Research on Evolution of Regional Synergetic Cross-border E-Commerce Ecosystem
Ma Xiuhong,Ji Ran 한국무역보험학회 2019 무역보험연구 Vol.20 No.2
Based on the ecosystem theory, the theory of regional synergetic cross-border e-commerce ecosystem is put forward. According to the theory, regional synergetic cross-border e-commerce ecosystem is composed of environment and various species. Its evolution is the result of game between environment and components and among components. Especially, the synergetic development of regional ecological communities has an important impact on ecosystem evolution. Its evolution process is gradual, including four stages: synergetic constrution, synergetic expansion, synergetic co-opetition and synergetic innovation. On this basis, taking the cross-border e-commerce ecosystem in Beijing-Tianjin-Hebei as an example, this paper applies the theory of regional synergetic cross-border e-commerce ecosystem to analyzed the status quo of environment and species of cross-border e-commerce ecosystem in Beijing-Tianjin-Hebei and the impact of its basic relationship. The results show that the cross-border e-commerce ecosystem in Beijing-Tianjin-Hebei is in the stage of synergetic expansion. On the advance of the cross-border e-commerce ecosystem in Beijing-Tianjin-Hebei, policy support and supervision, scientific and technological innovation, cross-border logistics support and integrated service system construction will be valued, and the focal point will be strengthening regional synergy by building regional core competitiveness, rational positioning and dislocation development.
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Resveratrol directly targets COX-2 to inhibit carcinogenesis
Zykova, Tatyana A.,Zhu, Feng,Zhai, Xiuhong,Ma, Wei-Ya,Ermakova, Svetlana P.,Lee, Ki Won,Bode, Ann M.,Dong, Zigang Wiley Subscription Services, Inc., A Wiley Company 2008 Molecular carcinogenesis Vol.47 No.10
<P>Targeted molecular cancer therapies can potentially deliver treatment directly to a specific protein or gene to optimize efficacy and reduce adverse side effects often associated with traditional chemotherapy. Key oncoprotein and oncogene targets are rapidly being identified based on their expression, pathogenesis and clinical outcome. One such protein target is cyclooxygenase-2 (COX-2), which is highly expressed in various cancers. Research findings suggest that resveratrol (RSVL; 3,5,4′-trihydroxy-trans-stilbene) demonstrates nonselective COX-2 inhibition. We report herein that RSVL directly binds with COX-2 and this binding is absolutely required for RSVL's inhibition of the ability of human colon adenocarcinoma HT-29 cells to form colonies in soft agar. Binding of COX-2 with RSVL was compared with two RSVL analogues, 3,3′,4′,5′,5-pentahydroxy-trans-stilbene (RSVL-2) or 3,4′,5-trimethoxy-trans-stilbene (RSVL-3). The results indicated that COX-2 binds with RSVL-2 more strongly than with RSVL, but does not bind with RSVL-3. RSVL or RSVL-2, but not RSVL-3, inhibited COX-2-mediated PGE<SUB>2</SUB> production in vitro and ex vivo. HT-29 human colon adenocarcinoma cells express high levels of COX-2 and either RSVL or RSVL-2, but not RSVL-3, suppressed anchorage independent growth of these cells in soft agar. RSVL or RSVL-2 (not RSVL-3) suppressed growth of COX-2<SUP>+/+</SUP> cells by 60% or 80%, respectively. Notably, cells deficient in COX-2 were unresponsive to RSVL or RSVL-2. These data suggest that the anticancer effects of RSVL or RSLV-2 might be mediated directly through COX-2. © 2008 Wiley-Liss, Inc.</P>
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