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Sensitivity of surface characteristics on the simulation of wind-blown-dust source in North America
Park, S.H.,Gong, S.L.,Gong, W.,Makar, P.A.,Moran, M.D.,Stroud, C.A.,Zhang, J. Pergamon Press ; Elsevier [distribution] 2009 Atmospheric environment Vol.43 No.19
Recently, a wind-blown-dust-emission module has been built based on a state-of-the-art wind erosion theory and evaluated in a regional air-quality model to simulate a North American dust storm episode in April 2001 (see Park, S.H., Gong, S.L., Zhao, T.L., Vet, R.J., Bouchet, V.S., Gong, W., Makar, P.A., Moran, M.D., Stroud, C., Zhang, J. 2007. Simulation of entrainment and transport of dust particles within North America in April 2001 (''Red Dust episode''). J. Geophys. Res. 112, D20209, doi:10.1029/2007JD008443). A satisfactorily detailed assessment of that module, however, was not possible because of a lack of information on some module inputs, especially soil moisture content. In this paper, the wind-blown-dust emission was evaluated for two additional dust storms using improved soil moisture inputs. The surface characteristics of the wind-blown-dust source areas in southwestern North America were also investigated, focusing on their implications for wind-blown-dust emissions. The improved soil moisture inputs enabled the sensitivity of other important surface characteristics, the soil grain size distribution and the land-cover, to dust emission to be investigated with more confidence. Simulations of the two 2003 dust storm episodes suggested that wind-blown-dust emissions from the desert areas in southwestern North America are dominated by emissions from dry playas covered with accumulated alluvial deposits whose particle size is much smaller than usual desert sands. As well, the source areas in the northwestern Texas region were indicated to be not desert but rather agricultural lands that were ''activated'' as a wind-blown-dust sources after harvest. This finding calls for revisions to the current wind-blown-dust-emission module, in which ''desert'' is designated to be the only land-cover category that can emit wind-blown dust.
Prolonged Insulin Independence After Islet Allotransplants in Recipients with Type 1 Diabetes
Bellin, M. D.,Kandaswamy, R.,Parkey, J.,Zhang, H.-J.,Liu, B.,Ihm, S. H.,Ansite, J. D.,Witson, J.,Bansal-Pakala, P.,Balamurugan, A. N.,Papas, K.,Sutherland, D. E. R.,Moran, A.,Hering, B. J. Wiley (Blackwell Publishing) 2008 American journal of transplantation Vol.8 No.11
<P>We sought to determine the long-term outcomes in type 1 diabetic recipients of intraportal alloislet transplants on a modified immunosuppressive protocol. Six recipients with hypoglycemia unawareness received one to two islet infusions. Induction therapy was with antithymocyte globulin (ATG) plus etanercept for tumor necrosis factor-alpha blockade. Recipients received cyclosporine and everolimus for maintenance immunosuppression for the first year posttransplant, with mycophenolic acid or mycophenolate mofetil subsequently substituted for everolimus. Recipients have been followed for 1173 +/- 270 days since their last infusion for islet graft function (insulin independence, hemoglobin A(1c) levels and C-peptide production) and for adverse events associated with the study protocol. Of the six recipients, five were insulin-independent at 1 year, and four continue to be insulin-independent at a mean of 3.4 +/- 0.4 years posttransplant. None of the six recipients experienced recurrence of severe hypoglycemia. Measured glomerular filtration rate decreased from 110.5 +/- 21.2 mL/min/1.73 m(2) pretransplant to 82.6 +/-19.1 mL/min/1.73 m(2) at 1 year posttransplant. In conclusion, islet transplants restored insulin independence for a mean of >3 years in four of six recipients treated with ATG and etanercept induction therapy and with cyclosporine and, initially, everolimus for maintenance. Our results suggest this immunosuppressive protocol may allow long-term graft survival.</P>
Choi, M.,Kadara, H.,Zhang, J.,Parra, E.R.,Rodriguez-Canales, J.,Gaffney, S.G.,Zhao, Z.,Behrens, C.,Fujimoto, J.,Chow, C.,Kim, K.,Kalhor, N.,Moran, C.,Rimm, D.,Swisher, S.,Gibbons, D.L.,Heymach, J.,Kaf Elsevier 2017 Annals of oncology Vol.28 No.1
<P>Conclusion(s): Our findings pinpoint mutated genes that may impact clinical outcome as well as personalized strategies for targeted immunotherapies in early-stage LUSC.</P>
The Scattering and Intrinsic Structure of Sagittarius A* at Radio Wavelengths
Johnson, Michael D.,Narayan, Ramesh,Psaltis, Dimitrios,Blackburn, Lindy,Kovalev, Yuri Y.,Gwinn, Carl R.,Zhao, Guang-Yao,Bower, Geoffrey C.,Moran, James M.,Kino, Motoki,Kramer, Michael,Akiyama, Kazunor American Astronomical Society 2018 The Astrophysical journal Vol.865 No.2
Kadara, H,Choi, M,Zhang, J.,Parra, E.R.,Rodriguez-Canales, J.,Gaffney, S.G.,Zhao, Z.,Behrens, C.,Fujimoto, J.,Chow, C.,Yoo, Y.,Kalhor, N.,Moran, C.,Rimm, D.,Swisher, S.,Gibbons, D.L.,Heymach, J.,Kafta Elsevier 2017 ANNALS OF ONCOLOGY Vol.28 No.1
<P>Conclusion(s): Our study highlights molecular and immune phenotypes that warrant further analysis for their roles in clinical outcomes and personalized immune-based therapy of LUAD.</P>
Jung, K.C.,Simond, D.M.,Moran, C.,Hawthorne, W.J.,Jeon, J.T.,Jin, D.I.,Lee, J.H. Asian Australasian Association of Animal Productio 2008 Animal Bioscience Vol.21 No.11
The xenotransplantation of pig organs and cells can be related with a risk of transmission of infectious diseases to human. Previous findings indicate that the regulatory region of PERV for retroviral transcription, replication and integration into the cellular DNA is located on the 5' Long Terminal Repeat (LTR). The objective of this study is the investigation of methylation and deletion status of the PERV 5' LTR region which can be used for regulating PERV expression. We compared the sequences of genomic DNA and bisulfite-treated genomic DNA from PK-15 cells expressing PERV to observe the methylation status of the 5' LTR. Our results showed that the CpG sites of U3 were methylated and methylation was inconsistent in the R and U5 regions. Also, variable numbers of 18 bp repeats and 21 bp repeats were detected on 5' LTR by sequencing analysis. The consistent U3 methylation might be indicative of host suppression of expression of the retroviruses.
Effects of black carbon aging on air quality predictions and direct radiative forcing estimation
PARK, S.H.,GONG, S.L.,BOUCHET, V.S.,GONG, W.,MAKAR, P.A.,MORAN, M.D.,STROUD, C.A.,ZHANG, J. Blackwell Publishing Ltd 2011 Tellus. Series B, Chemical and physical meteorolog Vol.63 No.5
<P><B>ABSTRACT</B></P><P>An aging scheme for black carbon (BC) aerosol was implemented into a regional air‐quality forecast model to study the impact of BC aging on air quality predictions. Three different assumptions for the mixing state of BC—external mixture, internal mixture and gradual aging—were used to simulate the distribution of BC particles over North America in April 2002. Cloud –condensation nuclei number and BC wet deposition rate increased significantly and BC mass column loading decreased as a result of BC aging. With the gradual aging process incorporated into the model, the comparison of ground level BC concentration predictions with surface observations was slightly improved. Estimation of the average direct radiative forcing of BC over the spatial domain of this study showed that the factor of direct forcing enhancement by BC aging was much smaller than the mixing state effect factor. The effect of increased wet deposition due to aging compensated partially for the effect of increased absorbance suggesting that the change in the hygroscopic properties of BC due to aging must be taken into account to quantify accurately the effect of BC aging on climate.</P>