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Manganese induces neuroinflammation via NF-κB/ROS NLRP3 pathway in rat brain striatum and HAPI cells
Xinyuan Zhao,Lifeng Yin,Yifan Wu,Muxi Han,Yin Zhuang,Yewen Cong,Yiming Liu,Gang Chen,Junkang Jiang 대한독성 유전단백체 학회 2019 Molecular & cellular toxicology Vol.15 No.2
Backgrounds: Chronic exposure to excessive Mn can result in neurodegenerative symptoms, whose precise molecular mechanism remains largely unclear. Here, we measured the role and mechanism of NLRP3 in Mninduced neuroinflammation in vivo and vitro. Methods: The effects of Mn on NLRP3 activation were investigated by Westernblot, IHC, immunofluorescence analysis, as well as ELISA. We assessed NF-κB activation through measurement of phosphorylation and nuclear translocation. The mechanisms bywhich Mn induced NLRP3 activation were assessed by specific inhibitors. Results: We found that Mn exposure facilitated the activation of NLRP3 inflammasome to promote the production of IL-1β and IL-18 in dose- and time-dependent manners in HAPI cells. In addition, the NLRP3 inflammasome was also dramatically activated in microglia of rat brain striatum after Mn exposure. We also found increased ROS and NF-κB activation. Notably, the activation of NLRP3 was significantly attenuated by pretreatment with NF-κB and ROS inhibitors. Conclusion: These findings suggest that NLRP3 activation plays an important role in Mn-induced neuroinflammation, and it is associated with NF-κB and ROS.
Eucommia ulmoides Bark Protects Against Renal Injury in Cadmium-Challenged Rats
Erwei Liu,Lifeng Han,Jialong Wang,Wei He,Haihua Shang,Xiumei Gao,Tao Wang 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.3
Eucommia ulmoides Oliver is a perennial woody plant distributed widely in China. To characterize some major compounds in E. ulmoides bark extract, six compounds were identified via high-performance liquid chromatography qualitative analysis. E. ulmoides bark extract protects against cadmium-induced oxidative damage in rat kidneys. Two compounds of E. ulmoides bark extract, geniposide and genipin, which were identified both in serum and in kidney tissue, showed inhibitory effects on nitric oxide production. This study provides biological evidence supporting the usefulness of E. ulmoides bark against cadmium-induced toxic oxidative stress in rat kidney tissue.
Optimal design of spoke double-layer cable-net structures based on an energy principle
Mingmin Ding,Bin Luo,Lifeng Han,Qianhao Shi,Zhengxing Guo 국제구조공학회 2020 Structural Engineering and Mechanics, An Int'l Jou Vol.74 No.4
An optimal design method for a spoke double-layer cable-net structure (SDLC) is proposed in this study. Simplified calculation models of the SDLC are put forward to reveal the static responses under vertical loads and wind loads. Next, based on an energy principle, the relationship among the initial prestress level, cross-sectional areas of the components, rise height, sag height, overall displacement, and relative deformation is proposed. Moreover, a calculation model of the Foshan Center SDLC is built and optimized. Given the limited loading cases, material properties of the components, and variation ranges of the rise height and sag height, the self-weight and initial prestress level of the entire structure can be obtained. Because the self-weight of the cables decreases with increasing of the rise height and sag height, while the self-weight of the inner strut increases, the total weight of the entire structure successively exhibits a sharp reduction, a gradual decrease, a slow increase, and a sharp increase during the optimization process. For the simplified model, the optimal design corresponds to the combination of rise height and sag height that results in an appropriate prestress level of the entire structure with the minimum total weight.
Zhizhu Decoction Promotes Gastric Emptying and Protects the Gastric Mucosa
Wei He,Yi Zhang,Xinrui Wang,Lingling Guo,Lifeng Han,Erwei Liu,Tao Wang 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.4
The aim of this study was to evaluate the effects of the Zhizhu decoction on gastric emptying and gastric mucosal protection. The Zhizhu decoction is composed of Aurantii fructus and Atractylodes macrocephala Rhizoma. Results showed that oral administration of the Zhizhu decoction accelerated gastric emptying in mouse and protected gastric mucosa from ethanol-induced ulcers in rat. Our investigations demonstrated that the Zhizhu decoction accelerated gastric emptying, at least in part, by activating the muscarinic and 5-HT3 receptors. The gastroprotective effect is involved in its antioxidant effects and increased vascular endothelial growth factor expression.
Boosting oxygen reduction catalysis with abundant copper single atom active sites
Li, Feng,Han, Gao-Feng,Noh, Hyuk-Jun,Kim, Seok-Jin,Lu, Yalin,Jeong, Hu Young,Fu, Zhengping,Baek, Jong-Beom The Royal Society of Chemistry 2018 Energy & environmental science Vol.11 No.8
<P>With their high catalytic activity, stability, selectivity, and 100% atom utilization, single atomic non-noble metal based materials are valuable alternatives to efficient but expensive Pt based catalysts. For efficient catalysis, single-atom catalysts must expose abundant single atomic metal active centers. Here, we report the rational design and synthesis of a Cu single-atom catalyst with high Cu content of over 20.9 wt%, made of single atomic Cu anchored into an ultrathin nitrogenated two-dimensional carbon matrix (Cu-N-C). The high Cu content was achieved by the introduction of additional N species, which can securely trap and protect the Cu atoms. During oxygen reduction, the single atomic Cu exhibited over 54 times higher mass activity than metallic Cu nanoparticles at a potential of 0.85 V <I>versus</I> a reversible hydrogen electrode (RHE). Furthermore, the Cu-N-C exhibited 3.2 times higher kinetic current at 0.85 V (<I>vs.</I> RHE), and a much lower Tafel slope (37 mV dec<SUP>−1</SUP>), as well as better methanol/carbon monoxide tolerance and long-term stability than commercial Pt/C. Density functional theory (DFT) calculations reveal that the Cu active sites exhibit improved O-O bond stretching and favorable adsorption energies of O2 and OOH for four-electron oxygen reduction.</P>
Li, Feng,Zhao, Xianglong,Mahmood, Javeed,Okyay, Mahmut Sait,Jung, Sun-Min,Ahmad, Ishfaq,Kim, Seok-Jin,Han, Gao-Feng,Park, Noejung,Baek, Jong-Beom American Chemical Society 2017 ACS NANO Vol.11 No.7
<P>The hydrogen evolution reaction (HER) is one of the most important pathways for producing pure and clean hydrogen. Although platinum (Pt) is the most efficient HER electrocatalyst, its practical application is significantly hindered by high cost and scarcity. In this work, an MoxS with incorporated Mo vacancies and macroporous inverse opal-like (IOL) structure (MoxC-IOL) was synthesized and studied as a low-cost efficient HER electrocatalyst. The macroporous IOL structure was controllably fabricated using a facile-hard template strategy. As a result of the combined benefits of the Mo vacancies and structural advantages, including appropriate hydrogen binding energy, large exposed surface, robust IOL structure and fast mass/charge transport, the synthesized MoxC-IOL exhibited significantly enhanced HER electrocatalytic performance with good stability, with performance comparable or superior to Pt wire in both acidic and alkaline solutions.</P>