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RISS 인기검색어
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- 저자 : Liangfeng Jiang (검색결과 4 건)
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Microstructure Evolution and Erosion-Corrosion Resistance of Amorphous Ni-P Coatings
Xiulin Ji,Shuang Jiang,Hongbin Li,Chunyan Yan,Liangfeng Jiang 대한금속·재료학회 2012 METALS AND MATERIALS International Vol.18 No.4
Amorphous Ni-P coatings with 7.8 wt% P were electrodeposited successfully from an electrolytic bath containing 15 g/L H3PO3. Its microstructure evolution by heat treatment and erosion-corrosion resistance are investigated in this paper. From room temperature to 500 °C, there were three exothermic crystalline phases of Ni5P2, Ni3P and Ni precipitated from the amorphous base. The microstructure evolution of the amorphous Ni-P deposits follows the sequence of amorphous, amorphous-noncrystalline, (Ni5P2 + Ni3P),then (Ni5P2 + Ni3P + Ni) with increasing heat treatment temperature. The mass loss rate of amorphous Ni-P coatings is approximately 14 mg/h and the synergism of erosion-corrosion was larger than half of the total mass loss at an impingement velocity of 8.37 m/s under saline-sand slurry. The erosion-corrosion resistance of amorphous Ni-P coatings can be enhanced obviously by heat treatment because of the elevated hardness and corrosion resistance.
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The Correlation between Thyrotropin and Dyslipidemia in a Population-based Study
Li Lu,Beibei Wang,Zhongyan Shan,Fengwei Jiang,Xiaochun Teng,Yanyan Chen,Yaxin Lai,Jiani Wang,Haibo Xue,Sen Wang,Chenyan Li,He Liu,Ningna Li,Jiashu Yu,Liangfeng Shi,Xin Hou,Qian Xing,Xue Bai,Weiping Te 대한의학회 2011 Journal of Korean medical science Vol.26 No.2
This study investigated the relationship between serum thyrotrophin levels and dyslipidemia in subclinical hypothyroid and euthyroid subjects. A total of 110 subjects with subclinical hypothyroidism and 1,240 euthyroid subjects enrolled in this study. Patients with subclinical hypothyroidism had significantly lower high density lipoprotein cholesterol (HDL-C) levels than those who were euthyroid. The lipid profiles were each categorized and mean thyrotrophin levels were higher in subjects in the dyslipidemia subclasses than subjects in the normal subclasses. Thyrotrophin was positively associated with serum triglyceride and negatively associated with serum HDL-C in women. Thyrotrophin was also positively associated with total cholesterol (TC) in the overweight population along with TC and LDL-C in overweight women. In the euthyroid population, thyrotrophin was positively associated with TC in the overweight population. In conclusion, serum thyrotrophin was correlated with dyslipidemia in subclinical hypothyroid and euthyroid subjects; the correlation was independent of insulin sensitivity.
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Pharmacokinetics, Tissue Distribution, Metabolism, and Excretion of Ginsenoside Rg1 in Rats
Liang Feng,Ling Wang,Changjiang Hu,Xuehua Jiang 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.12
The pharmacokinetics, tissue distribution, metabolism, and excretion of ginsenosides Rg1 were studied in Wistar rats, by measuring the concentrations of Rg1 and its metabolites in the blood, tissues, bile, urine, and feces after dosing. After intravenous (i.v.) administration, the elimination half-lives of Rg1 and its metabolites were 1.82, 5.87, and 6.87 h, and the area under the curves were 1595.7, 597.5, and 805.6 ng· h/mL, respectively. After oral administration, the elimination half-lives of Rg1 and its metabolites were 2.25, 6.73, 5.44, and 5.06 h, and the area under the curves were 2363.5, 4185.5, 3774.3, and 396.2 ng· h/mL, respectively. After i.v. administration, Rg1 and its metabolites were well distributed to the tissues analyzed except for the brain. The maximum concentration of Rg1 was reached in all tissues at 5 min post dose, and it was eliminated from most of the tissues except for the kidney faster than it was eliminated from the blood. The maximum concentration of the metabolites was reached in all tissues between 4 and 6 h post dose. After i.v. administration, the recovery of the Rg1 prototype in the urine and bile was 27.96% and 60.77%, respectively. The metabolism of Rg1 in the intestine was via a hydrolization pathway, with the 6-and 20-glucoside bond hydrolyzed gradually under the catalysis of β-glucosaccharase, and then the metabolites were reabsorbed into the blood. Finally, the total recovery of the Rg1 prototype and its metabolites in the urine and feces were 51.31% and 47.46%, respectively.
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Liang Feng,Ling Wang,Xuehua Jiang 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.2
Coumarin components from Psoralea corylifolia L. are novel drugs in which psoralen and isopsoralen are the active components. The pharmacokinetics, tissue distribution and excretion of the two compounds were studied by liquid chromatography-tandem mass spectrometry after intravenous administration to Wistar rats. The elimination half-lives of psoralen and isopsoralen were 4.88 and 5.35 h. After dosing, the area under the curves of the tissues decreased in the following order: liver > lung > heart > kidney > spleen > brain for psoralen; and kidney > lung > liver > heart > spleen > brain for isopsoralen. After dosing, 51.27% of psoralen and 56.25% of isopsoralen were excreted as prototype, and urine was the major excretion route. In addition, the pharmacokinetics of psoralen and isopsoralen after oral administration to Wistar rats were also studied. The elimination half-lives of psoralen and isopsoralen were 4.13 and 5.56 h, and their relative bioavailabilities were 61.45% and 70.35%. Overall, the results show that coumarin components from P. corylifolia L. have high oral bioavailability, they are rapidly and widely distributed into tissues after intravenous administration, but they are slowly cleared and excreted.
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