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- 저자 : Lei Sun (검색결과 287 건)
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MiR-886-5p Inhibition Inhibits Growth and Induces Apoptosis of MCF7 Cells
Zhang, Lei-Lei,Wu, Jiang,Liu, Qiang,Zhang, Yan,Sun, Zhu-Lei,Jing, Hong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.4
Background and Aims: To explore the molecular mechanisms of miR-886-5p in breast cancer., we examined roles in inhibiting growth and migration of MCF-7 cells. Methods: MiR-886-5p mimics and inhibitors were used to express or inhibit MiR-886-5p, respectively, and MTT and clone formation assays were used to determine the survival and proliferation. Hoechst 33342/ PI double staining was applied to detect apoptosis. The expression of caspase-3, caspase-8, caspase-9, MT1-MMP, VEGF-C and VEGF-D was detected by Western blotting, and the levels of MMP2 and MMP9 secreted from MCF-7 cells were assessed by ELISA. MCF-7 cell migration was determined by wound healing and Transwell assays. Results: We found that the growth of MCF-7 cells was inhibited upon decreasing miR-886-5p levels. Inhibiting miR-866-5p also significantly induced apoptosis and decreased the migratory capacity of these cells. The expression of VEGF-C, VEGF-D, MT1-MMP, MMP2, and MMP9 was also found to be decreased as compared to controls. Conclusions: Our data show that downregulation of miR-886-5p expression in MCF-7 cells could significantly inhibit cell growth and migration. This might imply that inhibiting miR-886-5p could be a therapeutic strategy in breast cancer.
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Sun, Lei,Hendon, Christopher H.,Minier, Mikael A.,Walsh, Aron,Dincă,, Mircea American Chemical Society 2015 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.137 No.19
<P/><P>Reaction of FeCl<SUB>2</SUB> and H<SUB>4</SUB>DSBDC (2,5-disulfhydrylbenzene-1,4-dicarboxylic acid) leads to the formation of Fe<SUB>2</SUB>(D<B>S</B>BDC), an analogue of M<SUB>2</SUB>(D<B>O</B>BDC) (MOF-74, DOBDC<SUP>4–</SUP> = 2,5-dihydroxybenzene-1,4-dicarboxylate). The bulk electrical conductivity values of both Fe<SUB>2</SUB>(D<B>S</B>BDC) and Fe<SUB>2</SUB>(D<B>O</B>BDC) are ∼6 orders of magnitude higher than those of the Mn<SUP>2+</SUP> analogues, Mn<SUB>2</SUB>(DEBDC) (E = O, S). Because the metals are of the same formal oxidation state, the increase in conductivity is attributed to the loosely bound Fe<SUP>2+</SUP> β-spin electron. These results provide important insight for the rational design of conductive metal–organic frameworks, highlighting in particular the advantages of iron for synthesizing such materials.</P>
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Lei Sun,Yingying Cai,Ick Soo Kim,Qilong Sun 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.2
The rapid development of electronic technology and intensive use of communication devices have caused the inevitable leakage of electromagnetic waves, leading to serious electromagnetic pollution. To drive this problem, we fabricated Fe₃O₄ decorated reduced graphene oxide (Fe₃O₄-rGO) nanocomposites for electromagnetic wave absorption by an in situ reduction process. The as-prepared Fe₃O₄-rGO showed a typical sandwich-like structure, Fe₃O₄ nanoparticles were flaky in shape and strongly attached on rGO by C-O-Fe bond. The hysteresis loops revealed the super-paramagnetic behavior of the Fe₃O₄-rGO nanocomposites at room temperature, which has a considerable contribution to electromagnetic wave absorption. When testing the electromagnetic wave absorption properties, the Fe₃O₄-rGO nanocomposites exhibited multiple dielectric relaxations and magnetic resonance, which can be ascribed to the well-designed structure, the strong chemical bond between Fe₃O₄ and rGO, as well as super-paramagnetic characteristics. As a result, the maximum reflection loss reached -49.53 dB at 6.32 GHz for a thickness of 3.4 mm while the highest effective absorption bandwidth was 2.96 GHz.
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CHISELED NICKEL HYDROXIDE NANOPLATES GROWTH ON GRAPHENE SHEETS FOR LITHIUM ION BATTERIES
LEI-LEI TIAN,XIAN-YONG WEI,QUAN-CHAO ZHUANG,CHAO WU,RUI-LUN XIE,ZHI-MIN ZONG,YONG-LI CUI,SHI-GANG SUN 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2013 NANO Vol.8 No.6
The morphologies and structures of Ni(OH)2–graphene hybrid materials were tailored by using different mineralizers in this work. It was revealed that the synergic effects of the highly oxidized graphene sheets and the mineralizers played a crucial role in controlling the morphology and structure of the nanocomposites, and Na2CO3 is a very effective mineralizer for growing chiseled 2D nanoplates of Ni(OH)2 on graphene sheets. When produced with NaOH, fragmental Ni(OH)2 crystals with irregular shapes erratically decorated on graphene sheets. In contrast, chiseled Ni(OH)2 hexagonal nanoplates grown on graphene sheets were obtained when Na2CO3 was used as the mineralizer. These unique 2D–2D nanoarchitectures with higher contact area between the nanocrystals and graphene substrate can increase the interfacial interaction and then efficiently improve the structural stability of the composite material, thus exhibiting an enhanced Li storage capacity and excellent cycling performance of 562 mAh g-1 after the 36th cycle.
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Parthenolide-Induced Apoptosis, Autophagy and Suppression of Proliferation in HepG2 Cells
Sun, Jing,Zhang, Chan,Bao, Yong-Li,Wu, Yin,Chen, Zhong-Liang,Yu, Chun-Lei,Huang, Yan-Xin,Sun, Ying,Zheng, Li-Hua,Wang, Xue,Li, Yu-Xin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.12
Purpose: To investigate the anticancer effects and underlying mechanisms of parthenolide on HepG2 human hepatocellular carcinoma cells. Materials and Methods: Cell viability was assessed by MTT assay and cell apoptosis through DAPI, TUNEL staining and Western blotting. Monodansylcadaverin(MDC) and AO staining were used to detect cell autophagy. Cell proliferation was assessed by Ki67 immunofluorescence staining. Results: Parthenolide induced growth inhibition in HepG2 cells. DAPI and TUNEL staining showed that parthenolide could increase the number of apoptotic nuclei, while reducing the expression of the anti-apoptotic protein Bcl-2 and elevating the expression of related proteins, like p53, Bax, cleaved caspase9 and cleaved caspase3. Parthenolide could induce autophagy in HepG2 cells and inhibited the expression of proliferation-related gene, Ki-67. Conclusions: Parthenolide can exert anti-cancer effects by inducing cell apoptosis, activating autophagy and inhibiting cell proliferation.
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The Role of Splicing Factors in Adipogenesis and Thermogenesis
Lei Sun,Yadanar Than Naing 한국분자세포생물학회 2023 Molecules and cells Vol.46 No.5
Obesity is a significant global health risk that can cause a range of serious metabolic problems, such as type 2 diabetes and cardiovascular diseases. Adipose tissue plays a pivotal role in regulating energy and lipid storage. New research has underlined the crucial role of splicing factors in the physiological and functional regulation of adipose tissue. By generating multiple transcripts from a single gene, alternative splicing allows for a greater diversity of the proteome and transcriptome, which subsequently influence adipocyte development and metabolism. In this review, we provide an outlook on the part of splicing factors in adipogenesis and thermogenesis, and investigate how the different spliced isoforms can affect the development and function of adipose tissue.
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Sun Yao,Li Yao,Sun Xin,Wu Qiong,Yang Chunhui,Wang Lei 한국식물학회 2022 Journal of Plant Biology Vol.65 No.5
Phosphatidylinositol-specific phospholipase C (PI-PLC) catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate into diacylglycerol and inositol 1,4,5-trisphosphate. It can play an essential role in plant stress response and signaling. However, the functions of PLCs remain unclear in wooden plants. This study carried out the bioinformatics analysis of the PLC gene family in poplar. The expression pattern analysis suggested the transient up-regulation of PsnPLC in salt stress conditions. The transgenic tobacco plants overexpressing PsnPLC were generated by the Agrobacterium-mediated leaf disc method. The transgenic lines showed a significant increase in plant height, SOD and POD activity, and proline content under salt stress. By contrast, transgenic lines showed a decreased malondialdehyde content under salt stress. Comparative transcriptome analysis indicated that the overexpression of PsnPLC mainly affects membrane-associated GO terms and signaling pathways, and the differential expression of salt-responsive genes may contribute to the enhanced salt tolerance. Overall, the results indicated that PsnPLC plays an essential role in modulating salt tolerance in transgenic tobacco.
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Lei Xu,Lei Xu,Wen-Da Wang,Jian-Gang Sun 한국강구조학회 2017 International Journal of Steel Structures Vol.17 No.4
The present study established a numerical investigation on the behavior of concrete filled steel tube reinforced concrete (CFSTRC) columns subjected to fire. A finite element analysis (FEA) model was built to simulate the performance of CFSTRC columns under combined loading and fire. The FEA model was verified by the experimental results of CFSTRC columns subjected to fire. The comparison demonstrated an acceptable accuracy for the proposed FEA model. Afterwards, the FEA model was used to analyze the failure modes, the redistribution of internal force, the changes and development of the stress and strain, and the contact stress between the tube and concrete of CFSTRC columns subjected to fire. Influencing factors that may affect the bearing capacity of the CFSTRC columns subjected to fire were analyzed. The bearing capacity and stiffness of the CFSTRC columns gradually decreased in the fire; the parameters such as the fire duration time, sectional dimension, slenderness ratio, and sectional core area ratio significantly influenced the bearing capacity of the CFSTRC columns. Finally, a simplified calculating formula was proposed to calculate the influence factors of the bearing capacity of the CFSTRC columns subjected to ISO-834 standard fire. The formula-calculated results were well in agreement with the finite element analysis results, which provide a simple and feasible method for evaluating the fire-resistance design of these types of components in practical engineering.
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Lei Zhao,Lei Zhu,Hailin Sun,Lu Yang,Xi Chen 한국강구조학회 2020 International Journal of Steel Structures Vol.20 No.3
To study the reinforcement eff ect of the external stiff ening ring reinforced and unreinforced X-joints having a circular hollow section subjected to brace tensile load, an experimental and computer-simulated research has been done. Six full-scale X-joints are examined in this study: three reinforced specimens and three corresponding unreinforced ones. The test specimens cover diff erent brace to chord diameters ratios ( β ) of 0.25, 0.51, and 0.73. The experimental facilities and detailed parameters are presented. The experimental results including failure modes, load–displacement curves, and ultimate capacity are analyzed and compared. Two failure modes, weld failure and chord plastifi cation, are observed in the tests. The test results reveal an ultimate load enhancement in the reinforced joints by approximately 50% in comparison with the unreinforced joints and an initial stiff ness increase of 248.1% for the β of 0.25 and approximately 49–76% for the β of 0.51 and 0.73. A fi nite element model using shell elements is developed, which accurately predicts the static performance of the X-joints subjected to brace tensile load with and without external stiff ening rings.
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