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비규격 스틸커튼월 부재의 적용을 위한 로봇 레이저용접 성능에 관한 연구
나상호 ( Na¸ Sangho ),이장현 ( Lee¸ Janghyun ),박영미 ( Park¸ Youngmi ),김성진 ( Kim¸ Sungjin ) 한국건축시공학회 2021 한국건축시공학회 학술발표대회 논문집 Vol.21 No.2
In irregular curtain walls, the nominal stress required for each member varies greatly depending on the shape, so it is inefficient to design members based on the maximum required stress. Then, built-up members are absolutely necessary, but built-up members manufactured by Manpower-welding cannot be constructed in an irregular curtain wall building because it' not precise. In order to address the problems, this paper presents why Robotic-laser-welding should be used in irregular curtain walls using Gwanggyo Galleria Department Store involving 3D printing as an example. Results verify the performance of Robot-Laser-Welding as an efficient solution for precise steel curtain wall members.
Dynamic Regulation of TLE3 Expression during Spermatogenesis in Mouse Testis
Sangho Lee,Sohyeon Moon,Minha Cho,Miseon Park,Boreum Song,Ok-Hee Lee,Hoon Jang,Kyung-Ah Lee,Sunghan Shim,Jung Jae Ko,Youngsok Choi 한국동물생명공학회(구 한국동물번식학회) 2017 Reproductive & Developmental Biology(Supplement) Vol.41 No.2
Spermatogenesis is the process of proliferation and differentiation of spermatogonial stem cells into adult spermatozoa within seminiferous tubules. Sperm cells undergo extensive epigenetic modifications during spermatogenesis. One of the epigenetic modifications, histone acetylation induces a loose chromatin structure and active transcription which facilitates binding of transcription factors at sperm chromosome. Therefore, histone acetylation is known to play an important role in spermatogenesis. However, factors involved in histone acetylation during spermatogenesis are not well known. We found a factor TLE3(Transducin Like Enhancer of Split 3). The transcriptional co-repressor TLE family is known to regulate histone acetylation by interacting with histone deacetylase( HDAC). We examined the expression level of TLE3 in various mouse tissues. As a result of RT-PCR, TLE3 showed significantly higher expression in testis than that in other tissues. Immunofluorescent and Immunohistochemical analysis revealed that TLE3 protein was located in sertoli cell and spermatid in seminiferous tubules of adult mouse testis. In addition, the differential regulation in TLE3 protein expression site was observed in the testis during postnatal development. We also analyzed the expression pattern of HDAC2, which is known to cooperate with TLE3. Both HDAC2 and TLE3 protein were detected in spermatogonial stem cells at one-weeks-old mouse, however, Their expression site were transferred to sertoli cell at six-weeks-old mouse. aken together, TLE3 may play a role in regulating histone acetylation via interaction with HDAC2 in the testis. Futher studies are needed to look into a relation between TLE3 and histone acetylation during spermatogenesis and postnatal development in testis.
Lee Sangho,Lee Han-Teo,Kim Young Ah,Lee Il-Hwan,Kang Seong-Jun,Sim Kyeongpyo,Park Chung-Gyu,Choi Kyungho,Youn Hong-Duk 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
The C-terminal fragment of CABIN1 interacts with calcineurin and represses the transcriptional activity of the nuclear factor of activated T cells (NFAT). However, the specific sequences and mechanisms through which it binds to calcineurin are unclear. This study determined that decameric peptide (CABIN1 residues 2146–2155) is minimally required for binding to calcineurin. This peptide contains a unique “PPTP” C-terminal sequence and a “PxIxIT” N-terminal motif. Furthermore, p38MAPK phosphorylated the threonine residue of the “PPTP” sequence under physiological conditions, dramatically enhancing the peptide’s binding affinity to calcineurin. Therefore, the CABIN1 peptide inhibited the calcineurin-NFAT pathway and the activation of T cells more efficiently than the VIVIT peptide without affecting calcineurin’s phosphatase activity. The CABIN1 peptide could thus be a more potent calcineurin inhibitor and provide therapeutic opportunities for various diseases caused by the calcineurin-NFAT pathway.
이상호(Sangho Lee),김종인(Jongin Kim),이규진(Kyujin Lee),이근호(Geunho Lee) 한국자동차공학회 2013 한국자동차공학회 부문종합 학술대회 Vol.2013 No.5
Recently, increasing awareness of necessity of the environment-friendly Hybrid Electric Vehicle and Electric Vehicle (HEV and EV), EV model driving application is researching and developing actively. Interior Permanent Magnet Synchronous Motor (IPMSM) is mainly used to the EV application for obtain a high density output torque. In practice, a significant safety accident can occurred easily due to the control influence of IPMSM. Therefore, the stability control algorithm is so critical that should be implemented indeed. When EV operating in the high-speed region, large current will be consumed and the battery voltage is going to fall down rapidly. Such as this situation, the existing control systems are absence of algorithm that respect to the varying output voltage of battery. In this paper, a method that compensate d - axis current is proposed to ensure to maintain the speed time when the battery voltage is fall down occurred. Proposed the method is verified by the simulation.