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Lee, sungbok Richard,Lee, Sang-Min,Park, Su-Jung,Lee, Suk-Won,Lee, Do Yun,Im, Byung-Jin,Ahn, Su-Jin The Korean Academy of Prosthodonitics 2015 The Journal of Advanced Prosthodontics Vol.7 No.3
PURPOSE. The purpose of this study was to find out the effect of immediate dentin sealing (IDS) on bond strength of ceramic restoration under various thermocycling periods with DBA (dentin bonding agent system). MATERIALS AND METHODS. Fifty freshly extracted human mandibular third molars were divided into 5 groups (1 control and 4 experimental groups) of 10 teeth. We removed enamel layer of sound teeth and embedded them which will proceed to be IDS, using All Bond II. A thermocycling was applied to experimental groups for 1, 2, 7, 14 days respectively and was not applied to control group. IPS Empress II for ceramic was acid-etched with ceramic etchant (9.5% HF) and silane was applied. Each ceramic disc was bonded to specimens with Duo-link, dual curable resin cement by means of light curing for 100 seconds. After the cementation procedures, shear bond strength measurement and SEM analysis of the fractured surface were done. The data were analyzed with a one-way ANOVA and Tukey multiple comparison test (${\alpha}$=.05). RESULTS. There were no statistically significant differences between 4 experimental groups and control group, however the mean value started to decrease in group 7d, and group 14d showed the lowest mean bond strength in all groups. Also, group 7d and 14d showed distinct exposed dentin and collapsed hybrid layer was observed in SEM analysis. CONCLUSION. In the present study, it can be concluded that ceramic restorations like a laminate veneer restoration should be bonded using resin cement within one week after IDS procedure.
Tunneling decay of self-gravitating vortices
Dupuis, É,ric,Gobeil, Yan,Lee, Bum-Hoon,Lee, Wonwoo,MacKenzie, Richard,Paranjape, Manu B.,Yajnik, Urjit A.,Yeom, Dong-han,Gwak, B.,Kang, G.,Kim, C.,Kim, H.-C.,Lee, C.-H.,Lee, J.,Lee, S.,Lee, W. EDP Sciences 2018 The European Physical Journal Conferences Vol.168 No.-
<P>We investigate tunneling decay of false vortices in the presence of gravity, in which vortices are trapped in the false vacuum of a theory of scalar electrodynamics in three dimensions. The core of the vortex contains magnetic flux in the true vacuum, while outside the vortex is the appropriate topologically nontrivial false vacuum. We numerically obtain vortex solutions which are classically stable; however, they could decay via tunneling. To show this phenomenon, we construct the proper junction conditions in curved spacetime. We find that the tunneling exponent for the vortices is half that for Coleman-de Luccia bubbles and discuss possible future applications.</P>
GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal
Lee, Sukwon,Song, Beomjong,Kim, Jeongyeon,Park, Kyungjoon,Hong, Ingie,An, Bobae,Song, Sangho,Lee, Jiwon,Park, Sungmo,Kim, Jihye,Park, Dongeun,Lee, C Justin,Kim, Kyungjin,Shin, Ki Soon,Tsien, Richard W Nature Publishing Group, a division of Macmillan P 2013 NATURE NEUROSCIENCE Vol.16 No.10
Fear renewal, a widely pursued model of post-traumatic stress disorder and phobias, refers to the context-specific relapse of conditioned fear after extinction. However, its molecular mechanisms are largely unknown. We found that renewal-inducing stimuli, generally believed to be insufficient to induce synaptic plasticity, enhanced excitatory synaptic strength, activity of synaptic GluA2-lacking AMPA receptors and Ser831 phosphorylation of synaptic surface GluA1 in the lateral nucleus of the amygdala (LAn) of fear-extinguished rats. Consistently, the induction threshold for LAn synaptic potentiation was considerably lowered after extinction, and renewal occluded this low-threshold potentiation. The low-threshold potentiation (a potential cellular substrate for renewal), but not long-term potentiation, was attenuated by dialysis into LAn neurons of a GluA1-derived peptide that competes with Ser831-phosphorylated GluA1. Microinjections of the same peptide into the LAn attenuated fear renewal, but not fear learning. Our findings suggest that GluA1 phosphorylation constitutes a promising target for clinical treatment of aberrant fear-related disorders.
Lee, Tae-Yeon,Lee, Dong-Seol,Kim, Hyun-Man,Ko, Jea Seung,Gronostajski, Richard M.,Cho, Moon-Il,Son, Ho-Hyun,Park, Joo-Cheol SAGE Publications 2009 The Journal of histochemistry and cytochemistry Vol.57 No.5
<P>We reported previously that Nfic-deficient mice exhibit short and abnormal molar roots and severely deformed incisors. The objective of this study is to address the mechanisms responsible for these changes using morphological, IHC, and RT-PCR analysis. Nfic-deficient mice exhibited aberrant odontoblasts and abnormal dentin formation in molar roots and the labial crown analog of incisors. The most striking changes observed in these aberrant odontoblasts were the loss of intercellular junctions and the decreased expression of ZO-1 and occludin. As a result, they became dissociated, had a round shape, and lost their cellular polarity and arrangement as a sheet of cells. Furthermore, the dissociated odontoblasts became trapped in dentin-like mineralized tissue, resembling osteodentin in the overall morphology. These findings suggest that loss of the Nfic gene interferes with the formation of intercellular junctions that causes aberrant odontoblast differentiation and abnormal dentin formation. Collectively, these changes in odontoblasts contributed to development of molars with short and abnormal roots in Nfic-deficient mice.</P>
Lee, Sang Heon,Derby, Richard,Sul, Dong geun,Hong, Jung wha,Kim, Gon Ho,Kang, Seok,Kim, Nack Hwan,Yoo, Seung Han,Lee, Seok Jun,Hong, Young Ki,Lee, Jeong Eun Blackwell Publishing Inc 2011 Pain medicine Vol.12 No.3
<P><B>Abstract</B></P><P><B>Study Design. </B> An institutional, prospective clinical data analysis.</P><P><B>Objective. </B> To evaluate the safety and efficacy of a new navigable percutaneous disc decompression device (L'DISQ) in patients with lumbar disc herniation with radicular pain.</P><P><B>Methods and Outcome Measures. </B> We performed disc decompressions using L'DISQ on 27 patients with persistent disabling back and leg pain for 1 month or longer (average 6.48 months) due to a herniated lumbar intervertebral disc. Baseline data were prospectively gathered before the index procedure and at 1, 4, 12, and 24 weeks post‐procedure. Data included pain intensity (visual analog scale [VAS]), measure of disability (Oswestry Disability Index [ODI] and Rolando–Morris Questionnaire [RM]), health‐related quality of life (Bodily Pain Scale of Short Form‐36 version 2 [SF‐36 BP]), and passive straight leg raising test (SLR).</P><P><B>Results. </B> The VAS fell from 7.08 ± 1.22 to 1.84 ± 0.99 scores at 24 weeks post‐procedure. At 24 weeks, the ODI had fallen from 41.88 ± 10.61 to 16.66 ± 8.55% and the RM from 11.52 ± 3.91 to 2.68 ± 1.97 points. The SF‐36 BP dropped significant improvement from 32.89 ± 5.83 to 49.57 ± 4.96 scales. In the SLR test, the angular change of 24 weeks showed considerable improvement from 60.20 ± 20.02 to 83.00 ± 14.29 degrees. No major complication occurred, although two cases developed a disc reherniation 1 month post‐procedure.</P><P><B>Conclusions. </B> The L'DISQ device is specifically designed to remove herniated disc using a wand that can be navigated into a disc protrusion or extrusion. Following decompression, we measured clinically significant pain improvement and decreased disability for patients with both radicular and axial pain caused by protruded and extruded discs.</P>
Regulation of Hepatic Gluconeogenesis by an ER-Bound Transcription Factor, CREBH
Lee, Min-Woo,Chanda, Dipanjan,Yang, Jianqi,Oh, Hyunhee,Kim, Su Sung,Yoon, Young-Sil,Hong, Sungpyo,Park, Keun-Gyu,Lee, In-Kyu,Choi, Cheol Soo,Hanson, Richard W.,Choi, Hueng-Sik,Koo, Seung-Hoi Elsevier 2010 Cell metabolism Vol.11 No.4
<P><B>Summary</B></P><P>Endoplasmic reticulum (ER)-bound transcription factor families are shown to be involved in the control of various metabolic pathways. Here, we report a critical function of ER-bound transcription factor, CREBH, in the regulation of hepatic gluconeogenesis. Expression of CREBH is markedly induced by fasting or in the insulin-resistant state in rodents in a dexamethasone- and PGC-1α-dependent manner, which results in the accumulation of active nuclear form of CREBH (CREBH-N). Overexpression of constitutively active CREBH activates transcription of <I>PEPCK-C</I> or <I>G6Pase</I> by binding to its enhancer site that is distinct from the well-characterized CREB/CRTC2 regulatory sequences in vivo. Of interest, knockdown of CREBH in liver significantly reduces blood glucose levels without altering expression of genes involved in the ER stress signaling cascades in mice. These data suggest a crucial role for CREBH in the regulation of hepatic glucose metabolism in mammals.</P> <P><B>Highlights</B></P><P>► PGC-1α/GR activates CREBH expression under fasting or insulin-resistant conditions ► CREBH enhances hepatic gluconeogenesis via a CRTC2-dependent manner ► Depletion of CREBH in the liver ameliorates fasting hyperglycemia in diabetic mice</P>
( Richard Leesungbok ),( Suk Won Lee ),( Su Jin Ahn ),( Kyung Hee Kim ),( Su Hee Jung ),( Soo Jeong Park ),( Do Yun Lee ),( Dae Hyeok Yang ),( Il Keun Kwon ) 한국조직공학·재생의학회 2012 조직공학과 재생의학 Vol.9 No.3
The purpose of this study is two-fold: to compare differences in the development of osteoblast differentiation processes between human bone marrow mesenchymal stem cells (MSCs) and human periodontal ligament cells (PLCs) cultured on microgrooved titanium (Ti) substrata and to investigate the effects of microgroove depth on PLCs` osteoblast differentiation. Using photolithography, 60 μm-wide and 10 or 20 μm-deep microgrooves were fabricated on the Ti substrata (NE60/10 or NE60/20). Subsequent acid etching was applied to the fabricated microgrooved Ti to yield the etched microgrooves (E60/10 and E60/20). Smooth and acid-etched Ti were used as the controls(NE0 and E0). Alkaline phosphatase activity and extracellular calcium deposition assays were performed after various timelines of culture on both MSCs and PLCs grown on NE0 and E60/10. For PLCs cultured on NE0, NE60/10, NE60/20, E0, E60/10 and E60/20, cell adhesion, cell proliferation, osteoblast differentiation were determined, followed by the analysis on various osteogenic gene expressions. By comparing the extracellular matrix maturation and mineralization processes on smooth and microgrooved Ti substrata, it was determined that PLCs require more time for osteoblast differentiation than MSCs. Also, E60/10 allowed for the highest levels of adhesion, proliferation, osteoblast differentiation, and osteogenic gene expression by PLCs. PLCs could be an excellent alternative to MSCs for use in future studies investigating cellular processes using microgrooved Ti substrata and other modified surfaces. Optimal Ti microgroove dimensions and osteogenic differentiation timelines are necessary to promote various cellular activities in human PLCs.