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Role Distribution in insolvency Law : Canada
Mireille-France LeBlanc 법무부 2010 선진상사법률연구 Vol.- No.52
Mireille-France LeBlanc is a member of the Law Society of Upper Canada since 2001 and has worked as counsel in Department of Justice Cananda, International Private Law Section since 2007. She holds a law degree from Université de Moncton in 1995 and master degree in Business Administration from Université de Moncton in 1999 and in International Law from University of Ottawa in 2001. She had also worked as law clerk in Federal Court of Canada, Trial Division from 1999 to 2000 and as senior legal policy analyst, Department of Industry Canada,Corporate and Insolvency Law Policy Directorate from 2000 to 2005. Then, she served as senior advisor to the Assistant Deputy Minister, Department of Human Resources and Social Development Canada from 2005 to 2007. She is specialized in Corporate and Commercial Law, Legal Policy Development and International Negotiations.
Studies of Corrosion using Scanning Kelvin Probe Force Microscopy and AFM Scratching
Frankel, G. S.,Leblanc, P. 한국부식방식학회 2002 Corrosion Science and Technology Vol.31 No.6
The development of techniques linked to the atomic force microscope (AFM) has enabled the evaluation of physical and chemical properties of sub-micron structures. Scanning Kelvin Probe Microscopy (SKPFM) and in-situ AFM scratching have been particularly useful for studying corrosion phenomena. SKPFM generates a map of the potential distribution across a sample with a resolution of 100 nm. Furthermore, the open circuit potential of various pure metals in solution is linearly related to the Volta potential value measured in air immediately after exposure. SKPFM is a useful tool to assess the practical nobility of a surface. This technique has been successfully applied to the heterogeneous microstructure of AA2024-T3 and provided clear evidence regarding the shape, position, compositional inhomogeneities and local practical nobility of copper-rich intermetallic particles. The reactivity of these particles has been studied in detail. AFM scratching is an extremely controlled method to locally disturb the protective oxide film on a metal surface in solution. As with other approaches that utilize in situ scratching, the stability of the passive film and the tendency for stabilization of localized corrosion can be monitored. However, the lateral imaging capabilities of the AFM provides an approach to study the role of different microstructural features in the process of localized corrosion stabilization. Finally, AFM scratching can be used to open up small windows in a protective organic coating to reveal selected microstructural features. This allows the study of the corrosion behavior of these features in isolation from the rest of the microstructure or to study the interaction of different selected microstructural features. This approach is useful for understanding the interaction between different types of intermetallic particles in AA2024-T3.
Widespread Occurrence of a CYP51A Pseudogene in Calonectria pseudonaviculata
( Stefanos Stravoravdis ),( Nicholas R. Leblanc ),( Robert E. Marra ),( Jo Anne Crouch ),( Jonathan P. Hulvey ) 한국균학회 2020 Mycobiology Vol.48 No.1
Calonectria pseudonaviculata and C. henricotiae are two closely related fungal species responsible for boxwood blight disease of ornamental shrubs (Buxus spp.) in the U.S. and Europe. A previous study has shown isolates of the latter species, which is restricted to Europe, to be less sensitive to tetraconazole, an azole fungicide. In this study, we have analyzed the CYP51 paralogs for polymorphism in 26 genomes, representing geographically disparate populations of C. pseudonaviculata (n=19) and C. henricotiae (n=7), from the U.S., Europe, Asia, and New Zealand. The presence of a CYP51A pseudogene and lack of a functional CYP51A paralog in all C. pseudonaviculata genomes examined is a novel discovery for fungi and could have implications for the evolution of resistance to antifungal chemicals.
Potent synthetic and endogenous ligands for the adopted orphan nuclear receptor Nurr1
Jang Yongwoo,Kim Woori,Leblanc Pierre,Kim Chun-Hyung,Kim Kwang-Soo 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Until recently, Nurr1 (NR4A2) was known as an orphan nuclear receptor without a canonical ligand-binding domain, featuring instead a narrow and tight cavity for small molecular ligands to bind. In-depth characterization of its ligand-binding pocket revealed that it is highly dynamic, with its structural conformation changing more than twice on the microsecond-to-millisecond timescale. This observation suggests the possibility that certain ligands are able to squeeze into this narrow space, inducing a conformational change to create an accessible cavity. The cocrystallographic structure of Nurr1 bound to endogenous ligands such as prostaglandin E1/A1 and 5,6-dihydroxyindole contributed to clarifying the crucial roles of Nurr1 and opening new avenues for therapeutic interventions for neurodegenerative and/or inflammatory diseases related to Nurr1. This review introduces novel endogenous and synthetic Nurr1 agonists and discusses their potential effects in Nurr1-related diseases.