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- 저자 : Lalitkumar Vora (검색결과 2 건)
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Tumor-derived Systems as Novel Biomedical Tools - Turning the Enemy into an Ally
Nimeet Desai,Pratik Katare,Vaishali Makwana,Sagar Salave,Lalitkumar K. Vora,Jyotsnendu Giri 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Cancer is a complex illness that presents significant challenges in its understanding and treatment. The classic definition, "a group of diseases characterized by the uncontrolled growth and spread of abnormal cells in the body," fails to convey the intricate interaction between the many entities involved in cancer. Recent advancements in the field of cancer research have shed light on the role played by individual cancer cells and the tumor microenvironment as a whole in tumor development and progression. This breakthrough enables the utilization of the tumor and its components as biological tools, opening new possibilities. This article delves deeply into the concept of "tumor-derived systems”, an umbrella term for tools sourced from the tumor that aid in combatting it. It includes cancer cell membrane-coated nanoparticles (for tumor theranostics), extracellular vesicles (for tumor diagnosis/therapy), tumor cell lysates (for cancer vaccine development), and engineered cancer cells/organoids (for cancer research). This review seeks to offer a complete overview of the tumor-derived materials that are utilized in cancer research, as well as their current stages of development and implementation. It is aimed primarily at researchers working at the interface of cancer biology and biomedical engineering, and it provides vital insights into this fast-growing topic.
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CRISPR/Cas9 assisted stem cell therapy in Parkinson's disease
Poojitha Pinjala,Kamatham Pushpa Tryphena,Renuka Prasad,Dharmendra Kumar Khatri,선웅,Shashi Bala Singh,Dalapathi Gugulothu,Saurabh Srivastava,Lalitkumar Vora 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Since its discovery in 2012, CRISPR Cas9 has been tried as a direct treatment approach to correct the causative gene mutation and establish animal models in neurodegenerative disorders. Since no strategy developed until now could completely cure Parkinson’s disease (PD), neuroscientists aspire to use gene editing technology, especially CRISPR/Cas9, to induce a permanent correction in genetic PD patients expressing mutated genes. Over the years, our understanding of stem cell biology has improved. Scientists have developed personalized cell therapy using CRISPR/Cas9 to edit embryonic and patient-derived stem cells ex-vivo. This review details the importance of CRISPR/Cas9-based stem cell therapy in Parkinson’s disease in developing PD disease models and developing therapeutic strategies after elucidating the possible pathophysiological mechanisms.
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