http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Kim, Yoo-Jin,Kim, Yoon-Sang,Larochelle, Andre,Renaud, Gabriel,Wolfsberg, Tyra G.,Adler, Rima,Donahue, Robert E.,Hematti, Peiman,Hong, Bum-Kee,Roayaei, Jean,Akagi, Keiko,Riberdy, Janice M.,Nienhuis, Ar American Society of Hematology 2009 Blood Vol.113 No.22
<B>Abstract</B><P>We previously reported that lentiviral vectors derived from the simian immunodeficiency virus (SIV) were efficient at transducing rhesus hematopoietic repopulating cells. To evaluate the persistence of vector-containing and -expressing cells long term, and the safety implications of SIV lentiviral vector-mediated gene transfer, we followed 3 rhesus macaques for more than 4 years after transplantation with transduced CD34+ cells. All 3 animals demonstrated significant vector marking and expression of the GFP transgene in T cells, B cells, and granulocytes, with mean GFP+ levels of 6.7% (range, 3.3%-13.0%), 7.4% (4.2%-13.4%), and 5.6% (3.1%-10.5%), respectively. There was no vector silencing in hematopoietic cells over time. Vector insertion site analysis of granulocytes demonstrated sustained highly polyclonal reconstitution, with no evidence for progression to oligoclonality. A significant number of clones were found to contribute at both 1-year and 3- or 4-year time points. No vector integrations were detected in the MDS1/EVI1 region, in contrast to our previous findings with a γ-retroviral vector. These data show that lentiviral vectors can mediate stable and efficient long-term expression in the progeny of transduced hematopoietic stem cells, with an integration profile that may be safer than that of standard Moloney murine leukemia virus (MLV)-derived retroviral vectors.</P>
Chen, H.,Jin, C.,Huang, B.,Fontaine, N. K.,Ryf, R.,Shang, K.,Gré,goire, N.,Morency, S.,Essiambre, R.-J.,Li, G.,Messaddeq, Y.,LaRochelle, S. Nature Publishing Group 2016 Nature photonics Vol.10 No.8
Space-division multiplexing (SDM), whereby multiple spatial channels in multimode and multicore optical fibres are used to increase the total transmission capacity per fibre, is being investigated to avert a data capacity crunch and reduce the cost per transmitted bit. With the number of channels employed in SDM transmission experiments continuing to rise, there is a requirement for integrated SDM components that are scalable. Here, we demonstrate a cladding-pumped SDM erbium-doped fibre amplifier (EDFA) that consists of six uncoupled multimode erbium-doped cores. Each core supports three spatial modes, which enables the EDFA to amplify a total of 18 spatial channels (six cores × three modes) simultaneously with a single pump diode and a complexity similar to a single-mode EDFA. The amplifier delivers >20 dBm total output power per core and <7 dB noise figure over the C-band. This cladding-pumped EDFA enables combined space-division and wavelength-division multiplexed transmission over multiple multimode fibre spans.
Demonstration of Cladding-Pumped Six-Core Erbium-Doped Fiber Amplifier
Haoshuo Chen,Fontaine, Nicolas K.,Ryf, Roland,Cang Jin,Bin Huang,Kuanping Shang,Essiambre, Rene-Jean,Lixian Wang,Hayashi, Tetsuya,Nagashima, Takuji,Sasaki, Takashi,Messaddeq, Younes,LaRochelle, Sophie IEEE 2016 Journal of Lightwave Technology Vol.34 No.8
<P>We demonstrate cladding-pumped six-core Erbium-doped fiber amplifiers (EDFAs) using two different pump coupling schemes: edge-coupled and side-coupled pumping, where a single multimode laser diode can be applied to pump all cores. Using two in-line cladding-pumped EDFAs at the input and output of a 31-km coupled-six-core fiber, we realized 465-km space-division multiplexing and wavelength division multiplexing transmission in a recirculating loop and achieved a spectral efficiency of 18 bits/s/Hz. Through side-coupled pumping, the cladding-pumped six-core EDFA produced >18-dBm output power per core and had <;6-dB noise figure across the C-band.</P>
Huang, Bin,Chen, Haoshuo,Fontaine, Nicolas K.,Jin, Cang,Shang, Kuanping,Ryf, Roland,Essiambre, Rene-Jean,Ung, Bora,Messaddeq, Younes,LaRochelle, Sophie,Li, Guifang IEEE 2017 Journal of Lightwave Technology Vol.35 No.4
<P>We directly measure the spatially and spectrally resolved gain of erbium doped multicore and few mode fiber amplifiers using a coherent swept wavelength interferometer operated in the reflection mode. It greatly simplifies the characterization of multispatial mode amplifiers because it enables characterization of the mode-dependent gain with only a single mode-selective multiplexer at the input. The gains for both multicore fiber amplifier and three spatial modes (LP<SUB>01</SUB> and <TEX>${\rm{LP}}_{{11}}$</TEX>) amplifier are measured. Measurements for multicore fiber amplifier are conducted using two pump schemes, core pump and cladding pump. Also, the comparison with the cutback experiments shows the validity of this technique.</P>