정신분열병에 대한 Risperidone의 효과 및 안전성에 관하여

신석철,왕성근,지익성,이선우,이규광,이봉희,이진영,황선희,신용재,배경도,김정란 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.1

In order to evaluate the efficacy and safety of risperidone, 10 patients with chronic schizophrenia were examined for 8 weeks in a silgle-open study. After the wash-out period of 1 week, risperidone was administered. Efficacy was evaluated by means of Positive and Negative syndrome Scale for Schizophernia(PANSS) and Clinical Global Impression(CGI). Safety assessment included the Extrapyramidal Symptom Rating Scale(ESRS), vital signs, body weight, ECG, and laboratory tests. The results were as follows 1) On the PANSS total score, there was significant improvement of total score after 1 week (P<.05) of administratiom. 2) On the PANSS positive and negative subscal, there were significant improvement of posotive and negative scores after 2 weeks (P<.05) of administration. 3) On the PANSS general psychopatholgy subscals, there were significant improvement of general psychopathologyscores after 1 week (P<.05) of administratiom. 4) On the CGI, there was significant decreasement of clinical impression of severity of schizophrenia score after 2 week (P<.05) of administration. 5) A statistically significant increase in body weight (P<.05) was observed after 8 weeks of administration. 6) EPS reached the peak at the end of the 1st week of administration of risperidone (11.8± 24.25) but they were easily relieved by addition of benztropine and clonazepam. There was not significant change in laboratory tests, vital sign, ECG after 8 weeks of administration. These results suggest that Risperidone is an effective antipsychotics and clinically safe except for increased body weight in chronic schizophrenia.

HPLC/FLD를 이용한 성별·연령별 혈장 homocysteine 정상치 조사

이경옥,류광석,이규범,이경옥,류광석,이규범 대한임상검사정도관리학회 1999 臨床檢査와 精度管理 Vol.21 No.1

화학적 요부 교감신경절 차단에서 한 분절 차단과 두 분절 차단의 비교

김종일,이규종,이상곤,민병우,반종석,문철준 대한마취과학회 2001 Korean Journal of Anesthesiology Vol.41 No.4

Chemical Lumbar Sympathetic Block: Comparison of One- Versus Two-needle Techniques Chul-Jun Mun, M.D., Kyu-Jong Lee, M.D., Sang-Gon Lee, M.D., Jong-Il Kim, M.D.^* Jong-Suk Ban, M.D., and Byung-Woo Min, M.D. Department of Anesthesiology, Fatima Hospital, Daegu, Korea ^*Kim Jong Il Pain Clinic, Daegu, Korea Background: It was frequently noticed in the course of performing a two-needle sympathectomy, that satisfactory spread of contrast solution could be produced by injection through only one of the needles. This led to a closer examination of the merits of single-needle technique. Methods: Forty patients were randomized into two groups. Patients in the single-needle group (n = 20) were injected at the second or third lumbar sympathetic ganglia, while patients in the two-needle group (n = 20) were injected at the second and thired lumbar sympathetic ganglia. Lumbar sympathetic blocks were performed using 3 ml of alcohol and the spread of injectate was verified with C-arm fluoroscopy. The indicators of a successful sympathetic block are increasing skin temperature, decreasing pain, and anhidrosis in the distal extremity. Results: The duration of anhidrosis was 12.2 ?? 2.6 months (mean ?? SD) in the single-needle group versus 13.6 ?? 3.6 months (mean << SD) in the two-needle group. Conclusions: As these results were not significantly different from those obtained in patients having considered to be effective for a neurolytic ;i,bar sympathectomy. (korean J Anesthesiol 2001; 41: 439~443)

유사학과 조정 및 교양교과과정개편에 관한 연구

이종범,김규연,전지용,이춘의,홍석주 朝鮮大學校 1995 교과교육연구 Vol.17 No.-

全北大學校 綜合計劃(Master Plan)에 關한 硏究(Ⅰ)

李鍾純,張明洙,洪錫杓,朴漢圭 全北大學校 1977 論文集 Vol.19 No.-

This report outlines a ten-year(1976-1986) academic and physical development plan of Jeonbug National University. It was prepared over a period of ten months from April, 1976, to February, 1977, by a committee of five professors under the supervision of Dr. Chong Soon Lee. For a final report, the committee not only reviewed the past trend and patterns in the University's development and its present structures and conditions, both academic and physical, but also constantly consulted with Dr. Chong Supp Shim, president, the faculty, and experts in the field through meetings and questionaires. Consultation with them was paticularly needed in envisioning the future directions and possibilities for developing the University. The report presented here is a version revised and approved by the deans council of the University. Since its foundation in 1951, Jeonbug National University has grown from a small provincial institution into a full-scale national university. It now comprises seven colleges and three graduate schools, the students currently enrolled numbering around 5,500 and the faculty and administrative staff consisting of 750 employees. In keeping with the rapid growth of the nation and the governmental emphasis on developing provincial universities, the University is expected within ten years to develop into an academic institution consisting of eight colleges and six graduate schools. The number of undergraduate departments will increase from 40 to 61, and the number of students in attendance will amount to 10,000. In order to cope with this rapid increase in the number of departments and students, the academic plan of this report preseents a time-table of setting up new departments and makes a proposal for restructuring the University's academic and administrative systems. It also recommends that with the inception of the Research Foundation research activities will be systemitized and coordinated around ten major research institutes at the University. The physical development plan of the University has been in urgent need. The planning committe laid out a road construction plan mapping the entrances and major traffic routes on the campus. It also made proposals as to future building sites, centering around the central library under construction. The Medical School and its hospital, now in downtown Jeonju, are planned to be built on the 2nd campus east of the main campus. The University High School is also planned to move to the eastern part of the main campus. Besides the further construction of classroom and laboratory buildings, the University plans to construct an auditorium, an audio-visual center, a museum, a gymnasium, a new administration building, and other facilities. For the completion of these buildings, the estimated cost will amount to 200 billion won in total.

엔지오텐신이 Norepinephrine의 신혈관 반응에 미치는 영향

이석호,김종규,양훈모,민영기,임한혁 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.2

To determine the effect of angiotensin Ⅱ(ANG Ⅱ)-induced hypertension on the renal hemodynamic response of norepinephrine(NE), mongrel dog instrumented for checking of renal blood flow(RBF) was followed as the step increases every 2 minutes in the rate of norepinephrine infusion into the renal artery during 5 conditions (C : control, C+PD : control+pressure decompression of aorta, ACEI : angiotensin converting enzyme inhibitor, ACEI+ANG Ⅱ : angiotensin converting enzyme inhibitor+ANG Ⅱ, ACEI+ANG Ⅱ+PD : angiotensin converting enzyme inhibitor+ANG Ⅱ+pressure decompression of aorta) Without relation of increase (C, C+PD) or decrease (ACEI+ANG Ⅱ, ACEI+ANG Ⅱ+PD) of the plasma ANG Ⅱ level when NE is infused into vessel, there were no differences in RBF response to NE infusion between C and C+PD and between ACEI+ANG Ⅱ and ACEI+ANG Ⅱ+PD, which implies that renal arterial pressure(RAP) does not play an important role in controling the renal hemodynamic response to NE. When renin angiotensin system was blocked by captopril without adding to ANG Ⅱ supply (ACEI), RBF can be severe decreased to approximately 90% at much lower rates of NE infusion than occurred when the sufficient concentration of ANG Ⅱ were present in the plasma. As the increased sensitivity of NE did not occur at lower renal arterial pressure, when ANGⅡ was present in the plasma in sufficient concentrations, it seems that protective effect on renal function is possible by ANGⅡ during renal sympathetic stimulation.

양극성 정동장애 및 정신분열증 환자군에서 성별에 따른 TRH 자극검사

이규환,신석호,백인호 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.1

This study was designed to evaluate the hypothalamic-pituitary-thyroid axis abnormalities and the possible influence of gender on the TSH response to TRH in bipolar patients and schizophrenics by using TRH stimulation test. The subjects were consisted of 34 bipolar patients(male : 14, female : 20) and 24 schizophrenics(male : 11, female : 13). The results were as follows ; 1) There was a significant difference in the baseline TSH level of female subjects before TRH administration between bipolar patients and schizophrenics. 2) The TSH levels at 60 and 90 minutes after TRH administration in female bipolar patients were significantly higher from those of female schizophrenics(P〈0.05). 3) In female subjects, the response of TSH level after TRH administration was significantly different between the two groups(P〈0.005).

움직임 보상을 통한 움직임 기반의 디인테레이싱 기법

이성규,강석규,이동호 漢陽大學校 工學技術硏究所 2001 工學技術論文集 Vol.10 No.-

본 논문에서는 움직임 보상을 이용한 움직임 기반의 디인터레이싱 알고리즘을 제안한다. 정확한 움직임 추정을 위해 전처 리로서 EBMF(Edge Based Median Filter)를 사용하며 2 개의 같은 위상을 갖는 필드와 1개의 다른 위상을 갖는 필드를 이용한 새로운 BMA(Block Matching Algorithm) 움직임 보상 방법을 제안한다. 시간축 필터로서 모션 미싱 에러를 제거하기 위해 입력 영상의 움직임 영역에 따라 각각 다른 임계값을 적용하는 AMPDF(Adaptive Minimum Pixel Difference filter)를 적용하였으며 MMD(Maximum Motion Detection)와 SAD(Sum of Difference)를 이용하여 빠른 움직임 영역에서 화질을 향상시켰다. 최종적으로 잘못된 움직임 보상에 기인하는 화질의 열화를 방지하기 위한 후처리로서 움직임 보정 필터를 제안한다. 모의 실험을 통해 제안하는 방법이 기존의 방법에 비해 우수한 성능을 갖는 것을 확인하였다. In this paper, we propose a motion-adaptive de-interlacing method using motion compensated interpolation. In a conventional motion compensated method, a simple pre-filter such as line averaging is applied to interpolate missing lines before the motion estimation. However, this method causes interpolation error because of inaccurate motion estimation and compensation. In the proposed method, EBMF(Edge Based Median Filter) as a pre-filter is applied, and new matching method, which uses two same-parity fields and opposite-parity field as a reference, is proposed. For further improvement, motion correction filter is proposed to reduce the interpolation error caused by incorrect motion. Simulation results showed that the proposed method provides better performance than existing methods.

甲狀腺製劑 投與中의 甲狀腺機能動態

李圭寶,孫惠卿,黃基錫 慶北大學校 醫科大學 1982 慶北醫大誌 Vol.23 No.2

1982年 1月부터 1982年 8月사이에 慶北醫大附屬病院 核醫學科에서 甲狀腺製劑(Comthyroid)를 投與받고 있는 患者中 3∼6個月사이에 甲狀腺機能檢査를 比較觀察할 수 있었던 35例를 檢査한 結果 다음과 같은 所見을 얻었다. RAIU檢査는 甲狀腺製劑 投與前에 比하여 6時間値나 24時間値가 모두 有意하게 正常以下로 低下되었으나, 血中 T_3와 T_4 値는 少數例에서 上昇되어있었으나 全體的으로 別 有意한 上昇은 없었다. 臨床的으로 腺腫의 約半數例에서 縮小效果가 있었으며 藥濟服用으로 因한 副作用은 없었다. 甲狀腺腫의 抑制法으로 投與하는 甲狀腺製劑의 效果는 臨床的으로 甲狀腺 hormone의 生體에 對한 影響이나 副作用은 없이 뇌하수체-甲狀腺軸에만 作用하여 甲狀腺機能抑制 또는 腺腫縮小를 招來할 수 있다고 思料된다. In order to evaluate the effects of thyroid hormone preparation upon the thyroid function, authors investigated comparative thyroid function tests including of RAIU, serum T_3, and T_4 before and after Comthyroid therapy from January to August 1982 in 35 cases of nontoxic goiter. RAIU both in 6 hrs and 24 hrs were significantly decreased during medication, whereas serum T_4 and T_3 showed no appreciable change. There was no case of side reaction from the regimen, however size of goiter seemed regressed more or less in more than half of the cases.

CFRP 복합재 적층판의 파괴메카니즘에 관한 연구

이권범,박환규,홍석주,김기형 조선대학교 동력자원연구소 1996 動力資源硏究所誌 Vol.18 No.1

In this study, when CFRP lamimates are subjected to static loading by the indentation of steel ball to examine a failure mechanism of lamimates, the fracture surface of interlaminar delamination generated at interfaces is investigated by the scanning electron microscopy (SEM). When orthotropic CFRP laimates stacked with two interface are subjected to static loading, interlaminar delaminations extend from the loading side to delamination edge even at any interface, and the fracture surface fo interlaminar delamination generated at two interfaces is symmertrically formed. In the CFRP laminates, the fracture mechanism sppears mainly to be the mixed mode(modes Ⅰ+Ⅱ), and the ratio of mixed mode varies partially. After the fracture initiates at the interface near the loading side with mode Ⅰ, the mixed mode gradually developes, but the total surface at the opposite plane to the loading side fractures with the mixed mode(modes Ⅰ+Ⅱ). While transverse cracks are generated, the direction of shear stresses reverses itself ar the delaminated surface, clarified by the hackle direction of fracture surface.