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      • 3차원 CFD 모형을 이용한 원형 교각의 국부세굴 특성 해석

        오현식·김경호·양승룡 충북대학교 건설기술연구소 2008 충북대학교 건설기술연구소 논문집 Vol.27 No.1

        Scour is a natural phenomenon, which occurs whenever a solid object is placed on loose sedimentary material, such as sand, in moving water. The flow of water is close to any such obstruction causes local increases in water velocity together with eddies and vortices. The flow phenomena are complex due to the presence of a boundary layer as well as and adverse pressure gradient set up by the bridge pier. Many researchers have conducted a vast number of experiments in laboratory flumes to investigate the local scour depth around a bridge pier. A few empirical formulas predicting the maximum scout depth have been developed under various experimental conditions. However, most of the experiments have been carried out in flumes under idealized conditions. such as steady flow, uniform sediment, simplified geometry, etc. The purpose of the study is to simulate accurately the flow field and scouring processes using a three-dimensional numerical flow model. In this study, for analyzing the mechanism of scouring process, CFD(computational fluid dynamics) model is used, based on the VOF(Volume of fluid) theory and finite differential equation. For the flow model, the simulated three-dimensional flatbed flow field(without bed slop) is compared with experimental data obtained by established scour equation and data. The results showed that 3D scouring flow field simulated by CFD model have almost the same phasis as experimental results.

      • KCI등재

        응급실 내원환자에 대한 병원전 응급체계와 후송체계에 대한 조사

        김영식,황성오,임경수,윤양구 大韓應急醫學會 1992 대한응급의학회지 Vol.3 No.1

        A prospective research of 1,573 patients who visited emergency room was completed by the emergency physician of Wonju College of Medicine of Yonsei University, and Youngdong Hospital. This prospective study demonstrate the problems of prehospital emergency care and transfer system of the emergency patient. Among 1,573 patients, 86.9% were admitted to the Emergency room by the non-emergency vehicle such as taxi and bus, and only 13.1% was admitted via ambulance. At the situation of emergency, the most of patients and patient`s families could not call for the help to emergency telemetry center because only 3.1% among total patients knew the emergency call number(Tel. No: 129). Because the emergency delivery system between emergency centers from Level. Ⅰ, Ⅱ to Level Ⅲ was not established yet, only 492 patients(31.3%) were transferred from Level Ⅰ, Ⅱ emergency room to our emergency room to our emergency center but 1081 patients(68.7%) were admitted directly to Level Ⅲ emergency center from emergency fields. Among 1,081 patients who visited Level Ⅲ emergency center directly, only 240 patients(23%) were admitted for further treatment, but in transferred cases(492 patients), 271 patients(55%) were admitted. Especially in the injured patients, severely injured patients(ISS 16) occupied only 6% among 441 patients who visited directly, but it occupied 21% among 150patients who were transferrd from local community hospital. This result means that many non-urgent patients visited Level Ⅲ emergency centers without the previous visiting of Level ⅠⅡ emergency room. This study reveals that EMSS(Emergency Medical Services System) including the telemetry systems must be organized in short-time to reduce the mortality and morbidity of emergency patients. First, the educations about the emergency call system and First Aids to the people must be stsryed initially through the school and mass-media such as television and radio network. Second, emergency delivery system between Level Ⅰ,Ⅱ,Ⅲ emergency center must be organized for the effective and rapid transportaion of acute ill patients.

      • KCI등재

        Selective inhibition of V600E-mutant BRAF gene induces apoptosis in thyroid carcinoma cell lines

        Kyoung Sik Park,Madhuri Saindane,Eun Yeol Yang,TongYi Jin,Harikrishna Reddy Rallabandi,Alexander Heil,Sang Eun Nam,Young Bum Yoo,Jung-Hyun Yang,Jong Bin Kim,Seo-Young Park,Won Seo Park,Yeo-Kyu Youn 대한외과학회 2021 Annals of Surgical Treatment and Research(ASRT) Vol.100 No.3

        Purpose: Papillary thyroid cancer (PTC) has a high incidence of BRAF<SUP>V600E</SUP> mutation. The purpose of this study was to evaluate the potential relationship between thyroiditis and BRAF<SUP>V600E</SUP> mutation status in patients with PTC. We investigated how a selective inhibitor of BRAF<SUP>V600E</SUP> PLX4032 affects the proliferation and inflammatory cytokine levels of thyroid cancer. Methods: Two thyroid cancer cell lines TPC1 and 8505C were treated with PLX4032, an analysis was done on cell growth, cell cycle, the degree of apoptosis, and levels of inflammatory cytokines. To identify the functional links of BRAF, we used the STRING database. Results: Docking results illustrated PLX4032 blocked the kinase activity by exclusively binding on the serine/threonine kinase domain. STRING results indicated BRAF is functionally linked to mitogen-activated protein kinase. Both cell lines showed a dose-dependent reduction in growth rate but had a different half maximal inhibitory concentration value for PLX4032. The reaction to PLX4032 was more sensitive in the 8505C cells than in the TPC1 cells. PLX4032 induced a G2/M phase arrest in the TPC1 cells and G0/G1 in the 8505C cells. PLX4032 induced apoptosis only in the 8505C cells. With PLX4032, the TPC1 cells showed decreased levels of vascular endothelial growth factor, granulocyte-macrophage colony-stimulating factor, chemokine (C-C motif) ligand 2/monocyte chemoattractant protein 1, whereas the 8505C cells showed significantly decreased levels of IL-8, serpin E1/plasminogen activator inhibitor-1, and matrix metalloproteinase (MMP)-3. Conclusion: PLX4032 was cytotoxic in both TPC1 and 8505C cells and induced apoptosis. In the 8505C cells, inflammatory cytokines such as IL-8 and MMP-3 were down-regulated. These findings suggest the possibility that the BRAF<SUP>V600E</SUP> mutation needs to target inflammatory signaling pathways in the treatment of thyroid cancer.

      • The characteristics of reproduction places of Prosopocoilus astacoides blanchardi (Coleoptera: Lucanidae)

        Kyoung Sik Yang,Woonchul Ko,MIhee Ko,Doseung Lee,Jong chul Lee,Yoonji Lee,Yong-Hwan Jung 한국응용곤충학회 2018 한국응용곤충학회 학술대회논문집 Vol.2018 No.10

        두점박이사슴벌레(Prosopocoilus astacoides blanchardi)는 딱정벌레목(Coleoptera) 사슴벌레과(Lucanidae)에 속하는 종으로 국내에서는 제주도에만 분포하며, 2012년 5월 31일에 멸종위기 야생생물 Ⅱ급 보호종으로 지정되었다. 본 연구는 2014년 5월부터 2018년 8월까지 두점박이사슴벌레가 번식 및 개체군이 유지되는 기주목 12그루를 대상으로 번식지의 특성을 연구하였다. 기주목은 상수리나무(Quercus acutissima) 11그루, 떡갈나무(Q.dentata) 1그루로 분포 해발고도는 150m~355m이며, 기주목의 수고와 흉고는 각 4.5m~10m, 17cm~34cm였다. 특히, 기주목에는 두점박이사슴벌레가 은신할 수 있는 보리밥나무(Elaeagnus macrophylla), 송악(Hedera rhombea), 담쟁이덩굴(Parthenocissus tricuspidata), 마삭줄(Trachelospermum asiaticum), 청미래덩굴(Smilax china), 밀나물(S. riparia), 칡(Pueraria lobata), 으아리(Clematis mandshurica), 사위질빵(C. apiifolia), 며느리밑씻개(Polygonum senticosum), 줄사철나무(Euonymus fortunei), 남오미자(Kadsura japonica) 등의 덩굴성 식물이 기주목의 줄기를 잠식해 있었고, 잠식률은 5%~80%까지 다양했다. 하지만 덩굴성 식물의 줄기잠식률이 낮으면, 기주목에 갈라진 틈이 있거나 군락을 이루고 있어 은신처가 있었고, 단독으로 기주목이 있는 곳은 줄기잠식률이 40%~80% 매우 높았다. 본 연구를 통해 두점박이사슴벌레는 번식 및 개체군 유지를 위해 포식자를 피하고 먹이를 구하기 위해 덩굴성 식물이 줄기를 잠식하고 있는 참나무속(Quercus)의 기주목에 주로 서식하는 것으로 판단된다.

      • SCOPUSKCI등재

        Community Analysis of the Moths in the Gotjawal Terrains of Jeju Island, Korea

        Yang, Kyoung-Sik,Kim, Sang-Bum,Kim, Seong-Yoon,Lee, Ga-Eun,Kim, Won-Taek The Ecological Society of Korea 2006 Journal of Ecology and Environment Vol.29 No.4

        Collection of moths in four Gotjawal terrains of Jeju Island was conducted using black light trap, beginning July through September 2005. The insects investigated were classified into 146 species, 15 families and 7 superfamilies, and Noctuoidea appeared to have accounted for 41.1%, or 60 species, which was the largest number among them, followed by Geometroidea. Ercheia niveostrigata was found to have been the dominant species over the entire area. The diversity index showed the highest at Aewol Gotjawal and the lowest at Hangyeong-Andeog Gotjawal. Aewol Gotjawal formed a cluster with Gujwa- Sungsan Gotjawal at the lowest chord distance (0.75). At the higher chord distance of 0.82, Jocheon- Hamdeog Gotjawal fused the cluster of Aewol Gotjawal and Gujwa-Sungsan Gotjawal. Hangyeong-Andeog Gotjawal fused with the rest three terrains, forming a single cluster at the highest chord distance of 0.89.

      • A survey on the distribution of dung beetles in cattle pasture and horse pasture in Jeju, Korea

        Kyoung Sik Yang,Woonchul Ko,MIhee Ko,Doseung Lee,Jong chul Lee,Yoonji Lee,Yong-Hwan Jung 한국응용곤충학회 2018 한국응용곤충학회 학술대회논문집 Vol.2018 No.10

        제주도내 소 방목지와 말 방목지에서 소똥구리류의 분포를 조사하였다. 본 조사는 2018년 5월부터 9월까지 소 방목지와 인접한 말 방목지 각 3곳(조천읍, 제1 산록도로, 안덕면)을 대상으로 월 3회 실시하였으며, 각 지역마다 함정덫(Pit-fall Trap)을 5m 간격으로 5개씩 설치하여 닭내장으로 유인하였다. 조사결과 소 방목지는 뿔소똥구리(Copris ochus) 21개체, 멸종위기Ⅱ급 보호종인 애기뿔소똥구리(C. tripartitus) 64개체, 렌지소똥풍뎅이(Onthophagus lenzii) 778개체, 모가슴소똥풍뎅이(O. fodiens) 31개체, 창뿔소똥구리(Liatongus phanaeoides) 2개체로 총 5종 896개체가 조사되었고, 종풍부도(Richness Index, RI)에서 다수종(Abundant)은 렌지소똥풍뎅이 1종 이었고, 나머지 종은 희소종(Rare)으로 나타내었다. 종다양도(H’)는 조천읍(0.29), 제 1산록도로(1.06), 안덕면(0.72)로 나타났다. 말 방목지는 각 14개체, 42개체, 205개체, 51개체, 1개체로 총 5종 313개체가 조사되었고, 다수종은 렌지소똥풍뎅이 1종, 보통종(Common)은 애기뿔소똥구리, 모가슴소똥풍뎅이 2종이었고, 나머지 종은 희소종(Rare)으로 나타내었다. 종다양도(H’)는 조천읍(0.76), 제 1산록도로(1.22), 안덕면(1.03)로 나타났다. 본 조사결과 소똥구리류의 종다양도는 말 방목지가 높았지만 조사기간 동안 안덕면에서는 4개체가 잡히면서 종다양도가 높았고, 소 방목지는 렌지소똥풍뎅이의 개체수가 대부분을 차지하면서 종다양도는 낮았지만, 소똥구리류는 소 방목지에 주로 서식하는 것으로 판단된다.

      • SCOPUSKCI등재

        Fauna and Relative Abundance of the Insects Collected by Black Light Traps in Gotjawal Terrains of Jeju Island, Korea (Exclusion of Lepidoptera)

        Yang, Kyoung-Sik,Kim, Sang-Bum,Kim, Seong-Yoon,Jeong, Sang-Bae,Kim, Won-Taek The Ecological Society of Korea 2006 Journal of Ecology and Environment Vol.29 No.2

        An investigation of fauna and community of insects in Gotjawal Terrain, Jeju-do, had been conducted with a way of black light trap from July to September, 2005. The investigated insects were classified into 217 species, 75 families, and 11 orders respectively. Coleoptera that occupied 55.3 percent among them and was consisted of 120 species was the richest group and Hemiptera followed it. The density of Physopelta gutta was highest but Physopelta cincticollis was overall the dominant species in all sampling areas. The species diversity index was highest at Jocheon-Hamdeog Gotjawal in Jeju-do, while it was lowest in Gujwa-Sungsan Gotjawal. Clustering analysis revealed that the insect communities of four localities were grouped in only one cluster. Included in the species unreported in Jeju Island were Menida musiva and Pentatoma japonica in Hemiptera, Philonthus wuesthoffi in Coleoptera, and Phanerotoma flava in Hymenoptera.

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