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Kyomin Choi,Ohyun Kwon,Bum Chun Suh,Jeeyoung Oh,Sungkun Cho,Eunhee Sohn,In Soo Joo 대한신경과학회 2023 Journal of Clinical Neurology Vol.19 No.3
Background and Purpose The description of pain is the most-important indicator leading to the adequate treatment of patients with neuropathic pain (NeP). The purpose of this study was to identify and characterize the unique features of Korean verbal descriptions in patients with peripheral NeP. Methods This study included 400 patients (167 males and 233 females) and their 1,387 paindescription responses. Patients with peripheral NeP freely described their symptoms in Korean. Collected verbal descriptions were grouped according to terminologies with similar meanings. Participants completed validated patient-reported outcome scales including the neuropathic pain symptom inventory (NPSI) and painDETECT questionnaire (PD-Q). The frequencies of each verbal pain descriptor were compared between the NPSI and PD-Q scores. Results ‘Jeorim’ (tingling) was the most common among 17 types of organized verbal pain descriptors, and the ‘Sirim’ (cold) symptom had a significantly higher rate of use in the 2 highseverity groups when participants were classified by their total scores on the NPSI and PD-Q. Conclusions Korean verbal NeP descriptors were significantly diverse. The Jeorim (tingling) and Sirim (cold) descriptors can be utilized in evaluations of Korean patients with NeP.
Kyomin Choi,Ohyun Kwon,Bum Chun Suh,Eunhee Sohn,In Soo Joo,오지영 대한의학회 2022 Journal of Korean medical science Vol.37 No.3
Background: A culturally validated Korean version of the PainDETECT Questionnaire (PD-Q) was used to identify neuropathic pain components (NeP) in patients suffering from chronic pain. The purpose of this study was to determine if the Korean PD-Q can be used to subgroup patients with peripheral NeP according to sensory symptom profiles. Methods: This study included 400 Korean patients with peripheral neuropathic pain diagnosed as probable or definite NeP. The total scores and subscores for each item in PD-Q were transformed into a Z-score for standardization. Hierarchical cluster analysis was performed to identify clusters of subjects by PD-Q scores. Results: The mean total PD-Q score of the study participants was 14.57 ± 6.46. A hierarchical cluster analysis identified 5 clusters with distinct pain characteristic profiles. Cluster 1 had relatively severe burning and tingling sensations. The mean total PD-Q score for cluster 2 was the lowest of the 5 clusters. Cluster 3 tended to be vulnerable to pain in response to cold/heat stimulation. Cluster 4 showed relatively severe pain induced by physical stimuli, such as light touch or slight pressure. Cluster 5 had high scores for all NeP symptoms. Conclusion: This study demonstrates the ability of patients to cluster by symptoms using the Korean PD-Q. Subgrouping of peripheral neuropathic pain by sensory symptom profile may be useful in making effective drug treatment decisions.
Characteristics of South Korean Patients with Hereditary Transthyretin Amyloidosis
Choi, Kyomin,Seok, Jin-Myoung,Kim, Byoung-Joon,Choi, Young-Cheol,Shin, Ha-Young,Sunwoo, Il-Nam,Kim, Dae-Seong,Sung, Jung-Joon,Lee, Ga Yeon,Jeon, Eun-Seok,Kim, Nam-Hee,Min, Ju-Hong,Oh, Jeeyoung 대한신경과학회 2018 Journal of Clinical Neurology Vol.14 No.4
<P><B>Background and Purpose</B></P><P>This retrospective cross-sectional study included 18 patients from unrelated families harboring mutations of the transthyretin gene (<I>TTR</I>), and analyzed their characteristics and geographical distribution in South Korea.</P><P><B>Methods</B></P><P>The included patients had a diagnosis of systemic amyloidosis, clinical symptoms, such as amyloid neuropathy or cardiomyopathy, and confirmation of a <I>TTR</I> gene mutation using genetic analysis recorded between April 1995 and November 2014.</P><P><B>Results</B></P><P>The mean age at disease onset was 49.6 years, and the mean disease duration from symptom onset to diagnosis was 3.67 years. Fifteen of the 18 patients were classified as mixed phenotype, 2 as the neurological phenotype, and only 1 patient as the cardiac phenotype. The most-common mutation pattern in South Korea was Asp38Ala, which was detected in eight patients. Thirteen patients reported their family hometowns, and five of the eight harboring the Asp38Ala mutation were from the Gyeongsang province in southeast Korea. The other eight patients exhibited a widespread geographical distribution. A particularly noteworthy finding was that the valine at position 30 (Val30Met) mutation, which was previously reported as the most-common <I>TTR</I> mutation worldwide and also the most common in the Japanese population, was not detected in the present South Korean patients.</P><P><B>Conclusions</B></P><P>South Korean patients with hereditary TTR amyloidosis exhibited heterogeneous <I>TTR</I> genotypes and clinical phenotypes. The findings of this study suggest that the distribution of TTR amyloidosis in South Korea is due to de novo mutations and/or related to the other countries in East Asia.</P>
Generation Characteristics of Nanoparticles Emitted from Subways in Operation
Lee, Yongil,Choi, Kyomin,Jung, Wonseog,Versoza, Michael E.,Barabad, Mona Loraine M.,Kim, Taesung,Park, Duckshin [Chinese Association for Aerosol Research in Taiwa 2018 Aerosol and air quality research Vol.18 No.9
<P> In this study, measurements were carried out to identify the generation characteristics of wear particles emitted under a subway cabin during operation. Along with a fast mobility particle sizer, probes were installed under a subway cabin and in a subway tunnel to measure the size distributions of nanoparticles at 1-s intervals. Based on the particle density measured under the cabin minus that measured in the tunnel, the size distribution of wear particles generated under the cabin during deceleration was estimated to be bimodal at 165.5 nm and 6.98 nm. These particles were most likely generated from wheel-rail contact, as the train utilized electric braking (no mechanical force applied). In addition, a change in the wear mechanism appears to have arisen due to the increased temperature of the wheel-rail contact while nanoparticles were being emitted, leading to an initial generation of 165.5-nm particles followed by 6.98-nm particles 1 s later. </P>
Long-term Retention Rate of Zonisamide in Patients With Epilepsy: An Observational Study
Kim, Dong Wook,Choi, Kyomin,Moon, Heui-Soo,Oh, Jeeyoung by Lippincott Williams Wilkins. 2014 Clinical neuropharmacology Vol.37 No.5
INTRODUCTION: Zonisamide (ZNS) is an antiepileptic drug with a broad spectrum of action mechanisms. Although ZNS is usually indicated for the adjunctive treatment of partial seizures in Western countries, it has long been used for partial and generalized seizures as monotherapy or adjunctive treatment in South Korea and Japan. The present study was to evaluate the long-term retention rate of ZNS in clinical practice. METHODS: This was a retrospective, single-center, long-term observational study. A total of 148 patients (82 men, 66 women; 14–85 years) who were treated with ZNS as monotherapy or adjunctive treatment were included. Zonisamide was administrated with a starting dose of 100 mg/d, and optimal-dose adjustments were made according to individual clinical responses. Efficacy and tolerability were analyzed during a 6-year follow-up. RESULTS: The overall retention rate was 66.1% at 1-year and 55.1% at 6-year follow-up. Patients with monotherapy (70.8% vs 44.1%) and generalized seizures (71.6% vs 48.2%) were more likely to continue ZNS at 6-year follow-up compared with those with adjunctive therapy and partial seizures. The most common cause of discontinuation was adverse events such as somnolence, rash, and gastrointestinal problems. CONCLUSIONS: Our study shows the high retention rate of ZNS in the treatment of patients with epilepsy. The retention rate of ZNS was comparable with those of other antiepileptic drugs including lamotrigine, topiramate, and levetiracetam, and it can be suggested that ZNS can be considered for monotherapy and for the patients with generalized seizures.
Ahn Sohyun,홍윤호,Lee Dong Hyeon,Joo Sae Kyung,Jung Yong Jin,Sohn Sung-Yeon,Choi Kyomin,김원 대한의학회 2022 Journal of Korean medical science Vol.37 No.7
Background: Muscle cramp is possibly related to peripheral nerve hyperexcitability (PNH), and one of the most debilitating symptoms frequently encountered in patients with liver cirrhosis. We investigated whether pregabalin, a gamma-aminobutyric acid analogue, can suppress neuronal excitability and reduce muscle cramps in cirrhotic patients. Methods: We conducted a randomized, double-blind, placebo-controlled trial in which study participants with cirrhosis from a single tertiary center were enrolled. Primary endpoint was the relative change in cramp frequency from the run-in to standard dose treatment phase (4 weeks per each). Secondary endpoints included the responder rate, and the changes in cramp frequency during sleep, pain intensity, health-related quality of life (Liver Disease Quality of Life Instrument, Short Form-36) and electrophysiological measures of PNH. Results: This study was terminated early because of insufficient accrual. 80% (n = 56) of the target number of participants (n = 70) were randomized to pregabalin (n = 29) or placebo (n = 27). Median baseline frequency of muscle cramps (interquartile range) was 5.8 (3.5–10) per week in the pregabalin group and 6.5 (4.0–10) in the placebo group (P = 0.970). The primary analysis showed a significant reduction in cramp frequency with pregabalin compared to placebo (−36% vs. 4.5% for the percentage change, P = 0.010). Secondary outcomes did not differ significantly between the two groups. Adverse effects with pregabalin were mainly dizziness and lethargy. Conclusion: With multiple problems emerging from premature termination in mind, the results suggested an acceptable safety profile and favorable effect of pregabalin in reducing muscle cramps compared to placebo in cirrhotic patients.
Kim, Koeun,Kim, Yeonkyoung,Park, Sewon,Yang, Hyun Ji,Park, Sung Ji,Shin, Kyomin,Woo, Jung-Je,Kim, Saheum,Hong, Sung You,Choi, Nam-Soon Elsevier 2018 Journal of Power Sources Vol.396 No.-
<P><B>Abstract</B></P> <P>An ethyl 4,4,4-trifluorobutyrate (ETFB) additive, with ester and partially fluorinated alkyl moieties, is employed to stabilize the interface structure of Ni-rich layered LiNi<SUB>0.7</SUB>Co<SUB>0.15</SUB>Mn<SUB>0.15</SUB>O<SUB>2</SUB> (NCM) cathodes and graphite anodes. The analysis of the surface chemistry of the electrodes shows that ETFB serves as a bifunctional additive for constructing protective layers on both electrodes in a full cell. Cycling tests reveal that the addition of 1% ETFB leads to excellent capacity retention (84.8%) for the NCM/graphite full cell, which also delivers a superior discharge capacity of 167 mAh g<SUP>−1</SUP> and a high Coulombic efficiency of over 99.8% after 300 cycles at 45 °C. The ETFB-derived protective layer effectively reduces intergranular cracking in secondary NCM cathode particles upon repeated charge-discharge cycling and limits the dissolution of transition metal ions from the cathode at high temperatures. In addition, after ETFB reduction, the graphite anode develops a thermally stable interface structure, which suppresses the self-discharge of graphite coupled with the NCM cathode at 60 °C.</P> <P><B>Highlights</B></P> <P> <UL> <LI> ETFB modifies the interface structure of NCM cathodes and graphite anodes. </LI> <LI> ETFB-added electrolyte improves cycling performance of NCM/graphite full cells. </LI> <LI> SEI layer formed via ETFB reduces intergranular cracking of NCM cathodes. </LI> <LI> ETFB suppresses self-discharge of charged graphite anodes at 60 °C. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>