난소암 환자에 대한 복합 화학요법 ( PAC Regimen ) 의 독성에 관한 연구

김두상(DS Kim),김문신(MS Kim),김용철(YC Kim),박형무(HM Park),유명숙(MS Yoo),신호문(HM Shin),김동명(DM Kim),조수현(SH Cho),조태승(TS Cho),환윤영(YY Hwang),심재철(JC Sim) 대한산부인과학회 1984 Obstetrics & Gynecology Science Vol.27 No.2

한양의대 산부인과학교실에서 1978년 10월부터 1982년 9월까지 PAC regimen(제1일에 adriamycin 50mg/㎡, 제2일에 cis-platinum 50mg/㎡, 제3~7일에 cyclophosphamide 150mg/ ㎡)으 로 화학치료를 받은 상피성난소암환자 16예를 대상으로 그 독성을 조사 분석하여 타 보고 자들의 성적과 비교 관찰한 바 다음과 같은 결론을 얻었다. 1. 혈액학적 독성은 총 16예중 10예(62.5%)에서 발생하였으며 혈소판 감소증은 3예 (18.8%), 백 혈구감소증 6예(37.5%), 빈혈 6예(37.5%)로 나타났으며 수혈은 1예(6.3%)에 실시하였다. 2. 신장에 대한 독성은 총 16예중 7예(43.8%)에서 각각 BUN증가 4예(25%) 혈청 creatinine 증 가 3예(18.8%)로 나타났으나, 전예가 경증이었다. 3. 가장 빈발하고 고통스러운 독성은 오심 구토로 전예에서 발생하였으며 perphenazine과 diazepam으로 어느정도 극복할 수 있었다. 4. 기타 말초신경독성은 5예(31.3%), 청력장애 1예(25%), 주관적인 시력장애 3예(18/8%), 간장 독성 1예(6.3%)였고 탈모증은 전예(100%)에서 발생하였다. The toxicity of PAC regimen was evaluated in 17 patients of ovarian epithelial carcinoma at the Edpartmane of Obstet. Nad Gynecol., Hanyang University Hospiatal from October, 1978 through september 1982. The PAC regimen consists of adriamycin 50mg/㎡ on the first day, cis-platinum 50mg/㎡ on the second day, and cyclophos-phanide 150mg/㎡ on the third to seventh day. It was repeated every 4 weeks. The results were as follow: 1. The hematologic toxicity occurred in 62.5%(10/16) of the patients, including thrombocytenia 18.8%(3/16), leukipenia 37.5%(6/16), and anemia 37.5%(6/16). For only one case, transfusion was require. 2. Nephrotoxicity occurred in 43.8%(7/160), including an elevation of BUN 25.0%(4/16) and an elevation of serum creatinine 18.8%(3/16). But all were in mild degree. 3. For the symptoms of gastrointestinal tract were nausea and vomiting which occurred in all cases and most distressing problems. All patients, however, were well tolerated with perphenazine and diazepam. 4. Peripheral neurotoxicity occurred in 31.3%(5/16), ototoxicity in 25.0%(1/4), blurred vision in 18.8%(3/16), hepatotoxicity in 6.3%(1/16) and alopecia in 100%.

Study on the polymorphism between brown midrib mutants and Hwangkeumchal using SSR markers toward sorghum QTL mapping on excessive water stress

JY Park,AR Kim,SY Yoo,JI Kim,TW Jung,SH Woo,HY Heo,TW Kim,TS Ko 한국육종학회 2013 한국육종학회 심포지엄 Vol.2013 No.07

Excessive water stress can cause severe damage to sorghum and results in significant yield reduction. The aim of this study is to identify quantitative trait loci (QTL) for excessive water stress in sorghum. As a first step, two out of 21 bmr mutants were selected for their superior agronomic performance and Chlorophyll a fluorescence OJIP transient, and were crossed with an elite Korean cultivar, Hwangkeumchal, to construct mapping populations. One hundred ten out of 236 SSR primers showed polymorphism between two parens, which cover ten chromosomes of sorghum from different published SSR linkage maps of sorghum. Development of recombinant inbred lines from the crosses ‘25M2-0698 x Hwangkeumchal’ and ‘25M2-0404 x Hwangkeumchal’ are in progress using the single seed descendent method for generation acceleration.

Assessment of genetic diversity among Korean sorghum (Sorghum bicolor (L.) Moench) resources using SSR markers

JY Park,AR Kim,SY Yoo,JI Kim,TW Jung,SH Woo,HY Heo,TW Kim,TS Ko 한국육종학회 2013 한국육종학회 심포지엄 Vol.2013 No.07

Grain sorghum is the fifth most important crop grown in the world for either a major food crop or animal feed. It is important to identify the genetic diversity of sorghum genetic resources for cultivar development and evaluation of sorghum accessions in Korea. Two hundred thirty six SSR primer sets, which are evely distributed across the sorghum genome, were used to assess the genetic variation of 23 sorghum accessions with a US cultivar, BTx623. Results showed that SSR markers were highly polymorphic among the sorghum collections and the average alleles per locus were 3.15 with the average of 0.436 PIC (polymorphism information content) values. The sorghum accessions in this study were unequally separated and were clustered into 4 groups. The results showed that there was a sufficient SSR polymorphism with SSR primers used among Korean sorghum accessions, and the development of genetic map and marker-assisted selection for cultivated sorghum would be feasible with further studies.

Surface Modification of Titanium Implant by Anodic Oxidation Treatment and Bisphosphate Immobilization

Kim WG,Lee SJ,Soh YJ,Lee MH,Kim HS,Kim BI,Bae TS 대한치과재료학회 2011 대한치과기재학회 학술대회 Vol.2011 No.5

제왕절개 후 발생한 태반용종 1 예

김동진,신영관,김준태,윤미림,김태수,황호민 대한산부인과학회 1995 Obstetrics & Gynecology Science Vol.38 No.2

저자는 최근 본 병원 산부인과에서 제왕절개후 2년만에 발견된 태반 용종의 한 사례를 경험 하였기에 이에 대한 간단한 문헌적 고찰과 함께 보고하는 바이다. A placental polyp is an intrauterine, polypoid or pedunculated mass of placental tissue retained after an incomplete abortion or term pregnancy. While several cases of placental ployp after vaginal delivery and abortion have been reported, few cases of placental polyp after cesarian section were reported before. However, recently, we happened to meet such case, and we present here the history of the case and brief review of related literature.

자궁외임신의 진단과 치료에 있어서 최근경향

김종덕,김관식,최범석,김태실,방해미,조장철 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.11

This retrospective study was undertaken to investigate the current clinical trend in the management of ectopic pregnancy. 562 patients of ectopic pregnancy were admitted and mana-ged at the Department of Obstetrics and Gynecology, Chonbuk National University Hospital fr-om Jan. 1. 1985 to Dec. 31. 1996. All cases had a reliable medical record and were divided into two groups, of which group A includes patients admitted from Jan. 1. 1985 to Dec. 31. 1990, group B from the Jan. 1. 1991 to Dec. 31. 1996. The results were obtained as follows. 1. The number of cases of ectopic pregnancy were 248 in group A and 314 in group B. 2. The age group of 20 to 29 years of age was top ranked in group A(49.6%) as well as in group B(46.8%). The age group of 30 to 39 years was 43.2% in group A and 46.6% in group B, respectively. 3. In group A, the case who experienced two deliveries was 31.9%, and nulliparous woman was 30.6%. In group B, the case who experienced two deliveries was 33.1%, nulliparous woman was 33.1%. 4. On reviewing the past medical history, ectopic pregnancy was 11.2% in group A, 10.8% in group B, respectively. Pelvic inflammatory disease was 8.1% in group A and 11.0% in group B, respectively. 5. The interval between the last menstrual period and the onset of symptoms was prevalently in 4 to 8 weeks(64.5% in group A, 61.8% in group B). The terval of 12 weeks or more was 2.0% in group A and 6.0% in group B, respectively. 6. In considering the chief complaints, low abdominal pain was 85.9% and vaginal spotting was 69.0% in group A. On the other hand, low abdominal pain was 91.4% and vaginal spotting was 76.4% in group B, meanwhile nausea & vomitting was 8.6% and dizziness was 3.5% in group A, there were 23.4% of nausea & vomitting and 9.7% of dizziness in group B, 7. In relation of the diagnostic methods, the positive rate of culdocentesis in group B was lower than the rate in group A. Diagnostic laparoscopy was done in 5.6% of group A and 14% of group B. The detection rate of adnexal mass and fluid collection in the pelvic cavity was higher in group B than in group A on the ultrasonographic examination. 8. Initial hemoglobin value of 10.1mg/dl or more was 70.9% in group A and 73.2% in group B. The value of 8.0gm/dl or less was 6.4% in group A and 7.0% of group B, respectively. Initial systolic pressure of 110mmHg or more was 74.6% in group A and 66.6% in group B. The systolic pressure of 90mmHg or less was 3.6% in group A and 8.3% in group B. 9. The conceptus was almost implantd in the fallopian tube. The ampullary portion was the most common site of ectopic implantation in both groups. 10. Intraabdominal hemorrhage of 500ml or less in amount was 52.4% in group A and 61.1% in group B, individually. However transfusion was not given in 55.6% of group A and in 71.0% of group B. 11. In the therapeutic modalities, laparotomy was performed in 96.8% of group A and in 82.8% of group B, respectively. The pelviscopic operation was done in 2.4% of group A and in 22.3% of group B. In conclusion, ectopic pregnancy was diagnosed increasingly prior to the onset of the hypovolemic symptoms according to developement of high-resolution ultrasonogram, diagnostic laparoscopy and β-hCG test, therefore the use of minimally invasive techniques in the management of ectopic pregnancy was increasing.

불임환자에서 자궁근종절제술 후 임신성공률

김종덕,류철희,김관식,김난경,조한구,김태실 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.10

Uterine myoma is the one of the most common tumor of female genital tract. It causes infertility and many other complications associated with pregnancy. This study was undertaken to evaluate the efficacy of transabdominal myomectomy on 48 patients who suffered from infertility and hibitual abortion at the Department of Obstetricas and Gynecology in Chonbuk National Uniersity Hospital from 1985 to 1994. The results are as follos: 1. Average age of patients was 32.2. The number of nulligravida patients was 17 and infertility duration raged from 12 months to 156 months. 2. Twenty two out of 48 women(45.8%) were conceived. 3. Pregnancy rate after myomectomy showed some difference dependign on surgical indication. In case, the uterine myoma was the only surgical indication, the pregnancy rate was 68.8%, while the rate was 26.7% when other factors of infertility were combined with uterine myoma. 4. The average time period from operation to conception was 13.8 months. Fifteen of the 22(68.2%) conceived in the first year after operation and 19(80.4%) conceived within two years. 5. Pregnancy rate also depended on the age of patients. Forteen out of 21 patients of under 30th conceived, while only 18 out of 72 patients above 30th conceived and there was no pregnancy over 36 years of age. 6. Finally pregnancy rate according to the size and number of myoma was studies. Fifty percent of solitary myoma patients conceived, while only 35.7% of multiple myoma patients conceived. Pregnancy rate of the patient of solitary myoma with diffrent size was similar, indicating moma size was not an influencing factor to the pregnancy rate. In conclusion myomectomy can be strongly recommended with good success expectation for the infertile women if uterine myoma be considered as the main cause of infertility while other causes are not clear, particularly below 35 years of age.

선천성 태아 성상세포종 1 예

김훈,김태상,이재동,최윤석,김익수,채진호,서준영 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.8

저자들은 임신 제36주 5일에 태아 선천성 두개내 종양으로 진단 후 자궁내 사망한 태아 부검 소견상 성상세포종으로 밝혀진 산모 1예를 경험하였기에 간단한 문헌 고찰과 함께 보고하는 바이다. Congenital intracranial tumors are very rare. We report a case of the astrocytoma confirmed by autopsy after stillbirth at 37+5 weeks gestation. Prenatal ultrasound revealed relatively well defined, large, lobulated, heterogeneous hyperechoic lesion, which involve the left cerebral hemisphere and displace the falx cerebri opposite side. Hydramnios was not seen. The methods of delivery are cesarean section or vaginal delivery according to intrapartum destructive procedures. We have reviewed with attention to sonographic characteristics, associated findings of the congenital astrocytoma and management and progress of congenital astrocytoma with brief review of literatures.

조기진통의 예측지표로서 자궁경부 및 질내 태아파이브로넥틴의 임상적 유용성

김수평,이종건,나종구,김사진,김용욱,이종승,변태섭,정인광,나윤택 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.10

Prematurity is the major cause of neonatal mortaliy and morbidity. The prediction and early arrest of preterm uterine contractions is the mainstay of the management of the preterm labor. Several biophysical methods and biochemical markers are available, but not satisfactory for the prediction of preterm labor. The aim of this study is to determine the clinical efficacy of fetal fibronectin as a biochemical predictor of preterm labor. Fetal fibronectin was obtained at external os and posterior vaginal fornix in 118 women who have irregular uterine contractions with intact membranes and, in 113 women who complained of watery vaginal discharges without visible leakage. The cervicovaginal fetal fibronectin was measured quantitatively by fetal fibranectin immunoassay in 118 patients and qualitatively by fetal fibronectin membrane immunoassay in 113 patients. The results were considered positive when specimens had a fetal fibronectin concentration above 50 ng/ml in women who have irregular uterine contractions with intact membranes. The results obtained were as follows; 1. Fetal fibronectin concentrations in women with or without irregular uterine contractions with cervix dilatation($lt;=2cm) and intact membranes were 229.18+-68 ng/ml, 16.8+-9.2 ng/ml, respectively. 2. In the efficacy of fetal fibronectin for the prediction of preterm labor in women who have irregular uterine contractions and intact membrane, the sensitivity, specificity, positive predictive value and negative predictive value are 83.3%, 85.2%, 65.8% and 93.8%, respectively. There were significant correlation between the positivity of the fetal fibronectin and interval(diagnosis to delivery), gestational weeks at delivery and neonatal body weight. 3. In the efficacy of fetal fibronectin for the prediction of preterm labor in women who complained of watery vaginal discharges without visible leakage, the sensitivity, specificity, positive predictive value and negative predictive value are 62.5%, 93.3%, 71.4% and 90.2%, respectively. There were significant correlation between the positivity of the fetal fibronectin and interval(diagnosis to delivery), gestational weeks at delivery and neonatal body weight. 4. in the association between fetal fibronectin membrane immunoassay and nitrazine test in women who complained of watery vaginal discharges without visible leakage, the accuracy was 83.2%. This results reflect that positive cerviovaginal fetal fibronectin in women who have irregular uterine contractions or in women who complained of watery vaginal discharges maybe a useful biochemical predictor for the prediction of preterm labor.

Post-Transfusion Prupura 1 례

김동진,신영관,차용재,김준길,김준태,김태수 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.10

PTP는 동양인에서는 매우 드문 증후군으로서, 대부분의 경우 진단이 안되거나 ITP로 잘못 진단하는 경우가 많다. 특히 수혈을 많이하는 산부인과 의사로서 경산부에 수혈했을때 발병 가능성이 있으며 일단 PTP가 의심이 되면 즉시 치료를 시작해야 한다는 사실을 알아야 할 것으로 생각되며, 본 저자들은 경산부에서 발생된 PTP 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Post-transfusionpurpura(PTP) is believed to be a rare clinical syndrome characterized by the acute occurrence of severe purpura with thrombocytopenia approximately 1 week after blood transfusion. This syndrome occurs predominantly in patients who lack the platelet-specific alloantigen, and has been previously sensitized by prior transfusion or pregnancy. The typical patient is a middle-aged, multiparous white woman. Diagnosis may be suspected by normal clotting studies, bone marrow biopsy showing increased megakaryocytes, and demonstration of a potent antibody reactive against platelets by appropriate serologic tests. Treatment with corticosteroid and platelet transfusion is ineffective. Exchange trasfusion or plasmapheresis has led to improved survival in this disease. Recent reports indicate that IV IgG may become a effective treatment. We exprienced a case of PTP in a multiparous woman received first blood transfusion during Cesarean section. Here we report this case with brief review of literature.