http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
김혜인 ( Hye In Kim ),( Seonmi Nam ),( Yejin Park ),( Yun Ji Jung ),( Ha Yan Kim ),( Kyung Won Kim ),( Myung Hyun Sohn ),( Young-han Kim ),( Joon-ho Lee ),( Soo Jong Hong ),( Ja-young Kwon ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-
Objective: In this study, we evaluated the prevalence of allergic disease in offsprings delivered via the delivery modes of vaginal delivery vs. planned Cesarean section vs. Cesarean section with labor. Methods: This study included 175 mother-neonate pairs from Severance Hospital who were enrolled in the Cohort for Childhood Origin of Asthma and allergic diseases study. Information regarding prenatal environmental factors, delivery, and diagnosis of allergic diseases was obtained from a questionnaire and medical record review. Patients with at least 3 years of follow-up data were included in this study. Results were adjusted for sex, birthweight, gestational age at birth, season of birth, neonatal intensive care unit admission, parity, breastfeeding, and maternal factors. Results: A total of 175 offsprings were eligible for analysis. Among the subjects, 52.0% were delivered by vaginal delivery, 34.3% by planned Cesarean section, and 16.6% by Cesarean section with labor. Fifty-nine offsprings (33.7%) were diagnosed with allergic disease at a median age of 1 year (range 0.5-3 years). The prevalence of allergic disease was not associated with delivery mode after adjusting for confounding variables. Time period from membrane rupture to delivery, duration of the active phase, and the beginning of the pelvic division prior to Cesarean section were not associated with allergic disease development in offsprings. Conclusion: Cesarean section, irrespective of the occurrence of labor before surgery, did not increase the prevalence of allergic disease in infants up to 3 years of age.
Truong, A.-Tai,Kim, Byounghee,Kim, Somin,Kim, Moonjung,Kim, Jungmin,Kim, Seonmi,Yoon, Byoungsu International Bee Research Association [etc.] 2019 Journal of apicultural research Vol.58 No.5
<P> Israeli acute paralysis virus (IAPV) is one of the main pathogens involved in the collapse of honey bee colonies. However, because the virus exhibits a high level of genetic variation and some IAPV strains exhibit high degrees of homology with related viruses, the detection of IAPV in infected honey bees is relatively challenging. To address this obstacle, the aim of the present study was to develop a new detection method that relies on multiple detection sites within the IAPV genome and on Ultra-rapid real-time polymerase chain reaction (UR-qPCR). The new system simultaneously targeted a RNA-dependent RNA polymerase gene <I>(RdRp)</I> and two capsid genes (<I>VP3</I> and <I>VP1</I>). This multi-point PCR approach was highly efficient, with the ability to detect 100% of IAPV infections, and outperformed single-point PCR, which was only able to detect 86.96-95.6% of IAPV infections. Sequence analysis indicated that <I>RdRp</I> was more variable than the two capsid genes, and the specificity of the proposed method was demonstrated by the detection of IAPV from samples co-infected by IAPV and KBV. Importantly, both freezing-thawing RNA isolation and UR-qPCR could be performed in 27min and 40s. Therefore, the present provides an useful tool for the rapid identification of IAPV in apiaries. </P>
Kim, Jeongjin,Woo, Jeonghoon,Park, Young-Gyun,Chae, Sujin,Jo, Seonmi,Choi, Jeong Woo,Jun, Hong Young,Yeom, Young Il,Park, Seong Hoon,Kim, Kyung Hwan,Shin, Hee-Sup,Kim, Daesoo The Society 2011 The Journal of neuroscience Vol.31 No.11
<P>Hypoxic damage to the prefrontal cortex (PFC) has been implicated in the frontal lobe dysfunction found in various neuropsychiatric disorders. The underlying subcortical mechanisms, however, have not been well explored. In this study, we induced a PFC-specific hypoxia-like damage by cobalt-wire implantation to demonstrate that the role of the mediodorsal thalamus (MD) is critical for the development of frontal lobe dysfunction, including frontal lobe-specific seizures and abnormal hyperactivity. Before the onset of these abnormalities, the cross talk between the MD and PFC nuclei at theta frequencies was enhanced. During the theta frequency interactions, burst spikes, known to depend on T-type Ca(2+) channels, were increased in MD neurons. In vivo knockout or knockdown of the T-type Ca(2+) channel gene (Ca(V)3.1) in the MD substantially reduced the theta frequency MD-PFC cross talk, frontal lobe-specific seizures, and locomotor hyperactivity in this model. These results suggest a two-step model of prefrontal dysfunction in which the response to a hypoxic lesion in the PFC results in abnormal thalamocortical feedback driven by thalamic T-type Ca(2+) channels, which, in turn, leads to the onset of neurological and behavioral abnormalities. This study provides valuable insights into preventing the development of neuropsychiatric disorders arising from irreversible PFC damage.</P>