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( Yuki Wada ),( Hideyuki Tamai ),( Akira Kawashima ),( Naoki Shingaki ),( Yoshiyuki Mori ),( Masanori Kawaguchi ),( Kosaku Moribata ),( Hisanobu Deguchi ),( Kazuki Ueda ),( Izumi Inoue ),( Takao Maeki 대한소화기학회 2014 Gut and Liver Vol.8 No.4
Background/Aims: The present study aimed to clarify whether virological response within 2 weeks after therapy initiation can predict a null response to pegylated interferon α-2b plus ribavirin therapy in patients with high viral load genotype 1b hepatitis C. Methods: The participants consisted of 72 patients with high viral load genotype 1b. The dynamics of viral load within 2 weeks were measured. Results: Significant differences between null responders and nonnull responders were noted for interleukin (IL)-28B genotype, amino acid 70 substitution, α-fetoprotein, low-density lipoprotein cholesterol, hyaluronic acid, and viral response. The area under the curve (AUC) for the receiver operating characteristic curve of the hepatitis C virus (HCV) RNA level decline at 2 weeks (AUC=0.993) was the highest among the factors predicting the null response. When the cutoff value for the HCV RNA level decline at 2 weeks was set at 0.80 log, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy in predicting a null response were 82%, 96%, 82%, 96%, and 94%, respectively. In comparison, values for the non-TT and mutant type of amino acid 70 substitution were similar to those for HCV RNA level decline at 2 weeks. Conclusions: Virological response at 2 weeks or the combination of IL-28B and amino acid 70 substitution are accurate predictors of a null response. (Gut Liver 2014;8:421-427)
Experimental Flight of KIT Student’s Rocket in France
Koji Okuda,Yuji Ujimoto,Yuta Otsuka,Takaya Sato,Takuya Shidooka,Daijiro Semba,Kenichi Tominaga,Junichi Fukuda,Yuta Yamamoto,Kazuki Wada,Shinichi Sagara,Koichi Yonemoto 한국항공우주학회 2008 한국항공우주학회 학술발표회 논문집 Vol.- No.-
KIT Student's Rocket has been developed by a student group of Kyushu Institute of Technology lor rocket launch campaign held at La Courtine in France since 2006. This paper introduces the newest design of rocket. The rocket has the body length of 2120㎜, and weighs 14.6㎏ and can reach to an altitude of about 700㎜ by a solid rocket motor provided by CNES (the French Centre National D’Etudes Spatiales). The rocket is controlling rolling attitude during ascent phase and then deploying a parafoil at the apogee of the trajectory for recovery guidance to an aiming point.
Depression Promotes the Onset of Irritable Bowel Syndrome through Unique Dysbiosis in Rats
( Takeshi Takajo ),( Kengo Tomita ),( Hanae Tsuchihashi ),( Shingo Enomoto ),( Masaaki Tanichi ),( Hiroyuki Toda ),( Yoshikiyo Okada ),( Hirotaka Furuhashi ),( Nao Sugihara ),( Akinori Wada ),( Kazuki 대한간학회 2019 Gut and Liver Vol.13 No.3
Background/Aims: Although studies using conventional animal models have shown that specific stressors cause irritable bowel syndrome (IBS), it is unclear whether depression itself causes IBS. Our aim was to establish a rat model to determine if depression itself promotes the onset of IBS and to elucidate the role of gut microbiota in brain-gut axis pathogenesis during coincident depression and IBS. Methods: Rat models of depression were induced using our shuttle box method of learned helplessness. Visceral hypersensitivity was evaluated by colorectal distension (CRD) to diagnose IBS. Gut microbiota compositions were analyzed using high-throughput sequencing. In the subanalysis of rats without depression-like symptoms, rats with posttraumatic stress disorder (PTSD) were also examined. Results: The threshold value of CRD in depressed rats was significantly lower than that in control rats. Microbial community analysis of cecal microbiota showed that the relative abundance of Clostridiales incertae sedis, the most prevalent microbe, was significantly lower in depressed rats than in control rats. The distribution pattern of the microbiota clearly differed between depressed rats and control rats. Neither visceral hypersensitivity nor the composition of gut microbiota was altered in rats with PTSD-like phenotypes. Conclusions: Our rat model of depression is useful for clarifying the effect of depression on IBS and suggests that depression itself, rather than specific stressors, promotes the onset of IBS. Further, we provided evidence that various psychiatric diseases, viz., depression and PTSD, are associated with unique gut microbiota profiles, which could differentially affect the onset and progression of coincident IBS. (Gut Liver 2019;13:325-332)