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A microfluidic Chip based on electrochemical method for the detection of β-amyloid (1-42)
Kamrul Islam,장유철(You-Cheol Jang),Sandeep Kumar Jha,이현호(Hyun Ho Lee),김용상(Yong-Sang Kim) 대한전기학회 2010 대한전기학회 학술대회 논문집 Vol.2010 No.7
Numerous studies have identified β-amyloid (1-42) protein (Aβ-42) in the cerebrospinal fluid as a potential biomarker of Alzheimer's disease. It is of particular interest to establish the diagnosis before reaching the stage of clinical severity. The current methods for studying amyloid detection, however, is often time-consuming, expensive, and labor intensive, making the analytical process very slow. Thus, a critical need exists for an analytical system that would enable the rapid investigation of amyloid formation with a very small amount of amyloidogenic peptides and reagents. In our present work, we report a simple microfluidic self-assembly of amyloid aggregates on gold surface that were modified with Au nano-particles by self-assembly using 1,6-hexandithiol as cross-linkers. The vital advantage of this method include retaining the bioactivity and environment similar to nature for protein immobilization while using minimal amounts of reagents, highly sensitive detection, low cost and short analytical time.
An Electrochemical Assay for Restriction Endonuclease Activity Using Graphene Monolayer
Islam, Kamrul,Chand, Rohit,Han, Dawoon,Shin, Ik-Soo,Kim, Yong-Sang The Electrochemical Society 2014 Journal of the Electrochemical Society Vol.161 No.12
<P>Herein, we report a new electrochemical assay for the endonuclease activity using a graphene monolayer. The approach involves a methylene blue (MB) tagged double-stranded (ds) DNA as an enzyme substrate with a single-stranded (ss) segment at the end for anchoring on graphene through π-π stacking. The nuclease enzyme mediates DNA hydrolysis following the release of dsDNA-MB from the graphene surface, which reduces the electrochemical current signal. The protocol was validated for the HaeIII and EcoRV restriction endonuclease enzyme. We also assayed the activity of methyltransferase enzyme and inhibition of restriction by HaeIII. The method allows real-time measurement and quantitative assay for endonuclease activities in a simple manner.</P>
Islam, Md. Kamrul,Kim, Soyeon,Kim, Hee-Kyung,Kim, Yeoun-Hee,Lee, Young-Mi,Choi, Garam,Baek, Ah Rum,Sung, Bo Kyung,Kim, Minsup,Cho, Art E.,Kang, Hyojeung,Lee, Gang-Ho,Choi, Seon Hee,Lee, Taekwan,Park, American Chemical Society 2018 Bioconjugate chemistry Vol.29 No.11
<P>In this study, we designed and synthesized a highly stable manganese (Mn<SUP>2+</SUP>)-based hepatobiliary complex by tethering an ethoxybenzyl (EOB) moiety with an ethylenediaminetetraacetic acid (EDTA) coordination cage as an alternative to the well-established hepatobiliary gadolinium (Gd<SUP>3+</SUP>) chelates and evaluated its usage as a <I>T</I><SUB>1</SUB> hepatobiliary magnetic resonance imaging (MRI) contrast agent (CA). This new complex exhibits higher <I>r</I><SUB>1</SUB> relaxivity (2.3 mM<SUP>-1</SUP> s<SUP>-1</SUP>) than clinically approved Mn<SUP>2+</SUP>-based hepatobiliary complex Mn-DPDP (1.6 mM<SUP>-1</SUP> s<SUP>-1</SUP>) at 1.5 T. Mn-EDTA-EOB shows much higher kinetic inertness than that of clinically approved Gd<SUP>3+</SUP>-based hepatobiliary MRI CAs, such as Gd-DTPA-EOB and Gd-BOPTA. In addition, in vivo biodistribution and MRI enhancement patterns of this new Mn<SUP>2+</SUP> chelate are comparable to those of Gd<SUP>3+</SUP>-based hepatobiliary MRI CAs. The diagnostic efficacy of the new complex was demonstrated by its enhanced tumor detection sensitivity in a liver cancer model using in vivo MRI.</P> [FIG OMISSION]</BR>
Islam, Md. Kamrul,Kim, Soyeon,Kim, Hee-Kyung,Park, Subin,Lee, Gang-Ho,Kang, Hyo Jeung,Jung, Jae-Chang,Park, Joon-Suk,Kim, Tae-Jeong,Chang, Yongmin American Chemical Society 2017 Journal of medicinal chemistry Vol.60 No.7
<P>A novel manganese(II) complex based on an ethylenediaminetetraacetic acid (EDTA) coordination cage bearing a benzothiazole aniline (BTA) moiety (Mn-EDTA-BTA) was designed and synthesized for use as a liver-specific MRI contrast agent with high chelation stability. In addition to forming a hydrophilic, stable complex with Mn2+, this new Mn chelate was rapidly taken up by liver hepatocytes and excreted by the kidneys and biliary system. The kinetic inertness and R-1 relaxivity of the complex were much higher than those of mangafodipir trisodium (MnDPDP), a clinically approved liver-specific MRI contrast agent. The diagnostic utility of this new Mn complex in MRI was, demonstrated by high-sensitivity tumor detection in an animal model of liver cancer.</P>
Effects of Biofertilizer on Growth and Yield of Rice
Bhuiyan Mohammad Kamrul Islam,Rico Cyren M.,Mintah Lemuel O.,Kim Man-Keun,Shon Tae-Kwon,Chung Il-Kyung,Lee Sang-Chul The Korean Society of Crop Science 2006 Korean journal of crop science Vol.51 No.4
The effect of biofertilizer (compound of microbial inoculants or groups of micro-organisms) on growth and yield of rice was investigated. The experiment was carried out in a randomized complete block design with 3 replications and 7 treatments namely: $RF=N-P_2O_{5-}K_2O$ (11-5.5-4.8 kg $10a^{-1}$); half of the recommended fertilizer rate, $HRF=N-P_2O_5-K_2O$ (5.5-2.75-2.4 kg $10a^{-1}$); HRF+Bio 250=HRF combined with 250 kg biofertilizer $10a^{-1}$; HRF+Bio 500=HRF combined with 500 kg biofertilizer $10a^{-1}$; Bio 250=250 kg biofertilizer $10a^{-1}$; Bio 500=500 kg biofertilizer $10a^{-1}$; and NF = No Fertilizer. Results showed that the recorded values of plant height, tiller number and chlorophyll content at 40 to 60 days after transplanting (DAT) in HRF+Bio 500 were significantly higher than those recorded in the RF treatment. Similar observations between these two treatments were only recorded from 60 DAT onwards. Yield components were also superior in HRF+Bio 500 treatment and comparable to that of RF. The highest grain yield obtained in HRF+Bio 500 treatment (785.8 kg $10a^{-1}$) was statistically similar to that of RF (739.8 kg $10a^{-1}$) but significantly higher than that of NF (506.7 kg $10a^{-1}$). Finally, head grain recovery (90.9) was low while chalkiness (0.03) was high at HRF+Bio 500 treatment as compared with RF, which were (96.1) and (0.3), respectively. Results showed that combined treatment of HRF and 500 kg biofertilizer $10a^{-1}$ has similar effects on the growth and yield of rice with that of RF.
Self-organized HGBBDSA Approach for the Power Allocation in OFDMA-based Heterogeneous Network
Mohammad Kamrul Hasan,Ahmad Fadzil Ismail,Shayla Islam,Wahidah Hashim 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.7
This paper studied the power allocation and downlink interference issues in orthogonal frequency-division-multiple-access (OFDMA) system to mitigate the interference issues. In Orthogonal Frequency Division Multiplexing Access (OFDMA) frameworks, resource allotment to the subcarrier is crucial attributable to the deficient assets accessible at the base station. In OFDMA, subcarrier and power distribution are not separate, along with these lines this two portion are not self-overseeing. This paper examines the power allo-cation approach through exploring the HGBBDSA approach. The integration of GA with Biogeography Based Optimization algorithm benchmarked over the Particle Swarm Op-timization (PSO). The both of the algorithms cross usefulness is evaluated and looked at the exhibitions in Heterogeneous Network (HetNet). The reenactment results demonstrate that the HGBBDSA approach efficiently allocates the power than that of existing PSO approach.
Biogeography-based Interference Mitigation Scheme for OFDMA System in Heterogeneous Network
Mohammad Kamrul Hasan,Ahmad Fadzil Ismail,Aisha-Hassan Abdalla,Wahidah Hashim,Shayla Islam 보안공학연구지원센터 2016 International Journal of Multimedia and Ubiquitous Vol.11 No.10
In Heterogeneous Network (HetNet), the small base station such as femtocells are deployed in indoor and multiple business complexes in order to extend the coverage and capacity. The deployment of co-channel (i.e. shared channel) for femtocells along with macrocell induces the severe interference issues. This is because of effects on SINR and thereby capacity become deteriorated. Therefore, this paper investigates the interference mitigation techniques and come out with a proposal to improve the Signal to Interference Noise Ratio (SINR) performance as well as total capacity in Heterogeneous Network (HetNet).The simulation results show that the achieved capacity is maximized than the existing technique.
Mohammad Kamrul Hasan,Ahmad Fadzil Ismail,Wahidah Hashim,Shayla Islam 보안공학연구지원센터 2016 International Journal of Future Generation Communi Vol.9 No.9
In orthogonal frequency division multiplexing Access (OFDMA) systems resource allocation to the subcarrier is essential owing to the insufficient resources available at the base station. In OFDMA, subcarrier and power allocation are not separate; thereby this two allocation are not self-governing. This paper proposes the subcarrier allocation approach through investigating previous methods, and also the Enhanced Particle Swarm Optimization (PSO) algorithm is analyzed. The both of the algorithms cross functionality is analyzed and compared the performance of the subcarrier allocation of OFDMA systems in Heterogeneous Network (HetNet). The simulation results show that the PSO approach efficiently allocates the OFDMA subcarriers.
A Numerical Framework for the Analysis of Handoff Delay Component in Proxy NEMO Environment
Shayla Islam,Aisha-Hassan A. Hashim,Azween Abdullah,Mohammad Kamrul Hasan 보안공학연구지원센터 2016 International Journal of Future Generation Communi Vol.9 No.8
Network Mobility Basic Support Protocol (NEMO-BSP), the existing IETF standard for mobile network support, signifies an important portion for future heterogeneous wireless access networks. The reason is to provide continuous Internet connectivity during movement of Mobile Router (MR) in NEMO. This paper conducted a quantitative analysis on the handoff delay component of NEMO-BSP as well as its existing enhancements, i.e., Fast NEMO (F-NEMO) handoffs, and an Extension of F-NEMO (EF-NEMO), using the numerical framework. The mathematical scenario includes two access routers, one local home agent and up to 20 MRs that interrelate by two different wireless access networks are mainly WiFi and WiMAX. The analysis offers quantitative outcomes of the performance enhancements achieved via the proposed improvements concerning handoff delay gain, packet loss, and packet loss ratio. The numerical results assist in understanding the influence of link switching delay, mobility rate, and radius on the handoff delay gain, packet loss, and packet loss ratio. The results of this analysis will also be aided to pick an appropriate mobility management scheme for Proxy NEMO environment.