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Senthilkumar P.,Vinoth K.,Maria Sylvester M.,Karunakaran D.J.S.Anand,Deshmukh Avadhut Ramrao,Hudge Pravin,Ganesh T.,Kumbharkhane A.C. 한국물리학회 2022 Current Applied Physics Vol.38 No.-
The dielectric behavior of stearic acid in 1,4-dioxane medium at various temperature 303 K–288 K and frequency regime (10 MHz–30 GHz) determined from the complex dielectric permittivity spectra obtained by Time Domain Reflectometry(TDR). In this frequency range, the dielectric study gives the electrostatic interaction as well as orientational polarizability of complex mixtures of long chain molecules significantly. Dielectric parameters were calculated from the complex spectra of the binary mixture by non linear least square fit method. The excess permittivity (εE), correlation factors were calculated for the binary system. Thermal parameters(ΔH-enthalpy, ΔS-entropy and ΔG-Gibbs free energy) were calculated and the direction of reaction is determined. The FTIR spectrum of the binary system recorded and the assignments are discussed. The FTIR spectral assignments confirm the molecular interactions.
( Jin Woo Song ),( Kevin K Brown ),( Simon Lf Walsh ),( Anand Devaraj ),( Wim A Wuyts ),( Claudia Valenzuela ),( Rainer-georg Goeldner ),( Susanne Stowasser ),( Rozsa Schlenker-herceg ),( Athol U Well 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Background Several studies have suggested that the progression of fibrosing ILDs is more rapid in patients with a usual interstitial pneumonia (UIP) pattern on HRCT. In the INBUILD trial, nintedanib slowed the rate of decline in FVC in subjects with fibrosing ILDs and a progressive phenotype. We assessed the effect of nintedanib in subgroups by HRCT pattern at baseline. Methods In the INBUILD trial, subjects (n=663) with a progressive fibrosing ILD were randomized to receive nintedanib or placebo. Randomization was stratified by HRCT pattern (UIP-like fibrotic pattern or other fibrotic patterns) based on central review. In pre-specified analyses, we assessed the effects of nintedanib in subgroups of subjects with a UIP-like fibrotic pattern and other fibrotic patterns on HRCT at baseline. Results At baseline, 62.1% of total subjects had a UIP-like fibrotic pattern on HRCT. In subjects who received placebo, the adjusted mean annual rate (SE) of decline in FVC was -209.2 (19.1) mL/year in subjects with a UIP-like fibrotic pattern on HRCT and -155.4 (23.6) mL/year in subjects with other fibrotic patterns on HRCT. The difference between the nintedanib and placebo groups in the annual rate of decline in FVC was 127.8 (95% CI: 74.3, 181.2) mL/year in subjects with a UIP-like fibrotic pattern on HRCT and 75.4 (95% CI: 9.5, 141.4) mL/year in subjects with other fibrotic patterns on HRCT (treatment-by-subgroup-by-time interaction p=0.23) (Table). The effects of nintedanib vs placebo on change from baseline in K-BILD questionnaire total score at week 52, time to acute exacerbation of ILD or death over 52 weeks, and time to death over 52 weeks between the subgroups by HRCT pattern are shown in the Table. Conclusions In the INBUILD trial, the effect of nintedanib on slowing the rate of FVC decline was consistent regardless of fibrotic pattern on HRCT.
K. Anand,R.M. Gengan,A. Phulukdaree,A. Chuturgoon 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.21 No.1
Stable gold nanoparticles (AuNPs) were synthesised from aqueous 1 M chloroauric acid and Moringaoleifera flower aqueous extract. The UV–vis spectrum of AuNPs displays the surface plasmon resonanceat 540 nm. The AuNPs were characterized using transmission electron microscopy, scanning electronmicroscopy, energy dispersive X-ray analysis and dynamic light scattering whilst Fourier transforminfrared and 1H-NMR spectroscopy were used to probe the type of capping agents. The AuNPs wereassessed for their catalytic reduction of nitrophenol and nitroaniline by UV–vis and showed a rapidreduction within 3 min thereby indicating degradation of industrial effluents. Furthermore, the AuNPsmay possess good anti-cancer properties.
Zero-Field Ambient-Pressure Quantum Criticality in the Stoichiometric Non-Fermi Liquid System CeRhBi
Anand, Vivek K.,Adroja, Devashibhai T.,Hillier, Adrian D.,Shigetoh, Keisuke,Takabatake, Toshiro,Park, Je-Geun,McEwen, Keith A.,Pixley, Jedediah H.,Si, Qimiao Physical Society of Japan 2018 Journal of the Physical Society of Japan Vol.87 No.6
A CoMFA Study of Quinazoline-based Anticancer Agents
Anand Balupuri, Pavithra K. Balasubramanian, Seung Joo Cho 조선대학교 기초과학연구원 2015 조선자연과학논문집 Vol.8 No.3
Cancer has emerged as one of the leading cause of deaths worldwide. A three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis was performed on a series of quinazoline-based anticancer agents. Purpose of the study is to understand the structural basis for their inhibitory activity. Comparative molecular field analysis (CoMFA) technique was employed to develop 3D-QSAR model. Ligand-based alignment scheme was used to generate a reliable CoMFA model. The model produced statistically significant results with a cross-validated correlation coefficient (q2) of 0.589 and a non-cross-validated correlation coefficient (r2) of 0.928. Model was further validated by bootstrapping and progressive scrambling analysis. This study could assist in the design of novel and more potent anticancer agents.
Anand K. Sajnani,Sanket G. Shah,Mudasir Rashid,Abhiram Natu,Poonam B. Gera,Sanjay Gupta 전남대학교 의과학연구소 2021 전남의대학술지 Vol.57 No.3
Histone modifications have been demonstrated to play a significant role in oral squamous cell carcinoma (OSCC) epigenetic regulation. An in-silico analysis of The Cancer Genome Atlas (TCGA) of various histone acetyl transferases (HATs) and histone deacetylases (HDACs) suggested that HATs do not differ between normal and tumor samples whereas HDAC2 and HDAC1 change maximally and marginally respectively between normal and tumor patients with no change being noted in HDAC6 expression. Hence, this investigation was carried out to validate the expression states of HDAC 1, 2 and 6 mRNAs in buccal mucosa and tongue SCC samples in an Indian cohort. Buccal mucosa and tongue squamous cell carcinoma tissues with intact histopathology were processed for RNA isolation followed by cDNA synthesis which was then subjected to q-PCR for HDACs. The average RNA yield of the tongue tissue sample was ∼2 mg/mg of tissue and the A260/280 ratios were between 2.03 and 2.06. The average RNA yield of buccal mucosa tissue sample was ∼1 mg/mg of tissue and the A260/280 ratio were between 2.00 and 2.08. We have demonstrated that HDAC2 was overexpressed in tongue and buccal mucosa samples. Over-expression of HDAC2 imply potential use of HDACi along with standard chemotherapeutic drug in oral cancer treatment.
Comparative Molecular Field Analysis of Pyrrolopyrimidines as LRRK2 Kinase Inhibitors
Anand Balupuri, Pavithra K. Balasubramanian, Seung Joo Cho 조선대학교 기초과학연구원 2016 조선자연과학논문집 Vol.9 No.1
Leucine rich repeat kinase 2 (LRRK2) is a highly promising target for Parkinson’s disease (PD) that affects millions of people worldwide. A three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis was performed on a series of pyrrolopyrimidine-based selective LRRK2 kinase inhibitors. This study was performed to rationalize the structural requirements responsible for the inhibitory activity of these compounds. A reliable 3D-QSAR model was developed using comparative molecular field analysis (CoMFA) technique. The model produced statistically acceptable results with a cross-validated correlation coefficient (q2) of 0.539 and a non-cross- validated correlation coefficient (r2) of 0.871. Robustness of the model was further evaluated by bootstrapping and progressive scrambling analysis. This work could assist in designing more potent LRRK2 inhibitors.
A CoMFA Study of Glycogen Synthase Kinase 3 Inhibitors
Anand Balupuri, Pavithra K. Balasubramanian, Seung Joo Cho 조선대학교 기초과학연구원 2015 조선자연과학논문집 Vol.8 No.1
Glycogen synthase kinase 3 (GSK-3) is a serine/threonine protein kinase that has recently emerged as a promising target in drug discovery. It is involved in multiple cellular processes and associated with the pathogenesis of several diseases. A three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis was performed on a series of GSK- 3 inhibitors to understand the structural basis for inhibitory activity. Comparative molecular field analysis (CoMFA) method was used to derive 3D-QSAR models. A reliable CoMFA model was developed using ligand-based alignment scheme. The model produced statistically acceptable results with a cross-validated correlation coefficient (q2) of 0.594 and a non-cross-validated correlation coefficient (r2) of 0.943. Robustness of the model was checked by bootstrapping and progressive scrambling analysis. This study could assist in the design of novel compounds with enhanced GSK-3 inhibitory activity.