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Jung, Sungwook,Park, Joonhyuck,Bang, Jiwon,Kim, Jae-Yeol,Kim, Cheolhee,Jeon, Yongmoon,Lee, Seung Hwan,Jin, Ho,Choi, Sukyung,Kim, Bomi,Lee, Woo Jin,Pack, Chan-Gi,Lee, Jong-Bong,Lee, Nam Ki,Kim, Sungjee American Chemical Society 2017 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.139 No.22
<P>Photoswitching or modulation of quantum dots (QDs) can be promising for many fields that include display, memory, and super-resolution imaging. However, such modulations have mostly relied on photomodulations of conjugated molecules in QD vicinity, which typically require high power of high energy photons at UV. We report a visible light-induced facile modulation route for QD-dye conjugates. QD crystal violets conjugates (QD-CVs) were prepared and the crystal violet (CV) molecules on QD quenched the fluorescence efficiently. The fluorescence of QD-CVs showed a single cycle of emission burst as they go through three stages of (i) initially quenched off to (ii) photoactivated on as the result of chemical change of CVs induced by photoelectrons from QD and (iii) back to photodarkened off by radical-associated reactions. Multicolor on-demand photopatterning was demonstrated using QD-CV solid films. QD-CVs were introduced into cells, and excitation with visible light yielded photomodulation from off to on and off by nearly ten fold. Individual photoluminescence dynamics of QD-CVs was investigated using fluorescence correlation spectroscopy and single QD emission analysis, which revealed temporally stochastic photoactivations and photodarkenings. Exploiting the stochastic fluorescence burst of QD-CVs, simultaneous multicolor super-resolution localizations were demonstrated.</P>
Jung, Sungwook,Nam, Jutaek,Hwang, Sekyu,Park, Joonhyuck,Hur, Jaehyun,Im, Kyuhyun,Park, Nokyoung,Kim, Sungjee American Chemical Society 2013 ANALYTICAL CHEMISTRY - Vol.85 No.16
<P>We report a nanoparticle-based probe that can be used for a “turn-on” theragnostic agent for simultaneous Raman imaging/diagnosis and photothermal therapy. The agent consists of a 10 nm spherical gold nanoparticle (NP) with pH-responsive ligands and Raman probes on the surface. They are engineered to exhibit the surface with both positive and negative charges upon mildly acidic conditions, which subsequently results in rapid aggregations of the gold NPs. This aggregation simultaneously provides hot spots for the SERS probe with the enhancement factor reaching 1.3 × 10<SUP>4</SUP> and shifts the absorption to far-red and near-infrared (which is optimal for deep tissue penetration) by the coupled plasmon resonances; this shift was successfully exploited for low-threshold photothermal therapy. The theragnostic gold NPs are cancer-specific because they aggregate rapidly and accumulate selectively in cancerous cells. As the result, both Raman imaging and photothermal efficacy were turned on under a cancerous local environment. In addition, the relatively small hydrodynamic size can have the potential for better access to targeted delivery in vivo and facilitated excretion after therapy.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancham/2013/ancham.2013.85.issue-16/ac401390m/production/images/medium/ac-2013-01390m_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ac401390m'>ACS Electronic Supporting Info</A></P>