Examining Microdroplet Characteristics of Electrospray Electric Precipitation for Direct and Indirect Voltage Application Methods

Jiwon Choi(Jiwon Choi),Keesin Jeong(Keesin Jeong),Haiyoung Jung(Haiyoung Jung) 한국화재소방학회 2022 International Journal of Fire Science and Engineer Vol.36 No.4

Dust and fine dust exist in various forms and can lead to various problems such as dust explosion and air pollution. To reduce them, recently, research on electrospray electric precipitation, among various dust collection methods, has been actively conducted. In this study, comparative analysis experiments were performed on microdroplet generation characteristics for direct and indirect charging methods of electrospray electric precipitation. A visualization device was fabricated to generate microdroplets, and microdroplets were photographed with a high-magnification camera according to each charging method. The size and number of microdroplets were then analyzed via ImageJ software.

Optimal anesthesia protocols for successful intraoperative neuromonitoring during thyroid surgery

Jiwon Lee(Jiwon Lee),Jung-Man Lee(Jung-Man Lee),Young Jun Chai(Young Jun Chai) 대한신경모니터링학회 2022 Journal of Neuromonitoring & Neurophysiology Vol.2 No.2

There are several factors related to anesthesia that are required for successful intraoperative neuromonitoring (IONM) during thyroid and parathyroid surgery, including proper placement of endotracheal tube, adequate neuromuscular blockade, use of appropriate neuromuscular blockade reversal agent, and pain management. In this review, we summarize the anesthesia issues related to IONM during thyroid and parathyroid surgery.

Some Biological Consequences of the Inhibition of Na,K-ATPase by Translationally Controlled Tumor Protein (TCTP)

Jung, Jiwon,Ryu, Seonhyung,Ki, In A,Woo, Hyun Ae,Lee, Kyunglim MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.6

<P>Na,K-ATPase is an ionic pump that regulates the osmotic equilibrium and membrane potential of cells and also functions as a signal transducer. The interaction of Na,K-ATPase with translationally controlled tumor protein (TCTP) results, among others, in the inhibition of the former’s pump activity and in the initiation of manifold biological and pathological phenomena. These phenomena include hypertension and cataract development in TCTP-overexpressing transgenic mice, as well as the induction of tumorigenesis signaling pathways and the activation of Src that ultimately leads to cell proliferation and migration. This review attempts to collate the biological effects of Na,K-ATPase and TCTP interaction and suggests that this interaction has the potential to serve as a possible therapeutic target for selected diseases.</P>

Unsupervised Liver Segmentation using Domain Adaptation in MRI

Jiwon Jung(정지원),Ehwa Yang(양이화),Woo Kyoung Jeong(정우경),Kyoung Doo Song(송경두),Jae-Hun Kim(김재훈) 한국통신학회 2022 한국통신학회 학술대회논문집 Vol.2022 No.2

Liver segmentation is an essential procedure in Computer-Aided Diagnosis (CAD), surgery, and volume measurement for radiotherapy. But it is still a challenging task to extract liver tissue parenchyma due to nearby organs with similar intensities. When we segment the liver using supervised deep learning, fully-annotated datasets are needed. However, it is hard to obtain well-annotated labels because of their diverse appearances such as size and shape. Also, it takes expensive costs for labeling. In this paper, we performed unsupervised liver segmentation in unlabeled Magnetic Resonance Imaging (MRI) datasets using deep learning. To generate labels of MRI, the domain adaptation technique is applied with CT images containing well-annotated labels. We trained the segmentation model with the MRI dataset which is transferred from CT images and evaluated the model on real MRI datasets. The performance of our model shows 88% dice similarity coefficient accuracy. This study could be one of the solutions to handle the difficulty to train deep learning models with unlabeled datasets.

Malignancy after Pediatric Kidney Transplantation: The 30-Year Experience of a Single Center

Jiwon Jung,박영서,Duck Jong Han 대한소아신장학회 2020 Childhood kidney diseases Vol.24 No.2

Objectives: We aimed to investigate the incidence, manifestations, and outcomes of malignancy after pediatric kidney transplantation (KT) at our center over 30 years. Methods: We retrospectively reviewed the medical records of 155 patients under 18 years of age who underwent KT between January 1990 and February 2020 at Asan Medical Center. Results: Twelve patients (7.7%) were diagnosed with a malignancy after KT. Malignancy was diagnosed after a mean period of 6.4±5.9 years (median 4.6, range 0.5–20.6 years) after KT. Nine (75.0%) of the 12 cancer patients were diagnosed with post-transplant lymphoproliferative disease (PTLD), and the other three had papillary thyroid cancer, mucoepidermoid cancer of the hard palate, and T-cell acute lymphoblastic leukemia, respectively. PTLD was diagnosed within a mean of 3.7±3.4 years (median 3.7, range 0.5–9.8 years) after KT. Five patients diagnosed with PTLD were cured without recurrence. Three patients with PTLD died from the disease, and one patient with mucoepidermoid cancer from a non-PTLD malignancy died after progression, despite surgical resection and chemotherapy. Three (33.3%) of the nine survivors progressed to end-stage renal disease (ESRD) after completing cancer treatment. No patient with post-transplant malignancy (PTM) experienced critical renal deterioration during cancer treatment. Conclusion: PTLD was the most common PTM, occurring at 5.8% of the pediatric KT patients after KT in our center. Careful follow up is needed particularly considering the risk of PTLD after KT in children.

Malignancy after Pediatric Kidney Transplantation: The 30-Year Experience of a Single Center

Jung, Jiwon,Park, Young Seo,Han, Duck Jong Korean Society of Pediatric Nephrology 2020 Childhood kidney diseases Vol.24 No.2

Objectives: We aimed to investigate the incidence, manifestations, and outcomes of malignancy after pediatric kidney transplantation (KT) at our center over 30 years. Methods: We retrospectively reviewed the medical records of 155 patients under 18 years of age who underwent KT between January 1990 and February 2020 at Asan Medical Center. Results: Twelve patients (7.7%) were diagnosed with a malignancy after KT. Malignancy was diagnosed after a mean period of 6.4±5.9 years (median 4.6, range 0.5-20.6 years) after KT. Nine (75.0%) of the 12 cancer patients were diagnosed with post-transplant lymphoproliferative disease (PTLD), and the other three had papillary thyroid cancer, mucoepidermoid cancer of the hard palate, and T-cell acute lymphoblastic leukemia, respectively. PTLD was diagnosed within a mean of 3.7±3.4 years (median 3.7, range 0.5-9.8 years) after KT. Five patients diagnosed with PTLD were cured without recurrence. Three patients with PTLD died from the disease, and one patient with mucoepidermoid cancer from a non-PTLD malignancy died after progression, despite surgical resection and chemotherapy. Three (33.3%) of the nine survivors progressed to end-stage renal disease (ESRD) after completing cancer treatment. No patient with post-transplant malignancy (PTM) experienced critical renal deterioration during cancer treatment. Conclusion: PTLD was the most common PTM, occurring at 5.8% of the pediatric KT patients after KT in our center. Careful follow up is needed particularly considering the risk of PTLD after KT in children.

Evaluation of In-Hospital Cluster of COVID-19 Associated With a Patient With Prolonged Viral Shedding Using Whole-Genome Sequencing

Jung Jiwon,Lee Jungmin,Kim Sun-Kyung,Park Soyeon,Lim Young-Ju,Kim Eun Ok,Park Heedo,Park Man-Seong,Kim Sung-Han 대한의학회 2022 Journal of Korean medical science Vol.37 No.39

Background: Patients with hematologic malignancies may produce replication-competent virus beyond 20 days of SARS-CoV-2 infection. However, data regarding the transmission of SARS-CoV-2 from patients with prolonged viral shedding is limited. Methods: In May 2022, four additional cases of COVID-19 were reported in a hematologic ward at a tertiary care hospital in South Korea, after an 8-week isolation of a patient with prolonged viral shedding. We performed whole-genome sequencing (WGS) of SARS-CoV-2 to evaluate the possibility of post-isolation transmission from this prolonged viral shedding. Results: A patient (case 1) with acute myeloid leukemia was released from isolation 54 days after the diagnosis of COVID-19 based on rising Ct value of up to 29.3, and moved to a sixpatient room. On days 10 and 11 post-isolation, his doctor (case 2) and 2 patients who were his roommates (case 3, 4) had positive SARS-CoV-2 PCR results. Additionally, 16 days postisolation, another patient (case 5) in a remote room had positive SARS-CoV-2 PCR result. All the three patients were hospitalized for ≥ 14 days when they were diagnosed with SARS-CoV-2 infection. Except for case 3, the remaining 4 cases were available for WGS, which revealed that case 1 exhibited a 7 nucleotides difference in comparison to cases 4 and 5 and case 2 displayed a 20 nucleotides difference compared with case 1, while sequences of cases 4 and 5 were identical. Conclusions: Despite the possibility of transmission from the patient with prolonged viral shedding, no evidence of the transmission of SARS-CoV-2 from the patient with prolonged positive RT-PCR using WGS was found.

Nosocomial Outbreak of COVID-19 in a Hematologic Ward

Jung Jiwon,Jungmin Lee,Seongmin Jo,Bae Seongman,Ji Yeun Kim,Cha Hye Hee,Lim Young-Ju,Kwak Sun Hee,Hong Min Jee,Kim Eun Ok,Bae Joon-Yong,Kang Changmin,Sung Minki,Park Man-Seong,Kim Sung-Han 대한감염학회 2021 Infection and Chemotherapy Vol.53 No.2

Background: Coronavirus disease 2019 (COVID-19) outbreaks occur in hospitals in many parts of the world. In hospital settings, the possibility of airborne transmission needs to be investigated thoroughly. Materials and Methods: There was a nosocomial outbreak of COVID-19 in a hematologic ward in a tertiary hospital, Seoul, Korea. We found 11 patients and guardians with COVID-19 through vigorous contact tracing and closed-circuit television monitoring. We found one patient who probably had acquired COVID-19 through airborne-transmission. We performed airflow investigation with simulation software, whole-genome sequencing of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Results: Of the nine individuals with COVID-19 who had been in the hematologic ward, six stayed in one multi-patient room (Room 36), and other three stayed in different rooms (Room 1, 34, 35). Guardian in room 35 was close contact to cases in room 36, and patient in room 34 used the shared bathroom for teeth brushing 40 minutes after index used. Airflow simulation revealed that air was spread from the bathroom to the adjacent room 1 while patient in room 1 did not used the shared bathroom. Airflow was associated with poor ventilation in shared bathroom due to dysfunctioning air-exhaust, grill on the door of shared bathroom and the unintended negative pressure of adjacent room. Conclusion: Transmission of SARS-CoV-2 in the hematologic ward occurred rapidly in the multi-patient room and shared bathroom settings. In addition, there was a case of possible airborne transmission due to unexpected airflow.

Recurrence of Classic Scabies in a Patient Who had Unchanged Tie String of the T-Cannula

Jung Jiwon,Jeong Jihye,Hong Min Jee,Kim Eun Ok,Kim Min-Jae,Chang Sung Eun,Kim Sung-Han 대한감염학회 2022 Infection and Chemotherapy Vol.54 No.2

A 64-year old woman who underwent lung transplantation and had T-cannula contracted classic scabies from her daughter. The patient was treated with 5% permethrin 10 times and had two consecutive negative follow-up microscopic examinations. However, the patient had recurrent symptoms and diagnosed with recurrent classic scabies 22 days after the last treatment. Unchanged tie string and unapplied topical agent around the T-cannula skin lesion may be reasons for recurrence. Thus, accurate application of topical treatment and changing the tie string of the t-cannula is needed to prevent a recurrence.

Frequent Occurrence of SARS-CoV-2 Transmission among Non-close Contacts Exposed to COVID-19 Patients

Jung Jiwon,Lee Jungmin,Kim Eunju,Namgung Songhee,Kim Younjin,Yun Mina,Lim Young-Ju,Kim Eun Ok,Bae Seongman,Kim Mi-Na,Lee Sun-Mi,Park Man-Seong,Kim Sung-Han 대한의학회 2021 Journal of Korean medical science Vol.36 No.33

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission among non-close contacts is not infrequent. We evaluated the proportion and circumstances of individuals to whom SARS-CoV-2 was transmitted without close contact with the index patient in a nosocomial outbreak in a tertiary care hospital in Korea. From March 2020 to March 2021, there were 36 secondary cases from 14 SARS-CoV-2 infected individuals. Of the 36 secondary cases, 26 (72%) had been classified as close contact and the remaining 10 (28%) were classified as non-close contact. Of the 10 non-close contact, 4 had short conversations with both individuals masked, 4 shared a space without any conversation with both masked, and the remaining 2 entered the space after the index had left. At least one quarter of SARSCoV-2 transmissions occurred among non-close contacts. The definition of close contact for SARS-CoV-2 exposure based on the mode of droplet transmission should be revised to reflect the airborne nature of SARS-CoV-2 transmission.