Characterization of Plasma with Heating Treatment of ITO on the Efficiency of Polymer Solar Cells

Jung Woo Kim,Nam Hun Kim,Hyoungsub Kim,Donggeun Jung,Heeyeop Chae 한국진공학회 2010 한국진공학회 학술발표회초록집 Vol.38 No.-

Formaldehyde exposure induces airway inflammation by increasing eosinophil infiltrations through the regulation of reactive oxygen species production

Jung, Woon-Won,Kim, Eun-Mi,Lee, Eun-Hee,Yun, Hee-Jung,Ju, Hyang-Ran,Jeong, Moon-Jin,Hwang, Kwang-Woo,Sul, Donggeun,Kang, Hyung-Sik Elsevier 2007 Environmental toxicology and pharmacology Vol.24 No.2

<P><B>Abstract</B></P><P>Formaldehyde (FA) is a well-known cytotoxic irritant to the airways, but the mechanism of airway inflammation due to FA has not been clarified. In the present study, C57BL/6 mice were exposed to two concentrations (5 and 10ppm) of FA for 6h/day, 5days/week, for 2 weeks. The FA-exposed mice had much higher number of CCR3<SUP>+</SUP> eosinophils than control mice, and showed upregulated gene expression of CC-chemokine receptor-3 (CCR3), eotaxin and intercellular adhesion molecules-1 (ICAM-1) as well as an increased expression of proinflammatory and Th2 cytokines, such as interleukin (IL)-1β, IL-4 and IL-5. In addition, FA exposure revealed a considerable increase in the serum levels of IgG1, IgG3, IgA and IgE compared to controls. Histopathological analysis of the lung tissues demonstrated eosinophils and mononuclear cell infiltration of the alveolar cell walls and alveolar spaces. Gene expression of thioredoxin (TRX), redox-regulating antioxidant proteins, was markedly suppressed in FA-exposed mice, and thereby intracellular ROS levels were increased along with increased FA concentration. These results were consistent with an increase in the number of CCR3-expressing eosinophils, and indicate that FA-induced ROS was generated from eosinophils recruited to the inflammatory sites of the airways.</P>

Stacked Gold Nanodisks for Bimodal Photoacoustic and Optical Coherence Imaging

Wi, Jung-Sub,Park, Jisoo,Kang, Heesung,Jung, Donggeun,Lee, Sang-Won,Lee, Tae Geol American Chemical Society 2017 ACS NANO Vol.11 No.6

<P>Herein, we report on biological imaging nanoprobes: physically synthesized gold nanodisks that have inherent optical advantages a wide range of resonant wavelengths, tunable ratio of light absorption-to-scattering, and responsiveness to random incident light due to their two-dimensional circular nanostructure. Based on our proposed physical synthesis where gold is vacuum deposited onto a prepatterned polymer template and released from the substrate in the form of a nanodisk, monodisperse two-dimensional gold nanodisks were prepared with independent control of their diameter and thickness. The optical benefits of the Au nanodisk were successfully demonstrated by the measurement of light absorbance of the nanodisks and the application of stacked nanodisks, where a smaller sized Au nanodisk was laid atop a larger nanodisk, as bimodal contrast agents for photoacoustic microscopy and optical coherence tomography.</P>

An Evaluation of the Neonatal Immune System Using a <i>Listeria</i> Infection Model

Byun, Hyun-Jung,Jung, Woon-Won,Lee, Jong-Bae,Chung, Hee Yong,Sul, Donggeun,Kim, Sang Joon,Park, Chung-Gyu,Choi, Inho,Hwang, Kwang Woo,Chun, Taehoon S. Karger AG 2007 NEONATOLOGY Vol.92 No.2

<P><I>Background:</I> T helper 1 (Th1)/T helper 2 (Th2)-biased cytokine regulation may be another reason that neonates are much more susceptible to infectious disease than are adults. <I>Objectives:</I> We attempted to determine the ability of neonatal mice to direct the Th1 phenotype against <I>Listeria monocytogenes</I> (LM), because LM, an intracellular Gram-positive bacterium, induces profound cellular immunity by Th1 cells in vivo. <I>Methods:</I> In order to determine whether neonatal mice evidence strong Th1 activity during LM infection, neonatal mice were compared with adult mice with regard to susceptibility to LM, cytotoxic T lymphocyte activity, and cytokine profiles. Neonatal gene profiles relevant to Th1 and Th2 differentiation during LM infection were also compared between neonatal and adult mice, via real-time PCR and RT-PCR. <I>Results:</I> Neonatal mice were found to be far more susceptible to LM infection than adult mice, due to a lack in the induction of cytotoxic T cell activity, coupled with poor IFN-γ secretion. Further, LM-infected neonatal mice evidenced much lower levels of expression of Th1-type immune components, including IL-12, IFN-γ, Delta-4 and T-bet, as compared to those features in adult mice. These results may be due to the comparably lower expressions of mannose-bind lectins and some of toll-like receptors (TLRs) such as TLR-5, -6 and -9, necessary mediators to develop Th1 immune responses. <I>Conclusions:</I> Neonatal mice may not mount an adequate Th1 type immune response due to a significantly lower expression of Th1-type immune components as compared to adult mice, even when forced into a Th1-prone environment.</P><P>Copyright © 2007 S. Karger AG, Basel</P>

Strategies Against Human Papillomavirus Infection and Cervical Cancer

Jung Woon-Won,Chun Taehoon,Sul Donggeun,Hwang Kwang Woo,Kang Hyung-Sik,Lee Duck Joo,Han In-Kwon The Microbiological Society of Korea 2004 The journal of microbiology Vol.42 No.4

Papillomaviruses infect a wide variety of animals, including humans. The human papillomavirus (HPV), in particular, is one of the most common causes of sexually transmitted disease. More than 200 types of HPV have been identified by DNA sequence data, and 85 HPV genotypes have been well char­acterized to date. HPV can infect the basal epithelial cells of the skin or inner tissue linings, and are, accordingly, categorized as either cutaneous or mucosal type. HPV is associated with a panoply of clin­ical conditions, ranging from innocuous lesions to cervical cancer. In the early 1980s, studies first reported a link between cervical cancer and genital HPV infection. Genital HPV infections are now rec­ognized to be a major risk factor in at least $95\%$ of cervical cancers. 30 different HPV genotypes have been identified as causative of sexually transmitted diseases, most of which induce lesions in the cervix, vagina, vulva, penis, and anus, as the result of sexual contact. There is also direct evidence demon­strating that at least four of these genotypes are prerequisite factors in cervical cancer. The main aim of this review was to evaluate the current literature regarding the pathovirology, diagnostics, vaccines, therapy, risk groups, and further therapeutic directions for HPV infections. In addition, we reviewed the current status of HPV infections in South Korean women, as evidenced by our data.

Highly efficient process capability indices under contaminated data

Donggeun Lee,Ryeji Jung 대한산업공학회 2017 대한산업공학회 추계학술대회논문집 Vol.2017 No.11

In order to improve manufacturing process, process capability indices have been popularly used. Process capability represents the performance of a process when condition is normal and in-control. This paper propose a new process capability indices based on the Hodge Lehmann and Shamos estimators. The new method performs well under the normal condition and outperforms the existing methods under the contamination.

Intervertebral Disc Degeneration-induced Expression of Pain-related Molecules: Glial Cell-derived Neurotropic Factor as a Key Factor

Jung, Woon-Won,Kim, Hyun-Sook,Shon, Jong-Ryeul,Lee, Min,Lee, Sang-Heon,Sul, Donggeun,Na, Heung Sik,Kim, Joo Han,Kim, Byung-Jo Lippincott Williams Wilkins, Inc. 2011 JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY Vol.23 No.4

BACKGROUND: Discogenic low back pain has been shown to develop into chronic intractable pain due to an unknown pathogenesis. To study the mechanism of discogenic pain, we analyzed the serial expression of pain-related molecules in the dorsal root ganglia (DRG) and thalamus using a newly developed rat model of disc degeneration. METHODS: Ten microliters of complete Freund’s adjuvant was injected into the L5-6 disc of male Sprague-Dawley rats for 10 minutes using a 26-gauge needle. Using a behavioral test, rats with significant pain were selected and subsequently serial gene expression of pain-related molecules in the DRG and the thalamus was analyzed by reverse transcriptase polymerase chain reaction. RESULTS: The expression of tumor necrosis factor-α and interleukin-1&bgr; significantly increased at 4 and 8 weeks in the DRG of rats with pain. Furthermore, interleukin-6 was significantly increased at 4 weeks in the DRG; however, these cytokines did not show a significant change in the thalamus. Calcitonin gene-related peptide and substance P were significantly increased in DRG at 4 and 8 weeks and in the thalamus at 2 and 4 weeks. The level of nerve growth factor-&bgr; did not significantly increase in the DRG or thalamus, whereas glial cell line-derived neurotropic factor (GDNF) was significantly increased at 2 weeks and was sustained through 8 weeks in both the DRG and thalamus. CONCLUSIONS: The disc degeneration rat model described herein led to significant pain of a chronic nature. The gradual and persistent increase of GDNF in both the thalamus and DRG suggests that GDNF might be a key factor in the development of intractable, chronic discogenic pain.

Surface analysis of protein‐resistant, plasma‐polymerized ethylene glycol thin films

Choi, Changrok,Jung, Donggeun,Moon, Dae Won,Lee, Tae Geol John Wiley Sons, Ltd. 2011 Surface and interface analysis Vol.43 No.1

<P><B>Abstract</B></P><P>Poly(ethylene glycol) (PEG) has been widely used in biomedical applications because of its protein‐resistant and nontoxic properties. In this study, a plasma‐polymerized ethylene glycol (PPEG) thin film was deposited on a substrate using a capacitively coupled plasma chemical vapour deposition (CCP‐CVD) method with various plasma powers and ethylene glycol as a precursor. The surfaces of the PPEG thin films were characterized using time‐of‐flight secondary ion mass spectrometry (ToF‐SIMS) along with a principal component analysis (PCA), and XPS. We confirmed that the PPEG thin film deposited at low plasma power closely resembles PEG polymers in terms of surface chemical composition and protein‐resistant property. To make patterned surfaces with protein‐resistant property for proteins, a PPEG thin film was first uniformly deposited on a glass slide and patterns were produced on the PPEG coated surface by depositing a plasma‐polymerized amine film through a metal shadow mask. When we spotted proteins on the patterned surface, they were immobilized only onto the plasma‐polymerized amine areas but not onto the PPEG areas. These results show that PPEG surfaces would be useful for the construction of various protein arrays. Copyright © 2010 John Wiley & Sons, Ltd.</P>

Two-dimensioanl Plasmonic Nanodisks for Biological Imaging

Jisoo Park,Donggeun Jung,Tae Geol Lee,Jung-Sub Wi 한국진공학회 2015 한국진공학회 학술발표회초록집 Vol.2015 No.2

Prediction of the Salinization in Reclaimed Land by Soil and Groundwater Characteristics

( Jihun Jeon ),( Donggeun Kim ),( Taejin Kim ),( Keesung Kim ),( Hosup Jung ),( Younghwan Son ) 한국농공학회 2021 한국농공학회논문집 Vol.63 No.6

It is becoming more important to utilize reclaimed lands in South Korea, due to the increasing competition for its usage among different sectors. However, the high groundwater level and poor permeability are exposing them to deterioration by salinization. Salinization is difficult to predict because the pattern changes according to various characteristics of soil and groundwater. In this study, the capillary rising time was studied by the water content profile in the soil. The prediction equation of soil salinity was developed based on simulation result of the CHEMFLO model. to enable prediction considering various soil water content and groundwater level. The two terms constituting the equation showed the coefficients of determination of 0.9816 and 0.9824, respectively. Using the prediction equation of the study, the surface salinity can be easily predicted from the initial surface salinity and the salinity of the groundwater. In the future, more precise predictions will be possible with the results of studies on the hydraulic characteristics of various reclaimed soils, changes in water content profile by seasonal and climate events.