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Reduced Active Switch Front-End Multipulse Rectifier With Medium-Frequency Transformer Isolation
Sandoval, Jose Juan,Krishnamoorthy, Harish Sarma,Enjeti, Prasad N.,Choi, Sewan IEEE 2017 IEEE TRANSACTIONS ON POWER ELECTRONICS - Vol.32 No.10
<P>This paper presents a reduced switch count multipulse rectifier with medium-frequency (MF) transformer isolation. The proposed topology consists of a three-phase push-pull based ac to dc rectifier with a MF ac link employing two active switches. A three-phase, five-limb, multiwinding MF transformer is employed for isolation. The secondary side of the transformer is connected in a zig-zag configuration and is fed to two six-pulse diode rectifiers, achieving 12-pulse rectifier operation. The primary advantage of the proposed system is reduction in size/weight/volume compared to the conventional 60 Hz magnetic transformer isolation rectifier system. Operating the transformer at 600 Hz is shown to result in three times reduction in size. Furthermore, the proposed system employs only two active semiconductor switching devices operating under a simple pulse width modulation scheme. Also, the zig-zag transformer connection helps to balance leakage inductance on the secondary side. Detailed analysis, simulation, and experimental results on a 208V(l-l), 3.15 kW laboratory prototype are presented to validate the performance of the proposed approach.</P>
Eli Mireya Sandoval-Gallegos,Esther Ramı´rez-Moreno,Juan Gayosso-De Lucio,Jose´ Arias-Rico,Nelly Cruz-Cansino,Mario I. Ortiz,Raquel Carin˜o-Corte´s 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.1
Cardiovascular diseases (CVDs) are the leading causes of death in the world, and epidemiological evidence points to dietary habits, stress, and obesity as major risk factors promoting pathological conditions like atherosclerosis, hypertension, and thrombosis. Current therapeutic approaches for CVDs rely on lifestyle changes and/or the use of drug agents. However, since the efficacy of such interventions is often limited by poor compliance and/or significant side effects, continued research on new preventive and therapeutic approaches is much needed. Our study is aimed to determine the bioaccessibility, total content of phenolic compounds, and antioxidant capacity (DPPH·, ABTS·+) of a methanolic extract from Mangifera indica L. leaves (MEM), and its lipid-lowering effect on an induced dyslipidemia model in Wistar rats. Our results showed that mangiferin is the main component of MEM. The extract showed a total content of polyphenol compounds of 575.28 gallic acid equivalents per dry matter basis (GAE/g db), antioxidant activity 77.68 μmol Trolox equivalents per gram (TE/g) db as measured by DPPH· and 20,630 μmol TE/g db by ABTS·+, and 12% of phenolic compounds were bioaccessible, and 100 mg/kg of MEM reduced hyperlipidemia levels induced in Wistar rats. Further study on the potential use of MEM as a nutraceutical to prevent CVDs in high-fat diet consumers is required.
Hang Su,Juan Sandoval,Pierre Vieyres,Gérard Poisson,Giancarlo Ferrigno,Elena De Momi 제어·로봇·시스템학회 2018 International Journal of Control, Automation, and Vol.16 No.6
In this paper, a safety-enhanced collaborative control framework is proposed for tele-operated minimally invasive surgery (MIS) using a redundant 7-DoF serial robot. The redundant manipulators offer a safe physical collaborative flexible workspace for nurse or surgeon (assisting physicians, patient support) undergoing surgery. The novel framework integrates a Cartesian compliance control strategy to guarantee that the tele-operated surgical tool always goes through the trocar position, and a safety-enhanced null-space collaborative strategy to constrainthe swivel motion in an assumed safe range. Two event-based operative procedures (hands-on motion and teleoperation) are performed in torque level to achieve the whole surgical task. Finally, experimental studies with virtual surgical tasks were conducted to validate the effectiveness of the proposed framework, using the KUKA LWR 4+ robot and Sigma 7 master device. It provided an online flexible and safe collaborative way without degradation of the quality of the surgical task.
Evaluation of ASCE 61-14 NSPs for the estimation of seismic demands in marginal wharves
J. Paul Smith-Pardo,Juan C. Reyes,Juan D. Sandoval,Wael M. Hassan 국제구조공학회 2019 Structural Engineering and Mechanics, An Int'l Jou Vol.69 No.1
The Standard ASCE 61-14 proposes the Substitute Structure Method (SSM) as a Nonlinear Static Procedure (NSP) to estimate nonlinear displacement demands at the center of mass of piers or wharves under seismic actions. To account for bidirectional earthquake excitation according to the Standard, results from independent pushover analyses in each orthogonal direction should be combined using either a 100/30 directional approach or a procedure referred to as the Dynamic Magnification Factor, DMF. The main purpose of this paper is to present an evaluation of these NSPs in relation to four wharf model structures on soil conditions ranging from soft to medium dense clay. Results from nonlinear static analyses were compared against benchmark values of relevant Engineering Design Parameters, EDPs. The latter are defined as the geometric mean demands that are obtained from nonlinear dynamic analyses using a set of 30 two-component ground motion records. It was found that SSM provides close estimates of the benchmark displacement demands at the center of mass of the wharf structures. Furthermore, for the most critical pile connection at a landside corner of the wharf the 100/30 and DMF approaches produced displacement, curvature, and force demands that were reasonably comparable to corresponding benchmark values.
Epigenetic regulation of vitamin D metabolism in human lung adenocarcinoma.
Ramnath, Nithya,Nadal, Ernest,Jeon, Chae Kyung,Sandoval, Juan,Colacino, Justin,Rozek, Laura S,Christensen, Paul J,Esteller, Manel,Beer, David G,Kim, So Hee Lippincott Williams Wilkins 2014 JOURNAL OF THORACIC ONCOLOGY Vol.9 No.4
<P>1α,25-Dihydroxyvitamin D3 (1,25-D3) is antiproliferative in preclinical models of lung cancer, but in tumor tissues, its efficacy may be limited by CYP24A1 expression. CYP24A1 is the rate limiting catabolic enzyme for 1,25-D3 and is overexpressed in human lung adenocarcinoma (AC) by unknown mechanisms.</P>
Luz M. Ramos-Ponce,Mireille Vega,Edith Colunga-Urbina,Georgina C. Sandoval-Fabián,Nagamani Balagurusamy,Juan Carlos Contreras-Esquivel,Francisco J. Rodriguez-Gonzalez 한국식품과학회 2010 Food Science and Biotechnology Vol.19 No.3
A colorimetric method for quantitative measurement of free amino groups of water soluble chitin derivatives is described. The method utilizes genipin as a natural and specific reagent for determining the concentration of free amino groups in samples of water soluble chitin derivatives. The blue color adduct (complex) formed during genipin reaction with free amino groups was measured at about 589 nm and Beer-Lambert’s law obeyed over the concentration range of 50 to 300 mg/L. Parameters of analytical conditions were considered and kept constant during the experimental procedure. Highly acetylated water soluble chitin derivatives can be differentiated from water soluble chitosan using this genipin method. The colorimetric method with genipin was proved to be a rapid and efficient technique to determine the free amino groups in water soluble chitin derivatives. This method can also be applied for the detection of the enzymatic activity of chitindeacetylase.
Screening of Industrial Enzymes for Deproteinization of Shrimp Head for Chitin Recovery
Angel U. Valdez-Peña,Adriana Hernandez-Rivera,Iliana M. De-la-Garza-Rodriguez,Judith D. Espinoza-Perez,Georgina C. Sandoval-Fabian,Nagamani Balagurusamy,Juan Carlos Contreras-Esquivel 한국식품과학회 2010 Food Science and Biotechnology Vol.19 No.2
Food grade proteolytic enzymes were examined for deproteinization of shrimp head. Shrimp head was easily deproteinized by Alcalase® and trypsin at a pH of 8.0. Alcalase was chosen as the most efficient commercial enzyme for deproteinization of shrimp head. Alcalase treatment of shrimp head recorded 61% of weight loss on dry basis and a residual protein of 275 mg/g dried shrimp head. The enzymatically deproteinized shrimp head was later demineralized with lactic acid using microwave radiation at 400W. The combination of enzymatic and physicochemical treatments promoted the chitin recovery from dried shrimp head under eco-friendly conditions.