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Epigenetic regulation of vitamin D metabolism in human lung adenocarcinoma.
Ramnath, Nithya,Nadal, Ernest,Jeon, Chae Kyung,Sandoval, Juan,Colacino, Justin,Rozek, Laura S,Christensen, Paul J,Esteller, Manel,Beer, David G,Kim, So Hee Lippincott Williams Wilkins 2014 JOURNAL OF THORACIC ONCOLOGY Vol.9 No.4
<P>1α,25-Dihydroxyvitamin D3 (1,25-D3) is antiproliferative in preclinical models of lung cancer, but in tumor tissues, its efficacy may be limited by CYP24A1 expression. CYP24A1 is the rate limiting catabolic enzyme for 1,25-D3 and is overexpressed in human lung adenocarcinoma (AC) by unknown mechanisms.</P>
Pablo Mandó,Manglio Rizzo,Constanza Perez de la Puente,Mercedes Maino,Carolina Ponce,Maria Teresa Pombo,Mora Amat,Maria Victoria Costanzo,Adrian Nervo,Jorge Nadal,Veronica Fabiano,Jose Loza,Carlos Mar 한국유방암학회 2017 Journal of breast cancer Vol.20 No.2
Purpose: Several studies have shown that estrogen receptor (ER) and progesterone receptor (PR) expression and human epidermal growth factor receptor 2 (HER2) expression may vary during tumoral progression. We aimed to describe and compare ER, PR, and HER2 expressions in primary breast tumors and synchronic axillary nodal metastases, and evaluate phenotypic correlations between them. Methods: Patients were identified prospectively through surgical procedures between September 2013 and July 2016. The status of ER, PR, HER2, and Ki-67 were pathologically analyzed in breast cancers and axillary nodal metastases; these patients were classified based on the breast cancer phenotypes into five subgroups. Results: Synchronic axillary nodal metastases were observed in 127 patients. In breast cancers and nodal metastases, correlation analyses of ER, PR, and Ki-67 expression showed a statistical dependence and concordance between these samples was unambiguously demonstrated through Bland-Altman plots for each determination. Primary breast tumors were classified as follows: luminal A, 41.6%; luminal B, 40.0%; luminal B/HER2, 9.6%; HER2, 2.4%; triple negative, 6.4%. Alterations in phenotype were observed in 28% of patients. The most frequent phenotypic alteration was from luminal B to A (36.4%). Ten cases (30.3%) showed alterations with therapeutic implications; six gained HER2 overexpression, and four, hormonal receptor (HR) expression. A moderate strength of agreement (Cohen’s κ coefficient, 0.59; 95% confidence interval, 0.48−0.71) was observed. In multivariate analyses, high histologic grade (odds ratio [OR], 2.79; p<0.047) and high Ki-67 expression (OR, 1.05; p<0.037) were independent factors predictive of phenotypic alterations. Conclusion: Strong correlations were observed in HR and Ki-67 expressions between primary breast tumors and axillary nodal metastases, and a moderate concordance was observed in their phenotypical characteristics. Nevertheless, alterations did exist, and one-third of these changes may have therapeutic implications. The nodal metastases of tumors with high grade and high Ki-67 expression may need to be analyzed, to obtain complete therapeutic information.
Uppsala Consensus Statement on Environmental Contaminants and the Global Obesity Epidemic
Lind, Lars,Lind, P. Monica,Lejonklou, Margareta H.,Dunder, Linda,Bergman, Å,ke,Guerrero-Bosagna, Carlos,Lampa, Erik,Lee, Hong Kyu,Legler, Juliette,Nadal, Angel,Pak, Youngmi Kim,Phipps, Richard P. National Institute of Environmental Health Science 2016 Environmental health perspectives Vol.124 No.5
<P>Summary: From the lectures presented at the 2nd International Workshop on Obesity and Environmental Contaminants, which was held in Uppsala, Sweden, on 8–9 October 2015, it became evident that the findings from numerous animal and epidemiological studies are consistent with the hypothesis that environmental contaminants could contribute to the global obesity epidemic. To increase awareness of this important issue among scientists, regulatory agencies, politicians, chemical industry management, and the general public, the authors summarize compelling scientific evidence that supports the hypothesis and discuss actions that could restrict the possible harmful effects of environmental contaminants on obesity.</P>