An Introduction to Metadesign

John Wood 경희대학교 부설 디자인연구원 2010 예술· 디자인학연구 Vol.13 No.1

metadesign must beco-creative, trans-disciplinary, integrated , and self-aware.lmportantly , it must also be language-oriented. Human behaviour is always influenced by previous habits and future desires. These, in turn , are influence by the words we usewhen we make decisions. For example, when they talk about ‘the crisis’ ,why do newspapers always mean the ‘economic crisis’ ,rather than the environmental crisis? This is a worryingsymptom of our current mindset. Mankind is one decade into the 21st century and we are still confused about the difference between 'economy' and 'ecology'. In metadesigning we have invented the term ‘re-Ianguaging’ to describe the creative process that changes how we see the world. For example, the notion of ‘economic growth’ always sounds so much more positive and exciting than ideassuch as ‘conservation’ or ‘sustainability’ . Although societiesmustwork towards what Eva Brundtland (1987) called ‘sustainable development’ we need to design a better term for it. Human beings are muchhappier when they feel they are ‘growing , or expanding things, rather than ‘conserving’ or ‘sustaining’ them. In experiential terms it doesn’t much matter whetherthe ‘growth’ refers to living things, or to numbers on a balance sheet. Instead of seeking ‘sustainability’ metadesigners may prefer to cultivate ‘synergies’ , then synergizethem with other synergies. 'Synergy', by the way, is simply a way to get something for nothing. By combining existing resources in a clever enough way, we will become very busy at creating new abundances without calling upon new resources. Ultimately, this means we will achieve a global ‘synergy-of-synergies’ In more familiar terms, it means we will reduce our levels of consumption without realizing it.

Valaciclovir

( Martin John Wood ) 대한피부과학회 1999 초록집 Vol.37 No.20

A 6-Point TACS Score Predicts In-Hospital Mortality Following Total Anterior Circulation Stroke

Adrian D Wood,Nicholas D Gollop,Joao H Bettencourt-Silva,Allan B Clark,Anthony K Metcalf,Kristian M Bowles,Marcus D Flather,John F Potter,Phyo Kyaw Myinta 대한신경과학회 2016 Journal of Clinical Neurology Vol.12 No.4

Background and Purpose Little is known about the factors associated with in-hospital mortality following total anterior circulation stroke (TACS). We examined the characteristics and comorbidity data for TACS patients in relation to in-hospital mortality with the aim of developing a simple clinical rule for predicting the acute mortality outcome in TACS. Methods A routine data registry of one regional hospital in the UK was analyzed. The sub¬jects were 2,971 stroke patients with TACS (82% ischemic; median age=81 years, interquar¬tile age range=74–86 years) admitted between 1996 and 2012. Uni- and multivariate regres¬sion models were used to estimate in-hospital mortality odds ratios for the study covariates. A 6-point TACS scoring system was developed from regression analyses to predict in-hospi¬tal mortality as the outcome. Results Factors associated with in-hospital mortality of TACS were male sex [adjusted odds ratio (AOR)=1.19], age (AOR=4.96 for ≥85 years vs. <65 years), hemorrhagic subtype (AOR=1.70), nonlateralization (AOR=1.75), prestroke disability (AOR=1.73 for moderate disability vs. no symptoms), and congestive heart failure (CHF) (AOR=1.61). Risk stratifica¬tion using the 6-point TACS Score [T=type (hemorrhage=1 point) and territory (nonlateral¬ization=1 point), A=age (65–84 years=1 point, ≥85 years=2 points), C=CHF (if present=1 point), S=status before stroke (prestroke modified Rankin Scale score of 4 or 5=1 point)] reli-ably predicted a mortality outcome: score=0, 29.4% mortality; score=1, 46.2% mortality [negative predictive value (NPV)=70.6%, positive predictive value (PPV)=46.2%]; score=2, 64.1% mortality (NPV=70.6, PPV=64.1%); score=3, 73.7% mortality (NPV=70.6%, PPV=73.7%); and score=4 or 5, 81.2% mortality (NPV=70.6%, PPV=81.2%). Conclusions We have identified the key determinants of in-hospital mortality following TACS and derived a 6-point TACS Score that can be used to predict the prognosis of particular patients.

Fat location defines sensation.

Oh, Uhtaek,Wood, John N National Academy of Sciences 2009 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.106 No.44

A History of Falls is Associated with a Significant Increase in Acute Mortality in Women after Stroke

Emma J. Foster,Raphae S. Barlas,Adrian D Wood,Joao H. Bettencourt-Silva,Allan B Clark,Anthony K Metcalf,Kristian M Bowles,John F Potter,Phyo K. Myint 대한신경과학회 2017 Journal of Clinical Neurology Vol.13 No.4

Background and Purpose The risks of falls and fractures increase after stroke. Little is known about the prognostic significance of previous falls and fractures after stroke. This study examined whether having a history of either event is associated with poststroke mortality. Methods We analyzed stroke register data collected prospectively between 2003 and 2015. Eight sex-specific models were analyzed, to which the following variables were incrementally added to examine their potential confounding effects: age, type of stroke, Oxfordshire Community Stroke Project classification, previous comorbidities, frailty as indicated by the prestroke modified Rankin Scale score, and acute illness parameters. Logistic regression was applied to investigate in-hospital and 30-day mortality, and Cox proportional-hazards models were applied to investigate longer-term outcomes of mortality. Results In total, 10,477 patients with stroke (86.1% ischemic) were included in the analysis. They were aged 77.7±11.9 years (mean±SD), and 52.2% were women. A history of falls was present in 8.6% of the men (n=430) and 20.2% of the women (n=1,105), while 3.8% (n=189) of the men and 12.9% of the women (n=706) had a history of both falls and fractures. Of the outcomes examined, a history of falls alone was associated with increased in-hospital mortality [odds ratio (OR)=1.33, 95% confidence interval (CI)=1.03–1.71] and 30-day mortality (OR=1.34, 95% CI=1.03–1.73) in women in the fully adjusted models. The Cox proportional-hazards models for longer-term outcomes and the history of falls and fractures combined showed no significant results. Conclusions The history of falls is an important factor for acute stroke mortality in women. A previous history of falls may therefore be an important factor to consider in the short-term stroke prognosis, particularly in women.

A Comparison of Radiographic Alignment between Bilateral and Unilateral Interbody Cages in Patients Undergoing Transforaminal Lumbar Interbody Fusion

Lambrechts Mark James,Heard Jeremy,D’Antonio Nicholas,Bodnar John,Schneider Gregory,Bloom Evan,Canseco Jose,Woods Barrett,Kaye Ian David,Kurd Mark Faisal,Rihn Jeffrey,Hilibrand Alan,Schroeder Gregory 대한척추외과학회 2023 Asian Spine Journal Vol.17 No.4

Study Design: Retrospective cohort study.Purpose: To compare radiographic outcomes between unilateral and bilateral cage placement in transforaminal lumbar interbody fusions (TLIF) and to determine if the rate of fusion at the 1-year postoperative point was different in patients who received bilateral versus unilateral cages.Overview of Literature: There is no clear evidence to dictate whether bilateral or unilateral cages promote superior radiographic or surgical outcomes in TLIF.Methods: Patients >18 years old who underwent primary one- or two-level TLIFs at our institution were identified and propensitymatched in a 3:1 fashion (unilateral:bilateral). Patient demographics, surgical characteristics, and radiographic outcomes, including vertebral endplate obliquity, segmental lordosis, subsidence, and fusion status, were compared between groups.Results: Of the 184 patients included, 46 received bilateral cages. Bilateral cage placement was associated with greater subsidence (1.06±1.25 mm vs. 0.59±1.16 mm, <i>p</i>=0.028) and enhanced restoration of segmental lordosis (5.74°±14.1° vs. −1.57°±10.9°, <i>p</i>=0.002) at the 1-year postoperative point, while unilateral cage placement was associated with an increased correction of endplate obliquity (−2.02°±4.42° vs. 0.24°±2.81°, <i>p</i><0.001). Bilateral cage placement was significantly associated with radiographic fusion on bivariate analysis (89.1% vs. 70.3%, <i>p</i>=0.018) and significantly predicted radiographic fusion on multivariable regression analysis (estimate, 1.35; odds ratio, 3.87; 95% confidence interval, 1.51–12.05; <i>p</i>=0.010).Conclusions: Bilateral interbody cage placement in TLIF procedures was associated with restoration of lumbar lordosis and increased fusion rates. However, endplate obliquity correction was significantly greater for patients who received a unilateral cage.

RET signaling is required for survival and normal function of nonpeptidergic nociceptors.

Golden, Judith P,Hoshi, Masato,Nassar, Mohammed A,Enomoto, Hideki,Wood, John N,Milbrandt, Jeffrey,Gereau, Robert W,Johnson, Eugene M,Jain, Sanjay The Society 2010 The Journal of neuroscience Vol.30 No.11

<P>Small unmyelinated sensory neurons classified as nociceptors are divided into two subpopulations based on phenotypic differences, including expression of neurotrophic factor receptors. Approximately half of unmyelinated nociceptors express the NGF receptor TrkA, and half express the GDNF family ligand (GFL) receptor Ret. The function of NGF/TrkA signaling in the TrkA population of nociceptors has been extensively studied, and NGF/TrkA signaling is a well established mediator of pain. The GFLs are analgesic in models of neuropathic pain emphasizing the importance of understanding the physiological function of GFL/Ret signaling in nociceptors. However, perinatal lethality of Ret-null mice has precluded the study of the physiological role of GFL/Ret signaling in the survival, maintenance, and function of nociceptors in viable mice. We deleted Ret exclusively in nociceptors by crossing nociceptor-specific Na(v)1.8 Cre and Ret conditional mice to produce Ret-Na(v)1.8 conditional knock-out (CKO) mice. Loss of Ret exclusively in nociceptors results in a reduction in nociceptor number and size, indicating that Ret signaling is important for the survival and trophic support of these cells. Ret-Na(v)1.8 CKO mice exhibit reduced epidermal innervation but normal central projections. In addition, Ret-Na(v)1.8 CKO mice have increased sensitivity to cold and increased formalin-induced pain, demonstrating that Ret signaling modulates the function of nociceptors in vivo. Enhanced inflammation-induced pain may be mediated by decreased prostatic acid phosphatase (PAP), as PAP levels are markedly reduced in Ret-Na(v)1.8 CKO mice. The results of this study identify the physiological role of endogenous Ret signaling in the survival and function of nociceptors.</P>

Review of vacuum pump designations using different standards/test methodologies

Andrew CHEW,Richard HORLER,Pete JONES,Peter LAMB,John WOOD 한국진공학회 2016 한국진공학회 학술발표회초록집 Vol.2016 No.8

Development of Macroporous Chitosan Scaffolds for Eyelid Tarsus Tissue Engineering

Michelle T. Sun,Andrea J. O’Connor,Imogen Milne,Dhee Biswas,Robert Casson,John Wood,Dinesh Selva 한국조직공학과 재생의학회 2019 조직공학과 재생의학 Vol.16 No.6

BACKGROUND: Reconstruction of large eyelid defects remains challenging due to the lack of suitable eyelid tarsus tissue substitutes. We aimed to evaluate a novel bioengineered chitosan scaffold for use as an eyelid tarsus substitute. METHODS: Three-dimensional macroporous chitosan hydrogel scaffold were produced via cryogelation with specific biomechanical properties designed to directly match characteristics of native eyelid tarsus tissue. Scaffolds were characterized by confocal microscopy and tensile mechanical testing. To optimise biocompatibility, human eyelid skin fibroblasts were cultured from biopsy-sized samples of fresh eyelid skin. Immunological and gene expression analysis including specific fibroblast-specific markers were used to determine the rate of fibroblast de-differentiation in vitro and characterize cells cultured. Eyelid skin fibroblasts were then cultured over the chitosan scaffolds and the resultant adhesion and growth of cells were characterized using immunocytochemical staining. RESULTS: The chitosan scaffolds were shown to support the attachment and proliferation of NIH 3T3 mouse fibroblasts and human orbital skin fibroblasts in vitro. Our novel bioengineered chitosan scaffold has demonstrated biomechanical compatibility and has the ability to support human eyelid skin fibroblast growth and proliferation. CONCLUSIONS: This bioengineered tissue has the potential to be used as a tarsus substitute during eyelid reconstruction, offering the opportunity to pre-seed the patient’s own cells and represents a truly personalised approach to tissue engineering.

The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons

Cho, Hawon,Yang, Young Duk,Lee, Jesun,Lee, Byeongjoon,Kim, Tahnbee,Jang, Yongwoo,Back, Seung Keun,Na, Heung Sik,Harfe, Brian D,Wang, Fan,Raouf, Ramin,Wood, John N,Oh, Uhtaek Nature Publishing Group, a division of Macmillan P 2012 NATURE NEUROSCIENCE Vol.15 No.7

Nociceptors are a subset of small primary afferent neurons that respond to noxious chemical, thermal and mechanical stimuli. Ion channels in nociceptors respond differently to noxious stimuli and generate electrical signals in different ways. Anoctamin 1 (ANO1 also known as TMEM16A) is a Ca<SUP>2+</SUP>-activated chloride channel that is essential for numerous physiological functions. We found that ANO1 was activated by temperatures over 44 째C with steep heat sensitivity. ANO1 was expressed in small sensory neurons and was highly colocalized with nociceptor markers, which suggests that it may be involved in nociception. Application of heat ramps to dorsal root ganglion (DRG) neurons elicited robust ANO1-dependent depolarization. Furthermore, knockdown or deletion of ANO1 in DRG neurons substantially reduced nociceptive behavior in thermal pain models. These results indicate that ANO1 is a heat sensor that detects nociceptive thermal stimuli in sensory neurons and possibly mediates nociception.